The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome
Open accessAbstract
SUMMARY Pathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy which likely contributes to AIDS progression. To identify candidate etiologies for AIDS enteropathy, we used next generation sequencing to define the enteric virome during SIV infection in nonhuman primates. Pathogenic, but not non-pathogenic, SIV infection was associated with significant expansion of the enteric virome. We identified at least 32 previously undescribed enteric viruses during pathogenic SIV infection and confirmed their presence using viral culture and PCR testing. We detected unsuspected mucosal adenovirus infection associated with enteritis as well as parvovirus viremia in animals with advanced AIDS, indicating the pathogenic potential of SIV-associated expansion of the enteric virome. No association between pathogenic SIV infection and the family-level taxonomy of enteric bacteria was detected. Thus, enteric viral infections may contribute to AIDS enteropathy and disease progression. These findings underline the importance of metagenomic analysis of the virome for understanding AIDS pathogenesis.
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Self-citationMicrobial Translocation Across the GI Tract
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“Interestingly, natural hosts for SIV such as African green monkeys develop persistent high-level viremia but do not develop AIDS (termed herein ‘‘nonpathogenic’’ SIV infection) (Brenchley and Douek, 2012; Brenchley et al., 2010; Sodora et al., 2009).”
InfluentialSelf-citationFinkbeiner, S. R., Li, Y., Ruone, S., Conrardy, C., Gregoricus, N., Toney, D., Virgin, H. W., Anderson, L. J., Vinjé, J., Wang, D., et al. (2009) · Journal of Virology · doi:10.1128/jvi.00998-09 · Cited by 224
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Archaea and fungi of the human gut microbiome: correlations with diet and bacterial residents
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Goodrich, J. K., Di Rienzi, S. C., Poole, A. C., Koren, O., Walters, W. A., Caporaso, J. G., Knight, R., & Ley, R. E. (2014) · Cell · doi:10.1016/j.cell.2014.06.037 · Cited by 714
Early life dynamics of the human gut virome and bacterial microbiome in infants
Lim, E. S., Zhou, Y., Zhao, G., Bauer, I. K., Droit, L., Ndao, I. M., Warner, B. B., Tarr, P. I., Wang, D., & Holtz, L. R. (2015) · Nature Medicine · doi:10.1038/nm.3950 · Cited by 658
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Metadata
- Authors
- Handley, S. A., Thackray, L. B., Zhao, G., Presti, R., Miller, A. D., Droit, L., Abbink, P., Maxfield, L. F., Kambal, A., Duan, E., Stanley, K., Kramer, J., Macri, S. C., Permar, S. R., Schmitz, J. E., Mansfield, K., Brenchley, J. M., Veazey, R. S., Stappenbeck, T. S., Wang, D., Barouch, D. H., & Virgin, H. W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 151
- Issue
- 2
- Pages
- 253-266
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2154774779
- Cited by
- 278
- References
- 9
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Handley, S. A., Thackray, L. B., Zhao, G., Presti, R., Miller, A. D., Droit, L., Abbink, P., Maxfield, L. F., Kambal, A., Duan, E., Stanley, K., Kramer, J., Macri, S. C., Permar, S. R., Schmitz, J. E., Mansfield, K., Brenchley, J. M., Veazey, R. S., Stappenbeck, T. S., . . . Virgin, H. W. (2012). Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome. Cell. https://doi.org/10.1016/j.cell.2012.09.024
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