Intravital imaging
Open accessAbstract
Until recently, the idea of observing life deep within the tissues of a living mouse, at a resolution sufficient to pick out cellular behaviors and molecular signals underlying them, remained a much-coveted dream. Now, a new era of intravital fluorescence microscopy has dawned. In this Primer, we review the technologies that made this revolution possible and demonstrate how intravital imaging is beginning to provide quantitative and dynamic insights into cell biology, immunology, tumor biology, and neurobiology.
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New imaging modalities will likely extend possibilities for imaging of nanodrugs.
“These new modalities will likely extend possibilities for the imaging of nanodrugs [147,148].”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [148]
The sections on vascular networks and single-cell drug responses describe emerging intravital imaging methods that could improve observation of drug delivery and distribution. The paper also discusses imaging with nanoparticle probes, but it does not specifically say that new modalities will extend imaging of nanodrugs. (LLM, conf=0.82)
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“These new modalities will likely extend possibilities for the imaging of nanodrugs [147,148].”
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- Authors
- Pittet, M. J., & Weissleder, R.
- Affiliations
- Harvard University (US)
- ORCID
- Weissleder, Ralph
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 147
- Issue
- 5
- Pages
- 983-991
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3824153
- OpenAlex
- W4252712324
- Cited by
- 466
- References
- 74
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 22 · 2023: 16 · 2022: 25 · 2021: 47 · 2020: 28 · 2019: 31 · 2018: 27 · 2017: 34 · 2016: 39 · 2015: 44 · 2014: 41 · 2013: 41 · 2012: 30
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Cancer Institute (P50CA086355, R01CA164448, U54CA126515)
- National Institute of Allergy and Infectious Diseases (R01AI084880)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- intravital imaging, intravital fluorescence microscopy, deep tissue imaging, mouse model, cell behavior, molecular signals, tumor biology, neurobiology
- MeSH terms
- Animals, Cell Communication, Humans, Neoplasm Metastasis, Neoplasms, Mice, Molecular Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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