The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

Sebastián, Carlos, Zwaans, Bernadette M.M., Silberman, Dafne M., Gymrek, Melissa, Goren, Alon, Zhong, Lei, Ram, Oren, Truelove, Jessica +16 more·2012·Cell

DOI 10.1016/j.cell.2012.10.047

Cited by (664)

Items 201–300 of 664

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity
Rafael M. Ioris, Mirco Galiè, Giorgio Ramadori, Jason G. Anderson, Anne Charollais, Georgia Konstantinidou, Xavier Brénachot, Ebru Aras, Algera Goga, Nicholas Ceglia et al. · 2017 · Cell Reports
SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ
Danish Khan, Tarannum Ara, Venkatraman Ravi, Raksha Rajagopal, Himani Tandon, Jayadevan Parvathy, Edward A. Gonzalez, Ninitha Asirvatham‐Jeyaraj, Swati Krishna, Sneha Mishra et al. · 2021 · Cell Reports
Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling
Sneha Mishra, Claudia Cosentino, Ankit Kumar Tamta, Danish Khan, Shalini Srinivasan, Venkatraman Ravi, Elena Abbotto, Bangalore Prabhashankar Arathi, Shweta Anil Kumar, Aditi Jain et al. · 2022 · Nature Communications
Astragaloside IV sensitizes non–small cell lung cancer cells to gefitinib potentially via regulation of SIRT6
Peng-Chen Dai, De-Ling Liu, Lei Zhang, Jia Ye, Qing Wang, Hong-Wen Zhang, Lin Xiu-hua, Guoxiang Lai · 2017 · Tumor Biology
Epigenetics and metabolism at the crossroads of stress-induced plasticity, stemness and therapeutic resistance in cancer
Dinoop Ravindran Menon, Heinz Hammerlindl, Joachim Torrano, Helmut Schaider, Mayumi Fujita · 2020 · Theranostics
Caloric restriction induced epigenetic effects on aging
Jingfang Zhai, William H. Kongsberg, Yinbo Pan, Canhua Hao, Xiaojing Wang, Jie Yun Sun · 2023 · Frontiers in Cell and Developmental Biology
Increased Amino Acid Uptake Supports Autophagy-Deficient Cell Survival upon Glutamine Deprivation
Nan Zhang, Xin Ping Yang, Fengjie Yuan, Luyao Zhang, Yanan Wang, Lina Wang, Zebin Mao, Jianyuan Luo, Hongquan Zhang, Wei‐Guo Zhu et al. · 2018 · Cell Reports
Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D 3 in colorectal cancer
Jialin Shang, Zhehui Zhu, Ying‐Yi Chen, Jinglue Song, Yuji Huang, Kun Song, Jie Zhong, Xinyuan Xu, Jiacheng Wei, Chengxiang Wang et al. · 2020 · Theranostics
Sirt6 regulates lifespan in Drosophila melanogaster
Jackson R. Taylor, Jason G. Wood, Evan Mizerak, Samuel J. Hinthorn, Julianna Liu, Matthew Finn, Sarah Gordon, Louis Zingas, Cheng-Yi Chang, Mark A. Klein et al. · 2022 · Proceedings of the National Academy of Sciences
Posttranslational modification of Sirt6 activity by peroxynitrite
Shuqun Hu, Hua Liu, Yonju Ha, Xuemei Luo, Massoud Motamedi, Mahesh P. Gupta, Jian‐xing Ma, Ronald G. Tilton, Wenbo Zhang · 2014 · Free Radical Biology and Medicine
NAD+: A key metabolic regulator with great therapeutic potential
Ghazal Sultani, Azrah Samsudeen, Brenna Osborne, Nigel A. Turner · 2017 · Journal of Neuroendocrinology
Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6
Marci Wood, Stacia Rymarchyk, Song Guo Zheng, Yana Cen · 2017 · Archives of Biochemistry and Biophysics
Quercetin based derivatives as sirtuin inhibitors
Vladimír Heger, Jonna Tyni, Attila Hunyadi, Ľubica Horáková, Maija K. Lahtela-Kakkonen, Minna Rahnasto‐Rilla · 2019 · Biomedicine & Pharmacotherapy
Sirtuin 6 promotes transforming growth factor‐β1/H 2 O 2 / HOC l‐mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence
Xinxia Feng, Jing Luo, Mei Liu, Wei Yan, Zhenzhen Zhou, Yujia Xia, Wei Tu, Peiyuan Li, Zuo‐Hua Feng, Dean Tian · 2015 · Cancer Science
Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6
Wallace H. Liu, Jie Zheng, Jessica L. Feldman, Mark A. Klein, Vyacheslav I. Kuznetsov, Craig L. Peterson, Patrick R. Griffin, John M. Denu · 2020 · Nature Communications
Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling
Kezheng Peng, Chenye Zeng, Yuqi Gao, Binliang Liu, Liyuan Li, Kang Xu, Yuemiao Yin, Ying Qiu, Mingkui Zhang, Fei Ma et al. · 2023 · Acta Pharmaceutica Sinica B
Genome-wide analysis of functional sirtuin chromatin targets in yeast
Mingguang Li, Veena Valsakumar, Kunal Poorey, Stefan Bekiranov, Jeffrey S. Smith · 2013 · Genome biology
Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer
Guoyu Huang, Jun Cheng, Fudong Yu, Xisheng Liu, Chenwei Yuan, Chenchen Liu, Xiao-Lei Chen, Zhihai Peng · 2016 · Oncology Reports
Sirtuins Expression and Their Role in Retinal Diseases
Sankarathi Balaiya, Khaled K. Abu‐Amero, Altaf A. Kondkar, K V Chalam · 2017 · Oxidative Medicine and Cellular Longevity
NAD+ Deficits in Age-Related Diseases and Cancer
Amanda Garrido, Nabil Djouder · 2017 · Trends in cancer
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma
Liz M. Garcia‐Peterson, Mary Ann Ndiaye, Chandra K. Singh, Gagan Chhabra, Wei Huang, Nihal Ahmad · 2017 · Genes & Cancer
Modulation of p53 during bacterial infections
Christine Siegl, Thomas Rudel · 2015 · Nature Reviews Microbiology
Mechanism of activation for the sirtuin 6 protein deacylase
Mark A. Klein, Can Liu, Vyacheslav I. Kuznetsov, John B. Feltenberger, Weiping Tang, John M. Denu · 2020 · Journal of Biological Chemistry
A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity
Prashanth Kumar Bajpe, Anirudh Prahallad, Hugo M. Horlings, Irıs D. Nagtegaal, Roderick L. Beijersbergen, René Bernards · 2014 · Oncogene
Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT 6
María Aurelia Zorrilla-Zubilete, Ada Yeste, Francisco Javier Quintana, Debra Toiber, Raúl Mostoslavsky, Dafne Magalı́ Silberman · 2017 · Journal of Neurochemistry
ROS-Mediated Apoptotic Cell Death of Human Colon Cancer LoVo Cells by Milk δ-Valerobetaine
Nunzia D’Onofrio, Nunzio Antonio Cacciola, Elisa Martino, Francesca Borrelli, Ferdinando Fiorino, Assunta Lombardi, Gianluca Neglia, Maria Luisa Balestrieri, Giuseppe Campanile · 2020 · Scientific Reports
Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation
Stephanie Dobersch, Karla Rubio, Indrabahadur Singh, Stefan Günther, Johannes Graumann, Julio Cordero, Rafael Castillo‐Negrete, Minh Bao Huynh, Aditi Mehta, Peter Braubach et al. · 2021 · Nature Communications
Targeting cancer-specific metabolic pathways for developing novel cancer therapeutics
Soumik Pal, Amit Kumar Sharma, Sam Padalumavunkal Mathew, Bithiah Grace Jaganathan · 2022 · Frontiers in Immunology
Targeting aberrant cancer metabolism – The role of sirtuins
Robert Kleszcz, Jarosław Paluszczak, Wanda Baer‐Dubowska · 2015 · Pharmacological Reports
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio Gaetano Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, A. Khalifa et al. · 2021 · Cancer & Metabolism
Expression of SIRT1 and SIRT3 varies according to age in mice
Young-Ho Kwon, Jong‐Sik Kim, Chae-Yeong Lee, Hyun Kim · 2015 · Anatomy & Cell Biology
Epigenetic mechanisms underlying lifespan and age-related effects of dietary restriction and the ketogenic diet
Cesar L. Moreno, Charles V. Mobbs · 2016 · Molecular and Cellular Endocrinology
SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC
Namgyu Lee, Hye Guk Ryu, Jung‐Hee Kwon, Dae‐Kyum Kim, Sae Rom Kim, Hee-Jung Wang, Kyong‐Tai Kim, Kwan Yong Choi · 2016 · PLoS ONE
SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway
Jianmei Zhou, Ang Wu, Xiaoting Yu, Jianwei Zhu, Hui Dai · 2017 · Oncology Reports
Serum proton NMR metabolomics analysis of human lung cancer following microwave ablation
Jian-Ming Hu, Huangtao Sun · 2018 · Radiation Oncology
Impact of nutrient overload on metabolic homeostasis
Haowen Qiu, Vicki L. Schlegel · 2018 · Nutrition Reviews
Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling
Junhong Tian, Leilei Yuan · 2018 · Biomedicine & Pharmacotherapy
The dual role of sirtuins in cancer: biological functions and implications
Lu Yu, Yanjiao Li, Siyuan Song, Yalin Zhang, Yiping Wang, Hailian Wang, Zhengteng Yang, Yi Wang · 2024 · Frontiers in Oncology
Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling
Federica Simeoni, Luisa Tasselli, Shinji Tanaka, Lidia Villanova, Mayumi Hayashi, Kazuishi Kubota, Fujio Isono, Benjamin Aaron Garcia, Eriko Michishita-Kioi, Katrin F. Chua · 2013 · Scientific Reports
The RNA-binding protein PCBP2 facilitates gastric carcinoma growth by targeting miR-34a
Cheng’en Hu, Yong-Chao Liu, Huidong Zhang, Guangjian Huang · 2014 · Biochemical and Biophysical Research Communications
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
Zhijun Han, Lei Liu, Yaxin Liu, Shanqing Li · 2014 · Europe PMC (PubMed Central)
SIRT6 Is Involved in the Progression of Ovarian Carcinomas via β-Catenin-Mediated Epithelial to Mesenchymal Transition
Jun Sang Bae, Sang Jae Noh, Kyoung Min Kim, See‐Hyoung Park, Usama Khamis Hussein, Ho Sung Park, Byung‐Hyun Park, Sang Hoon Ha, Ho Lee, Myoung Ja Chung et al. · 2018 · Frontiers in Oncology
Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia
Sylvia E. Perez, Jennifer C. Miguel, Bin He, Michael H. Malek‐Ahmadi, Eric E. Abrahamson, Miloš D. Ikonomović, Ira T. Lott, Eric W. Doran, Melissa J. Alldred, Stephen D. Ginsberg et al. · 2019 · Acta Neuropathologica
Epigenetic Regulation of TRAIL Signaling: Implication for Cancer Therapy
Mohammed I. Y. Elmallah, Olivier Micheau · 2019 · Cancers
HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma
Yixuan Li, Xiangyang Zhang, Shaoqi Zhu, Eden A. Dejene, Weiqun Peng, Antonia R. Sepulveda, Edward Seto · 2020 · Cancer Research
A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma
Jee-Eun Choi, Carlos Sebastián, Christina M. Ferrer, Caroline A. Lewis, Moshe Sade-Feldman, Thomas James LaSalle, Anna L. K. Gonye, Begona G. C. Lopez, Walid M. Abdelmoula, Michael Scott Regan et al. · 2021 · Nature Metabolism
Critical role of TRPC6 in maintaining the stability of HIF-1α in glioma cells under hypoxia
Shanshan Li, Jinkui Wang, Wei Yi, Yongjian Liu, Xia Ding, Bin Dong, Yinghui Xu, Yizheng Wang · 2015 · Journal of Cell Science
The biological significance of histone modifiers in multiple myeloma: clinical applications
Hiroto Ohguchi, Teru Hideshima, Kenneth Carl Anderson · 2018 · Blood Cancer Journal
FOXO3a‑SIRT6 axis suppresses aerobic glycolysis in melanoma
Zhen Dong, Jie Yang, Lin Li, Li Tan, Pengfei Shi, Jiayi Zhang, Xi Zoë Zhong, Lingjun Ge, Zonghui Wu, Hongjuan Cui · 2020 · International Journal of Oncology
Cancer cell metabolism connects epigenetic modifications to transcriptional regulation
Ashby J. Morrison · 2021 · FEBS Journal
Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis
Feng Wu, Liangliang Xu, Yalin Tu, Otto Ka-Wing Cheung, Lemuel L. M. Szeto, Myth T.S. Mok, Weiqin Yang, Wei Kang, Qin Cao, Paul B.S. Lai et al. · 2021 · Cancer Letters
Writers, Readers, and Erasers of Epigenetic Marks
Thomas B. Nicholson, Nicolás Veland, Taiping Chen · 2015 · Elsevier eBooks
Sirtuin 6 suppresses hypoxia‐induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis—A therapeutic implication in inflammatory bone resorption
Kuo‐Liang Hou, Sze‐Kwan Lin, Ling‐Hsiu Chao, Eddie Hsiang‐Hua Lai, Cheng‐Chi Chang, Chia‐Tung Shun, Wan‐Yu Lu, Jyh‐Horng Wang, Michael Hsiao, Chi‐Yuan Hong et al. · 2016 · BioFactors
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects
Patrizia Damonte, Giovanna Sociali, Marco Daniele Parenti, Debora Soncini, Inga Bauer, Silvia Boero, Alessia Grozio, Maria von Holtey, Francesco Piacente, Pamela Becherini et al. · 2017 · Bioorganic & Medicinal Chemistry
Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective
Haixiang Pei, Weikai Guo, Yangrui Peng, Hai Xiong, Yihua Chen · 2022 · Medicinal Research Reviews
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice
Zhu‐Qin Zhang, Sichong Ren, Ying Tan, Zuo-Zhi Li, Xiaoqiang Tang, Tingting Wang, De‐Long Hao, Xiang Zhao, Hou‐Zao Chen, De‐Pei Liu · 2016 · Scientific Reports
eEF-2 kinase is a critical regulator of Warburg effect through controlling PP2A-A synthesis
Yan Cheng, Xingcong Ren, Yun Yuan, Y Shan, L Li, Xiaochi Chen, L Zhang, Yoshinori Takahashi, Jun Yang, B Han et al. · 2016 · Oncogene
NAD+ in Cancer Prevention and Treatment: Pros and Cons
Borut Poljšak · 2016 · Journal of Clinical & Experimental Oncology
Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology
Maria Concetta Scuto, Angela Trovato Salinaro, Isabella Caligiuri, Maria Laura Ontario, Valentina Greco, Nello Sciuto, Roberto Crea, Edward J. Calabrese, Flavio Rizzolio, Vincenzo Canzonieri et al. · 2021 · Mechanisms of Ageing and Development
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Santu Kumar Saha, Anisur Rahman Khuda‐Bukhsh · 2013 · European Journal of Pharmacology
The Many Faces of Sirtuins: Sirtuins and the Warburg effect
Leonard Guarente · 2014 · Nature Medicine
Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer
Yong I. Cha, Hyun-Seok Kim · 2013 · BMB Reports
Characterization of physiological defects in adult SIRT6-/- mice
Victoria Peshti, Alexey Obolensky, Liat Nahum, Yariv Kanfi, MORAN RATHAUS, Maytal Avraham, Simon Tinman, Fredrick W. Alt, Eyal Banin, Haim Yosef Cohen · 2017 · PLoS ONE
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells
Nan Jing Huang, Zhiwei Liu, Jiabei Zhu, Zhongqi Cui, Yuguang Li, Yongchun Yu, Fenyong Sun, Qiuhui Pan, Qingyuan Yang · 2017 · Tumor Biology
Role of Sirtuins in Tumor Angiogenesis
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A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity
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Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway
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MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6.
Song Shi, Yuxia Yang, Minghui Liu, Boya Liu, Xin Ping Yang, Miao Yu, Hao Qi, Mengmeng Ren, Zhe Wang, Junhua Zou et al. · 2018 · Europe PMC (PubMed Central)
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Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice
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Discovery of Potent Small-Molecule SIRT6 Activators: Structure–Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity
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Carlos Sebastián, Raúl Mostoslavsky · 2015 · Seminars in Cell and Developmental Biology
The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat
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SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species
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Chandrima Das, Apoorva Bhattacharya, Swagata Adhikari, Atanu Mondal, Payel Mondal, Santanu Adhikary, Siddhartha Roy, Kenneth S. Ramos, Kamlesh Kumar Yadav, John A. Tainer et al. · 2024 · Oncogene
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Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance
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On‐Yu Hong, Hye‐Yeon Jang, Young‐Rae Lee, Sung Hoo Jung, Hyun Jo Youn, Jong‐Suk Kim · 2022 · Scientific Reports
Putative tumor suppression function of SIRT6 in endometrial cancer
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Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression
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Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer
Qi Jia, Chunhui Cui, Quanwen Deng, Lifeng Wang, Rihong Chen, Duanyang Zhai, Lang Xie, Jinlong Yu · 2018 · Oncology Letters
Mechanism of activation for the sirtuin 6 protein deacylase
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α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis
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The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma
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RFT2 is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenesis by sustaining cell proliferation and protecting against cell death
Xingran Jiang, Xiying Yu, Jin‐Hu Fan, Liping Guo, Changjun Zhu, Wei Bo Jiang, Shih‐Hsin Lu · 2014 · Cancer Letters
Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice
Shrestha Ghosh, Sheung Kin Ken Wong, Zhixin Jiang, Baohua Liu, Yi Wang, Quan Hao, Vera A. Gorbunova, Xinguang Liu, Zhongjun Zhou · 2018 · eLife
Human height genes and cancer
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