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Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding
Open accessAbstract
Circadian clocks in peripheral organs are tightly coupled to cellular metabolism and are readily entrained by feeding-fasting cycles. However, the molecular mechanisms involved are largely unknown. Here we show that in liver the activity of PARP-1, an NAD(+)-dependent ADP-ribosyltransferase, oscillates in a daily manner and is regulated by feeding. We provide biochemical evidence that PARP-1 binds and poly(ADP-ribosyl)ates CLOCK at the beginning of the light phase. The loss of PARP-1 enhances the binding of CLOCK-BMAL1 to DNA and leads to a phase-shift of the interaction of CLOCK-BMAL1 with PER and CRY repressor proteins. As a consequence, CLOCK-BMAL1-dependent gene expression is altered in PARP-1-deficient mice, in particular in response to changes in feeding times. Our results show that Parp-1 knockout mice exhibit impaired food entrainment of peripheral circadian clocks and support a role for PARP-1 in connecting feeding with the mammalian timing system.
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“When subjected to daytime feeding the liver of Parp-1 KO mice showed a significantly delayed phase inversion of clock gene expression, when compared with wild type mice, suggesting that PARP-1 activity is indeed implicated in the phase entrainment of peripheral oscillators [48].”
From Circadian control of glucose metabolism (2014) · cites this paper as [48]
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Cites
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
Self-citationPreitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198
Self-citationPoly(ADP-ribose): novel functions for an old molecule
Schreiber, V., Dantzer, F., Amé, J., & de MURCIA, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1963 · Cited by 1,975
Entrainment of the circadian clock in the liver by feeding
Stokkan, K.-A., Yamazaki, S., Tei, H., Sakaki, Y., & Menaker, M. (2001) · Science · doi:10.1126/science.291.5503.490 · Cited by 1,800
Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., & Schibler, U. (2008) · Cell · doi:10.1016/j.cell.2008.06.050 · Cited by 1,376
Self-citationCircadian Control of the NAD + Salvage Pathway by CLOCK-SIRT1
Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., & Sassone-Corsi, P. (2009) · Science · doi:10.1126/science.1170803 · Cited by 1,198
Role of poly(ADP-ribose) formation in DNA repair
Satoh, M. S., & Lindahl, T. L. (1992) · Nature · doi:10.1038/356356a0 · Cited by 1,196
Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels
Hardin, P. E., Hall, J. C., & Rosbash, M. (1990) · Nature · doi:10.1038/343536a0 · Cited by 1,156
A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock
Sato, T. K., Panda, S., Miraglia, L. J., Reyes, T. M., Rudic, R. D., McNamara, P., Naik, K. A., FitzGerald, G. A., Kay, S. A., & Hogenesch, J. B. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.018 · Cited by 1,146
Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD + Biosynthesis
Ramsey, K. M., Yoshino, J., Brace, C. S., Abrassart, D., Kobayashi, Y., Marcheva, B., Hong, H.-K., Chong, J. L., Buhr, E. D., Lee, C., et al. (2009) · Science · doi:10.1126/science.1171641 · Cited by 1,126
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
Rutter, J., Reick, M., Wu, L. C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060698 · Cited by 1,059
Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902 · cited 1×
“Indeed, transcriptome profiling studies revealed that many genes involved in metabolic control are rhythmically expressed (Green et al., 2008).”
Post-translational modifications regulate the ticking of the circadian clock
Gallego, M., & Virshup, D. M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2106 · Cited by 881
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.Preprint
Wang, Z. Q., Auer, B., Stingl, L., Berghammer, H., Haidacher, D., Schweiger, M. R., & Wagner, E. F. (1995) · Genes & Development · doi:10.1101/gad.9.5.509 · Cited by 774
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
Hassa, P. O., Haenni, S. S., Elser, M., & Hottiger, M. O. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00040-05 · Cited by 719
Self-citationBryne, J. C., Valen, E., Tang, M. E., Marstrand, T. T., Winther, O., da Piedade, I., Krogh, A., Lenhard, B., & Sandelin, A. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm955 · Cited by 702
Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658
Self-citationRipperger, J. A., & Schibler, U. (2006) · Nature Genetics · doi:10.1038/ng1738 · Cited by 604
Self-citationPaul, O. H. (2007) · Frontiers in bioscience · doi:10.2741/2909 · Cited by 601
Glucocorticoid hormones inhibit food‐induced phase‐shifting of peripheral circadian oscillators
Minh, N. L., Damiola, F., Tronche, F., Schütz, G., & Schibler, U. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7128 · Cited by 480
Self-citationMolecular Mechanisms of the Biological Clock in Cultured Fibroblasts
Yagita, K., Tamanini, F., van der Horst, G. T. J., & Okamura, H. (2001) · Science · doi:10.1126/science.1059542 · Cited by 470
Kraus, W. L. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.03.006 · Cited by 409
Importance of Poly(ADP-Ribose) Glycohydrolase in the Control of Poly(ADP-Ribose) Metabolism
Davidovic, L., Vodenicharov, M. D., Affar, E. B., & Poirier, G. G. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5263 · Cited by 326
Altmeyer, M., Messner, S., Hassa, P. O., Fey, M., & Hottiger, M. O. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp229 · Cited by 325
Self-citationRapid, Transcription-Independent Loss of Nucleosomes over a Large Chromatin Domain at Hsp70 Loci
Petesch, S. J., & Lis, J. T. (2008) · Cell · doi:10.1016/j.cell.2008.05.029 · Cited by 319
A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo
Yoo, S. H., Ko, C. H., Lowrey, P. L., Buhr, E. D., Song, E.-J., Chang, S., Yoo, O. J., Yamazaki, S., Lee, C., & Takahashi, J. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409763102 · Cited by 307
Hassa, P. O., Haenni, S. S., Buerki, C., Meier, N. I., Lane, W. S., Owen, H., Gersbach, M., Imhof, R., & Hottiger, M. O. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507553200 · Cited by 306
Self-citationLavery, D. J., & Schibler, U. (1993) · Genes & Development · doi:10.1101/gad.7.10.1871 · Cited by 300
Self-citationReinke, H., Saini, C., Fleury-Olela, F., Dibner, C., Benjamin, I. J., & Schibler, U. (2008) · Genes & Development · doi:10.1101/gad.453808 · Cited by 237
Self-citationThe Arabidopsis Circadian Clock Incorporates a cADPR-Based Feedback Loop
Dodd, A. N., Gardner, M. J., Hotta, C. T., Hubbard, K., Dalchau, N., Love, J., Assie, J.-M., Robertson, F. C., Jakobsen, M. K., Gonçalves, J. M., et al. (2007) · Science · doi:10.1126/science.1146757 · Cited by 214
Kauppinen, T. M., Chan, W., Suh, S. W., Wiggins, A. K., Huang, E. J., & Swanson, R. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508606103 · Cited by 208
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response
Mohammad, D. H., & Yaffe, M. B. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.004 · Cited by 157
Poly(ADP-ribose)polymerase: a novel finger protein
Mazen, A., Murcia, J. M., Molinete, M., Simonin, F., Gradwohl, G., Poirier, G. G., & de MURCIA, G. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.12.4689 · Cited by 114
Panda, S., Poirier, G. G., & Kay, S. A. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00200-9 · Cited by 107
Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging
Altmeyer, M., & Hottiger, M. O. (2009) · Aging · doi:10.18632/aging.100052 · Cited by 77
Self-citationZaniolo, K., Desnoyers, S., Leclerc, S., & Guérin, S. L. (2007) · BMC Molecular Biology · doi:10.1186/1471-2199-8-96 · Cited by 68
Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation
Haenni, S. S., Hassa, P. O., Altmeyer, M., Fey, M., Imhof, R., & Hottiger, M. O. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.03.008 · Cited by 56
Self-citation
Research works printed but not linked: 5
- Altmeyer, M., Messner, S., Hassa, P.O., Fey, M., and Hottiger, M.O. (2009). Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites. Nucleic Acids Res. 37, 3723–3738. · DOI
- Hassa, P.O., Haenni, S.S., Buerki, C., Meier, N.I., Lane, W.S., Owen, H., Gersbach, M., Imhof, R., and Hottiger, M.O. (2005). Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J. Biol. Chem. 280, 40450–40464. · DOI
- Kauppinen, T.M., Chan, W.Y., Suh, S.W., Wiggins, A.K., Huang, E.J., and Swanson, R.A. (2006). Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc. Natl. Acad. Sci. USA 103, 7136–7141. · DOI
- Preitner, N., Damiola, F., Lopez-Molina, L., Zakany, J., Duboule, D., Albrecht, U., and Schibler, U. (2002). The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110, 251–260. · DOI · Paper page
- Sato, T.K., Panda, S., Miraglia, L.J., Reyes, T.M., Rudic, R.D., McNamara, P., Naik, K.A., FitzGerald, G.A., Kay, S.A., and Hogenesch, J.B. (2004). A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 43, 527–537. · DOI
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Metadata
- Authors
- Asher, G., Reinke, H., Altmeyer, M., Gutierrez-Arcelus, M., Hottiger, M. O., & Schibler, U.
- Affiliations
- University of Geneva (CH)
- Heinrich Heine University Düsseldorf (DE)
- University of Zurich (CH)
- Corresponding author
- Asher, Gad
- Schibler, Ueli
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 142
- Issue
- 6
- Pages
- 943-953
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2126110821
- Cited by
- 340
- References
- 40
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 14 · 2023: 13 · 2022: 17 · 2021: 20 · 2020: 18 · 2019: 24 · 2018: 16 · 2017: 19 · 2016: 24 · 2015: 27 · 2014: 32 · 2013: 32 · 2012: 34
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- PARP1, poly(ADP-ribosyl)ation, circadian clock, feeding-fasting cycle, food entrainment, Clock/BMAL1, liver, PARP-1 knockout mice, NAD+ metabolism, circadian gene expression
- MeSH terms
- Poly (ADP-Ribose) Polymerase-1, Animals, Biological Clocks, Circadian Rhythm, Feeding Behavior, Liver, Poly(ADP-ribose) Polymerases, Mice, Knockout, Mice, Circadian Rhythm Signaling Peptides and Proteins
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