The presenilin hypothesis of Alzheimer’s disease: Evidence for a loss-of-function pathogenic mechanism.

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Regulation of NMDA receptor trafficking by amyloid-β

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A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

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Skeletal and CNS Defects in Presenilin-1-Deficient Mice

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Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration

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Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

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A presenilin‐1/γ‐secretase cleavage releases the E‐cadherin intracellular domain and regulates disassembly of adherens junctions

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APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

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Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling

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Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state

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Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms

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Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

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Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40

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Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease

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Evidence that the 42- and 40-amino acid forms of amyloid β protein are generated from the β-amyloid precursor protein by different protease activities

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Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ 42 production

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APP Processing and Synaptic Plasticity in Presenilin-1 Conditional Knockout Mice

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A Substrate-Based Difluoro Ketone Selectively Inhibits Alzheimer's γ-Secretase Activity

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A novel presenilin 1 mutation associated with Pick's disease but not β‐amyloid plaques

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β-Amyloid-(1–42) Impairs Activity-dependent cAMP-response Element-binding Protein Signaling in Neurons at Concentrations in Which Cell Survival Is Not Compromised

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A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis

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Presenilin 1 Facilitates the Constitutive Turnover of β-Catenin: Differential Activity of Alzheimer’s Disease–Linked PS1 Mutants in the β-Catenin–Signaling Pathway

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Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Aβ 42/40 ratios

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Mutant Human Presenilin 1 Protects presenilin 1 Null Mouse against Embryonic Lethality and Elevates Aβ1–42/43 Expression

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The Carboxyl Termini of β-Amyloid Peptides 1-40 and 1-42 Are Generated by Distinct γ-Secretase Activities

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The Effect of the Feedback Inhibitor, CTP, on Subunit Interactions in Aspartate TranscarbamylasePreprint

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Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein

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Dementia with prominent frontotemporal features associated with L113P presenilin 1 mutation

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Presenilin-1 P264L Knock-In Mutation: Differential Effects on Aβ Production, Amyloid Deposition, and Neuronal Vulnerability

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Secretase Targets for Alzheimer's Disease: Identification and Therapeutic Potential

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An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos

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FAD mutant PS-1 gene-targeted mice: increased Aβ42 and Aβ deposition without APP overproduction

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Novel Presenilin 1 Mutation (S170F) Causing Alzheimer Disease With Lewy Bodies in the Third Decade of Life

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The Biological and Pathological Function of the Presenilin-1 ΔExon 9 Mutation Is Independent of Its Defect to Undergo Proteolytic Processing

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Presenilins Mutated at Asp-257 or Asp-385 Restore Pen-2 Expression and Nicastrin Glycosylation but Remain Catalytically Inactive in the Absence of Wild Type Presenilin

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Presenilin 1 Mutations Activate γ42-Secretase but Reciprocally Inhibit ε-Secretase Cleavage of Amyloid Precursor Protein (APP) and S3-Cleavage of Notch

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A mutant PSEN1 causes dementia with lewy bodies and variant Alzheimer's disease

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Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression

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A Presenilin 1 Mutation Associated with Familial Frontotemporal Dementia Inhibits γ-Secretase Cleavage of APP and Notch

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Biochemical Characterization of the γ-Secretase Activity That Produces β-Amyloid Peptides

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A Pathogenic Presenilin-1 Deletion Causes Abberrant Aβ42 Production in the Absence of Congophilic Amyloid Plaques

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Calpain Inhibitor I Increases β-Amyloid Peptide Production by Inhibiting the Degradation of the Substrate of γ-Secretase

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Familial Alzheimer's disease mutations inhibit γ‐secretase‐mediated liberation of β‐amyloid precursor protein carboxy‐terminal fragment

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Specific Increase in Amyloid β-Protein 42 Secretion Ratio by Calpain Inhibition

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A novel presenilin mutation (M233V) causing very early onset Alzheimer's disease with Lewy bodies

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Presenilins in the Developing, Adult, and Aging Cerebral Cortex

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Aspartate transcarbamylase of Escherichia coli. Mechanisms of inhibition and activation by dicarboxylic acids and other anions.

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Modeling Clinically Heterogeneous Presenilin Mutations with Transgenic Drosophila

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Activated cAMP-response Element-binding Protein Regulates Neuronal Expression of Presenilin-1

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Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression

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Rank-Order of Potencies for Inhibition of the Secretion of Aβ40 and Aβ42 Suggests That Both Are Generated by a Single γ-Secretase

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Presenilin 1 Independently Regulates β-Catenin Stability and Transcriptional Activity

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Distinct Mechanisms by Mutant Presenilin 1 and 2 Leading to Increased Intracellular Levels of Amyloid β-Protein 42 in Chinese Hamster Ovary Cells

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Hippocampal Spatial Memory Impairments Caused by the Familial Alzheimer’s Disease-Linked Presenilin 1 M146V Mutation

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Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased Aβ42 secretion in mammalian cells but impaired Notch/lin-I2 signalling in C. elegans

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Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and γ‐secretase activity

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Twenty-nine missense mutations linked with familial Alzheimer's disease alter the processing of presenilin 1

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Toward the Characterization and Identification of γ‐Secretases Using Transition‐state Analogue Inhibitors

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The amyloid hypothesis of Alzheimer's disease at 25 years

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The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

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Amyloid Precursor Protein Processing and Alzheimer's Disease

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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

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The role of apolipoprotein E in Alzheimer's disease

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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

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Tau pathology and neurodegeneration

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Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

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The amyloid hypothesis for Alzheimer’s disease: A critical reappraisal

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Upregulated function of mitochondria‐associated ER membranes in Alzheimer disease

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Autophagy Failure in Alzheimer's Disease – Locating the Primary Defect

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Alzheimer's Disease: From Pathology to Therapeutic Approaches

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Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

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Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease

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The mechanism of γ‐Secretase dysfunction in familial Alzheimer disease

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Presenilins and -Secretase: Structure, Function, and Role in Alzheimer DiseasePreprint

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Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

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