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Breaking the Diffraction Barrier: Super-Resolution Imaging of Cells

Open access
Huang, Bo, Babcock, Hazen, Zhuang, Xiaowei·2010·Cell

Abstract

Anyone who has used a light microscope has wished that its resolution could be a little better. Now, after centuries of gradual improvements, fluorescence microscopy has made a quantum leap in its resolving power due, in large part, to advancements over the past several years in a new area of research called super-resolution fluorescence microscopy. In this Primer, we explain the principles of various super-resolution approaches, such as STED, (S)SIM, and STORM/(F)PALM. Then, we describe recent applications of super-resolution microscopy in cells, which demonstrate how these approaches are beginning to provide new insights into cell biology, microbiology, and neurobiology.

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Crossref · 10.1016/j.cell.2010.12.002

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Metadata

Authors
Huang, B., Babcock, H., & Zhuang, X.
Venue
Cell
Publisher
Elsevier BV
Published
2010-12
Volume
143
Issue
7
Pages
1047-1058
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2081178923
Cited by
1,156
References
6
FWCI
41.69
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Breaking the Diffraction Barrier: Super-Resolution Imaging of Cells. https://app.cochat.ai/papers/10.1016/j.cell.2010.12.002
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Huang, B., Babcock, H., & Zhuang, X. (2010). Breaking the Diffraction Barrier: Super-Resolution Imaging of Cells. Cell. https://doi.org/10.1016/j.cell.2010.12.002

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.