The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Measuring and Modeling Apoptosis in Single Cells
Open accessAbstract
Cell death plays an essential role in the development of tissues and organisms, the etiology of disease, and the responses of cells to therapeutic drugs. Here we review progress made over the last decade in using mathematical models and quantitative, often single-cell, data to study apoptosis. We discuss the delay that follows exposure of cells to prodeath stimuli, control of mitochondrial outer membrane permeabilization, switch-like activation of effector caspases, and variability in the timing and probability of death from one cell to the next. Finally, we discuss challenges facing the fields of biochemical modeling and systems pharmacology.
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Cites
Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
Nelson, D. E., Ihekwaba, A. E. C., Elliott, M., Johnson, J. R., Gibney, C. A., Foreman, B. E., Nelson, G., See, V., Horton, C. A., Spiller, D. G., et al. (2004) · Science · doi:10.1126/science.1099962 · Cited by 1,186
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Linking Stochastic Dynamics to Population Distribution: An Analytical Framework of Gene Expression
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Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario
Chipuk, J. E., Bouchier-Hayes, L., & Green, D. R. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401963 · Cited by 631
Pulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription
Ashall, L., Horton, C. A., Nelson, D. E., Paszek, P., Harper, C. V., Sillitoe, K., Ryan, S., Spiller, D. G., Unitt, J. F., Broomhead, D. S., et al. (2009) · Science · doi:10.1126/science.1164860 · Cited by 543
XIAP discriminates between type I and type II FAS-induced apoptosis
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Rules for Modeling Signal-Transduction Systems
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Linking data to models: data regression
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Inferring biological networks by sparse identification of nonlinear dynamics
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A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis.
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Metadata
- Authors
- Spencer, S. L., & Sorger, P. K.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 144
- Issue
- 6
- Pages
- 926-939
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1988501212
- Cited by
- 336
- References
- 9
- FWCI
- 14.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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