The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism
Open accessAbstract
The broad expression of the insulin receptor suggests that the spectrum of insulin function has not been fully described. A cell type expressing this receptor is the osteoblast, a bone-specific cell favoring glucose metabolism through a hormone, osteocalcin, that becomes active once uncarboxylated. We show here that insulin signaling in osteoblasts is necessary for whole-body glucose homeostasis because it increases osteocalcin activity. To achieve this function insulin signaling in osteoblasts takes advantage of the regulation of osteoclastic bone resorption exerted by osteoblasts. Indeed, since bone resorption occurs at a pH acidic enough to decarboxylate proteins, osteoclasts determine the carboxylation status and function of osteocalcin. Accordingly, increasing or decreasing insulin signaling in osteoblasts promotes or hampers glucose metabolism in a bone resorption-dependent manner in mice and humans. Hence, in a feed-forward loop, insulin signals in osteoblasts activate a hormone, osteocalcin, that promotes glucose metabolism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“OCN promoted the survival and function of pancreatic β-cells and increased insulin secretion [209], while insulin itself induced the release of OCN [210].”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [210]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Moreover, IL-6 increases production of OCN by osteoblasts [71] (2c), which itself stimulates transient pancreatic secretion of the anorexic hormone insulin and triggers a positive feed-forward mechanism that results in increased OCN and thus more insulin [28,209,210] (2d).”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [210]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cell Signaling by Receptor Tyrosine Kinases
Lemmon, M. A., & Schlessinger, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.011 · Cited by 7,929
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,344
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Self-citationCell Signaling by Receptor Tyrosine Kinases
Schlessinger, J. (2000) · Cell · doi:10.1016/s0092-8674(00)00114-8 · Cited by 3,774
Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · Cited by 3,258
Endocrine regulation of energy metabolism by the skeleton
Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.047 · Cited by 2,554
Self-citationIncreased bone formation in osteocalcin-deficient mice
Ducy, P. F., Morris, C., Boyce, B. F., Pinero, G. J., Story, B. M., Dunstan, C. R., Smith, E. A., Bonadio, J. F., Goldstein, S. A., Gundberg, C. M., et al. (1996) · Nature · doi:10.1038/382448a0 · Cited by 1,724
Genetic regulation of osteoclast development and function
Teitelbaum, S. L., & Ross, F. P. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1122 · Cited by 1,720
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., et al. (2003) · Nature · doi:10.1038/nature01667 · Cited by 1,487
Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296
Research works printed but not linked: 1
- Ferron, M., Hinoi, E., Karsenty, G., and Ducy, P. (2008). Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc. Natl. Acad. Sci. USA 105, 5266–5270. · DOI · Paper page
Cited by
Sorted by citations
Items 201–300 of 999
Błaszczyk, J. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010543 · Cited by 74
Mechanism and physical activities in bone-skeletal muscle crosstalk
Zhao, Z., Yan, K., Guan, Q., Guo, Q., & Zhao, C. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1287972 · Cited by 75
Dienelt, A., & Nieden, N. I. Z. (2010) · Stem Cells and Development · doi:10.1089/scd.2010.0205 · Cited by 91
Shimazu, J., Wei, J., & Karsenty, G. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.003 · Cited by 69
Incidence of Fractures in Patients With Type 2 Diabetes in the SAVOR-TIMI 53 Trial
Mosenzon, O., Wei, C., Davidson, J. A., Scirica, B. M., Yanuv, I., Rozenberg, A., Hirshberg, B., Cahn, A., Stahre, C., Strojek, K., et al. (2015) · Diabetes Care · doi:10.2337/dc15-1068 · Cited by 69
The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled
Rowe, P. S. (2012) · Cell Biochemistry and Function · doi:10.1002/cbf.2841 · Cited by 72
Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues
Pi, M., Kapoor, K., Wu, Y., Ye, R.-S., Senogles, S. E., Nishimoto, S. K., Hwang, D., Miller, D. D., Narayanan, R., Smith, J. C., et al. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1161 · Cited by 65
Altered thermogenesis and impaired bone remodeling in Misty mice
Motyl, K. J., Bishop, K. A., DeMambro, V., Bornstein, S. A., Le, P. T., Kawai, M., Lotinun, S., Horowitz, M. C., Baron, R., Bouxsein, M., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1943 · Cited by 66
Mandatori, D., Pelusi, L., Schiavone, V., Pipino, C., Pietro, N. D., & Pandolfi, A. (2021) · Nutrients · doi:10.3390/nu13041222 · Cited by 66
Novel insights into the coupling of osteoclasts and resorption to bone formation
Durdan, M., Azaria, R. D., & Weivoda, M. M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.10.008 · Cited by 69
Minireview: The Link Between Fat and Bone: Does Mass Beget Mass?
Zaidi, M., Buettner, C., Sun, L., & Iqbal, J. Z. (2012) · Endocrinology · doi:10.1210/en.2012-1022 · Cited by 65
Regulation of Glucose Handling by the Skeleton: Insights From Mouse and Human Studies
Liu, J., Rosen, C. J., Ducy, P. F., Kousteni, S., & Karsenty, G. (2016) · Diabetes · doi:10.2337/db16-0053 · Cited by 65
Ezekiel, I., Kasim, S. R., Ismail, Y. M. B., & Noor, A. F. M. (2018) · Ceramics International · doi:10.1016/j.ceramint.2018.04.128 · Cited by 65
Maddaloni, E., D’Onofrio, L., Lauria, A., Maurizi, A. R., Strollo, R., Palermo, A., Napoli, N., Angeletti, S., Pozzilli, P., & Manfrini, S. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0092-7 · Cited by 65
Rendina-Ruedy, E., Hembree, K. D., Sasaki, A., Davis, M. R., Lightfoot, S. A., Clarke, S. L., Lucas, E. A., & Smith, B. J. (2015) · Journal of Nutrition and Metabolism · doi:10.1155/2015/758080 · Cited by 64
Lin, Y., Chen, C., Chuang, T. Y., Lin, Y., Liu, H. Y., Mersmann, H. J., Wu, S., & Ding, S. (2014) · Bone · doi:10.1016/j.bone.2014.03.051 · Cited by 66
The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin
Chen, S., Synowsky, S. A., Tinti, M., & MacKintosh, C. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.07.005 · Cited by 64
Guedes, J. A. C., Esteves, J. V. D. C., Morais, M., Zorn, T. M. T., & Furuya, D. T. (2017) · Bone · doi:10.1016/j.bone.2017.11.020 · Cited by 65
Effects of Physiological Variations in Circulating Insulin Levels on Bone Turnover in Humans
Basu, R., Peterson, J. M., Rizza, R. A., & Khosla, S. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2877 · Cited by 63
A crosstalk between bone and gonads
Oury, F. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06360.x · Cited by 66
Lifestyle-Related Metabolic Disorders, Osteoporosis, and Fracture Risk in Asia: A Systematic Review
Sugimoto, T., Sato, M., Dehle, F. C., Brnabic, A. J. M., Weston, A. R., & Burge, R. T. (2015) · Value in Health Regional Issues · doi:10.1016/j.vhri.2015.09.005 · Cited by 63
London, G. M. (2012) · Journal of Nephrology · doi:10.5301/jn.5000187 · Cited by 61
Abdallah, B. M., Ditzel, N., Laborda, J., Karsenty, G., & Kassem, M. S. (2015) · Diabetes · doi:10.2337/db14-1642 · Cited by 63
Potential Role for Osteocalcin in the Development of Atherosclerosis and Blood Vessel Disease
Tacey, A., Qaradakhi, T., Brennan‐Speranza, T. C., Hayes, A., Zulli, A., & Levinger, I. (2018) · Nutrients · doi:10.3390/nu10101426 · Cited by 64
Olleros, C. R., & Díaz Curiel, M. (2019) · Journal of Osteoporosis · doi:10.1155/2019/2069176 · Cited by 61
Dai, Z., Butler, L. M., van Dam, R. M., Ang, L. W., Yuan, J., & Koh, W. (2014) · Journal of Nutrition · doi:10.3945/jn.113.187955 · Cited by 61
Regulation of glucose metabolism and the skeleton
Ng, K. W. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04133.x · Cited by 58
Endogenous Glucocorticoids and Bone
Zhou, H., Cooper, M. S., & Seibel, M. J. (2013) · Bone Research · doi:10.4248/br201302001 · Cited by 63
Osteocalcin, energy and glucose metabolism
Zanatta, L. C. B., Boguszewski, C. L., Borba, V. Z. C., & Kulak, C. A. M. (2014) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/0004-2730000003333 · Cited by 61
HDAC4 integrates PTH and sympathetic signaling in osteoblasts
Obri, A., Makinistoglu, M. P., Zhang, H., & Karsenty, G. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201403138 · Cited by 60
Şeref-Ferlengez, Z., Maung, S., Schaffler, M. B., Spray, D. C., Suadicani, S. O., & Thi, M. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155107 · Cited by 60
Isolation and Culture of Neonatal Mouse Calvarial Osteoblasts
Jonason, J. H., & O’Keefe, R. J. (2014) · Methods in molecular biology · doi:10.1007/978-1-62703-989-5_22 · Cited by 60
Brain to bone: What is the contribution of the brain to skeletal homeostasis?
Idelevich, A., & Baron, R. (2018) · Bone · doi:10.1016/j.bone.2018.05.018 · Cited by 62
Diabetes Mellitus-induced Bone Fragility
Kanazawa, I., & Sugimoto, T. (2018) · Internal Medicine · doi:10.2169/internalmedicine.0905-18 · Cited by 64
Bone Control of Muscle Function
Battafarano, G., Rossi, M., Marampon, F., Minisola, S., & Fattore, A. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041178 · Cited by 64
Figeac, F., Tencerová, M., Ali, D., Andersen, T. L., Appadoo, D. R. C., Kerckhofs, G., Ditzel, N., Kowal, J. M., Rauch, A., & Kassem, M. S. (2022) · Stem Cells · doi:10.1093/stmcls/sxab011 · Cited by 63
Regulation of Skeletal Development and Maintenance by Runx2 and Sp7
Komori, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810102 · Cited by 67
Detection of hydroxyapatite in calcified cardiovascular tissues
Lee, J. S., Morrisett, J. D., & Tung, C. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.07.023 · Cited by 58
Leukemia inhibitory factor: A paracrine mediator of bone metabolism
Sims, N. A., & Johnson, R. W. (2012) · Growth Factors · doi:10.3109/08977194.2012.656760 · Cited by 66
Insulin and osteocalcin: further evidence for a mutual cross-talk
Bilotta, F. L., Arcidiacono, B., Messineo, S., Greco, M., CHIEFARI, E. D., Britti, D., Nakanishi, T., FOTI, D. P., & Brunetti, A. (2017) · Endocrine · doi:10.1007/s12020-017-1396-0 · Cited by 59
Kang, H., Viollet, B., & Wu, D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.430389 · Cited by 60
Zhou, B., Li, H., Liu, J., Xu, L., Zang, W., Wu, S., & Sun, H. (2013) · Cell Cycle · doi:10.4161/cc.24929 · Cited by 58
Jiang, S., Cheng, H. W., Cui, L., Zhou, Z., & Hou, J. (2013) · Poultry Science · doi:10.3382/ps.2012-02800 · Cited by 59
The Potential Influence of Bone-Derived Modulators on the Progression of Alzheimer’s Disease
Yuan, J., Meloni, B. P., Shi, T., Bonser, A. M., Papadimitriou, J. M., Mastaglia, F. L., Zhang, C., Zheng, M., & Gao, J. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181249 · Cited by 58
Bone-organ axes: bidirectional crosstalk
Deng, A.-F., Wang, F., Wang, S., Zhang, Y., Bai, L., & Su, J. (2024) · Military Medical Research · doi:10.1186/s40779-024-00540-9 · Cited by 62
Li, R., Xu, W., Luo, S., Xu, H., Tong, G., Zeng, L., Zhu, D., & Weng, J. (2015) · Acta Diabetologica · doi:10.1007/s00592-015-0792-2 · Cited by 57
Systems Genetic Analysis of Osteoblast-Lineage Cells
Calabrese, G. M., Bennett, B. J., Orozco, L. D., Kang, H. M., Eskin, E., Dombret, C., Backer, O. D., Lusis, A. J., & Farber, C. R. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003150 · Cited by 59
Polgreen, L. E., Jacobs, D. R., Nathan, B. M., Steinberger, J., Moran, A., & Sinaiko, A. R. (2012) · Obesity · doi:10.1038/oby.2012.108 · Cited by 57
Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis
Riddle, R. C., Frey, J. L., Tomlinson, R. E., Ferron, M., Li, Y., DiGirolamo, D. J., Monier‐Faugere, M., Hussain, M. A., Karsenty, G., & Clemens, T. L. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00075-14 · Cited by 57
Capulli, M., Ponzetti, M., Maurizi, A., Piperni, S. G., Berger, T., Mak, T. W., Teti, A. M., & Rucci, N. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3406 · Cited by 57
The translational regulator FMRP controls lipid and glucose metabolism in mice and humans
Leboucher, A., Pisani, D. F., Martinez-Gili, L., Chilloux, J., Bermudez-Martin, P., Van Dijck, A., Ganief, T., Macek, B., Becker, J. A. J., Le Merrer, J., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.01.002 · Cited by 56
Association between obesity, metabolic risks and serum osteocalcin level in postmenopausal women
Lee, S. W., Jo, H. H., Kim, M. R., You, Y. O., & Kim, J. H. (2011) · Gynecological Endocrinology · doi:10.3109/09513590.2011.633660 · Cited by 55
Sapkota, B. R., Hopkins, R., Bjonnes, A., Ralhan, S. K., Wander, G. S., Mehra, N. K., Singh, J. R., Blackett, P. R., Saxena, R., & Sanghera, D. K. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.12.014 · Cited by 56
Local delivery of insulin/IGF-1 for bone regeneration: carriers, strategies, and effects
Zhang, X., Xing, H., Feng, Q., Liu, H., Gao, L., & Wang, X. (2020) · Nanotheranostics · doi:10.7150/ntno.46408 · Cited by 60
Vitamin K and cardiovascular complications in chronic kidney disease patients
Kaesler, N., Schurgers, L. J., & Floege, J. (2021) · Kidney International · doi:10.1016/j.kint.2021.06.037 · Cited by 55
Guo, S. (2013) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2013.06.003 · Cited by 56
Kim, K. J., Kim, K. M., Park, K. H., Choi, H. S., Rhee, Y., Lee, Y., Soo, B., Kim, M., Oh, S. M., Brown, J. K., et al. (2012) · Calcified Tissue International · doi:10.1007/s00223-012-9642-1 · Cited by 55
Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin
Shao, J., Wang, Z., Yang, T., Ying, H., Zhang, Y., & Liu, S. (2015) · International Journal of Endocrinology · doi:10.1155/2015/967673 · Cited by 56
Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes via activation of p300
Otani, T., Matsuda, M., Mizokami, A., Kitagawa, N., Takeuchi, H., Jimi, E., Inai, T., & Hirata, M. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1257-7 · Cited by 55
Glucose Metabolism in Osteoblasts in Healthy and Pathophysiological Conditions
Donat, A., Knapstein, P.-R., Jiang, S., Baranowsky, A., Ballhause, T.-M., Frosch, K.-H., & Keller, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084120 · Cited by 53
Knapen, M. H. J., Schurgers, L. J., Shearer, M. J., Newman, P., Theuwissen, E., & Vermeer, C. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451100626x · Cited by 54
Ben‐Porat, T., Elazary, R., Dagan, S. S., Goldenshluger, A., Brodie, R., Mintz, Y., & Weiss, R. (2018) · Advances in Nutrition · doi:10.1093/advances/nmx024 · Cited by 54
Al-Suhaimi, E. A., & Aljafary, M. A. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09517-9 · Cited by 56
Shahen, V. A., Gerbaix, M., Koeppenkastrop, S., Lim, S. F., McFarlane, K., Nguyen, A. N. L., Peng, X. Y., Weiss, N. B., & Brennan‐Speranza, T. C. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.04.001 · Cited by 53
AOYAMA, E., Watari, I., Podyma‐Inoue, K. A., Yanagishita, M., & Ono, T. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1787 · Cited by 53
Kuang, X., Liu, C., Guo, X., Li, K., Deng, Q., & Li, D. (2020) · Food & Function · doi:10.1039/c9fo03063h · Cited by 51
Nowicki, J. K., & Jakubowska‐Pietkiewicz, E. (2024) · Endocrinology and Metabolism · doi:10.3803/enm.2023.1895 · Cited by 53
Lu, C., Ivaska, K. K., Alén, M., Wang, Q., Törmäkangas, T., Xu, L., Wiklund, P., Mikkola, T. M., Pekkala, S., Tian, H., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2045 · Cited by 49
The “love–hate” relationship between osteoclasts and bone matrix
Rucci, N., & Teti, A. M. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.02.009 · Cited by 52
Quantification of Bone Fatty Acid Metabolism and Its Regulation by Adipocyte Lipoprotein Lipase
Bartelt, A., Koehne, T., Tödter, K., Reimer, R., Müller, B., Behler-Janbeck, F., Heeren, J., Scheja, L., & Niemeier, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061264 · Cited by 54
Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes
Thrailkill, K. M., Jo, C.-H., Cockrell, G. E., Moreau, C. S., Lumpkin, C. K., & Fowlkes, J. L. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1807-7 · Cited by 50
Motyl, K. J., Guntur, A. R., Carvalho, A., & Rosen, C. J. (2017) · Toxicologic Pathology · doi:10.1177/0192623317737065 · Cited by 55
Karimifard, M., Aminorroaya, A., Kachuei, A., Salamat, M. R., Alijanvand, M. H., Yamini, S. A., Karimifar, M., Feizi, A., & Amini, M. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12944 · Cited by 48
Alves, R. D. A. M., Demmers, J., Bezstarosti, K., van der Eerden, B. C. J., Verhaar, J. A. N., Eijken, M., & van Leeuwen, J. P. T. M. (2011) · Journal of Proteome Research · doi:10.1021/pr200522n · Cited by 49
Osteocalcin: a pivotal mediator or an innocent bystander in energy metabolism?
Razzaque, M. S. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq721 · Cited by 48
Bözec, A., Bakiri, L., Jiménez, M., Rosen, E. D., Catalá-Lehnen, P., Schinke, T., Schett, G. A., Amling, M., & Wagner, E. F. (2013) · Journal of Cell Science · doi:10.1242/jcs.134510 · Cited by 48
Elevated Fra-1 expression causes severe lipodystrophy
Luther, J., Drießler, F., Megges, M., Heß, A., Herbort, B., Mandic, V., Zaiss, M. M., Reichardt, A., Zech, C., Tuckermann, J. P., et al. (2011) · Journal of Cell Science · doi:10.1242/jcs.079855 · Cited by 47
Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A
Toni, L. D., Guidolin, D., Filippis, V. D., Tescari, S., Strapazzon, G., Rocca, M. S., Ferlin, A., Plebani, M., & Foresta, C. (2016) · Endocrinology · doi:10.1210/en.2016-1312 · Cited by 49
Negative impact of polycystic ovary syndrome on bone health: a systematic review and meta-analysis
Piovezan, J. M., Premaor, M. O., & Comim, F. V. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz020 · Cited by 49
Energy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights
Lecka‐Czernik, B., & Rosen, C. J. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2574 · Cited by 48
Paglia, D. N., Wey, A. J., Breitbart, E. A., Faiwiszewski, J., Mehta, S. K., Al‐Zube, L., Vaidya, S., Cottrell, J. A., Graves, D. T., Benevenia, J., et al. (2012) · Journal of Orthopaedic Research® · doi:10.1002/jor.22288 · Cited by 48
Promotion of insulin-induced glucose uptake in C2C12 myotubes by osteocalcin
Tsuka, S., Aonuma, F., Higashi, S., Ohsumi, T., Nagano, K., Mizokami, A., Kawakubo‐Yasukochi, T., Masaki, C., Hosokawa, R., Hirata, M., et al. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.123 · Cited by 48
Bone and the regulation of global energy balance
Zhang, Q., Riddle, R. C., & Clemens, T. L. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12348 · Cited by 48
Loss of Insulin Receptor in Osteoprogenitor Cells Impairs Structural Strength of Bone
Thrailkill, K. M., Bunn, R. C., Lumpkin, C. K., Wahl, E. C., Cockrell, G. E., Morris, L. M., Kahn, C. R., Fowlkes, J. L., & Nyman, J. S. (2014) · Journal of Diabetes Research · doi:10.1155/2014/703589 · Cited by 48
Efficacy of Osteoporosis Therapies in Diabetic Patients
Schwartz, A. V. (2016) · Calcified Tissue International · doi:10.1007/s00223-016-0177-8 · Cited by 49
Modulation of cognition and anxiety-like behavior by bone remodeling
Khrimian, L., Obri, A., & Karsenty, G. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.10.001 · Cited by 48
Insulin Signaling in Bone Marrow Adipocytes
Tencerová, M., Okla, M., & Kassem, M. S. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00552-8 · Cited by 48
Kapustin, A. N., & Shanahan, C. M. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.233601 · Cited by 48
Bone and fat: A relationship of different shades
Lecka‐Czernik, B., & Stechschulte, L. A. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.06.010 · Cited by 48
The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo
Levinger, I., Xu, L., ZHANG, X., Brennan‐Speranza, T. C., Volpato, B. H., Hayes, A., Jerums, G., Seeman, E., & McConell, G. K. (2015) · Osteoporosis International · doi:10.1007/s00198-015-3273-0 · Cited by 48
Skeletal energy homeostasis: a paradigm of endocrine discovery
Suchacki, K. J., Roberts, F. L., Lovdel, A., Farquharson, C., Morton, N. M., MacRae, V. E., & Cawthorn, W. P. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0147 · Cited by 46
Differential effects of high-fat diet and exercise training on bone and energy metabolism
Picke, A., Sylow, L., Møller, L. L. V., Kjøbsted, R., Schmidt, F. N., Steejn, M. W., Salbach‐Hirsch, J., Hofbauer, C., Blüher, M., Saalbach, A., et al. (2018) · Bone · doi:10.1016/j.bone.2018.07.015 · Cited by 48
Cachexia, a Systemic Disease beyond Muscle Atrophy
Wyart, E., Bindels, L. B., Mina, E., Menga, A., Stanga, S., & Porporato, P. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228592 · Cited by 51
Bone Matrix Proteins and Mineralization Process
Tamma, R., Carbone, C., & Colucci, S. C. (2013) · Springer eBooks · doi:10.1007/978-88-470-5483-7_2 · Cited by 47
Insulin Signaling in Arthritis
Tripolino, C., Ciaffi, J., Pucino, V., Ruscitti, P., van Leeuwen, N., Borghi, C., Giacomelli, R., Meliconi, R., & Ursini, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.672519 · Cited by 46
Deng, K.-L., Yang, W., Jin-li, H., Li, H., Feng, H., & Xiao, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182212126 · Cited by 46
Contributions of the Insulin/Insulin-Like Growth Factor-1 Axis to Diabetic Osteopathy
Fowlkes, J. L. (2012) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s1-003 · Cited by 46
Expanding the Role of Thyroid-Stimulating Hormone in Skeletal Physiology
Baliram, R., Latif, R., Zaidi, M., & Davies, T. F. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00252 · Cited by 46
Neuronal hypothalamic regulation of body metabolism and bone density is galanin dependent
Idelevich, A., Sato, K., Nagano, K., Rowe, G. C., Gori, F., & Baron, R. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99350 · Cited by 45
Bone: Another potential target to treat, prevent and predict diabetes
Liu, D., Mosialou, I., & Liu, J. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13330 · Cited by 45
Metadata
- Authors
- Ferron, M., Wei, J., Yoshizawa, T., Del Fattore, A., DePinho, R. A., Teti, A., Ducy, P., & Karsenty, G.
- Affiliations
- Columbia University (US)
- Harvard University (US)
- University of L'Aquila (IT)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 142
- Issue
- 2
- Pages
- 296-308
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2910411
- OpenAlex
- W1971400919
- Cited by
- 1,123
- References
- 49
- Citations by year
- 2026: 30 · 2025: 47 · 2024: 50 · 2023: 41 · 2022: 43 · 2021: 62 · 2020: 84 · 2019: 65 · 2018: 73 · 2017: 89 · 2016: 75 · 2015: 100 · 2014: 76 · 2013: 84 · 2012: 87
- FWCI
- 37.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078042)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045548)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Keywords
- insulin signaling, osteoblasts, osteocalcin, bone remodeling, bone resorption, glucose homeostasis, energy metabolism, uncarboxylated osteocalcin, decarboxylation, osteoclasts, feed-forward loop
- MeSH terms
- Animals, Cells, Cultured, Energy Metabolism, Extracellular Matrix, Glucose, Humans, Insulin, Mice, Inbred C57BL, Osteoblasts, Signal Transduction, Osteocalcin, Bone Remodeling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
