The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism
Open accessAbstract
The broad expression of the insulin receptor suggests that the spectrum of insulin function has not been fully described. A cell type expressing this receptor is the osteoblast, a bone-specific cell favoring glucose metabolism through a hormone, osteocalcin, that becomes active once uncarboxylated. We show here that insulin signaling in osteoblasts is necessary for whole-body glucose homeostasis because it increases osteocalcin activity. To achieve this function insulin signaling in osteoblasts takes advantage of the regulation of osteoclastic bone resorption exerted by osteoblasts. Indeed, since bone resorption occurs at a pH acidic enough to decarboxylate proteins, osteoclasts determine the carboxylation status and function of osteocalcin. Accordingly, increasing or decreasing insulin signaling in osteoblasts promotes or hampers glucose metabolism in a bone resorption-dependent manner in mice and humans. Hence, in a feed-forward loop, insulin signals in osteoblasts activate a hormone, osteocalcin, that promotes glucose metabolism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“OCN promoted the survival and function of pancreatic β-cells and increased insulin secretion [209], while insulin itself induced the release of OCN [210].”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [210]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Moreover, IL-6 increases production of OCN by osteoblasts [71] (2c), which itself stimulates transient pancreatic secretion of the anorexic hormone insulin and triggers a positive feed-forward mechanism that results in increased OCN and thus more insulin [28,209,210] (2d).”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [210]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cell Signaling by Receptor Tyrosine Kinases
Lemmon, M. A., & Schlessinger, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.011 · Cited by 7,929
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,344
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Self-citationCell Signaling by Receptor Tyrosine Kinases
Schlessinger, J. (2000) · Cell · doi:10.1016/s0092-8674(00)00114-8 · Cited by 3,774
Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · Cited by 3,258
Endocrine regulation of energy metabolism by the skeleton
Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.047 · Cited by 2,554
Self-citationIncreased bone formation in osteocalcin-deficient mice
Ducy, P. F., Morris, C., Boyce, B. F., Pinero, G. J., Story, B. M., Dunstan, C. R., Smith, E. A., Bonadio, J. F., Goldstein, S. A., Gundberg, C. M., et al. (1996) · Nature · doi:10.1038/382448a0 · Cited by 1,724
Genetic regulation of osteoclast development and function
Teitelbaum, S. L., & Ross, F. P. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1122 · Cited by 1,720
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., et al. (2003) · Nature · doi:10.1038/nature01667 · Cited by 1,487
Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296
Flagged first, then by citations
Research works printed but not linked: 1
- Ferron, M., Hinoi, E., Karsenty, G., and Ducy, P. (2008). Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc. Natl. Acad. Sci. USA 105, 5266–5270. · DOI · Paper page
Cited by
Sorted by citations
Building strong bones: molecular regulation of the osteoblast lineage
Long, F. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3254 · Cited by 1,211
Endocrine Regulation of Male Fertility by the Skeleton
Oury, F., Sumara, G., Sumara, O., Ferron, M., Chang, H., Smith, C. E., Hermo, L., Suarez, S., Roth, B. L., Ducy, P., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.004 · Cited by 628
Guo, S. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0327 · Cited by 648
New insights into the biology of osteocalcin
Zoch, M. L., Clemens, T. L., & Riddle, R. C. (2015) · Bone · doi:10.1016/j.bone.2015.05.046 · Cited by 612
Han, Y., You, X., Xing, W., Zhang, Z., & Zou, W. (2018) · Bone Research · doi:10.1038/s41413-018-0019-6 · Cited by 598
The contribution of bone to whole-organism physiology
Karsenty, G., & Ferron, M. (2012) · Nature · doi:10.1038/nature10763 · Cited by 537
Crockett, J. C., Rogers, M. J., Coxon, F. P., Hocking, L. J., & Helfrich, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.063032 · Cited by 532
Zhu, S., Chen, W., Masson, A., & Li, Y. (2024) · Cell Discovery · doi:10.1038/s41421-024-00689-6 · Cited by 538
Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions
Oury, F., Khrimian, L., Denny, C. A., Gardin, A., Chamouni, A., Goeden, N., Huang, Y.-Y., Lee, H., Srinivas, P., Gao, X.-B., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.042 · Cited by 484
Self-citationMC4R-dependent suppression of appetite by bone-derived lipocalin 2
Mosialou, I., Shikhel, S., Liu, J., Maurizi, A., Luo, N., He, Z., Huang, Y., Zong, H., Friedman, R. A., Barasch, J. M., et al. (2017) · Nature · doi:10.1038/nature21697 · Cited by 474
Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation
Wei, J., Shimazu, J., Makinistoglu, M. P., Maurizi, A., Kajimura, D., Zong, H., Takarada, T., Iezaki, T., Pessin, J. E., Hinoi, E., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.029 · Cited by 469
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise
Mera, P., Laue, K., Ferron, M., Confavreux, C. B., Wei, J., Galán-Díez, M., Lacampagne, A., Mitchell, S. J., Mattison, J. A., Chen, Y., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.004 · Cited by 438
Ferron, M., McKee, M. D., Levine, R. L., Ducy, P., & Karsenty, G. (2012) · Bone · doi:10.1016/j.bone.2011.04.017 · Cited by 414
Bone, sweet bone—osteoporotic fractures in diabetes mellitus
Hamann, C., Kirschner, S., Günther, K., & Hofbauer, L. C. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.233 · Cited by 395
Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease
Greenblatt, M. B., Tsai, J. N., & Wein, M. N. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2016.259085 · Cited by 376
Bone and muscle: Interactions beyond mechanical
Brotto, M. A. P., & Bonewald, L. F. (2015) · Bone · doi:10.1016/j.bone.2015.02.010 · Cited by 360
Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle
Komori, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207513 · Cited by 332
The Relevance of Mouse Models for Investigating Age-Related Bone Loss in Humans
Jilka, R. L. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt046 · Cited by 342
PPARγ: a circadian transcription factor in adipogenesis and osteogenesis
Kawai, M., & Rosen, C. J. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.155 · Cited by 328
Gpr158 mediates osteocalcin’s regulation of cognition
Khrimian, L., Obri, A., Ramos-Brossier, M., Rousseaud, A., Moriceau, S., Nicot, A.-S., Mera, P., Kosmidis, S., Karnavas, T., Saudou, F., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20171320 · Cited by 308
Self-citationSchurgers, L. J., Uitto, J., & Reutelingsperger, C. P. M. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.12.008 · Cited by 306
The role of osteoblasts in energy homeostasis
Dirckx, N., Moorer, M. C., Clemens, T. L., & Riddle, R. C. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0246-y · Cited by 292
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis
Oury, F., Ferron, M., Huizhen, W., Confavreux, C. B., Xu, L., Lacombe, J., Srinivas, P., Chamouni, A., Lugani, F., Lejeune, H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65952 · Cited by 276
Cytokines and abnormal glucose and lipid metabolism
Shi, J., Fan, J., Su, Q., & Yang, Z. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00703 · Cited by 282
Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278
The osteoblast: An insulin target cell controlling glucose homeostasis
Clemens, T. L., & Karsenty, G. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.321 · Cited by 276
Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems
Szwed, A., Płociński, P., Kupikowska-Stobba, B., Urbaniak, M. M., Rusek‐Wala, P., Szustakiewicz, K., Piszko, P. J., Krupa, A., Biernat, M., Gazińska, M. A., et al. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00609 · Cited by 303
Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication
Karsenty, G., & Olson, E. N. (2016) · Cell · doi:10.1016/j.cell.2016.02.043 · Cited by 284
New insights into osteoporosis: the bone–fat connection
Kawai, M., de Paula, F. J. A., & Rosen, C. J. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02564.x · Cited by 277
Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism
Quarles, L. D. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.218 · Cited by 276
Leveraging models of cell regulation and GWAS data in integrative network-based association studies
Califano, A., Butte, A. J., Friend, S. H., Ideker, T., & Schadt, E. E. (2012) · Nature Genetics · doi:10.1038/ng.2355 · Cited by 260
Hartmann, K., Koenen, M., Schauer, S., Wittig-Blaich, S., Ahmad, M., Baschant, U., & Tuckermann, J. P. (2016) · Physiological Reviews · doi:10.1152/physrev.00011.2015 · Cited by 251
Wei, J., Ferron, M., Clarke, C. J., Hannun, Y. A., Jiang, H., Blaner, W. S., & Karsenty, G. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72323 · Cited by 255
Type 2 diabetes and the skeleton: new insights into sweet bones
Shanbhogue, V. V., Mitchell, D. M., Rosen, C. J., & Bouxsein, M. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00283-1 · Cited by 242
Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1
Kajimura, D., Lee, H. W., Riley, K. J., Arteaga‐Solis, E., Ferron, M., Zhou, B., Clarke, C. J., Hannun, Y. A., DePinho, R. A., Guo, X.-D. E., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.009 · Cited by 244
FoxO1, the transcriptional chief of staff of energy metabolism
Kousteni, S. (2011) · Bone · doi:10.1016/j.bone.2011.06.034 · Cited by 248
Biochemical bone turnover markers in diabetes mellitus — A systematic review
Starup‐Linde, J., & Vestergaard, P. (2015) · Bone · doi:10.1016/j.bone.2015.02.019 · Cited by 239
Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a
Wei, J., Hanna, T., Suda, N., Karsenty, G., & Ducy, P. F. (2013) · Diabetes · doi:10.2337/db13-0887 · Cited by 237
Human β-Cell Proliferation and Intracellular Signaling
Kulkarni, R., Mizrachi, E.-B., Garcı́a-Ocaña, A., & Stewart, A. F. (2012) · Diabetes · doi:10.2337/db12-0018 · Cited by 243
FOXOs attenuate bone formation by suppressing Wnt signaling
Iyer, S. V., Ambrogini, E., Bartell, S. M., Li, H., Roberson, P. K., de Cabo, R., Jilka, R. L., Weinstein, R. S., O’Brien, C. A., Manolagas, S. C., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68049 · Cited by 233
The role of osteocalcin in human glucose metabolism: marker or mediator?
Booth, S. L., Centi, A. J., Smith, S. R., & Gundberg, C. M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.201 · Cited by 235
Jang, H. L., Jin, K., Lee, J., Kim, Y., Nahm, S. H., Hong, K. S., & Nam, K. T. (2013) · ACS Nano · doi:10.1021/nn405246h · Cited by 227
Osteocalcin in the brain: from embryonic development to age-related decline in cognition
Obri, A., Khrimian, L., Karsenty, G., & Oury, F. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.181 · Cited by 231
The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism
Ducy, P. F. (2011) · Diabetologia · doi:10.1007/s00125-011-2155-z · Cited by 219
GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo
Pi, M., Wu, Y., & Quarles, L. D. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.390 · Cited by 215
Regulation of energy metabolism by the skeleton: osteocalcin and beyond
Ferron, M., & Lacombe, J. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.022 · Cited by 211
Kim, M. J., Kim, C., Choi, Y. S., Kim, M., Park, C., & Suh, Y. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.03.014 · Cited by 216
Osteocalcin and its endocrine functions
Mizokami, A., Kawakubo‐Yasukochi, T., & Hirata, M. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.02.001 · Cited by 220
Diabetes, bone and glucose-lowering agents: basic biology
Lecka‐Czernik, B. (2017) · Diabetologia · doi:10.1007/s00125-017-4269-4 · Cited by 215
Bone structure and turnover in type 2 diabetes mellitus
Shu, A. R., Yin, M. T., Stein, E. M., Cremers, S., Dworakowski, E., Ives, R., & Rubin, M. R. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1595-0 · Cited by 205
The Great Beauty of the osteoclast
Cappariello, A., Maurizi, A., Veeriah, V., & Teti, A. M. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.06.017 · Cited by 203
BMI and BMD: the potential interplay between obesity and bone fragility
Palermo, A., Tuccinardi, D., Defeudis, G., Watanabe, M., D’Onofrio, L., Lauria Pantano, A., Napoli, N., Pozzilli, P., & Manfrini, S. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13060544 · Cited by 197
An overview of the metabolic functions of osteocalcin
Wei, J., & Karsenty, G. (2015) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9307-7 · Cited by 189
Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism
Brennan‐Speranza, T. C., Henneicke, H., Gasparini, S. J., Blankenstein, K. I., Heinevetter, U., Cogger, V. C., Svistounov, D., Zhang, Y., Cooney, G. J., Buttgereit, F., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63377 · Cited by 191
Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual
Kajimura, D., Hinoi, E., Ferron, M., Kode, A., Riley, K. J., Zhou, B., Guo, X.-D. E., & Karsenty, G. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102608 · Cited by 187
Vitamin K-Dependent Carboxylation of Osteocalcin: Friend or Foe?
Gundberg, C. M., Lian, J. B., & Booth, S. L. (2012) · Advances in Nutrition · doi:10.3945/an.112.001834 · Cited by 192
Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence
Saul, D., & Khosla, S. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac008 · Cited by 185
Podosome organization drives osteoclast-mediated bone resorption
Georgess, D., Machuca‐Gayet, I., Blangy, A., & Jurdic, P. (2014) · Cell Adhesion & Migration · doi:10.4161/cam.27840 · Cited by 181
A RANKL–PKCβ–TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclastsPreprint
Ferron, M., Settembre, C., Shimazu, J., Lacombe, J., Kato, S., Rawlings, D. J., Ballabio, A., & Karsenty, G. (2013) · Genes & Development · doi:10.1101/gad.213827.113 · Cited by 187
The Role of Osteoclast Energy Metabolism in the Occurrence and Development of Osteoporosis
Da, W., Tao, L., & Zhu, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.675385 · Cited by 185
IGF-1 regulation of key signaling pathways in bone
Guntur, A. R., & Rosen, C. J. (2013) · BoneKEy Reports · doi:10.1038/bonekey.2013.171 · Cited by 184
Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway
Rowe, P. S. N. (2012) · Critical Reviews™ in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v22.i1.50 · Cited by 173
The skeleton as an endocrine organ
DiGirolamo, D. J., Clemens, T. L., & Kousteni, S. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.157 · Cited by 183
Marrow fat metabolism is linked to the systemic energy metabolism
Lecka‐Czernik, B. (2011) · Bone · doi:10.1016/j.bone.2011.06.032 · Cited by 168
Mediation of the Acute Stress Response by the Skeleton
Berger, J. M., Singh, P. P., Khrimian, L., Morgan, D. A., Chowdhury, S., Arteaga‐Solis, E., Horváth, T. L., Domingos, A. I., Marsland, A. L., Yadav, V. K., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.012 · Cited by 173
Glucocorticoids and bone: Local effects and systemic implications
Henneicke, H., Gasparini, S. J., Brennan-Speranza, T. C., Zhou, H., & Seibel, M. J. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.12.006 · Cited by 168
Karner, C. M., & Long, F. (2017) · Bone · doi:10.1016/j.bone.2017.08.008 · Cited by 163
Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast
Frey, J. L., Li, Z., Ellis, J. M., Zhang, Q., Farber, C. R., Aja, S. M., Wolfgang, M. J., Clemens, T. L., & Riddle, R. C. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01343-14 · Cited by 168
Emerging therapeutic opportunities for skeletal restoration
Kawai, M., Mödder, U. I., Khosla, S., & Rosen, C. J. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3299 · Cited by 161
Mizokami, A., Yasutake, Y., Gao, J., Matsuda, M., Takahashi, I., Takeuchi, H., & Hirata, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057375 · Cited by 160
Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes
Liu, L.-F., Shen, W., Ueno, M., Patel, S., & Kraemer, F. B. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-212 · Cited by 153
Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes
Capozzi, M. E., DiMarchi, R. D., Tschöp, M. H., Finan, B., & Campbell, J. E. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00117 · Cited by 153
Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation
Yang, D., Yang, Y., Li, Y., & Han, R. (2019) · Annals of Nutrition and Metabolism · doi:10.1159/000500110 · Cited by 165
Guntur, A. R., & Rosen, C. J. (2012) · Endocrine Practice · doi:10.4158/ep12141.ra · Cited by 150
Δίπλα, Κ., Kraemer, R. R., Constantini, N., & Hackney, A. C. (2020) · HORMONES · doi:10.1007/s42000-020-00214-w · Cited by 182
Tencerova, M., Frost, M., Figeac, F., Nielsen, T., Ali, D., Lauterlein, J., Andersen, T. L., Haakonsson, A., Rauch, A., Madsen, J. S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.066 · Cited by 125
Altered Bone Development and an Increase in FGF-23 Expression in Enpp1−/− Mice
Mackenzie, N. C. W., Zhu, D., Milne, E., Hof, R. V., Martin, A., Quarles, L. D., Millán, J. L., Farquharson, C., & MacRae, V. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032177 · Cited by 145
Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts
Chowdhury, S., Schulz, L., Palmisano, B., Singh, P. P., Berger, J. M., Yadav, V. K., Mera, P., Ellingsgaard, H., Hidalgo, J., Brüning, J. C., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133572 · Cited by 148
An overview of osteocalcin progress
Li, J., Zhang, H., Yang, C., Li, Y., & Dai, Z. (2016) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-015-0734-7 · Cited by 143
Kim, S. P., Li, Z., Zoch, M. L., Frey, J. L., Bowman, C. E., Kushwaha, P., Ryan, K. A., Goh, B. C. K., Scafidi, S., Pickett, J. E., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.92704 · Cited by 144
Endocrine role of bone in the regulation of energy metabolism
Zhou, R., Guo, Q., Xiao, Y., Guo, Q., Huang, Y., Li, C., & Luo, X. (2021) · Bone Research · doi:10.1038/s41413-021-00142-4 · Cited by 157
Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism
Yoshikawa, Y., Kode, A., Xu, L., Mosialou, I., Silva, B. C. C., Ferron, M., Clemens, T. L., Economides, A. N., & Kousteni, S. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.417 · Cited by 142
Endocrine Actions of Osteocalcin
Patti, A., Gennari, L., Merlotti, D., Dotta, F., & Nuti, R. (2013) · International Journal of Endocrinology · doi:10.1155/2013/846480 · Cited by 148
Bone Development: Overview of Bone Cells and Signaling
Teti, A. M. (2011) · Current Osteoporosis Reports · doi:10.1007/s11914-011-0078-8 · Cited by 146
Almeida, M. (2012) · BoneKEy Reports · doi:10.1038/bonekey.2012.102 · Cited by 141
Wan, Y. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.006 · Cited by 137
Schwartz, A. V., Schafer, A. L., Grey, A. B., Vittinghoff, E., Palermo, L., Lui, L., Wallace, R. B., Cummings, S. R., Black, D. M., Bauer, D. C., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1865 · Cited by 135
An osteocalcin-deficient mouse strain without endocrine abnormalities
Diegel, C. R., Hann, S., Ayturk, U. M., Hu, J. C. W., Lim, K., Droscha, C. J., Madaj, Z., Foxa, G. E., Izaguirre, I., Core, V. V. A. T., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008361 · Cited by 141
Biology Without Walls: The Novel Endocrinology of Bone
Karsenty, G., & Oury, F. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153233 · Cited by 142
Bone function, dysfunction and its role in diseases including critical illness
Su, N. Y., Yang, J., Xie, Y., Du, X., Chen, H., Hong, Z., & Chen, L. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.27063 · Cited by 141
Sirtuins and FoxOs in osteoporosis and osteoarthritis
Almeida, M., & Porter, R. M. (2019) · Bone · doi:10.1016/j.bone.2019.01.018 · Cited by 131
Obesity and Bone Health: A Complex Link
Hou, J., He, C., He, W., Yang, M., Luo, X., & Li, C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.600181 · Cited by 139
Insulin resistance and bone: a biological partnership
Conte, C., Epstein, S., & Napoli, N. (2018) · Acta Diabetologica · doi:10.1007/s00592-018-1101-7 · Cited by 130
Inducible Brown Adipose Tissue, or Beige Fat, Is Anabolic for the Skeleton
Rahman, S., Lu, Y., Czernik, P. J., Rosen, C. J., Enerbäck, S., & Lecka‐Czernik, B. (2013) · Endocrinology · doi:10.1210/en.2012-2162 · Cited by 128
Diabetes, Diabetic Complications, and Fracture Risk
Oei, L., Rivadeneira, F., Zillikens, M. C., & Oei, E. H. G. (2015) · Current Osteoporosis Reports · doi:10.1007/s11914-015-0260-5 · Cited by 132
Idelevich, A., Rais, Y., & Ornan, E. M. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.230904 · Cited by 129
Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism
Sato, M., Asada, N., Kawano, Y., Wakahashi, K., Minagawa, K., Kawano, H., Sada, A., Ikeda, K., Matsui, T., & Katayama, Y. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.014 · Cited by 126
Novel insights into the relationship between diabetes and osteoporosis
de Paula, F. J. A., Horowitz, M. C., & Rosen, C. J. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1135 · Cited by 125
Novel biological markers of bone: from bone metabolism to bone physiology
Chapurlat, R. D., & Confavreux, C. B. (2016) · Rheumatology · doi:10.1093/rheumatology/kev410 · Cited by 131
Pathophysiology of bone loss in disuse osteoporosis
Alexandre, C., & Vico, L. (2011) · Joint Bone Spine · doi:10.1016/j.jbspin.2011.04.007 · Cited by 125
Metadata
- Authors
- Ferron, M., Wei, J., Yoshizawa, T., Del Fattore, A., DePinho, R. A., Teti, A., Ducy, P., & Karsenty, G.
- Affiliations
- Columbia University (US)
- Harvard University (US)
- University of L'Aquila (IT)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 142
- Issue
- 2
- Pages
- 296-308
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2910411
- OpenAlex
- W1971400919
- Cited by
- 1,123
- References
- 49
- Citations by year
- 2026: 30 · 2025: 47 · 2024: 50 · 2023: 41 · 2022: 43 · 2021: 62 · 2020: 84 · 2019: 65 · 2018: 73 · 2017: 89 · 2016: 75 · 2015: 100 · 2014: 76 · 2013: 84 · 2012: 87
- FWCI
- 37.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078042)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045548)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Keywords
- insulin signaling, osteoblasts, osteocalcin, bone remodeling, bone resorption, glucose homeostasis, energy metabolism, uncarboxylated osteocalcin, decarboxylation, osteoclasts, feed-forward loop
- MeSH terms
- Animals, Cells, Cultured, Energy Metabolism, Extracellular Matrix, Glucose, Humans, Insulin, Mice, Inbred C57BL, Osteoblasts, Signal Transduction, Osteocalcin, Bone Remodeling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
