The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism
Open accessAbstract
The broad expression of the insulin receptor suggests that the spectrum of insulin function has not been fully described. A cell type expressing this receptor is the osteoblast, a bone-specific cell favoring glucose metabolism through a hormone, osteocalcin, that becomes active once uncarboxylated. We show here that insulin signaling in osteoblasts is necessary for whole-body glucose homeostasis because it increases osteocalcin activity. To achieve this function insulin signaling in osteoblasts takes advantage of the regulation of osteoclastic bone resorption exerted by osteoblasts. Indeed, since bone resorption occurs at a pH acidic enough to decarboxylate proteins, osteoclasts determine the carboxylation status and function of osteocalcin. Accordingly, increasing or decreasing insulin signaling in osteoblasts promotes or hampers glucose metabolism in a bone resorption-dependent manner in mice and humans. Hence, in a feed-forward loop, insulin signals in osteoblasts activate a hormone, osteocalcin, that promotes glucose metabolism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“OCN promoted the survival and function of pancreatic β-cells and increased insulin secretion [209], while insulin itself induced the release of OCN [210].”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [210]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Moreover, IL-6 increases production of OCN by osteoblasts [71] (2c), which itself stimulates transient pancreatic secretion of the anorexic hormone insulin and triggers a positive feed-forward mechanism that results in increased OCN and thus more insulin [28,209,210] (2d).”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [210]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cell Signaling by Receptor Tyrosine Kinases
Lemmon, M. A., & Schlessinger, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.011 · Cited by 7,929
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,344
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Self-citationCell Signaling by Receptor Tyrosine Kinases
Schlessinger, J. (2000) · Cell · doi:10.1016/s0092-8674(00)00114-8 · Cited by 3,774
Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · Cited by 3,258
Endocrine regulation of energy metabolism by the skeleton
Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.047 · Cited by 2,554
Self-citationIncreased bone formation in osteocalcin-deficient mice
Ducy, P. F., Morris, C., Boyce, B. F., Pinero, G. J., Story, B. M., Dunstan, C. R., Smith, E. A., Bonadio, J. F., Goldstein, S. A., Gundberg, C. M., et al. (1996) · Nature · doi:10.1038/382448a0 · Cited by 1,724
Genetic regulation of osteoclast development and function
Teitelbaum, S. L., & Ross, F. P. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1122 · Cited by 1,720
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., et al. (2003) · Nature · doi:10.1038/nature01667 · Cited by 1,487
Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296
Flagged first, then by citations
Research works printed but not linked: 1
- Ferron, M., Hinoi, E., Karsenty, G., and Ducy, P. (2008). Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc. Natl. Acad. Sci. USA 105, 5266–5270. · DOI · Paper page
Cited by
Sorted by citations
Items 801–900 of 999
Traditional Japanese apricot (Prunus mume) induces osteocalcin in osteoblasts
Nomura, S., Kono, R., Imaoka, M., Tazaki, F., Okuno, Y., Utsunomiya, H., Takeda, M., & Nakamura, M. (2022) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbac013 · Cited by 5
McGrath, J. J., Savage, D., & Godwin, I. R. (2015) · Animal Production Science · doi:10.1071/an14450 · Cited by 5
The liver throws the skeleton a bone (resorption factor)
Chung, C., & Insogna, K. L. (2016) · Hepatology · doi:10.1002/hep.28688 · Cited by 5
Lin, Y., Chen, C., & Ding, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189063 · Cited by 5
Osteocytes and Homeostasis of Remote Organs
Sato, M. M., & Katayama, Y. (2015) · Current Osteoporosis Reports · doi:10.1007/s11914-015-0269-9 · Cited by 5
Cathepsins S, L, and K and Their Pathophysiological Relevance in Obesity
Lafarge, J.-C., Clément, K., & Guerre-Millo, M. (2011) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-011-9096-4 · Cited by 5
Regulation of Male Fertility by BonePreprint
Karsenty, G. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010934 · Cited by 5
Association between Metabolic Syndrome and the Musculoskeletal System
Shi, W., & Zhang, Q. (2023) · Nutrients · doi:10.3390/nu15204475 · Cited by 5
Liu, Y., Yang, Y., Li, Y., Ding, W., & Yang, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-86361-9 · Cited by 4
Borate‐Ion‐Stimulated Macrophages Promote Osteogenic Differentiation of Mesenchymal Stem Cells
Ikedo, K., Hatakeyama, H., Oguri, S., Obata, A., & Kasuga, T. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202502570 · Cited by 4
Bone as an endocrine regulator of lipid and energy metabolism
Liu, H., Zhao, J., Liu, L., Ying, W., Liu, S., Luo, E., & Rosen, C. J. (2026) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-026-10052-7 · Cited by 4
Low Bone Mineral Density as a Risk Factor for Liver Cirrhosis
Zhang, X., Cheung, K. S., Mak, L., Tan, K. C. B., Kung, A. W. C., Wong, I. C. K., & Cheung, C. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae223 · Cited by 4
Ruzicska, É., & Poór, G. (2011) · Orvosi Hetilap · doi:10.1556/oh.2011.29147 · Cited by 4
Mizuguchi, M., Yokoyama, T., Otani, T., Kuribara, S., Nabeshima, Y., Obita, T., Hirata, M., & Kawano, K. (2023) · FEBS Letters · doi:10.1002/1873-3468.14618 · Cited by 4
Boosting glycolysis to combat fragile bone in type 1 diabetes
Jin, Z., & Lee, B. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.08.009 · Cited by 4
Şahin, A. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub246.c1060 · Cited by 4
Sporun Karakter Gelişimine ve Sporcu Kimliğinin Oluşumuna Etkisi
Şahin, A. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub246.c1064 · Cited by 4
Liu, Y., Yang, Y., Li, Y., Ding, W., & Yang, X. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112705 · Cited by 4
Role of denosumab in lipid metabolism disorders: clinical significance and potential mechanisms
Lou, Y., Chen, H., Fei, S., Chen, X., Guo, L., & Pan, Q. (2025) · Archives of Osteoporosis · doi:10.1007/s11657-025-01546-z · Cited by 4
Del, A., & Teti, A. M. (2011) · InTech eBooks · doi:10.5772/23417 · Cited by 4
Kashiwagi, A., Fein, M. J., & Shimada, M. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.04.134 · Cited by 4
Zhong, X., WANG, H., & JIAN, X. (2013) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2013.1394 · Cited by 4
Wang, S., & Kaartinen, M. T. (2015) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155415597964 · Cited by 4
Yugang, W., Qiming, F., Rui, M., Wentao, L., & Tingting, T. (2014) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20131882 · Cited by 4
Azuma, K., & Inoue, S. (2017) · InTech eBooks · doi:10.5772/63983 · Cited by 4
Ma, H., Wang, P., Jin, D., Jia, T., Mao, H., Zhang, J., & Zhao, S. (2018) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20176980 · Cited by 4
Insulin Receptor deletion in S100a4-lineage cells accelerates age-related bone loss
Studentsova, V., Knapp, E. K., & Loiselle, A. E. (2019) · Bone Reports · doi:10.1016/j.bonr.2019.100197 · Cited by 4
The effects of a 226-km ironman triathlon race on bone turnover in amateur male triathletes
Wu, C., & Huang, T. (2019) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.19.09564-1 · Cited by 4
Bone: Functions, Structure and Physiology
Reis, J. D. C., & Oliveira, M. T. (2020) · Lecture notes in computational vision and biomechanics · doi:10.1007/978-3-030-37541-6_1 · Cited by 4
Lv, Q., Zhou, J., Liu, J., Kang, D., & Zhang, H. (2020) · Endocrine Journal · doi:10.1507/endocrj.ej20-0186 · Cited by 4
Revathi Duraisamy, M. D. S. (2021) · International Journal of Dentistry and Oral Science · doi:10.19070/2377-8075-21000893 · Cited by 4
From Stem to Sternum: The Role of Shp2 in the Skeleton
Jensen, N. R., Kelly, R. R., Kelly, K. D., Khoo, S. K., Sidles, S. J., & LaRue, A. C. (2022) · Calcified Tissue International · doi:10.1007/s00223-022-01042-3 · Cited by 4
Hyperglycaemia induced osteoporosis: Is there a hope with dipeptidyl peptidase-4 inhibitors?
Ahmed, F., Ahmad, S. S., Alam, M. M., Khatoon, A., Ali, R., Ahmad, J., Amina, N., Najmi, A. K., & Khan, M. A. (2023) · Health Sciences Review · doi:10.1016/j.hsr.2023.100135 · Cited by 4
Fuller, K. N. Z., Bohne, E. M., Mey, J. T., Blackburn, B. K., Miranda, V. R., Varady, K. A., Danielson, K. K., & Haus, J. M. (2023) · Metabolism Open · doi:10.1016/j.metop.2023.100264 · Cited by 5
Reference limits for osteocalcin in infancy and early childhood: A longitudinal birth cohort study
Berggren, S., Dahlgren, J., Andersson, O., Bergman, S., & Roswall, J. (2024) · Clinical Endocrinology · doi:10.1111/cen.15036 · Cited by 4
Osteocalcin and the Regulation of Glucose Metabolism
Vella, A. V., & Kumar, R. (2012) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-012-9126-x · Cited by 4
Deng, H., Lu, H., Dai, Y., Li, L., Cao, J., & Zhu, D. (2018) · BioMed Research International · doi:10.1155/2018/1751905 · Cited by 4
Yılmaz, V., Umay, E., Gündoğdu, İ., & Tezel, N. (2018) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-018-0359-1 · Cited by 4
Huang, T., Liu, H., Zhao, W., Li, J., & Wang, Y. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400076 · Cited by 4
Insulin released from titanium discs with insulin coatings-Kinetics and biological activity
Malekzadeh, B. Ö., Ransjö, M., Tengvall, P., Mladenović, Ž., & Westerlund, A. (2016) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33717 · Cited by 4
FGF23/Klotho New Regulators of Vitamin D Metabolism
David, V., & Quarles, L. D. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381978-9.10042-3 · Cited by 5
Characteristics of Bone Strength and Metabolism in Type 2 Diabetic Model Nagoya Shibata Yasuda Mice
Tanaka, H., Miura, T., Yamashita, T., Yoneda, M., & Takagi, S. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00275 · Cited by 4
Trim the gut, lose the weight — and the bone
Osataphan, S. A., & Patti, M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128745 · Cited by 4
Ajithkumar, P., Manju, L., & Deepa, M. (2019) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20193908 · Cited by 4
Beyond mineralisation: metabolic functions for matrix mineralisation regulators
Roberts, F. L., Markby, G. R., Dillon, S., Farquharson, C., & MacRae, V. E. (2020) · Journal of Endocrinology · doi:10.1530/joe-19-0460 · Cited by 4
Association between metabolic risks and bone mineral density in postmenopausal women
Seoung, J. Y., Lee, S. W., Kang, Y. M., Kim, M. J., Park, J. M., Moon, H. M., & Rhim, C. C. (2018) · Clinical and Experimental Obstetrics & Gynecology · doi:10.12891/ceog4341.2018 · Cited by 4
Gimble, J. M., Floyd, Z. E., Kassem, M. S., & NUTTALL, M. E. (2016) · Springer eBooks · doi:10.1007/978-3-319-25976-5_2 · Cited by 4
Basic Principles of Bone Cell Biology
Martin, T. J., Ng, K. W., & Sims, N. A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-415784-2.00002-6 · Cited by 4
The year in review: recent advances in musculoskeletal radiology and biology
Kamath, R. S., & Ouellette, H. A. (2009) · Skeletal Radiology · doi:10.1007/s00256-009-0821-8 · Cited by 4
Role of berberine in metabolic and bone changes in ovariectomized rats
Eid, Y. M., Nassar, S., El-Zanaty, R. A. E.-S. N. A. E.-S., & Barhoma, R. A. (2025) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2025.2465360 · Cited by 3
Wang, E. R., Huang, C. H., Huang, K. T., Shih, W. L., & Yeh, T.-C. (2025) · Applied Food Research · doi:10.1016/j.afres.2025.101334 · Cited by 3
Osteocalcin in a rat model of metabolic syndrome
Gancheva, S., Galunska, B. T., & Zhelyazkova-Savova, M. (2015) · Adipobiology · doi:10.14748/adipo.v7.1558 · Cited by 3
The Role of Bone Cell Energetics in Altering Bone Quality and Strength in Health and Disease
Chlebek, C., & Rosen, C. J. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00763-6 · Cited by 3
The skeleton: an overlooked regulator of systemic glucose metabolism in cancer?
Ronghe, R., & Tavares, A. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1481241 · Cited by 4
Tao, B., Li, Z., Zhao, H., Sun, L., Zhao, L., Li, X., Wang, W., Ning, G., & Liu, J. (2012) · Clinical Endocrinology · doi:10.1111/cen.12058 · Cited by 3
An update on diabetes related skeletal fragility
Abdalrahman, N., Chen, S. C., Wang, J. R., & Ahmed, S. F. (2015) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2015.984687 · Cited by 3
The Effects of Adiponectin on Bone Metabolism
Lin, Y., Chen, C., Chen, C. C., Lin, H. J., Mersmann, H. J., Wu, S., & Ding, S. (2014) · Journal of Biomedical Science and Engineering · doi:10.4236/jbise.2014.79062 · Cited by 3
Ohuchi, K., Miyakoshi, N., Kasukawa, Y., Segawa, T., Kinoshita, H., & Shimada, Y. (2015) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2015.09.001 · Cited by 3
Wan, Y. (2010) · Cited by 3
Yin, J., Wei, X., Zhao, Q., Sun, J., Zhou, W., & Zhao, W. (2022) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2022.2052895 · Cited by 3
Yuningsih, Wardani, D. W. K. K., Ali, M., Khotimah, H., Nurdiana, N., Riawan, W., Primihastuti, D., Cory’ah, F. A. N., Ariati, L. I. P., Primaditya, V., et al. (2022) · GSC Biological and Pharmaceutical Sciences · doi:10.30574/gscbps.2022.19.3.0230 · Cited by 3
Lademann, F., Rauner, M., Bonnet, N., Hofbauer, L. C., & Tsourdi, E. A. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091462 · Cited by 3
The Key Role of Bone Function Markers in Patients with Type (II) Diabetes Mellitus
Balaky, H. M., & Kakey, I. S. (2022) · Iraqi Journal of Science · doi:10.24996/ijs.2022.63.7.10 · Cited by 3
Osteocalcin: A new phenomenon for type 2 diabetes and obesity
Koçak, T., & Tek, N. A. (2023) · European Journal of Environment and Public Health · doi:10.29333/ejeph/12799 · Cited by 4
The Role of Non-collagenous Proteins and Other Matrix Molecules in Vertebrate Mineralization
Shapiro, I. M., & Landis, W. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-34304-9_8 · Cited by 4
Beyazçiçek, Ö., Beyazçiçek, E., Kubur, U., & Gok, A. (2024) · Nigerian Journal of Clinical Practice · doi:10.4103/njcp.njcp_884_23 · Cited by 7
A trend of osteocalcin in diabetes mellitus research: bibliometric and visualization analysis
Liu, Z., Mao, Y., Yang, K., Wang, S., & Zou, F. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1475214 · Cited by 3
Breast Cancer Metastases to Bone: Role of the Microenvironment
Jenna, E., & Светлана, В. (2011) · InTech eBooks · doi:10.5772/21741 · Cited by 3
Does Defective Bone Lead to Defective Muscle?
Bonewald, L. F. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2491 · Cited by 3
Pérez‐Castrillón, J. L., Riancho, J. A., de Luis, D. A., Sagrado, M. G., Domingo-Andrés, M., & Dueñas‐Laita, A. (2013) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2013.08.005 · Cited by 3
Namvaran, F., Rahimi‐Moghaddam, P., Azarpira, N., Dabbaghmanesh, M. H., Bakhshayeshkaram, M., & Namvaran, M. M. (2013) · Europe PMC (PubMed Central) · Cited by 3
The Role of Bone Remodelling in Maintaining and Restoring Bone Health: an Overview
Raubenheimer, E. J., Miniggio, H. D., Lemmer, L., & Heerden, W. V. (2017) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-017-9230-z · Cited by 3
Rosen, C. J. (2017) · Molecular and integrative toxicology · doi:10.1007/978-3-319-56192-9_15 · Cited by 3
Regeneration of Musculoskeletal Tissues
Stocum, D. L. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-384860-4.00006-x · Cited by 4
ATRAID regulates the action of nitrogen-containing bisphosphonates on bonePreprint
Surface, L. E., Burrow, D. T., Li, J., Park, J., Kumar, S., Lyu, C., Song, N., Yu, Z., Rajagopal, A., Bae, Y., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/338350 · Cited by 3
Editorial: Bone-organ axis: an expanding universe
Zhang, P., Wang, Y., Guo, Y., & Liu, X. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1574370 · Cited by 3
Chiral Supramolecular Hydrogels Regulating Both Osteoblastogenesis and Osteoclastogenesis
Wu, B., Dou, X., Baddi, S., Gao, F., Zhao, C., & Feng, C. (2025) · Gels · doi:10.3390/gels11020112 · Cited by 2
Kinoshita, S., Onuma, S., Yamazaki, N., Shibukawa, Y., Ozono, K., Michigami, T., & Kawai, M. (2025) · Endocrinology · doi:10.1210/endocr/bqaf026 · Cited by 2
Zhuo, H., & Zhang, X. (2025) · PLoS ONE · doi:10.1371/journal.pone.0327987 · Cited by 2
DIA-based serum proteomics in goat pregnancy: biomarkers & mechanisms
Xu, D., Wang, D., Zhou, L., Huang, Z., Sun, M., Cao, X., Zhou, J., Gao, X., He, J., Zhao, J., et al. (2025) · Research in Veterinary Science · doi:10.1016/j.rvsc.2025.105815 · Cited by 2
Beyond BMI : The role of diabetes and central obesity in fracture risk—Insights from the UK biobank
Cho, Y., Jhee, J. H., Jhee, J. H., & Park, H. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70074 · Cited by 2
Dutt, M., Liao, L., Kim, H. J., Blazev, R., Chan, A. S. M., Kore, H., Bezawork‐Geleta, A., Dong, L., Rivera, S., Wee, N. K. Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-68106-4 · Cited by 2
Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes
Lin, S., Narayanan, K., & Vashishth, D. (2026) · Advanced Science · doi:10.1002/advs.202518788 · Cited by 2
Physiopathologie de l’ostéoporose d’immobilisation
Alexandre, C., & Vico, L. (2011) · Revue du Rhumatisme · doi:10.1016/j.rhum.2011.03.004 · Cited by 2
Biochemical Markers of Bone Turnover
Greenblatt, M. B., Tsai, J. N., & Wein, M. N. (2020) · Contemporary Endocrinology · doi:10.1007/978-3-319-69287-6_9 · Cited by 2
Pancreas deficiency modifies bone development in the ovine fetus near term
Lanham, S. A., Blache, D., Oreffo, R. O. C., Fowden, A. L., & Forhead, A. J. (2021) · Journal of Endocrinology · doi:10.1530/joe-21-0189 · Cited by 2
Bukowiecka‐Matusiak, M., Burzyńska-Pędziwiatr, I., & Woźniak, L. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821232-5.00009-4 · Cited by 3
Rauner, M., & Hofbauer, L. C. (2016) · Springer eBooks · doi:10.1007/978-3-319-34238-2_1 · Cited by 2
Kaur, P., Dahiya, R., Kaur, G., Buttar, H. S., Wilson, D. W., & Télessy, I. G. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815238273124020010 · Cited by 2
Research advances in understanding crosstalk between organs and pancreatic β‐cell dysfunction
Huang, P., Zhu, Y., & Qin, J. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15787 · Cited by 2
Afsharian, Y. P., Rahimnejad, M., Rabiee, S. M., Feizi, F., & Seitz, H. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202400400 · Cited by 2
Innate [18F]Fluorodeoxyglucose PET bone networks of lung cancer patients predict survival
Ronghe, R., Gonzalez, T. C., Wimberley, C., Suchacki, K. J., & Tavares, A. (2025) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-025-07388-8 · Cited by 2
de Paula, F. J. A., & Rosen, C. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381978-9.10044-7 · Cited by 2
Mosbah, H., & Andréelli, F. (2012) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(12)70420-0 · Cited by 2
Role of Osteoblasts in Regulation of Energy Metabolism
Silva, B. C. C., & Kousteni, S. (2012) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-012-9128-8 · Cited by 2
Diabetes-related impairment in bone strength is established early in the life course
Casazza, K. (2013) · World Journal of Diabetes · doi:10.4239/wjd.v4.i4.145 · Cited by 2
Is there a relationship between bone and critical illness?
Zhang, Y., Du, X., & Chen, L. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2010.11.035 · Cited by 2
Heart Failure with Preserved Ejection Fraction: Myth or Reality?
ES, R. L. R. (2012) · Internal Medicine Open Access · doi:10.4172/2165-8048.1000e101 · Cited by 2
Significance of Organ Crosstalk in Insulin Resistance and Type 2 Diabetes
Bhatt, S., & Kulkarni, R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-415784-2.00017-8 · Cited by 2
Bone and adipose tissue formation
Luther, J., & David, J. (2016) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-016-0143-x · Cited by 2
Metadata
- Authors
- Ferron, M., Wei, J., Yoshizawa, T., Del Fattore, A., DePinho, R. A., Teti, A., Ducy, P., & Karsenty, G.
- Affiliations
- Columbia University (US)
- Harvard University (US)
- University of L'Aquila (IT)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 142
- Issue
- 2
- Pages
- 296-308
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2910411
- OpenAlex
- W1971400919
- Cited by
- 1,123
- References
- 49
- Citations by year
- 2026: 30 · 2025: 47 · 2024: 50 · 2023: 41 · 2022: 43 · 2021: 62 · 2020: 84 · 2019: 65 · 2018: 73 · 2017: 89 · 2016: 75 · 2015: 100 · 2014: 76 · 2013: 84 · 2012: 87
- FWCI
- 37.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078042)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045548)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Keywords
- insulin signaling, osteoblasts, osteocalcin, bone remodeling, bone resorption, glucose homeostasis, energy metabolism, uncarboxylated osteocalcin, decarboxylation, osteoclasts, feed-forward loop
- MeSH terms
- Animals, Cells, Cultured, Energy Metabolism, Extracellular Matrix, Glucose, Humans, Insulin, Mice, Inbred C57BL, Osteoblasts, Signal Transduction, Osteocalcin, Bone Remodeling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
