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The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding

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Asher, Gad, Reinke, Hans, Altmeyer, Matthias, Gutierrez-Arcelus, Maria, Hottiger, Michael O., Schibler, Ueli·2010·Cell
DOI 10.1016/j.cell.2010.08.016
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Abstract

Circadian clocks in peripheral organs are tightly coupled to cellular metabolism and are readily entrained by feeding-fasting cycles. However, the molecular mechanisms involved are largely unknown. Here we show that in liver the activity of PARP-1, an NAD(+)-dependent ADP-ribosyltransferase, oscillates in a daily manner and is regulated by feeding. We provide biochemical evidence that PARP-1 binds and poly(ADP-ribosyl)ates CLOCK at the beginning of the light phase. The loss of PARP-1 enhances the binding of CLOCK-BMAL1 to DNA and leads to a phase-shift of the interaction of CLOCK-BMAL1 with PER and CRY repressor proteins. As a consequence, CLOCK-BMAL1-dependent gene expression is altered in PARP-1-deficient mice, in particular in response to changes in feeding times. Our results show that Parp-1 knockout mice exhibit impaired food entrainment of peripheral circadian clocks and support a role for PARP-1 in connecting feeding with the mammalian timing system.

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Research works printed but not linked: 5

  1. Altmeyer, M., Messner, S., Hassa, P.O., Fey, M., and Hottiger, M.O. (2009). Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites. Nucleic Acids Res. 37, 3723–3738. · DOI
  2. Hassa, P.O., Haenni, S.S., Buerki, C., Meier, N.I., Lane, W.S., Owen, H., Gersbach, M., Imhof, R., and Hottiger, M.O. (2005). Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J. Biol. Chem. 280, 40450–40464. · DOI
  3. Kauppinen, T.M., Chan, W.Y., Suh, S.W., Wiggins, A.K., Huang, E.J., and Swanson, R.A. (2006). Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc. Natl. Acad. Sci. USA 103, 7136–7141. · DOI
  4. Preitner, N., Damiola, F., Lopez-Molina, L., Zakany, J., Duboule, D., Albrecht, U., and Schibler, U. (2002). The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110, 251–260. · DOI · Paper page
  5. Sato, T.K., Panda, S., Miraglia, L.J., Reyes, T.M., Rudic, R.D., McNamara, P., Naik, K.A., FitzGerald, G.A., Kay, S.A., and Hogenesch, J.B. (2004). A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 43, 527–537. · DOI

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Metadata

Authors
Asher, G., Reinke, H., Altmeyer, M., Gutierrez-Arcelus, M., Hottiger, M. O., & Schibler, U.
Affiliations
  • University of Geneva (CH)
  • Heinrich Heine University Düsseldorf (DE)
  • University of Zurich (CH)
Corresponding author
  • Asher, Gad
  • Schibler, Ueli
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
2010-09
Volume
142
Issue
6
Pages
943-953
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2010.08.016
OpenAlex
W2126110821
Cited by
340
References
40
Citations by year
2026: 5 · 2025: 15 · 2024: 14 · 2023: 13 · 2022: 17 · 2021: 20 · 2020: 18 · 2019: 24 · 2018: 16 · 2017: 19 · 2016: 24 · 2015: 27 · 2014: 32 · 2013: 32 · 2012: 34
FWCI
13.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords
PARP1, poly(ADP-ribosyl)ation, circadian clock, feeding-fasting cycle, food entrainment, Clock/BMAL1, liver, PARP-1 knockout mice, NAD+ metabolism, circadian gene expression
MeSH terms
Poly (ADP-Ribose) Polymerase-1, Animals, Biological Clocks, Circadian Rhythm, Feeding Behavior, Liver, Poly(ADP-ribose) Polymerases, Mice, Knockout, Mice, Circadian Rhythm Signaling Peptides and Proteins

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