The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
LINE-1 Retrotransposition Activity in Human Genomes
Open accessAbstract
Summary Long Interspersed Element-1 (LINE-1 or L1) sequences comprise the bulk of retrotransposition activity in the human genome; however, the abundance of highly active or ‘hot’ L1s in the human population remains largely unexplored. Here, we used a fosmid-based, paired-end DNA sequencing strategy to identify 68 full-length L1s which are differentially present among individuals but are absent from the human genome reference sequence. The majority of these L1s were highly active in a cultured cell retrotransposition assay. Genotyping 26 elements revealed that two L1s are only found in Africa and that two more are absent from the H952 subset of the Human Genome Diversity Panel. Therefore, these results suggest that ‘hot’ L1s are more abundant in the human population than previously appreciated, and that ongoing L1 retrotransposition continues to be a major source of inter-individual genetic variation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“LINE‐1 possesses high reverse transcriptase activity, which can transcribe mRNA to cDNA in the cytosol.75”
From Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer (2020) · cites this paper as [75]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
MUSCLE: multiple sequence alignment with high accuracy and high throughput
Edgar, R. C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh340 · Cited by 44,662
Kimura, M. (1980) · Journal of Molecular Evolution · doi:10.1007/bf01731581 · Cited by 29,778
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
PHYLIP-Phylogeny inference package (Version 3.2)
Felsenstein, J. (1989) · Cladistics · Cited by 17,682
The sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400
Jalview Version 2—a multiple sequence alignment editor and analysis workbench
Waterhouse, A. M., Procter, J. B., Martin, D. M. A., Clamp, M. E., & Barton, G. J. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp033 · Cited by 10,349
<tt>BLAT</tt> —The <tt>BLAST</tt> -Like Alignment Tool
Kent, W. J. (2002) · Genome Research · doi:10.1101/gr.229202 · Cited by 8,480
A haplotype map of the human genome
The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858
Accurate whole human genome sequencing using reversible terminator chemistry
Bentley, D. R., Balasubramanian, S., Swerdlow, H. P., Smith, G. P., Milton, J., Brown, C. G., Hall, K. P., Evers, D. J., Barnes, C. L., Bignell, H. R., et al. (2008) · Nature · doi:10.1038/nature07517 · Cited by 3,684
Prescribing Personalized Nutrition for Cardiovascular Health: Are We Ready?
Juma, S., Imrhan, V., Vijayagopal, P., & Prasad, C. (2014) · Lifestyle Genomics · doi:10.1159/000370213 · Cited by 1,908
The complete genome of an individual by massively parallel DNA sequencing
Wheeler, D. A., Srinivasan, M., Egholm, M., Shen, Y., Chen, L., McGuire, A., He, W., Chen, Y.-J., Makhijani, V., Roth, G. T., et al. (2008) · Nature · doi:10.1038/nature06884 · Cited by 1,838
The impact of retrotransposons on human genome evolution
Cordaux, R., & Batzer, M. A. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2640 · Cited by 1,692
The Sequence of the Human Genome
Venter, J. C., Smith, H. O., & Adams, M. D. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2014.237016 · Cited by 1,665
Dendroscope: An interactive viewer for large phylogenetic trees
Huson, D. H., Richter, D. C., Rausch, C. R., Dezulian, T., Franz, M., & Rupp, R. (2007) · BMC Bioinformatics · doi:10.1186/1471-2105-8-460 · Cited by 1,240
Paired-End Mapping Reveals Extensive Structural Variation in the Human Genome
Korbel, J. O., Urban, A. E., Affourtit, J. P., Godwin, B., Grubert, F., Simons, J. F., Kim, P. M., Palejev, D., Carriero, N. J., Du, L., et al. (2007) · Science · doi:10.1126/science.1149504 · Cited by 1,163
Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition
Feng, Q., Moran, J. V., Kazazian, H. H., & Boeke, J. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81997-2 · Cited by 1,139
Self-citationMapping and sequencing of structural variation from eight human genomes
Kidd, J. M., Cooper, G. M., Donahue, W. F., Hayden, H. S., Sampas, N., Graves, T., Hansen, N., Teague, B., Alkan, C., Antonacci, F., et al. (2008) · Nature · doi:10.1038/nature06862 · Cited by 1,119
Self-citationHot L1s account for the bulk of retrotransposition in the human population
Brouha, B., Schustak, J., Badge, R. M., Lutz-Prigge, S., Farley, A. H., Moran, J. V., & Kazazian, H. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831042100 · Cited by 1,073
Self-citationLINE-mediated retrotransposition of marked Alu sequences
Dewannieux, M., Esnault, C., & Heidmann, T. (2003) · Nature Genetics · doi:10.1038/ng1223 · Cited by 1,026
High frequency retrotransposition in cultured mammalian cells
Moran, J. V., Holmes, S. E., Naas, T. P., DeBerardinis, R. J., Boeke, J. D., & Kazazian, H. H. (1996) · Cell · doi:10.1016/s0092-8674(00)81998-4 · Cited by 1,022
Self-citationFine-scale structural variation of the human genome
Tüzün, E., Sharp, A. J., Bailey, J. A., Kaul, R., Morrison, V., Pertz, L. M., Haugen, E., Hayden, H. S., Albertson, D. G., Pinkel, D., et al. (2005) · Nature Genetics · doi:10.1038/ng1562 · Cited by 1,000
Self-citationA Human Genome Diversity Cell Line Panel
Cann, H. M., de Toma, C., Cazes, L., Legrand, M.-F., Morel, V., Piouffre, L., Bodmer, J. G., Bodmer, W. F., Bonné, B., Cambon‐Thomsen, A., et al. (2002) · Science · doi:10.1126/science.296.5566.261b · Cited by 997
Self-citationKazazian, H. H., Wong, C., Youssoufian, H., Scott, A. F., Phillips, D. G., & Antonarakis, S. E. (1988) · Nature · doi:10.1038/332164a0 · Cited by 960
The diploid genome sequence of an Asian individual
Wang, J., Wang, W., Li, R., Li, Y., Tian, G., Goodman, L., Fan, W., Zhang, J., Li, J., Zhang, J., et al. (2008) · Nature · doi:10.1038/nature07484 · Cited by 924
Exon Shuffling by L1 Retrotransposition
Moran, J. V., DeBerardinis, R. J., & Kazazian, H. H. (1999) · Science · doi:10.1126/science.283.5407.1530 · Cited by 635
Self-citationNatural mutagenesis of human genomes by endogenous retrotransposons
Iskow, R. C., McCabe, M. T., Mills, R. E., Torene, S., Pittard, W. S., Neuwald, A. F., Van Meir, E. G., Vertino, P. M., & Devine, S. E. (2010) · Cell · doi:10.1016/j.cell.2010.05.020 · Cited by 551
McKernan, K. J., Peckham, H. E., Costa, G. L., McLaughlin, S. F., Fu, Y., Tsung, E. F., Clouser, C. R., Duncan, C., Ichikawa, J. K., Lee, C. C., et al. (2009) · Genome Research · doi:10.1101/gr.091868.109 · Cited by 535
Self-citationDNA repair mediated by endonuclease-independent LINE-1 retrotransposition
Morrish, T. A., Gilbert, N., Myers, J. S., Vincent, B. J., Stamato, T. D., Taccioli, G. E., Batzer, M. A., & Moran, J. V. (2002) · Nature Genetics · doi:10.1038/ng898 · Cited by 488
Self-citationHuman L1 Retrotransposition Is Associated with Genetic Instability In Vivo
Symer, D. E., Connelly, C. J., Szak, S. T., Caputo, E. M., Cost, G. J., Parmigiani, G., & Boeke, J. D. (2002) · Cell · doi:10.1016/s0092-8674(02)00839-5 · Cited by 479
Genomic Deletions Created upon LINE-1 Retrotransposition
Gilbert, N., Lutz-Prigge, S., & Moran, J. V. (2002) · Cell · doi:10.1016/s0092-8674(02)00828-0 · Cited by 474
Self-citationMany human L1 elements are capable of retrotransposition
Sassaman, D. M., Dombroski, B. A., Moran, J. V., Kimberland, M. L., Naas, T., DeBerardinis, R. J., Gabriel, A., Swergold, G. D., & Kazazian, H. H. (1997) · Nature Genetics · doi:10.1038/ng0597-37 · Cited by 452
Self-citationAncestral, Mammalian-wide Subfamilies of LINE-1 Repetitive Sequences
Smit, A. F. A., Tóth, G. J., Riggs, A. D., & Jurka, J. (1995) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.0095 · Cited by 384
Mobile elements create structural variation: Analysis of a complete human genomePreprint
Xing, J., Zhang, Y., Han, K., Salem, A. H., Sen, S. K., Huff, C., Zhou, Q., Kirkness, E. F., Levy, S., Batzer, M. A., et al. (2009) · Genome Research · doi:10.1101/gr.091827.109 · Cited by 326
Master genes in mammalian repetitive DNA amplification
Deininger, P. L., Batzer, M. A., Hutchison, C. A., & Edgell, M. H. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90262-3 · Cited by 316
L1 (LINE-1) Retrotransposon Evolution and Amplification in Recent Human History
Boissinot, S., Chevret, P., & Furano, A. V. (2000) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a026372 · Cited by 312
Unit-Length Line-1 Transcripts in Human Teratocarcinoma Cells
Skowroński, J., Fanning, T. G., & Singer, M. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.4.1385 · Cited by 301
Multiple Fates of L1 Retrotransposition Intermediates in Cultured Human Cells
Gilbert, N., Lutz, S., Morrish, T. A., & Moran, J. V. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7780-7795.2005 · Cited by 293
Self-citationFrequent Human Genomic DNA Transduction Driven by LINE-1 RetrotranspositionPreprint
Pickeral, O. K., Makałowski, W., Boguski, M. S., & Boeke, J. D. (2000) · Genome Research · doi:10.1101/gr.10.4.411 · Cited by 279
Transduction of 3'-flanking sequences is common in L1 retrotransposition
Goodier, J. L. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.4.653 · Cited by 276
Active Alu retrotransposons in the human genomePreprint
Bennett, E. A., Keller, H., Mills, R. E., Schmidt, S., Moran, J. V., Weichenrieder, O., & Devine, S. E. (2008) · Genome Research · doi:10.1101/gr.081737.108 · Cited by 274
Self-citationRosenberg, N. A. (2006) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2006.00285.x · Cited by 261
Mobile Interspersed Repeats Are Major Structural Variants in the Human Genome
Huang, C. R. L., Schneider, A. M., Lu, Y., Niranjan, T., Shen, P., Robinson, M. A., Steranka, J. P., Valle, D. L., Civin, C. I., Wang, T., et al. (2010) · Cell · doi:10.1016/j.cell.2010.05.026 · Cited by 260
Cost, G. J., & Boeke, J. D. (1998) · Biochemistry · doi:10.1021/bi981858s · Cited by 242
Holmes, S. E., Dombroski, B. A., Krebs, C. M., Boehm, C. D., & Kazazian, H. H. (1994) · Nature Genetics · doi:10.1038/ng0694-143 · Cited by 237
Progress in understanding the biology of the human mutagen LINE-1
Babushok, D. V., & Kazazian, H. H. (2007) · Human Mutation · doi:10.1002/humu.20486 · Cited by 213
dbRIP: A highly integrated database of retrotransposon insertion polymorphisms in humans
Wang, J., Song, L., Grover, D., Azrak, S., Batzer, M. A., & Liang, P. (2006) · Human Mutation · doi:10.1002/humu.20307 · Cited by 206
A YY1-binding site is required for accurate human LINE-1 transcription initiation
Athanikar, J. N. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh698 · Cited by 200
Unconventional translation of mammalian LINE-1 retrotransposonsPreprint
Alisch, R. S., Garcia-Perez, J. L., Muotri, A. R., Gage, F. H., & Moran, J. V. (2006) · Genes & Development · doi:10.1101/gad.1380406 · Cited by 186
Self-citationRibonucleoprotein particle formation is necessary but not sufficient for LINE-1 retrotransposition
Kulpa, D. A., & Moran, J. V. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi354 · Cited by 181
Self-citationEndonuclease-independent LINE-1 retrotransposition at mammalian telomeres
Morrish, T. A., Garcia-Perez, J. L., Stamato, T. D., Taccioli, G. E., Sekiguchi, J., & Moran, J. V. (2007) · Nature · doi:10.1038/nature05560 · Cited by 178
Self-citationKimberland, M. L., Divoký, V., Prchal, J. T., Schwahn, U., Berger, W., & Kazazian, H. H. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.8.1557 · Cited by 173
Carroll, M. L., Roy‐Engel, A. M., Nguyen, S. V., Salem, A. H., Vogel, E., Vincent, B. J., Myers, J. S., Ahmad, Z., Nguyen, L., Sammarco, M. C., et al. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4847 · Cited by 168
Natural Genetic Variation Caused by Transposable Elements in Humans
Bennett, E. A., Coleman, L. E., Tsui, C. W., Pittard, W. S., & Devine, S. E. (2004) · Genetics · doi:10.1534/genetics.104.031757 · Cited by 168
A Comprehensive Analysis of Recently Integrated Human Ta L1 Elements
Myers, J. S., Vincent, B. J., Udall, H., Watkins, W. S., Morrish, T. A., Kilroy, G. E., Swergold, G. D., Henke, J., Henke, L., Moran, J. V., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/341718 · Cited by 158
Self-citationReading between the LINEs: Human Genomic Variation Induced by LINE-1 RetrotranspositionPreprint
Sheen, F.-M., Sherry, S. T., Risch, G., Robichaux, M. B., Nasidze, I. S., Stoneking, M., Batzer, M. A., & Swergold, G. D. (2000) · Genome Research · doi:10.1101/gr.149400 · Cited by 141
Genomic Characterization of Recent Human LINE-1 Insertions: Evidence Supporting Random InsertionPreprint
Ovchinnikov, I. V., Troxel, A. B., & Swergold, G. D. (2001) · Genome Research · doi:10.1101/gr.194701 · Cited by 125
Evidence consistent with human L1 retrotransposition in maternal meiosis I
Brouha, B., Meischl, C., Ostertag, E., de Boer, M., Zhang, Y., Neijens, H., Roos, D., & Kazazian, H. H. (2002) · The American Journal of Human Genetics · doi:10.1086/341722 · Cited by 122
Adaptive Evolution in LINE-1 Retrotransposons
Boissinot, S., & Furano, A. V. (2001) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a003765 · Cited by 122
Garcia-Perez, J. L., Doucet, A. J., Bucheton, A., Moran, J. V., & Gilbert, N. (2007) · Genome Research · doi:10.1101/gr.5870107 · Cited by 121
Self-citationDombroski, B. A., Scott, A. F., & Kazazian, H. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6513 · Cited by 119
Retrotransposition of Alu elements: how many sources?
Cordaux, R., Hedges, D. J., & Batzer, M. A. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.07.012 · Cited by 116
Lavie, L., Maldener, E., Brouha, B., Meese, E. U., & Mayer, J. M. (2004) · Genome Research · doi:10.1101/gr.2745804 · Cited by 113
The Insertional History of an Active Family of L1 Retrotransposons in HumansPreprint
Boissinot, S., Entezam, A., Young, L., Munson, P. J., & Furano, A. V. (2004) · Genome Research · doi:10.1101/gr.2326704 · Cited by 111
L1Base: from functional annotation to prediction of active LINE-1 elements
Penzkofer, T. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki044 · Cited by 108
Wei, W., Morrish, T. A., Alisch, R. S., & Moran, J. V. (2000) · Analytical Biochemistry · doi:10.1006/abio.2000.4675 · Cited by 105
Self-citationATLAS: A System to Selectively Identify Human-Specific L1 Insertions
Badge, R. M., Alisch, R. S., & Moran, J. V. (2003) · The American Journal of Human Genetics · doi:10.1086/373939 · Cited by 105
Self-citationSeleme, M. D. C., Vetter, M. R., Cordaux, R., Bastone, L. A., Batzer, M. A., & Kazazian, H. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601324103 · Cited by 104
Frikke-Schmidt, R. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.06.005 · Cited by 94
Crystal Structure of the Targeting Endonuclease of the Human LINE-1 Retrotransposon
Weichenrieder, O., Repanas, K., & Anastassis Perrakis, A. (2004) · Structure · doi:10.1016/j.str.2004.04.011 · Cited by 84
Under the genomic radar: The Stealth model of Alu amplificationPreprint
Han, K., Xing, J., Wang, H., Hedges, D. J., Garber, R. K., Cordaux, R., & Batzer, M. A. (2005) · Genome Research · doi:10.1101/gr.3492605 · Cited by 82
A modified indicator gene for selection of retrotransposition events in mammalian cells.
Freeman, J., Goodchild, N. L., & Mager, D. L. (1994) · PubMed · Cited by 67
Grimaldi, G., & Singer, M. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.2.321 · Cited by 66
Allelic Heterogeneity in LINE-1 Retrotransposition Activity
Lutz, S., Vincent, B. J., Kazazian, H. H., Batzer, M. A., & Moran, J. V. (2003) · The American Journal of Human Genetics · doi:10.1086/379744 · Cited by 63
Self-citationThe Unusual Phylogenetic Distribution of Retrotransposons: A HypothesisPreprint
Boeke, J. D. (2003) · Genome Research · doi:10.1101/gr.1392003 · Cited by 60
Phylemon: a suite of web tools for molecular evolution, phylogenetics and phylogenomics
Tárraga, J., Medina, I., Arbiza, L., Huerta‐Cepas, J., Gabaldón, T., Dopazo, J., & Dopazo, H. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm224 · Cited by 50
Estimating the age of retrotransposon subfamilies using maximum likelihood
Blue, E., Xing, J., Witherspoon, D. J., Jorde, L. B., & Rogers, A. R. (2009) · Genomics · doi:10.1016/j.ygeno.2009.04.002 · Cited by 13
Fosmid Libraries for Genomic Structural Variation Detection
Donahue, W. F., & Ebling, H. M. (2007) · Current Protocols in Human Genetics · doi:10.1002/0471142905.hg0520s54 · Cited by 9
Flagged first, then by citations
Cited by
Sorted by citations
Ten things you should know about transposable elements
Bourque, G., Burns, K. H., Gehring, M., Gorbunova, V., Seluanov, A., Hammell, M., Imbeault, M., Izsvák, Z., Levin, H. L., Macfarlan, T. S., et al. (2018) · Genome Biology · doi:10.1186/s13059-018-1577-z · Cited by 1,430
Advances in understanding cancer genomes through second-generation sequencing
Meyerson, M. M., Gabriel, S., & Getz, G. A. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2841 · Cited by 1,142
Landscape of Somatic Retrotransposition in Human Cancers
Lee, E., Iskow, R., Yang, L., Gokcumen, O., Haseley, P., Luquette, L. J., Lohr, J. G., Harris, C. C., Ding, L., Wilson, R. K., et al. (2012) · Science · doi:10.1126/science.1222077 · Cited by 762
Jin, Y., Tam, O. H., Paniagua, E., & Hammell, M. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv422 · Cited by 753
Haplotype-resolved diverse human genomes and integrated analysis of structural variation
Ebert, P., Audano, P. A., Zhu, Q., Rodriguez-Martin, B., Porubsky, D., Bonder, M. J., Sulovari, A., Ebler, J., Zhou, W., Serra Mari, R., et al. (2021) · Science · doi:10.1126/science.abf7117 · Cited by 702
Self-citation
Metadata
- Authors
- Beck, C. R., Collier, P., Macfarlane, C., Malig, M., Kidd, J. M., Eichler, E. E., Badge, R. M., & Moran, J. V.
- Affiliations
- University of Michigan (US)
- University of Leicester (GB)
- University of Washington (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Beck, Christine R.
- Moran, John V.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 141
- Issue
- 7
- Pages
- 1159-1170
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3013285
- OpenAlex
- W2035120673
- Semantic Scholar
- 67ee6ac6542db4f561b8ca3111a1b988d0d18f4a
- Cited by
- 632
- References
- 81
- Citations by year
- 2026: 39 · 2025: 40 · 2024: 19 · 2023: 37 · 2022: 44 · 2021: 43 · 2020: 38 · 2019: 43 · 2018: 32 · 2017: 49 · 2016: 36 · 2015: 39 · 2014: 30 · 2013: 42 · 2012: 32
- FWCI
- 54.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Funders
- National Science Foundation
- Howard Hughes Medical Institute
- Wellcome Trust (075163)
- National Institutes of Health
- National Human Genome Research Institute (P01HG004120, HG004120, T32HG000040)
- National Cancer Institute (5P30 CA 46592, P30CA046592)
- National Institute of General Medical Sciences (T32GM7544, T32GM007544, R01GM082970, GM060518, GM066695, R01GM060518, R01GM066695)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Keywords
- LINE-1 retrotransposition, long interspersed element-1, human genome
- MeSH terms
- Base Sequence, Gene Frequency, Genetics, Population, Humans, Molecular Sequence Data, Phylogeny, Genome, Human, Long Interspersed Nucleotide Elements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
