The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors
Open accessAbstract
Summary Promoter proximal pausing by initiated RNA polymerase II (Pol II) and regulated release of paused polymerase into productive elongation has emerged as a major mechanism of transcription activation. Reactivation of paused Pol II correlates with recruitment of SuperElongationComplexes (SECs) containing ELL/EAF family members, P-TEFb, and other proteins, but the mechanism of their recruitment is currently a major unanswered question. Here, we present evidence for a role of human Mediator subunit Med26 in this process. We identify in the conserved N-terminal domain of Med26 overlapping docking sites for SEC and a second ELL/EAF-containing complex, as well as general initiation factor TFIID. In addition, we present evidence consistent with the model that Med26 can function as a molecular switch that interacts first with TFIID in the Pol II initiation complex and then exchanges TFIID for complexes containing ELL/EAF and P-TEFb to facilitate transition of Pol II into the elongation stage of transcription.
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Metadata
- Authors
- Takahashi, H., Parmely, T. J., Sato, S., Tomomori-Sato, C., Banks, C. A. S., Kong, S. E., Szutorisz, H., Swanson, S. K., Martin-Brown, S., Washburn, M. P., Florens, L., Seidel, C. W., Lin, C., Smith, E. R., Shilatifard, A., Conaway, R. C., & Conaway, J. W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 146
- Issue
- 1
- Pages
- 92-104
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1984901090
- Cited by
- 347
- References
- 74
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Takahashi, H., Parmely, T. J., Sato, S., Tomomori-Sato, C., Banks, C. A. S., Kong, S. E., Szutorisz, H., Swanson, S. K., Martin-Brown, S., Washburn, M. P., Florens, L., Seidel, C. W., Lin, C., Smith, E. R., Shilatifard, A., Conaway, R. C., & Conaway, J. W. (2011). Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors. Cell. https://doi.org/10.1016/j.cell.2011.06.005
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