Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

Role of YAP/TAZ in mechanotransduction

Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092

TEAD mediates YAP-dependent gene induction and growth control

Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498

Elucidation of a universal size-control mechanism in Drosophila and mammals

Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370

Mutations in GNA11 in Uveal Melanoma

Raamsdonk, C. D. V., Griewank, K., Crosby, M. B., Garrido, M. C., Vemula, S. S., Wiesner, T., Obenauf, A. C., Wackernagel, W., Green, G., Bouvier, N., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000584 · Cited by 1,507

G-protein-coupled receptors and cancer

Dorsam, R. T., & Gutkind, J. S. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2069 · Cited by 1,448

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF β-TRCP

Zhao, B., Li, L., Tumaneng, K., Wang, C.-Y., & Guan, K.-L. (2010) · Genes & Development · doi:10.1101/gad.1843810 · Cited by 1,418

Lipidomics reveals a remarkable diversity of lipids in human plasma

Quehenberger, O., Armando, A. M., Brown, A. H., Milne, S. B., Myers, D. S., Merrill, A. H., Bandyopadhyay, S., Jones, K. N., Kelly, S., Shaner, R. L., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m009449 · Cited by 1,341

YAP1 increases organ size and expands undifferentiated progenitor cells

Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252

Mammalian G Proteins and Their Cell Type Specific Functions

Wettschureck, N., & Offermanns, S. (2005) · Physiological Reviews · doi:10.1152/physrev.00003.2005 · Cited by 1,225

The interplay between centrosomes and the Hippo tumor suppressor pathway

Bolgioni, A. F., & Ganem, N. J. (2015) · Chromosome Research · doi:10.1007/s10577-015-9502-8 · Cited by 21

Genetic and Functional Evidence Supports LPAR1 as a Susceptibility Gene for Hypertension

Xu, K., Ma, L., Li, Y., Wang, F., Zheng, G.-Y., Sun, Z., Jiang, F., Chen, Y., Liu, H., Dang, A., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05515 · Cited by 20

Sustained Adrenergic Activation of YAP1 Induces Anoikis Resistance in Cervical Cancer Cells

Li, Y., Yang, S., Sadaoui, N. C., Hu, W. M., Dasari, S. K., Mangala, L. S., Sun, Y., Zhao, S., Wang, L., Liu, Y., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101289 · Cited by 20

Roles of CCN2 as a mechano-sensing regulator of chondrocyte differentiation

Nishida, T., & Kubota, S. (2020) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2020.07.001 · Cited by 20

Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via Hippo pathway

Lin, L., Wen, J., Lin, B., Chen, H., Bhandari, A., Qi, Y., Zheng, D., & Wang, O. (2021) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmab016 · Cited by 20

Cellular feedback dynamics and multilevel regulation driven by the hippo pathway

Park, J., & Hansen, C. G. (2021) · Biochemical Society Transactions · doi:10.1042/bst20200253 · Cited by 19

Role of smooth muscle YAP and TAZ in protection against phenotypic modulation, inflammation, and aneurysm development

Daoud, F., Arévalo‐Martínez, M., Holst, J., Holmberg, J., Albinsson, S., & Swärd, K. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115307 · Cited by 20

Two-Pore-Domain Potassium Channel TREK–1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation

Zhang, Y., Fu, J., Han, Y., Feng, D., Yue, S., Zhou, Y., & Luo, Z. (2023) · Biomedicines · doi:10.3390/biomedicines11051279 · Cited by 23

Coagulation factor VIIa enhances programmed death-ligand 1 expression and its stability in breast cancer cells to promote breast cancer immune evasion

Paul, S., Das, K., Ghosh, A., Chatterjee, A., Bhoumick, A., Basu, A., & Sen, P. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.08.008 · Cited by 20

Simulated microgravity attenuates skin wound healing by inhibiting dermal fibroblast migration via F‐actin/YAP signaling pathway

Zhou, Y., Lv, W., Peng, X., Cheng, Y., Tu, Y., Song, G., & Luo, Q. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31126 · Cited by 21

Yes-Associated Protein Mediates the Transition from Inflammation to Fibrosis in Graves' Orbitopathy

Ko, J., Kim, Y. J., Choi, S. H., Lee, C. S., & Yoon, J. S. (2023) · Thyroid · doi:10.1089/thy.2023.0309 · Cited by 21

Role of the Hippo pathway in autoimmune diseases

Kong, H., Han, J., Gorbachev, D. O., & Zhang, X. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112336 · Cited by 20

Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathway

Zhang, S., Zhang, B., Liao, Z., Chen, Y., Guo, W., Wu, J., Liu, H., Weng, R., Su, D., Chen, G., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.02.027 · Cited by 20

Lysophosphatidic acid enhances human umbilical cord mesenchymal stem cell viability without differentiation via LPA receptor mediating manner

Li, N., Yan, Y., Fu, S., Li, R., Zhao, P., Xu, X., Yang, J. O., & Damirin, A. (2017) · APOPTOSIS · doi:10.1007/s10495-017-1399-6 · Cited by 20

YAP knockdown inhibits proliferation and induces apoptosis of human prostate cancer DU145 cells

Jin, X., Zhao, W., Zhou, P., & Niu, T. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.8352 · Cited by 20

An alternatively transcribed TAZ variant negatively regulates JAK‐STAT signaling

Fang, C., Li, J., Qi, S., Lei, Y., Zeng, Y. J., Yu, P., Hu, Z., Zhou, Y., Wang, Y., Dai, R., et al. (2019) · EMBO Reports · doi:10.15252/embr.201847227 · Cited by 20

YAP/TAZ: a promising target for squamous cell carcinoma treatment

Dong, X., Meng, L., Liu, P., Ji, R., Su, X., Xin, Y., & Jiang, X. M. (2019) · Cancer Management and Research · doi:10.2147/cmar.s197921 · Cited by 23

Lysophosphatidic acid protects against acetaminophen-induced acute liver injury

Bae, G. H., Lee, S. K., Kim, H. S., Lee, M., Lee, H. Y., & Bae, Y. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.203 · Cited by 20

Dynamically urethra-adapted and obligations-oriented trilayer hydrogels integrate scarless urethral repair

Yang, M., Zuo, M., Yang, R., Zhang, K., Jia, R., Yin, B., Wang, Y., Liu, M., Fang, W., Guo, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62851-2 · Cited by 19

Role of the SphK‐S1P‐S1PRs pathway in invasion of the nervous system by SARS‐CoV‐2 infection

Pan, Y., Gao, F., Zhao, S., Han, J., & Chen, F. (2021) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13483 · Cited by 19

The hippo pathway orchestrates cytoskeletal organisation during intervertebral disc degeneration

Zhang, C., Wang, F., Xie, Z., Chen, L., & Wu, X. (2021) · Acta Histochemica · doi:10.1016/j.acthis.2021.151770 · Cited by 19

Emerging roles for the YAP/TAZ transcriptional regulators in brain tumour pathology and targeting options

Strepkos, D., Markouli, M., Papavassiliou, K. A., Papavassiliou, A. G., & Piperi, C. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12762 · Cited by 21

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer

Xu, G., Yang, Z., Sun, Y., Dong, H., & Ma, J. (2021) · Discover Oncology · doi:10.1007/s12672-021-00430-9 · Cited by 19

Arsenic trioxide activates yes-associated protein by lysophosphatidic acid metabolism to selectively induce apoptosis of vascular smooth muscle cells

Yu, H., Hou, Z., Xiang, M., Yang, F., Ma, J., Yang, L., Ma, X., Zhou, L., He, F., Miao, M. Z., et al. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119211 · Cited by 19

Hippo Signaling in the Endometrium

Moon, S., Hwang, S., Kim, B., Lee, S., Kim, H., Lee, G., Hong, K., Song, H., & Choi, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073852 · Cited by 19

Activation of the ATX/LPA/LPARs axis induces a fibrotic response in skeletal muscle

Córdova-Casanova, A., Cruz-Soca, M., Chun, J. J. M., Casar, J. C., & Brandan, E. (2022) · Matrix Biology · doi:10.1016/j.matbio.2022.03.008 · Cited by 20

A derivant of ginsenoside CK and its inhibitory effect on hepatocellular carcinoma

Zhang, J., Tong, Y., Lu, X., Dong, F., Ma, X., Yin, S., He, Y., Liu, Y., Liu, Q., & Fan, D. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120698 · Cited by 19

Unraveling the Biology of Epithelioid Hemangioendothelioma, a TAZ–CAMTA1 Fusion Driven Sarcoma

Seavey, C. N., Pobbati, A. V., & Rubin, B. (2022) · Cancers · doi:10.3390/cancers14122980 · Cited by 20

Circular RNAs play roles in regulatory networks of cell signaling pathways in human cancers

Almouh, M., Razmara, E., Bitaraf, A., Ghazimoradi, M. H., Hassan, Z. M., & Babashah, S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120975 · Cited by 19

Mechanisms underlying divergent relationships between Ca2+ and YAP/TAZ signalling

Khalilimeybodi, A., Fraley, S. I., & Rangamani, P. (2022) · The Journal of Physiology · doi:10.1113/jp283966 · Cited by 20

LRP6/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells

Wang, J., Yang, H., Ma, X., Liu, J., Li, L., Chen, L., & Wei, F. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00420-5 · Cited by 19

Mitochondrial damage in a Takotsubo syndrome-like mouse model mediated by activation of β-adrenoceptor-Hippo signaling pathway

Wu, W., Lu, Q., Ma, S., Du, J.-C., Huynh, K., Duong, T., Pang, Z.-D., Donner, D. G., Meikle, P. J., Deng, X., et al. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00459.2022 · Cited by 19

Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation

Jiang, M., Ding, H.-Y., Huang, Y., Cheng, C. K., Lau, C. W., Xia, Y. Y., Yao, X., Wang, L., & Huang, Y. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01102-w · Cited by 18

LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability

Han, L., Jiang, Y., Shi, M., Gan, L., Wu, Z., Xue, M., Zhu, Y., Xiong, C., Wang, T., Lin, X., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04702-6 · Cited by 19

Intestinal Inflammation and Regeneration–Interdigitating Processes Controlled by Dietary Lipids in Inflammatory Bowel Disease

Kwon, S. J., Khan, M. S., & Kim, S. G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021311 · Cited by 20

The RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation

Lin, M., Zheng, X., Yan, J., Huang, F., Chen, Y., Ding, R., Wan, J., Zhang, L., Wang, C., Pan, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49045-y · Cited by 20

VGLL fusions define a new class of intraparenchymal central nervous system schwannoma

Schmid, S., Mirchia, K., Tietze, A., Liu, I., Siewert, C., Nückles, J., Schittenhelm, J., Behling, F., Snuderl, M., Hartmann, C. J., et al. (2024) · Neuro-Oncology · doi:10.1093/neuonc/noae269 · Cited by 21

Deregulation and Therapeutic Potential of the Hippo Pathway in Cancer

Lin, K. C., Park, H. W., & Guan, K. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050202 · Cited by 20

The versatile hippo pathway in oral-maxillofacial development and bone remodeling

Xiang, L., Yu, H., Zhang, X., Wang, B., Yuan, Y., Zhang, Q., Ye, R., Gong, P., & Wu, Y. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.05.017 · Cited by 19

Deregulation of the Hippo Pathway Promotes Tumor Cell Proliferation Through YAP Activity in Human Sporadic Vestibular Schwannoma

Zhao, F. Q., Yang, Z., Chen, Y., Zhou, Q., Zhang, J., Liu, J., Wang, B., He, Q., Zhang, L., Yu, Y., et al. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2018.06.010 · Cited by 19

LDL receptor‐related protein LRP6 senses nutrient levels and regulates Hippo signaling

Jeong, W., Kim, S.-Y., Lee, U., Zhong, Z. A., Savitsky, M., Kwon, H., Kim, J.-Y., Lee, T. B., Cho, J. W., Williams, B. O., et al. (2020) · EMBO Reports · doi:10.15252/embr.202050103 · Cited by 19

Long non‑coding RNA ASAP1‑IT1 suppresses ovarian cancer progression by regulating Hippo/YAP signaling

Wang, K., Hu, Y., Zhao, Y., & Ye, C. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4877 · Cited by 18

EGFR Activates a TAZ-Driven Oncogenic Program in Glioblastoma

Gao, M., Fu, Y., Zhou, W., Gui, G., Lal, B., Li, Y., Xia, S., Ji, H., Eberhart, C. G., Laterra, J., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-2773 · Cited by 19

Hippo Signaling in the Heart – Non-Canonical Pathways Impact Growth, Survival and Function –

Re, D. P. D. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-0426 · Cited by 20

Neural precursor cell‐expressed, developmentally down‐regulated 4 (NEDD4) regulates hydrogen peroxide‐induced cell proliferation and death through inhibition of Hippo signaling

Jeon, S., Kim, D. W., & Cho, J. (2019) · The FASEB Journal · doi:10.1096/fj.201901404r · Cited by 18

Rewiring of the cellular and inter-cellular landscape of the human colon during ulcerative colitisPreprint

Smillie, C. S., Biton, M., Ordovás-Montañés, J., Sullivan, K. M., Burgin, G., Graham, D. B., Herbst, R. H., Rogel, N., Slyper, M., Waldman, J., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/455451 · Cited by 18

Targeting GPCRs and Their Signaling as a Therapeutic Option in Melanoma

Raymond, J. H., Aktary, Z., Larue, L., & Delmas, V. (2022) · Cancers · doi:10.3390/cancers14030706 · Cited by 20

AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis

Shihan, M. H., Sharma, S. K., Cable, C., Prathigudupu, V., Chen, A. J., Mattis, A. N., & Chen, J. Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-55764-5 · Cited by 18

Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics

Xu, M., & Xu, B. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02309-7 · Cited by 20

Activation of yes‐associated protein mediates sphingosine‐1‐phosphate–induced proliferation and migration of pulmonary artery smooth muscle cells and its potential mechanisms

Shi, W., Wang, Q., Wang, J., Yan, X., Feng, W., Zhang, Q., Zhai, C., Chai, L., Li, S., Xie, X., et al. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30193 · Cited by 18

Aqueous extract of Taxus chinensis var. mairei regulates the Hippo-YAP pathway and promotes apoptosis of non-small cell lung cancer via ATF3 in vivo and in vitro

Zhang, G., Dai, S., Chen, Y., Wang, H., Chen, T., Shu, Q., Chen, S., Shou, L., & Cai, X. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111506 · Cited by 18

A Novel Small Molecular Prostaglandin Receptor EP4 Antagonist, L001, Suppresses Pancreatic Cancer Metastasis

He, J., Lin, X.-H., Meng, F., Zhao, Y., Wang, W., Zhang, Y., Chai, X., Zhang, Y., Yu, W., Yang, J., et al. (2022) · Molecules · doi:10.3390/molecules27041209 · Cited by 18

Click chemistry and optogenetic approaches to visualize and manipulate phosphatidic acid signaling

Tei, R., & Baskin, J. M. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101810 · Cited by 19

The Hippo pathway and its correlation with acute kidney injury

Zhang, C., 上海交通大学附属第一人民医院肾内科, 上. 2., Li, C., Xu, K., Zheng, Z., Cheng, G., Wu, H., Liu, J., & 复旦大学基础医学院病理科, 上. 2. (2022) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2022.110 · Cited by 18

Controlled mechanical loading improves bone regeneration by regulating type H vessels in a S1Pr1 ‐dependent manner

Yang, C., Liu, Y., Wang, Z., Lin, M., & Liu, C. (2022) · The FASEB Journal · doi:10.1096/fj.202200339rrr · Cited by 18

A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation

Drozdz, M. M., Doane, A. S., Alkallas, R., Desman, G. T., Bareja, R., Reilly, M., Bang, J., Yusupova, M., You, J., Eraslan, Z., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111412 · Cited by 18

Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury

Li, W., Ps, X., Kong, L., Feng, S., Shen, N., Huang, H., Wang, W., Xu, X., Wang, X., Wang, G., et al. (2023) · Translational research · doi:10.1016/j.trsl.2023.02.002 · Cited by 18

Promising small molecule anti-fibrotic agents: Newly developed or repositioned drugs targeting myofibroblast transdifferentiation

Ishikane, S., Arioka, M., & Takahashi‐Yanaga, F. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115663 · Cited by 18

AR activates YAP/TAZ differentially in prostate cancer

Salem, O., Jia, S., Qian, B., & Hansen, C. G. (2023) · Life Science Alliance · doi:10.26508/lsa.202201620 · Cited by 18

Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer

Schiavoni, G., Messina, B., Scalera, S., Memeo, L., Colarossi, C., Mare, M., Blandino, G., Ciliberto, G., Bon, G., & Maugeri‐Saccà, M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05027-8 · Cited by 20

Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer

Kotagiri, S., Blazanin, N., Xi, Y., Han, Y., Qudratullah, M., Liang, X., Wang, Y., Pandey, P., Mazhar, H., Lam, T., et al. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.09.004 · Cited by 18

Application Of Small Molecules Favoring Naïve Pluripotency during Human Embryonic Stem Cell Derivation

der Jeught, M. V., Taelman, J., Duggal, G., Ghimire, S., Lierman, S., Lopes, S. M. C. D. S., Deforce, D. L. D., Deroo, T., Sutter, P. D., & Heindryckx, B. (2015) · Cellular Reprogramming · doi:10.1089/cell.2014.0085 · Cited by 18

The Steroid Hormone 20-Hydroxyecdysone Promotes the Cytoplasmic Localization of Yorkie to Suppress Cell Proliferation and Induce Apoptosis

Wang, D., Li, X., Dong, D.-J., Huang, H., Wang, J., & Zhao, X. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.719856 · Cited by 17

Hippo pathway controls cell adhesion and context‐dependent cell competition to influence skin engraftment efficiency

Nishio, M., Miyachi, Y., Otani, J., Tane, S., Omori, H., Ueda, F., Togashi, H., Sasaki, T., Mak, T. W., Nakao, K., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802005r · Cited by 19

Lats1 and Lats2 are required for the maintenance of multipotency in the Müllerian duct mesenchyme

St‐Jean, G., Tsoi, M. F., Abedini, A., Levasseur, A., Rico, C., Morin, M., Djordjevic, B., Miinalainen, I., Kaarteenaho, R. L., Paquet, M., et al. (2019) · Development · doi:10.1242/dev.180430 · Cited by 18

Dual function of interleukin-23 Aptamer to suppress brain inflammation via attachment to macrophage stimulating 1 kinase and interleukin-23

Sardou, H. S., Jebali, A., & Iman, M. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.110619 · Cited by 18

The Hippo Pathway in Innate Anti-microbial Immunity and Anti-tumor Immunity

Zhang, Q., Zhou, R., & Xu, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01473 · Cited by 18

Rhophilin-2 Upregulates Glutamine Synthetase by Stabilizing c-Myc Protein and Confers Resistance to Glutamine Deprivation in Lung Cancer

Xiao, D., He, J., Guo, Z., He, H., Yang, S., Huang, L., Pan, H., & He, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.571384 · Cited by 18

Signal Transduction and Molecular Regulation in Fatty Liver Disease

Dong, X. C., Chowdhury, K., Huang, M., & Kim, H.-G. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0076 · Cited by 18

Design and rationale of a clinical trial to increase cardiomyocyte division in infants with tetralogy of Fallot

Khoudary, S. R. E., Fabio, A., Yester, J., Steinhauser, M. L., Christopher, A. B., Gyngard, F., Adams, P. S., Morell, V. O., Viegas, M. L., Silva, J. P. D., et al. (2021) · International Journal of Cardiology · doi:10.1016/j.ijcard.2021.07.020 · Cited by 18

Statins downregulate YAP and TAZ and exert anti‐cancer effects in canine mammary tumour cells

Vigneau, A., Rico, C., Boerboom, D., & Paquet, M. (2021) · Veterinary and Comparative Oncology · doi:10.1111/vco.12789 · Cited by 18

Histone Acetylation-Mediated Regulation of the Hippo Pathway

Basu, D., Reyes‐Múgica, M., & Rebbaa, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062478 · Cited by 20

The protective role of YAP1 on ER stress-induced cell death in vascular smooth muscle cells

Takaguri, A., Kubo, T., Mori, M., & Satoh, K. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.09.033 · Cited by 19

Overexpression of αCGRP promotes osteogenesis of periodontal ligament cells by regulation of YAP signaling

Xiang, L., Zhang, X., Yu, H., Wang, B., Lin, Z., & Gong, P. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27311 · Cited by 18

Spatio-selective activation of nuclear translocation of YAP with light directs invasion of cancer cell spheroids

Illes, B., Fuchs, A., Gegenfurtner, F. A., Ploetz, E., Zahler, S., Vollmar, A. M., & Engelke, H. (2021) · iScience · doi:10.1016/j.isci.2021.102185 · Cited by 18

LDHA-mediated YAP lactylation promotes the tumor progression of hepatocellular carcinoma by inducing YAP dephosphorylation and activation

Wei, X., Zou, L., Huang, Y., Qiu, C., Cheng, G., Chen, Y., & Rao, J. (2025) · Biology Direct · doi:10.1186/s13062-025-00655-6 · Cited by 17

The Emerging Link between the Hippo Pathway and Non-coding RNA

Shimoda, M., & Moroishi, T. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00795 · Cited by 16

G protein-coupled receptors as promising targets in cancer

Almeria, C. V. P., Setiawan, I. M., Siderius, M. H., & Smit, M. J. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2020.10.005 · Cited by 17

Microtubule Stabilization Enhances the Chondrogenesis of Synovial Mesenchymal Stem Cells

Li, J., Sun, Z., Lv, Z., Jiang, H., Liu, A., Wang, M., Tan, G., Guo, H., Sun, H., Wu, R., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.748804 · Cited by 19

P2RY6 Has a Critical Role in Mouse Skin Carcinogenesis by Regulating the YAP and β-Catenin Signaling Pathways

Xu, P., Wang, C., Xiang, W. Q., Liang, Y., Li, Y., Zhang, X., Guo, C., Liu, M., Shi, Y., Ye, X., et al. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.02.017 · Cited by 17

ACADL suppresses PD-L1 expression to prevent cancer immune evasion by targeting Hippo/YAP signaling in lung adenocarcinoma

Li, L., Wang, L., Wang, T.-L., & Zheng, F.-M. (2023) · Medical Oncology · doi:10.1007/s12032-023-01978-y · Cited by 17

Role of cell rearrangement and related signaling pathways in the dynamic process of tip cell selection

Guo, Y., Zhang, S., Wang, D., Heng, B. C., & Deng, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01364-1 · Cited by 18

Calcitonin gene-related peptide-modulated macrophage phenotypic alteration regulates angiogenesis in early bone healing

Kong, Q., Gao, S., Li, P., Sun, H., Zhang, Z., Yu, X., Deng, F., & Wang, T. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111766 · Cited by 20

Assembling a Hippo: the evolutionary emergence of an animal developmental signaling pathway

Phillips, J. E., Zheng, Y., & Pan, D. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.04.005 · Cited by 19

Podocalyxin-Like Protein 1 Regulates TAZ Signaling and Stemness Properties in Colon Cancer

Lee, W., Kuo, C.-C., Lin, B.-X., Cheng, C., Chen, K., & Lin, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102047 · Cited by 18

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Porazinski, S. R., & Ladomery, M. (2018) · Genes · doi:10.3390/genes9030161 · Cited by 16

Autocrine CXCL8-dependent invasiveness triggers modulation of actin cytoskeletal network and cell dynamics

Antonosante, A., Brandolini, L., d’Angelo, M., Benedetti, E., Castelli, V., Maestro, M. D., Luzzi, S., Giordano, A., Cimini, A., & Allegretti, M. (2020) · Aging · doi:10.18632/aging.102733 · Cited by 17

Effect of sphingosine-1-phosphate on activation of dormant follicles in murine and human ovarian tissue

Pors, S. E., Harðardóttir, L., Olesen, H. Ø., Riis, M. L., Jensen, L. B., Andersen, A. S., Cadenas, J., Grønning, A. P., Colmorn, L. B., Dueholm, M., et al. (2020) · Molecular Human Reproduction · doi:10.1093/molehr/gaaa022 · Cited by 21

GPNMB promotes the progression of diffuse large B cell lymphoma via YAP1-mediated activation of the Wnt/β-catenin signaling pathway

Wang, Z., Ran, X., Qian, S., Hou, H., Dong, M., Wu, S., Ding, M., Zhang, Y., Zhang, X., Zhang, M., et al. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108998 · Cited by 17

Emerging role of Hippo signalling in pancreatic biology: YAP re-expression and plausible link to islet cell apoptosis and replication

Sharma, A., Yerra, V. G., & Kumar, A. (2016) · Biochimie · doi:10.1016/j.biochi.2016.12.009 · Cited by 18

Cancer driver G-protein coupled receptor (GPCR) induced β-catenin nuclear localization: the transcriptional junction

Nag, J. K., Rudina, T., Maoz, M., Grisaru‐Granovsky, S., Uziely, B., & Bar‐Shavit, R. (2017) · Cancer and Metastasis Reviews · doi:10.1007/s10555-017-9711-z · Cited by 17

RhoA protects the podocytes against high glucose-induced apoptosis through YAP and plays critical role in diabetic nephropathy

Huang, Z., Peng, Y., Yu, H., Yu, X.-M., Zhou, J., & Xiao, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.08.204 · Cited by 17

Single-cell transcriptome analysis revealing mechanotransduction via the Hippo/YAP pathway in promoting fibroblast-to-myofibroblast transition and idiopathic pulmonary fibrosis development

Lu, J., Wang, Z., & Zhang, L. (2025) · Gene · doi:10.1016/j.gene.2025.149271 · Cited by 16

Dabigatran ameliorates airway smooth muscle remodeling in asthma by modulating Yes‐associated protein

Deng, Z., Xie, H., Cheng, W., Zhang, M., Liu, J., Huo, Y., Liao, Y., & Cheng, Y. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15485 · Cited by 16

The Hippo signaling pathway effector YAP promotes salivary gland regeneration after injury

Rocchi, C., Cinat, D., Martinez, P. S., Bruin, A. L. J.-D., Baanstra, M., Brouwer, U., Zuivre, C. D. A., Schepers, H., van Os, R. P., Barazzuol, L., et al. (2021) · Science Signaling · doi:10.1126/scisignal.abk0599 · Cited by 17

Identification of Small-molecule YAP-TEAD inhibitors by High-throughput docking for the Treatment of colorectal cancer

Li, L., Li, R., & Wang, Y. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105707 · Cited by 16

Emerging Role of YAP and the Hippo Pathway in Prostate Cancer

Koinis, F., Chantzara, E., Samarinas, M., Xagara, A., Kratiras, Z., Leontopoulou, V., & Kotsakis, A. P. (2022) · Biomedicines · doi:10.3390/biomedicines10112834 · Cited by 18

GPR81-mediated reprogramming of glucose metabolism contributes to the immune landscape in breast cancer

Li, X., Chen, Y., Wang, T., Liu, Z., Yin, G., Wang, Z., Sui, C., Zhu, L., & Chen, W. (2023) · Discover Oncology · doi:10.1007/s12672-023-00709-z · Cited by 16

G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression

Kajitani, N., Okada‐Tsuchioka, M., Inoue, A., Miyano, K., Masuda, T., Boku, S., Iwamoto, K., Ohtsuki, S., Uezono, Y., Aoki, J., et al. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01727-9 · Cited by 16

Fibrillar Collagen Type I Participates in the Survival and Aggregation of Primary Hepatocytes Cultured on Soft Hydrogels

Serna-Márquez, N., Rodríguez-Hernández, A., Ayala-Reyes, M., Martínez-Hernández, L. O., Peña-Rico, M. Á., Carretero-Ortega, J., Hautefeuille, M., & Vázquez-Victorio, G. (2020) · Biomimetics · doi:10.3390/biomimetics5020030 · Cited by 15

G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway

Zhou, X., Wang, Z., Huang, W., & Lei, Q. (2014) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmu108 · Cited by 28

G protein‐coupled receptors can control the Hippo/YAP pathway through Gq signaling

Zindel, D., Mensat, P., Vol, C., Homayed, Z., Charrier‐Savournin, F., Trinquet, E., Banères, J., Pin, J., Pannequin, J., Roux, T., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002159r · Cited by 35

The mammalian Hippo

Gα, O. (2016)

GPCR-Hippo Signaling in Cancer

Luo, J., & Yu, F. (2019) · Cells · doi:10.3390/cells8050426 · Cited by 112

G protein‐coupled receptors engage the mammalian Hippo pathway through F‐actin

Regué, L., Mou, F., & Avruch, J. (2013) · BioEssays · doi:10.1002/bies.201200163 · Cited by 28