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Cited by 231

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

RETRACTED: Directed Conversion of Alzheimer's Disease Patient Skin Fibroblasts into Functional Neurons

Open access
Qiang, Liang, Fujita, Ryousuke, Yamashita, Toru, Angulo, Sergio, Rhinn, Herve, Rhee, David, Doege, Claudia, Chau, Lily, Aubry, Laetitia, Vanti, William B., Moreno, Herman, Abeliovich, Asa·2011·Cell
DOI 10.1016/j.cell.2011.07.007
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Abstract

SUMMARY Directed conversion of mature human cells, as from fibroblasts to neurons, would be of potential clinical utility for neurological disease modeling and as cell therapeutics. Here we describe the efficient generation of induced neuronal (hiN) cells from adult skin fibroblasts of unaffected individuals and Alzheimer’s patients, using virally transduced transcription regulators and extrinsic support factors. hiN cells from unaffected individuals display morphological, electrophysiological, and gene expression profiles that typify glutamatergic forebrain neurons, and are competent to integrate functionally into the rodent CNS. hiN cells from familial Alzheimer disease (FAD) patients with Presenilin-1 or -2 mutations exhibit altered processing and localization of amyloid precursor protein (APP) and increased production of Aβ, relative either to hiN cells from unaffected individuals or to the source patient fibroblasts. These findings demonstrate directed conversion of human fibroblasts to a neuronal phenotype and reveal cell type-selective pathology in hiN cells derived from FAD patients.

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Show all 11 references

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Cited by

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Metadata

Authors
Qiang, L., Fujita, R., Yamashita, T., Angulo, S., Rhinn, H., Rhee, D., Doege, C., Chau, L., Aubry, L., Vanti, W. B., Moreno, H., & Abeliovich, A.
Venue
Cell
Publisher
Elsevier BV
Published
2011-08
Volume
146
Issue
3
Pages
359-371
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2011.07.007
OpenAlex
W2149560131
Cited by
231
References
11
FWCI
21.51
Type
journal article
Language
en
Status
Retracted
Update notices
Open access
bronze
Licence

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CoChat. (2026). Citation check: RETRACTED: Directed Conversion of Alzheimer's Disease Patient Skin Fibroblasts into Functional Neurons. https://app.cochat.ai/papers/10.1016/j.cell.2011.07.007
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Qiang, L., Fujita, R., Yamashita, T., Angulo, S., Rhinn, H., Rhee, D., Doege, C., Chau, L., Aubry, L., Vanti, W. B., Moreno, H., & Abeliovich, A. (2011). RETRACTED: Directed Conversion of Alzheimer's Disease Patient Skin Fibroblasts into Functional Neurons. Cell. https://doi.org/10.1016/j.cell.2011.07.007

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