The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
SNARE Proteins Are Required for Macroautophagy
Open accessAbstract
SUMMARY Macroautophagy mediates the degradation of long-lived proteins and organelles via the de novo formation of double-membrane autophagosomes that sequester cytoplasm and deliver it to the vacuole/lysosome; however, relatively little is known about autophagosome biogenesis. Atg8, a phosphatidylethanolamine-conjugated protein, was previously proposed to function in autophagosome membrane expansion, based on the observation that it mediates liposome tethering and hemifusion in vitro. We show here that with physiological concentrations of phosphatidylethanolamine, Atg8 does not act as a fusogen. Rather, we provide evidence for the involvement of exocytic Q/t-SNAREs in autophagosome formation, acting in the recruitment of key autophagy components to the site of autophagosome formation, and in regulating the organization of Atg9 into tubulovesicular clusters. Additionally, we found that the endosomal Q/t-SNARE Tlg2 and the R/v-SNAREs Sec22 and Ykt6 interact with Sso1-Sec9, and are required for normal Atg9 transport. Thus, multiple SNARE-mediated fusion events are likely to be involved in autophagosome biogenesis.
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Cites
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Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation
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Self-citationProtein-Lipid Interplay in Fusion and Fission of Biological Membranes
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Self-citationGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
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Self-citationMolecular definitions of autophagy and related processes
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Self-citationAutophagy modulation as a potential therapeutic target for diverse diseases
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Metadata
- Authors
- Nair, U., Jotwani, A., Geng, J., Gammoh, N., Richerson, D., Yen, W.-L., Griffith, J., Nag, S., Wang, K., Moss, T., Baba, M., McNew, J. A., Jiang, X., Reggiori, F., Melia, T. J., & Klionsky, D. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 146
- Issue
- 2
- Pages
- 290-302
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2019341627
- Cited by
- 434
- References
- 55
- FWCI
- 32.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nair, U., Jotwani, A., Geng, J., Gammoh, N., Richerson, D., Yen, W.-L., Griffith, J., Nag, S., Wang, K., Moss, T., Baba, M., McNew, J. A., Jiang, X., Reggiori, F., Melia, T. J., & Klionsky, D. J. (2011). SNARE Proteins Are Required for Macroautophagy. Cell. https://doi.org/10.1016/j.cell.2011.06.022
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
