The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
The Life History of 21 Breast Cancers
Open accessAbstract
Cancer evolves dynamically as clonal expansions supersede one another driven by shifting selective pressures, mutational processes, and disrupted cancer genes. These processes mark the genome, such that a cancer's life history is encrypted in the somatic mutations present. We developed algorithms to decipher this narrative and applied them to 21 breast cancers. Mutational processes evolve across a cancer's lifespan, with many emerging late but contributing extensive genetic variation. Subclonal diversification is prominent, and most mutations are found in just a fraction of tumor cells. Every tumor has a dominant subclonal lineage, representing more than 50% of tumor cells. Minimal expansion of these subclones occurs until many hundreds to thousands of mutations have accumulated, implying the existence of long-lived, quiescent cell lineages capable of substantial proliferation upon acquisition of enabling genomic changes. Expansion of the dominant subclone to an appreciable mass may therefore represent the final rate-limiting step in a breast cancer's development, triggering diagnosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Cancer whole genome sequencing (WGS) is now feasible, with thousands of matched tumor-normal pairs successfully sequenced to date, revealing novel biological insights2–4.”
From Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study (2019) · cites this paper as [3]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
A map of human genome variation from population-scale sequencing.
The 1000 Genomes Project Consortium (2010) · Nature · doi:10.1038/nature09534 · Cited by 7,877
The landscape of somatic copy-number alteration across human cancers
Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Howie, B. N., Donnelly, P., & Marchini, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000529 · Cited by 3,928
Stratton, M. R., Campbell, P. J., & Futreal, P. A. (2009) · Nature · doi:10.1038/nature07943 · Cited by 3,625
Self-citationCancer stem cells in solid tumours: accumulating evidence and unresolved questions
Visvader, J. E., & Lindeman, G. J. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2499 · Cited by 3,501
Patterns of somatic mutation in human cancer genomes
Greenman, C. D., Stephens, P., Smith, R., Dalgliesh, G. L., Hunter, C., Bignell, G. R., Davies, H. R., Teague, J. W., Butler, A. P., Stevens, C., et al. (2007) · Nature · doi:10.1038/nature05610 · Cited by 3,143
Self-citationTumour evolution inferred by single-cell sequencing
Navin, N., Kendall, J., Troge, J., Andrews, P., Rodgers, L., McIndoo, J., Cook, K., Stepansky, A., Levy, D., Esposito, D., et al. (2011) · Nature · doi:10.1038/nature09807 · Cited by 2,598
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- 1000 Genomes Project Consortium. (2010). A map of human genome variation from population-scale sequencing. Nature 467, 1061–1073. · DOI · Paper page
- Greenman, C.D., Pleasance, E.D., Newman, S., Yang, F., Fu, B., Nik-Zainal, S., Jones, D., Lau, K.W., Carter, N., Edwards, P.A., et al. (2012). Estimation of rearrangement phylogeny for cancer genomes. Genome Res. 22, 346–361. · DOI
- Van Loo, P., Nordgard, S.H., Lingjærde, O.C., Russnes, H.G., Rye, I.H., Sun, W., Weigman, V.J., Marynen, P., Zetterberg, A., Naume, B., et al. (2010). Allele-specific copy number analysis of tumors. Proc. Natl. Acad. Sci. USA 107, 16910–16915. · DOI
Cited by
Sorted by citations
Items 401–500 of 1,000
Deleterious Passengers in Adapting Populations
Good, B. H., & Desai, M. M. (2014) · Genetics · doi:10.1534/genetics.114.170233 · Cited by 68
Virmid: accurate detection of somatic mutations with sample impurity inference
Kim, S., Jeong, K., Bhutani, K., Lee, J. H., Patel, A. D., Scott, E., Nam, H., Lee, H., Gleeson, J. G., & Bafna, V. (2013) · Genome biology · doi:10.1186/gb-2013-14-8-r90 · Cited by 71
The PCAWG Evolution and Heterogeneity Working Group, Tarabichi, M., Martincorena, I., Gerstung, M., Leroi, A. M., Markowetz, F. M., Spellman, P. T., Morris, Q., Lingjærde, O. C., Wedge, D. C., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0258-x · Cited by 67
Self-citationAromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers
Miller, C. A., Gindin, Y., Lu, C., Griffith, O. L., Griffith, M., Shen, D., Hoog, J., Li, T., Larson, D. E., Watson, M. A., et al. (2016) · Nature Communications · doi:10.1038/ncomms12498 · Cited by 69
Mechanisms of breast cancer metastasis
Nathanson, D. S., Detmar, M. J., Padera, T. P., Yates, L. R., Welch, D. R., Beadnell, T. C., Scheid, A. D., Wrenn, E. D., & Cheung, K. J. (2021) · Clinical & Experimental Metastasis · doi:10.1007/s10585-021-10090-2 · Cited by 82
Metastasis Awakening: The challenges of targeting minimal residual cancer
Polzer, B. M., & Klein, C. A. (2013) · Nature Medicine · doi:10.1038/nm.3121 · Cited by 66
Wang, E., Zou, J., Zaman, N., Beitel, L. K., Trifiro, M. A., & Paliouras, M. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.06.001 · Cited by 70
Patchwork: allele-specific copy number analysis of whole-genome sequenced tumor tissue
Mayrhofer, M., DiLorenzo, S., & Isaksson, A. (2013) · Genome biology · doi:10.1186/gb-2013-14-3-r24 · Cited by 69
MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
Chen, X., Burkhardt, D. B., Hartman, A. A., Hu, X., Eastman, A. E., Sun, C., Wang, X., Zhong, M., Krishnaswamy, S., & Guo, S. (2019) · Nature Communications · doi:10.1038/s41467-019-13666-5 · Cited by 58
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
Anderson, N. D., Babichev, Y., Fuligni, F., Comitani, F., Layeghifard, M., Venier, R. E., Dentro, S. C., Maheshwari, A., Guram, S., Wunker, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24677-6 · Cited by 72
Self-citationBaslan, T., Kendall, J., Volyanskyy, K. Y., McNamara, K. L., Cox, H., D'Italia, S., Ambrosio, F. J., Riggs, M. G., Rodgers, L., Leotta, A., et al. (2020) · eLife · doi:10.7554/elife.51480 · Cited by 67
Sharma, S., Helchowski, C. M., & Canman, C. E. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.11.002 · Cited by 71
How to study and overcome tumor heterogeneity with circulating biomarkers: The breast cancer case
Appierto, V., Cosimo, S. D., Reduzzi, C., Pala, V., Cappelletti, V., & Daidone, M. G. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.04.007 · Cited by 69
Intra-tumor genetic heterogeneity in rectal cancer
Hardiman, K. M., Ulintz, P., Kuick, R. D., Hovelson, D. H., Gates, C., Bhasi, A., Grant, A. R., Liu, J., Cani, A. K., Greenson, J. K., et al. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.131 · Cited by 66
Ansari‐Pour, N., Zheng, Y., Yoshimatsu, T. F., Sanni, A., Ajani, M., Reynier, J.-B., Tapinos, A., Pitt, J. J., Dentro, S. C., Woodard, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27079-w · Cited by 66
Self-citationAPOBEC-Induced Mutagenesis in Cancer
Mertz, T. M., Collins, C. D., Dennis, M. A., Coxon, M., & Roberts, S. A. (2022) · Annual Review of Genetics · doi:10.1146/annurev-genet-072920-035840 · Cited by 65
Progress in the clinical detection of heterogeneity in breast cancer
Song, J., Chen, C., Yuan, J., & Sun, S. (2016) · Cancer Medicine · doi:10.1002/cam4.943 · Cited by 66
DNA damage repair in breast cancer and its therapeutic implications
Ali, R., Rakha, E. A., Madhusudan, S., & Bryant, H. E. (2016) · Pathology · doi:10.1016/j.pathol.2016.11.002 · Cited by 66
Li, B., Liu, J., Jia, Y., Wang, J., Xu, Z., Qin, T., Shi, Z., Song, Z., Peng, S., Huang, H., et al. (2017) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22510 · Cited by 66
The evolution of the unstable cancer genome
Burrell, R. A., & Swanton, C. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.11.011 · Cited by 66
Subtype‐specific micro‐RNA expression signatures in breast cancer progression
Haakensen, V. D., Nygaard, V., Greger, L., Aure, M. R. R., Fromm, B., Bukholm, I., Lüders, T., Chin, S., Git, A., Caldas, C., et al. (2016) · International Journal of Cancer · doi:10.1002/ijc.30142 · Cited by 65
Self-citationIntratumor heterogeneity in epigenetic patterns
Assenov, Y., Brocks, D., & Gerhäuser, C. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.01.010 · Cited by 67
Karanja, K. K., Lee, E. H., Hendrickson, E. A., & Campbell, J. L. (2014) · Cell Cycle · doi:10.4161/cc.28476 · Cited by 65
Ellison, G., Huang, S., Carr, T. H., Wallace, A. J., Ahdesmaki, M. J., Bhaskar, S. S., & MILLS, J. S. (2015) · BMC Clinical Pathology · doi:10.1186/s12907-015-0004-6 · Cited by 65
Toward precision medicine of breast cancer
Carels, N., Spinassé, L. B., Tilli, T. M., & Tuszyński, J. A. (2016) · Theoretical Biology and Medical Modelling · doi:10.1186/s12976-016-0035-4 · Cited by 65
Molecular signatures in breast cancer
Lal, S., Reed, A. E. M., Luca, X. M. D., & Simpson, P. T. (2017) · Methods · doi:10.1016/j.ymeth.2017.06.032 · Cited by 65
Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue
Vattathil, S., & Scheet, P. A. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.02.003 · Cited by 64
DiMarco, A. V., Qin, X., McKinney, B. J., Garcia, N. M. G., Alsten, S. C. V., Mendes, E. A., Force, J. M., Hanks, B. A., Troester, M. A., Owzar, K., et al. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0146 · Cited by 61
Shukla, N. N., Roberts, S. S., Baki, M. O., Mushtaq, Q. D., Goss, P. E., Park, B. H., Gundem, G., Tian, K., Geiger, H. M., Redfield, K., et al. (2017) · JCO Precision Oncology · doi:10.1200/po.17.00034 · Cited by 64
Self-citationPatterns of genomic evolution in advanced melanoma
Birkeland, E. E., Zhang, S., Poduval, D. B., Geisler, J., Nakken, S., Vodák, D., Meza‐Zepeda, L. A., Hovig, E. J., Myklebost, O., Knappskog, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05063-1 · Cited by 62
ASEQ: fast allele-specific studies from next-generation sequencing data
Romanel, A., Lago, S., Prandi, D., Sboner, A., & Demichelis, F. (2015) · BMC Medical Genomics · doi:10.1186/s12920-015-0084-2 · Cited by 63
The Making of a PreCancer Atlas: Promises, Challenges, and Opportunities
Srivastava, S., Ghosh, S., Kagan, J., Mazurchuk, R. V., Boja, E. S., Chuaqui, R. F., Chavarria-Johnson, E., Davidsen, T. M., Eary, J. F., Haim, T., et al. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.06.007 · Cited by 60
Qiao, Y., Quinlan, A. R., Jazaeri, A. A., Verhaak, R. G. W., Wheeler, D. A., & Marth, G. (2014) · Genome biology · doi:10.1186/preaccept-1691129011290725 · Cited by 61
Do platinum salts fit all triple negative breast cancers?
Gerratana, L., Fanotto, V., Pelizzari, G., Agostinetto, E., & Puglisi, F. (2016) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2016.06.004 · Cited by 67
Xiao, W., Bharadwaj, M. C., Levine, M. F., Farnoud, N. R., Pastore, F., Getta, B. M., Hultquist, A., Famulare, C. A., Medina-Martinez, J. S., Patel, M. A., et al. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018023531 · Cited by 62
Self-citationFarah, C. S., Jessri, M., Bennett, N. J., Dalley, A. J., Shearston, K., & Fox, S. A. (2019) · Oral Oncology · doi:10.1016/j.oraloncology.2019.07.005 · Cited by 62
In utero origin of myelofibrosis presenting in adult monozygotic twins
Sousos, N., Leathlobhair, M. N., Karali, C. S., Louka, E., Bienz, N., Royston, D. J., Clark, S., Hamblin, A. D., Howard, K., Mathews, V., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01793-4 · Cited by 60
Self-citationThe mutagenic forces shaping the genomes of lung cancer in never smokers
Díaz‐Gay, M., Zhang, T., Hoang, P. H., Leduc, C., Baine, M. K., Travis, W. D., Sholl, L. M., Joubert, P., Khandekar, A., Wei, Z., et al. (2025) · Nature · doi:10.1038/s41586-025-09219-0 · Cited by 85
Self-citationThe value of monitoring to control evolving populations
Fischer, A., Vázquez-Garćıa, I., & Mustonen, V. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409403112 · Cited by 63
Computational Cancer Biology: An Evolutionary Perspective
Beerenwinkel, N., Greenman, C., & Lagergren, J. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004717 · Cited by 63
Self-citationEvaluation and consequences of heterogeneity in the circulating tumor cell compartment
Brouwer, A., Laere, B. D., Peeters, D. J. E., Peeters, M., Salgado, R., Dirix, L. Y., & Laere, S. V. (2016) · Oncotarget · doi:10.18632/oncotarget.8015 · Cited by 64
The Discovery of Mutated Driver Pathways in Cancer: Models and Algorithms
Zhang, J., & Zhang, S. (2016) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2016.2640963 · Cited by 62
Leusink, F. K. J., van Es, R. J. J., de Bree, R., de Jong, R. J. B., van Hooff, S. R., Holstege, F. C. P., Slootweg, P. J., Brakenhoff, R. H., & Takes, R. P. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70395-9 · Cited by 60
Polymerase specific error rates and profiles identified by single molecule sequencing
Hestand, M. S., Houdt, J. V., Cristofoli, F., & Vermeesch, J. R. (2016) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2016.01.003 · Cited by 58
Takeshita, T., Yamamoto, Y., Yamamoto‐Ibusuki, M., Tomiguchi, M., Sueta, A., Murakami, K., Omoto, Y., & Iwase, H. (2017) · Oncotarget · doi:10.18632/oncotarget.18479 · Cited by 61
Walter, V. P., Fischer, C., Deutsch, T. M., Ersing, C., Nees, J., Schütz, F., Fremd, C., Grischke, E., Sinn, H., Brucker, S. Y., et al. (2020) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-05746-8 · Cited by 62
Genetic heterogeneity in breast cancer: the road to personalized medicine?
Baird, R. D., & Caldas, C. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-151 · Cited by 59
Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions
Ang, D. C., Warrick, A., Schilling, A., Beadling, C., Corless, C. L., & Troxell, M. L. (2013) · Modern Pathology · doi:10.1038/modpathol.2013.197 · Cited by 58
Pellacani, D., Tan, S., Lefort, S., & Eaves, C. J. (2019) · The EMBO Journal · doi:10.15252/embj.2018100330 · Cited by 55
Jager, M., Blokzijl, F., Sasselli, V., Boymans, S., Janssen, R., Besselink, N., Clevers, H., van Boxtel, R., & Cuppen, E. (2018) · Nature Protocols · doi:10.1038/nprot.2017.111 · Cited by 66
Concepts in solid tumor evolution
Sidow, A., & Spies, N. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.02.001 · Cited by 60
Stead, L. F., Sutton, K., Taylor, G. R., Quirke, P., & Rabbitts, P. H. (2013) · Human Mutation · doi:10.1002/humu.22365 · Cited by 57
Inferring early genetic progression in cancers with unobtainable premalignant disease
Leshchiner, I., Mroz, E. A., Cha, J., Rosebrock, D., Spiro, O., Bonilla‐Velez, J., Faquin, W. C., Lefranc-Torres, A., Lin, D. T., Michaud, W. A., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00533-y · Cited by 56
Relapse Timing Is Associated With Distinct Evolutionary Dynamics in Diffuse Large B-Cell Lymphoma
Hilton, L. K., Ngu, H. S., Collinge, B. J., Dreval, K., Ben‐Neriah, S., Rushton, C. K., Wong, J., Cruz, M., Roth, A. J. L., Boyle, M., et al. (2023) · Journal of Clinical Oncology · doi:10.1200/jco.23.00570 · Cited by 62
Syn, N. L. X., Yong, W. P., Goh, B. C., & Lee, S. C. (2016) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2016.1196187 · Cited by 59
STARCH: copy number and clone inference from spatial transcriptomics data
Elyanow, R., Zeira, R., Land, M., & Raphael, B. J. (2020) · Physical Biology · doi:10.1088/1478-3975/abbe99 · Cited by 56
Yang, K., Yu, W., Liu, H., Ding, F., Zhang, Y., Zhang, Y., Wang, W., Lou, F., Cao, S., Wang, H., et al. (2021) · The Oncologist · doi:10.1002/onco.13839 · Cited by 57
Álvarez, E. G., Demeulemeester, J., Otero, P., Jolly, C., García‐Souto, D., Pequeño‐Valtierra, A., Zamora, J., Tojo, M., Temes, J., Baez‐Ortega, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26805-8 · Cited by 61
Self-citationAPOBEC mutagenesis is a common process in normal human small intestine
Wang, Y., Robinson, P. S., Coorens, T. H. H., Moore, L., Lee-Six, H., Noorani, A., Sanders, M. A., Jung, H., Katainen, R., Heuschkel, R. B., et al. (2023) · Nature Genetics · doi:10.1038/s41588-022-01296-5 · Cited by 65
Self-citationNakshatri, H., Anjanappa, M., & Bhat‐Nakshatri, P. (2015) · Scientific Reports · doi:10.1038/srep13526 · Cited by 54
Discovery of the natural anti‐Gal antibody and its past and future relevance to medicine
Galili, U. (2013) · Xenotransplantation · doi:10.1111/xen.12034 · Cited by 56
Roberts, S. A., & Gordenin, D. A. (2014) · BioEssays · doi:10.1002/bies.201300140 · Cited by 56
Inferring structural variant cancer cell fraction
Cmero, M., Yuan, K., Ong, C. S., Schröder, J., PCAWG Evolution and Heterogeneity Working Group, Adams, D. J., Anur, P., Beroukhim, R., Boutros, P. C., Bowtell, D. D. L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14351-8 · Cited by 56
Self-citationA recurrent novel MGA–NUTM1 fusion identifies a new subtype of high-grade spindle cell sarcomaPreprint
Diolaiti, D., Cruz, F. S. D., Gundem, G., Bouvier, N., Boulad, M., Zhang, Y., Chou, A. J., Dunkel, I. J., Sanghvi, R., Shah, M. J., et al. (2018) · Molecular Case Studies · doi:10.1101/mcs.a003194 · Cited by 57
Self-citationSubclonal heterogeneity and evolution in breast cancer
Mavrommati, I., Johnson, F., Echeverria, G. V., & Natrajan, R. (2021) · npj Breast Cancer · doi:10.1038/s41523-021-00363-0 · Cited by 56
Clinical Integration of Next-Generation Sequencing Technology
Gullapalli, R. R., Lyons‐Weiler, M. A., Petrosko, P., Dhir, R., Becich, M. J., & LaFramboise, W. A. (2012) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2012.07.005 · Cited by 56
Translating neoadjuvant therapy into survival benefits: one size does not fit all
Mattos‐Arruda, L. D., Shen, R., Reis-Filho, J. S., & Cortés, J. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.35 · Cited by 52
Re-Evaluating Clonal Dominance in Cancer Evolution
Burrell, R. A., & Swanton, C. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.04.002 · Cited by 54
Precision medicine in pheochromocytoma and paraganglioma: current and future concepts
Björklund, P., Pacák, K., & Crona, J. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12507 · Cited by 59
Tumor propagating cells: drivers of tumor plasticity, heterogeneity, and recurrence
Vessoni, A. T., Filippi‐Chiela, E. C., Lenz, G., & Batista, L. F. Z. (2019) · Oncogene · doi:10.1038/s41388-019-1128-4 · Cited by 59
What are we learning from the cancer genome?
Collisson, E. A., Cho, R. J., & Gray, J. W. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.159 · Cited by 55
The dynamics of adaptive genetic diversity during the early stages of clonal evolution
Blundell, J. R., Schwartz, K., Francois, D., Fisher, D. S., Sherlock, G. J., & Levy, S. F. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-018-0758-1 · Cited by 54
A population genetics perspective on the determinants of intra-tumor heterogeneity
Hu, Z., Sun, R., & Curtis, C. N. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.03.001 · Cited by 54
The BRCA2 mutation status shapes the immune phenotype of prostate cancer
Jenzer, M., Keß, P., Nientiedt, C., Endris, V., Kippenberger, M., Leichsenring, J., Stögbauer, F., Haimes, J. D., Mishkin, S. J., Kudlow, B. A., et al. (2019) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-019-02393-x · Cited by 53
Toward a general evolutionary theory of oncogenesis
Ewald, P. W., & Ewald, H. A. S. (2012) · Evolutionary Applications · doi:10.1111/eva.12023 · Cited by 54
Bioinformatics for cancer immunology and immunotherapy
Charoentong, P., Angelova, M., Efremova, M., Gallasch, R., Hackl, H., Galon, J., & Trajanoski, Z. (2012) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-012-1354-x · Cited by 52
Big Bang Tumor Growth and Clonal EvolutionPreprint
Sun, R., Hu, Z., & Curtis, C. N. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028381 · Cited by 61
Inference of Tumor Phylogenies with Improved Somatic Mutation Discovery
Salari, R., Saleh, S. S., Kashef-Haghighi, D., Khavari, D., Newburger, D. E., West, R. B., Sidow, A., & Batzoglou, S. (2013) · Journal of Computational Biology · doi:10.1089/cmb.2013.0106 · Cited by 51
Elucidating acquired PARP inhibitor resistance in advanced prostate cancer
Seed, G., Beije, N., Yuan, W., Bertan, C. M., Goodall, J. R., Lundberg, A., Tyler, M., Figueiredo, I., Pereira, R., Baker, C., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.10.015 · Cited by 57
Tarabichi, M., Antoniou, A., Saiselet, M., Pita, J. M. G., Andry, G., Dumont, J. E., Detours, V., & Maenhaut, C. (2013) · Cancer and Metastasis Reviews · doi:10.1007/s10555-013-9431-y · Cited by 51
Inferring mutational timing and reconstructing tumour evolutionary histories
Turajlic, S., McGranahan, N., & Swanton, C. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.03.005 · Cited by 53
Different Facets of Copy Number Changes: Permanent, Transient, and Adaptive
Mishra, S., & Whetstine, J. R. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00652-15 · Cited by 53
Sex difference of mutation clonality in diffuse glioma evolution
Zhang, H., Liao, J., Zhang, X., Zhao, E., Liang, X., Luo, S., Shi, J., Yu, F., Xu, J., Shen, W., et al. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy154 · Cited by 50
The evolutionary history of 2,658 cancersPreprint
Gerstung, M., Jolly, C., Leshchiner, I., Dentro, S. C., González, S., Rosebrock, D., Mitchell, T. J., Rubanova, Y., Anur, P., Yu, K., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/161562 · Cited by 51
Self-citationRegional biases in mutation screening due to intratumoural heterogeneity of prostate cancer
Kim, T., Jung, S., Baek, I.-W., Lee, S., Choi, Y., Lee, J., Yeun‐Jun, C., & Lee, S. (2014) · The Journal of Pathology · doi:10.1002/path.4380 · Cited by 51
Clonal evolution during metastatic spread in high-risk neuroblastoma
Gundem, G., Levine, M. F., Roberts, S. S., Cheung, I. Y., Medina-Martinez, J. S., Feng, Y., Ossa, J. A., Chadoutaud, L., Rita, M., Asimomitis, G., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01395-x · Cited by 57
Self-citationMaguire, S. L., Peck, B., Wai, P. T., Campbell, J., Barker, H. E., Gulati, A., Daley, F. M., Vyse, S., Huang, P. H., Lord, C. J., et al. (2016) · The Journal of Pathology · doi:10.1002/path.4778 · Cited by 49
Wood, H. M., Daly, C. L., Chalkley, R., Şengüven, B., Ross, L., Egan, P. A., Chengot, P., Graham, J. L., Sethi, N., Ong, T. K., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0442-0 · Cited by 49
Clinical Trials of Precision Medicine through Molecular Profiling: Focus on Breast Cancer
Zardavas, D., & Piccart, M. J. (2015) · American Society of Clinical Oncology Educational Book · doi:10.14694/edbook_am.2015.35.e183 · Cited by 49
Lessons learned from the intrinsic subtypes of breast cancer in the quest for precision therapy
Norum, J. H., Andersen, K., & Sørlie, T. (2014) · British journal of surgery · doi:10.1002/bjs.9562 · Cited by 49
Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases
Durfee, C. C., Temiz, N. A., Levin-Klein, R., Argyris, P. P., Alsøe, L., Carracedo, S., de la Vega, A. A., Proehl, J., Holzhauer, A. M., Seeman, Z. J., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101211 · Cited by 52
Austreid, E., Lønning, P. E., & Eikesdal, H. P. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.885952 · Cited by 49
Ovarian cancer: Status of homologous recombination pathway as a predictor of drug response
Picciotto, N. D., Cacheux, W., Roth, A. D., Chappuis, P. O., & Labidi‐Galy, S. I. (2016) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2016.02.014 · Cited by 51
Intratumor Heterogeneity: Novel Approaches for Resolving Genomic Architecture and Clonal Evolution
Gupta, R. G., & Somer, R. A. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0070 · Cited by 49
An enhanced genetic model of colorectal cancer progression history
Yang, L., Wang, S., Lee, J. J.-K., Lee, S., Lee, E., Shinbrot, E., Wheeler, D. A., Kucherlapati, R., & Park, P. J. (2019) · Genome biology · doi:10.1186/s13059-019-1782-4 · Cited by 48
Maclachlan, K. H., Rustad, E. H., Derkach, A., Zheng-Lin, B., Yellapantula, V., Diamond, B., Hultcrantz, M., Ziccheddu, B., Boyle, E. M., Blaney, P., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25469-8 · Cited by 49
Murai, K., Dentro, S. C., Ong, S. H., Sood, R. K., Fernández‐Antorán, D., Herms, A., Kostiou, V., Abnizova, I., Hall, B. A., Gerstung, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33945-y · Cited by 52
Mutated tumor alleles are expressed according to their DNA frequency
Castle, J. C., Löewer, M., Boegel, S., Tadmor, A. D., Boisguérin, V., de Graaf, J., Paret, C., Diken, M., Kreiter, S., Türeci, Ö., et al. (2014) · Scientific Reports · doi:10.1038/srep04743 · Cited by 46
Kawazu, M., Kojima, S., Ueno, T., Totoki, Y., Nakamura, H. K., Kunita, A., Qü, W., Yoshimura, J., Soda, M., Yasuda, T., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006853 · Cited by 48
Computational approaches for discovery of mutational signatures in cancer
Baez‐Ortega, A., & Gori, K. C. (2017) · Briefings in Bioinformatics · doi:10.1093/bib/bbx082 · Cited by 48
Metadata
- Authors
- Nik-Zainal, S., Van Loo, P., Wedge, D. C., Alexandrov, L. B., Greenman, C. D., Lau, K. W., Raine, K., Jones, D., Marshall, J., Ramakrishna, M., Shlien, A., Cooke, S. L., Hinton, J., Menzies, A., Stebbings, L. A., Leroy, C., Jia, M., Rance, R., Mudie, L. J., Gamble, S. J., Stephens, P. J., McLaren, S., Tarpey, P. S., Papaemmanuil, E., Davies, H. R., Varela, I., McBride, D. J., Bignell, G. R., Leung, K., Butler, A. P., Teague, J. W., Martin, S., Jönsson, G., Mariani, O., Boyault, S., Miron, P., Fatima, A., Langerød, A., Aparicio, S. A. J. R., Tutt, A., Sieuwerts, A. M., Borg, Å., Thomas, G., Salomon, A. V., Richardson, A. L., Børresen-Dale, A.-L., Futreal, P. A., Stratton, M. R., & Campbell, P. J.
- Affiliations
- Wellcome Sanger Institute (GB)
- University of East Anglia (GB)
- King's College London (GB)
- Institut Curie (FR)
- Lyon 1 Université (FR)
- Dana-Farber Cancer Institute (US)
- Oslo University Hospital (NO)
- University of British Columbia (CA)
- Erasmus MC (NL)
- Lund University (SE)
- Brigham and Women's Hospital (US)
- University of Cambridge (GB)
- Corresponding author
- Campbell, Peter J.
- ORCID
- Wedge, David C.
- Alexandrov, Ludmil B.
- Lau, King Wai
- Raine, Keiran
- Jones, David
- Marshall, John
- Ramakrishna, Manasa
- Shlien, Adam
- Hinton, Jonathan
- Menzies, Andrew
- Jia, Mingming
- Tarpey, Patrick S.
- Papaemmanuil, Elli
- Davies, Helen R.
- Varela, Ignacio
- McBride, David J.
- Teague, Jon W.
- Martin, Sancha
- Jönsson, Goran
- Mariani, Odette
- Boyault, Sandrine
- Miron, Penelope
- Aparicio, Samuel A.J.R.
- Tutt, Andrew
- Sieuwerts, Anieta M.
- Borg, Åke
- Thomas, Gilles
- Richardson, Andrea L.
- Futreal, P. Andrew
- Stratton, Michael R.
- Campbell, Peter J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 149
- Issue
- 5
- Pages
- 994-1007
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3428864
- OpenAlex
- W2109991075
- Cited by
- 1,443
- References
- 39
- Citations by year
- 2026: 51 · 2025: 77 · 2024: 83 · 2023: 84 · 2022: 71 · 2021: 112 · 2020: 105 · 2019: 93 · 2018: 114 · 2017: 103 · 2016: 100 · 2015: 126 · 2014: 139 · 2013: 140 · 2012: 44
- FWCI
- 47.68
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-08-13)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Lirias (KU Leuven) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Apollo (cc-by)
- Funders
- Wellcome Trust (088340, 093867, WT088340MA, 098051)
- National Institute for Health and Care Research
- European Commission (242006)
- National Cancer Institute (CA 089393, P50CA089393)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- breast cancer, tumor evolution, clonal evolution, somatic mutations, mutational processes, clonal expansion, cancer genomics
- MeSH terms
- Algorithms, Breast Neoplasms, Cell Transformation, Neoplastic, Chromosome Aberrations, Female, Humans, Mutation, Point Mutation, Clonal Evolution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
