MYC on the Path to Cancer

Dang, Chi V.·2012·Cell

DOI 10.1016/j.cell.2012.03.003

Cited by (1,008)

Items 201–300 of 1,008

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MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer
Valentina R. Minciacchi, Cristiana Spinelli, Mariana Reis-Sobreiro, Lorenzo Cavallini, Sungyong You, Mandana Zandian, Xiaohong Li, Rajeev Mishra, Paola Chiarugi, Rosalyn M. Adam et al. · 2017 · Cancer Research
EGFR Mutation-Induced Alternative Splicing of Max Contributes to Growth of Glycolytic Tumors in Brain Cancer
Ivan Babić, Erik Steven Anderson, Kazuhiro Tanaka, Deliang Guo, Kenta Masui, Bing Li, Shaojun Zhu, Yuchao Gu, Genaro R. Villa, David Akhavan et al. · 2013 · Cell Metabolism
Super-enhancers in cancer
Palaniraja Thandapani · 2019 · Pharmacology & Therapeutics
LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway
Chunhua Wei, Xiaomin Dong, Hui Lü, Fan Tong, Lingjuan Chen, Ruiguang Zhang, Jihua Dong, Gang Wu, Gang Wu, Xiaorong Dong · 2019 · Journal of Experimental & Clinical Cancer Research
Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity
Cheryl M. Koh, Ekta Khattar, Shi Chi Leow, Chia Yi Liu, Julius Müller, Wei Xia Ang, Yinghui Li, Guido Franzoso, Shang Li, Ernesto Guccione et al. · 2015 · Journal of Clinical Investigation
Regulation ofMYCgene expression by aberrant Wnt/β-catenin signaling in colorectal cancer
Sherri A. Rennoll · 2015 · World Journal of Biological Chemistry
Different promoter affinities account for specificity in MYC-dependent gene regulation
Francesca Lorenzin, Uwe Benary, Apoorva Baluapuri, Susanne Walz, Lisa Anna Jung, Björn von Eyß, Caroline Kisker, Jana Wolf, Martin Eilers, Elmar Wolf · 2016 · eLife
Targeting cancer by binding iron: Dissecting cellular signaling pathways
Goldie Y.L. Lui, Žaklina Kovačević, Věra Richardson, Angelica M. Merlot, Danuta S. Kalinowski, Des Raymond Richardson · 2015 · Oncotarget
Targeting MTHFD2 in acute myeloid leukemia
Yana Pikman, Alexandre Puissant, Gabriela Alexe, Andrew A. Furman, Liying M. Chen, Stacey M. Frumm, Linda S. Ross, Nina Fenouille, Christopher F. Bassil, Caroline A. Lewis et al. · 2016 · The Journal of Experimental Medicine
Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus
Ping Hui Gao, Ji‐Han Xia, Csilla Sipeky, Xiaoming Dong, Qin Zhang, Yuehong Yang, Peng Zhang, Sara Pereira Cruz, Kai Zhang, Jing Zhu et al. · 2018 · Cell
Myc-Driven glycolysis is a therapeutic target in glioblastoma
Tateishi, Kensuke, Iafrate, A. John, Ho, Quan, Curry, William T., Batchelor, Tracy T., Flaherty, Keith T., Onozato, Maristela L., Lelic, Nina, Sundaram, Sudhandra, Cahill, Daniel P. et al. · 2016 · Clinical Cancer Research
MYC protein stability is negatively regulated by BRD4
Ballachanda N. Devaiah, Jie Mu, Ben Akman, Sheetal Uppal, Jocelyn D. Weissman, Dan Cheng, Laura Baranello, Zuqin Nie, David Levens, Dinah S. Singer · 2020 · Proceedings of the National Academy of Sciences
The Mevalonate Pathway, a Metabolic Target in Cancer Therapy
Borja Guerra, Carlota Recio, Haidée Aranda-Tavío, Miguel Guerra-Rodríguez, José Manuel García-Castellano, Leandro Fernández‐Pérez · 2021 · Frontiers in Oncology
C-MYC-induced upregulation of lncRNA SNHG12 regulates cell proliferation, apoptosis and migration in triple-negative breast cancer.
Ouchen Wang, Fan Yang, Yehuan Liu, Lin Lv, Ruimin Ma, Chuanzhi Chen, Jiao Wang, Qiufan Tan, Yue Cheng, Erjie Xia et al. · 2017 · Europe PMC (PubMed Central)
Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes
Lulu Sun, Yuqing Wang, Jin Cen, Xiaolong Ma, Lei Cui, Zhixin Qiu, Zhengtao Zhang, Hong Li, Run‐Zhou Yang, Chenhua Wang et al. · 2019 · Nature Cell Biology
c-Myc-Mediated Epigenetic Silencing of MicroRNA-101 Contributes to Dysregulation of Multiple Pathways in Hepatocellular Carcinoma
Lei Wang, Xiang Zhang, Lintao Jia, Si-Jun Hu, Jing Zhao, Jiandong Yang, Weihong Wen, Zhe Wang, Tao Wang, Jun Zhao et al. · 2013 · Hepatology
ATF4 and N‐Myc coordinate glutamine metabolism in MYCN ‐amplified neuroblastoma cells through ASCT2 activation
Ping Ren, Ming Yue, Daibiao Xiao, Ruijuan Xiu, Lei Gan, Hudan Liu, Guoliang Qing · 2014 · The Journal of Pathology
Cross-talk between the circadian clock and the cell cycle in cancer
Matúš Soták, Alena Sumová, Jiřı́ Pácha · 2014 · Annals of Medicine
The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer
Markus E. Diefenbacher, Nikita Popov, Sophia M. Blake, Christina Schülein‐Völk, Emma L. Nye, Bradley Spencer‐Dene, Laura A. Jaenicke, Martin Eilers, Axel Behrens · 2014 · Journal of Clinical Investigation
PGC-1α supports glutamine metabolism in breast cancer
Shawn McGuirk, Simon‐Pierre Gravel, Geneviève Deblois, David J. Papadopoli, Brandon Faubert, André Wegner, Karsten Hiller, Daina Zofija Avizonis, Uri David Akavia, Russell G. Jones et al. · 2013 · Cancer & Metabolism
Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma
Hien Thanh Dang, Atsushi Takai, Marshonna Forgues, Yotsawat Pomyen, Haiwei Mou, Wen Xue, Debashish Ray, Kevin Ha, Quaid Morris, Timothy R. Hughes et al. · 2017 · Cancer Cell
Role of MYC-Regulated Long Noncoding RNAs in Cell Cycle Regulation and Tumorigenesis
Tae‐Wan Kim, Young-Jun Jeon, Ri Cui, Ji-Hoon Lee, Yong Peng, Sung-Hak Kim, Esmerina Tili, Hansjüerg Alder, Carlo Maria Croce · 2015 · JNCI Journal of the National Cancer Institute
Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination
Xiaoguang Fang, Wenchao Zhou, Qiulian Wu, Zhi Huang, Yu Shi, Kailin Yang, Cong Chen, Qi Xie, Stephen C. Mack, Xiuxing Wang et al. · 2016 · The Journal of Experimental Medicine
Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism
Huasong Lu, Yuhua Xue, Guoying Karen Yu, Carolina Arias, Julie Lin, Susan K. Fong, Michel Faure, Ben Weisburd, Xiao‐Dan Ji, Alexandre Mercier et al. · 2015 · eLife
Mammalian MYC Proteins and Cancer
William P. Tansey · 2014 · New Journal of Science
Targeting cancer metabolism
Teicher, Beverly A., Linehan, W. Marston, Helman, Lee J. · 2012 · Clinical Cancer Research
Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?
Wen Zhang, Shaolin Zhang, Xiaohui Hu, Kin Yip Tam · 2015 · International Journal of Biological Sciences
PD-1/PD-L1 immune checkpoint blockade in breast cancer: research insights and sensitization strategies
Menglei Jin, Jun Fang, Junwen Peng, Xintian Wang, Ping Xing, Kunpeng Jia, Jianming Hu, Danting Wang, Yuxin Ding, Xinyu Wang et al. · 2024 · Molecular Cancer
Inhibitor of MYC identified in a Kröhnke pyridine library
Jonathan Ross Hart, Amanda L. Garner, Jing Yu, Yoshihiro Ito, Minghao Sun, Lynn A. Ueno, Jin‐Kyu Rhee, Michael M. Baksh, Eduard Stefan, Markus Hartl et al. · 2014 · Proceedings of the National Academy of Sciences
The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms
Qibo Huang, Jie Mo, Zhibin Liao, Xiaoping Chen, Bixiang Zhang · 2022 · Cell Death and Disease
Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
Jian Kang, C. Marcelo Sergio, Robert L. Sutherland, Elizabeth A. Musgrove · 2014 · BMC Cancer
EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation
Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing · 2022 · Nature Communications
Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle
François Lamoureux, Marc Baud’huin, Lidia Rodriguez Calleja, Camille Jacques, Martine Berreur, Françoise Rédiní, Fernando Lecanda, James E. Bradner, Dominique Heymann, Benjamin Ory · 2014 · Nature Communications
Mission Possible: Advances in MYC Therapeutic Targeting in Cancer
Brittany L. Allen-Petersen, Rosalie C. Sears · 2019 · BioDrugs
Progress in Understanding the IL-6/STAT3 Pathway in Colorectal Cancer
Yan Lin, Ziqin He, Jiazhou Ye, Ziyu Liu, Xiaomin She, Xing Gao, Rong Liang · 2020 · OncoTargets and Therapy
A highly annotated database of genes associated with platinum resistance in cancer
Dongqing Huang, Sara R. Savage, Anna Pamela Calinawan, Chenwei Lin, Bing Zhang, Pei Wang, Timothy K. Starr, Michael J. Birrer, Amanda G. Paulovich · 2021 · Oncogene
Reprogramming tumour-associated macrophages to outcompete cancer cells
Xian Zhang, Shun Li, I. Malik, Mytrang H. Do, Liang-Liang Ji, Chun Chou, Wei Shi, Kristelle J. Capistrano, Jing Zhang, Ting-Wei Hsu et al. · 2023 · Nature
Redox control of glutamine utilization in cancer
Lilia Alberghina, Daniela Gaglio · 2014 · Cell Death and Disease
Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC
Ekta Khattar, Vinay Tergaonkar · 2017 · Frontiers in Cell and Developmental Biology
MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state
Vittoria Poli, Luca Fagnocchi, Alessandra Fasciani, Alessandro Cherubini, Stefania Mazzoleni, Sara Ferrillo, Annarita Miluzio, Gabriella Gaudioso, Valentina Vaira, Alice Turdo et al. · 2018 · Nature Communications
Molecular Glue Discovery: Current and Future Approaches
Jeffrey A. Dewey, Clémence Delalande, Saara‐Anne Azizi, Vivian Lu, Dionysios A. Antonopoulos, G. Babnigg · 2023 · Journal of Medicinal Chemistry
Transcriptional control of cancer metastasis
Brian J. Ell, Yibin Kang · 2013 · Trends in Cell Biology
microRNA-155 positively regulates glucose metabolism via PIK3R1-FOXO3a-cMYC axis in breast cancer
Sinae Kim, Eun‐Ji Lee, Jaeyun Jung, Jong Won Lee, Hee Jung Kim, Jisun Kim, Hyun Ju Yoo, Hee Jin Lee, Sun Young Chae, Sang‐Min Jeon et al. · 2018 · Oncogene
miR‐15a‐5p, miR‐15b‐5p, and miR‐16‐5p inhibit tumor progression by directly targeting MYCN in neuroblastoma
Srinivas Prabhu Chava, C. Patrick Reynolds, Anup Singh Pathania, Santhi Gorantla, Larisa Y. Poluektova, Donald W. Coulter, Subash C. Gupta, Manoj Kumar Pandey, Kishore B. Challagundla · 2019 · Molecular Oncology
Hypoxic Glioma Stem Cell–Derived Exosomes Containing Linc01060 Promote Progression of Glioma by Regulating the MZF1/c-Myc/HIF1α Axis
Junjun Li, Tingting Liao, Hongya Liu, Hongliang Yuan, Taohui Ouyang, Jiajing Wang, Songshan Chai, Jinsong Li, Jingchao Chen, Xiang Li et al. · 2020 · Cancer Research
Degrons in cancer
Bálint Mészáros, Manjeet Kumar, Toby J. Gibson, Bora Uyar, Zsuzsanna Dosztányi · 2017 · Science Signaling
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer
Jing Li, Dongdong Cheng, Miaoxin Zhu, Huajian Yu, Zhen Pan, Lei Liu, Geng Qin, Hongyu Pan, Mingxia Yan, Ming Yao · 2018 · Theranostics
YAP/TAZ Initiates Gastric Tumorigenesis via Upregulation of MYC
Wonyoung Choi, Jeongsik Kim, Jaeoh Park, Da-Hye Lee, Daehee Hwang, Jeong‐Hwan Kim, Hassan Ashktorab, Duane T. Smoot, Seon‐Young Kim, Chan Choi et al. · 2018 · Cancer Research
Delivery strategies and potential targets for siRNA in major cancer types
So Jin Lee, Min Ju Kim, Ick Chan Kwon, Thomas M. Roberts · 2016 · Advanced Drug Delivery Reviews
Oxidative stress-induced diseases and tea polyphenols
Xiangbing Mao, Changsong Gu, Daiwen Chen, Bing Yu, Jun He · 2017 · Oncotarget
Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc
Daniel Massó-Vallés, Laura Soucek · 2020 · Cells
TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations
Fang Hua, Ke Li, Jiao-jiao Yu, Xiao-Xi Lv, Jun Yan, Xiao-Wei Zhang, Wei Sun, Heng Lin, Shuang Shang, Feng Wang et al. · 2015 · Nature Communications
Metformin targets c-MYC oncogene to prevent prostate cancer
Tunde O. Akinyeke, Satoko Matsumura, Xinying Wang, Yingjie Wu, Eric D. Schalfer, Anjana D. Saxena, Wenbo Yan, Susan K. Logan, Xin Li · 2013 · Carcinogenesis
c-Myc-Targeting PROTAC Based on a TNA-DNA Bivalent Binder for Combination Therapy of Triple-Negative Breast Cancer
Xintong Li, Ze Zhang, Fangyan Gao, Yuxuan Ma, Dongying Wei, Zhangwei Lu, Siqi Chen, Mengqi Wang, Yueyao Wang, Kun Xu et al. · 2023 · Journal of the American Chemical Society
Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription
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Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?
R. Brooks Robey, Judith Weisz, Nancy B. Kuemmerle, Anna C. Salzberg, Arthur S Berg, Dustin G. Brown, Laura L. Maurer, Roberta Palorini, Fahd Al‐Mulla, Rabeah Abbas Al-Temaimi et al. · 2015 · Carcinogenesis
MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation
Baluapuri, Apoorva, Hofstetter, Julia, Dudvarski Stankovic, Nevenka, Endres, Theresa, Bhandare, Pranjali, Vos, Seychelle Monique, Adhikari, Bikash, Schwarz, Jessica Denise, Narain, Ashwin, Vogt, Markus et al. · 2019 · Molecular Cell
Dysregulation of RNA polymerase I transcription during disease
Katherine M. Hannan, Elaine Sanij, Lawrence Ian Rothblum, Ross D. Hannan, Richard B. Pearson · 2012 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc
Yinghui Li, Zhen Wang, Hui Shi, Hang Li, Leilei Li, Runping Fang, Xiaoli Cai, Bowen Liu, Xiaodong Zhang, Lihong Ye · 2016 · Cancer Research
MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours
Andrew R. Green, Mohammed A. Aleskandarany, Devika Agarwal, Somaia Elbauomy Elsheikh, Christopher C. Nolan, Maria Diez, R. Douglas Macmillan, Graham Ball, Carlos Caldas, Srinivasan Madhusudan et al. · 2016 · British Journal of Cancer
PGK1-mediated cancer progression and drug resistance.
Yu He, Luo Yang, Dan Zhang, Xixi Wang, Peng Zhang, Haocheng Li, Samina Ejaz, Shufang Liang · 2019 · PubMed Central
mTORC2 in the center of cancer metabolic reprogramming
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Taming of the beast: shaping Myc-dependent amplification
Elmar Wolf, Charles Y. Lin, Martin Eilers, David Levens · 2014 · Trends in Cell Biology
MicroRNA‐17∼92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways
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Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis
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IRE1α RNase–dependent lipid homeostasis promotes survival in Myc-transformed cancers
Hong Jian Xie, Chih-Hang Anthony Tang, Jun Ho Song, Anthony Mancuso, Juan R. Del Valle, Jin Cao, Yan Xiang, Chi Van Dang, Roy Lan, Danielle J. Sanchez et al. · 2018 · Journal of Clinical Investigation
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Feven Tameire, Ioannis I. Verginadis, Constantinos Koumenis · 2015 · Seminars in Cancer Biology
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William J. Davis, Peter Z. Lehmann, Weimin Li · 2015 · Frontiers in Cell and Developmental Biology
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Ming Cui, Lei You, Xiaoxia Ren, Wenjing Zhao, Quan Liao, Yupei Zhao · 2016 · Biochemical and Biophysical Research Communications
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Shiyong Gao, Jian Gang, Miao Yu, Guosong Xin, Huixin Tan · 2021 · BMC Cancer
LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect
Xiang, Shaoxun, Gu, Hao, Jin, Lei, Thorne, Rick F., Zhang, Xu Dong, Wu, Mian · 2018 · Proceedings of the National Academy of Sciences
Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells
Rasola, Andrea, Neckers, Len, Picard, Didier · 2014 · Trends in Cell Biology
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Camilla Salvagno, Jay K. Mandula, Paulo C. Rodrı́guez, Juan R. Cubillos‐Ruiz · 2022 · Trends in cancer
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Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma
Jennifer R. Devlin, Katherine M. Hannan, Nadine Hein, Carleen M. Cullinane, Eric P. Kusnadi, Pui Yee Ng, Amee J. George, Jake Shortt, Megan J. Bywater, Gretchen Poortinga et al. · 2015 · Cancer Discovery
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Pei Yan Liu, Daniela Erriquez, Glenn M. Marshall, Andrew E. Tee, Patsie Polly, Mathew Wong, Bing Liu, Jessica Lilian Bell, Xu Dong Zhang, Giorgio Milazzo et al. · 2014 · JNCI Journal of the National Cancer Institute
LncRNA‐MIF, a c‐Myc‐activated long non‐coding RNA, suppresses glycolysis by promoting Fbxw7‐mediated c‐Myc degradation
Pengfei Zhang, Limian Cao, Pingsheng Fan, Yide Mei, Mian Wu · 2016 · EMBO Reports
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Zhongqi Ge, Jake S. Leighton, Yumeng Wang, Xinxin Peng, Zhongyuan Chen, Hu Chen, Yutong Sun, Fan Yao, Jun Li, Huiwen Zhang et al. · 2018 · Cell Reports
A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation
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METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway
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RETRACTED ARTICLE: The c-Myc–LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer
Tianlin He, Yi-Jie Zhang, Hui Jiang, Xiao-hui Li, Hai Zhu, Kai-Lian Zheng · 2015 · Medical Oncology · Retracted
Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma
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Metabolic rivalry: circadian homeostasis and tumorigenesis
Kenichiro Kinouchi, Paolo Sassone‐Corsi · 2020 · Nature reviews. Cancer
HMGA1: A Master Regulator of Tumor Progression in Triple-Negative Breast Cancer Cells
Sandeep N. Shah, Leslie Cope, Weijie Poh, Amy Belton, Sujayita Roy, C. Conover Talbot, Saraswati V. Sukumar, David L. Huso, Linda M S Resar · 2013 · PLoS ONE
Baicalin, the major component of traditional Chinese medicine Scutellaria baicalensis induces colon cancer cell apoptosis through inhibition of oncomiRNAs
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Glutamine Metabolism in Cancer
Ting Li, Christopher Copeland, Anne Le · 2021 · Advances in experimental medicine and biology
LncRNA-encoded peptides in cancer
Yaguang Zhang · 2024 · Journal of Hematology & Oncology
Tumor cell‐specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
Stefanie Peter, Jennyfer Bultinck, Kevin Myant, Laura A. Jaenicke, Susanne Walz, Judith Müller, Michael Gmachl, Matthias Treu, Guido Boehmelt, Carsten Patrick Ade et al. · 2014 · EMBO Molecular Medicine
State of the art in medical applications using non-thermal atmospheric pressure plasma
Hiromasa Tanaka, Kenji Ishikawa, Masaaki Mizuno, Shinya Toyokuni, Hiroaki Kajiyama, Fumitaka Kikkawa, Hans‐Robert Metelmann, Masaru Hori · 2017 · Reviews of Modern Plasma Physics
MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis
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