Cited by 3,390Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancerCancer, Hypoxia, and Metabolism

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MYC on the Path to Cancer

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Dang, Chi V.·2012·Cell

DOI 10.1016/j.cell.2012.03.003PMC PMC3345192

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Abstract

The MYC oncogene contributes to the genesis of many human cancers. Recent insights into its expression and function have led to therapeutic opportunities. MYC's activation by bromodomain proteins could be inhibited by drug-like molecules, resulting in tumor inhibition in vivo. Tumor growth can also be curbed by pharmacologically uncoupling bioenergetic pathways involving glucose or glutamine metabolism from Myc-induced cellular biomass accumulation. Other approaches to halt Myc on the path to cancer involve targeting Myc-Max dimerization or Myc-induced microRNA expression. Here the richness of our understanding of MYC is reviewed, highlighting new biological insights and opportunities for cancer therapies.

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Background
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Authors: Dang, C. V.
Affiliations: Abramson Cancer Center (US)
Corresponding author: Dang, Chi V.
ORCID: Dang, Chi V.
Venue: Cell
Publisher: Elsevier BV
Published: 2012-03
Volume: 149
Issue: 1
Pages: 22-35
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2012.03.003
PMC: PMC3345192
OpenAlex: W2021536610
Cited by: 3,390
References: 232
Citations by year: 2026: 218 · 2025: 267 · 2024: 300 · 2023: 299 · 2022: 280 · 2021: 332 · 2020: 283 · 2019: 250 · 2018: 209 · 2017: 215 · 2016: 215 · 2015: 166 · 2014: 179 · 2013: 144 · 2012: 33
FWCI: 17.26
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 503 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA057341, R01CA051497, P30CA016520)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: MYC oncogene, tumor initiation, bromodomain proteins, MYC inhibitors, tumor growth inhibition, bioenergetics, glucose metabolism, glutamine metabolism, biomass accumulation, microRNA expression, cancer therapy
MeSH terms: Animals, Cell Transformation, Neoplastic, Humans, Neoplasms, Gene Expression Regulation, Neoplastic, Genes, myc, Proto-Oncogene Proteins c-myc, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

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