The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

Sebastián, Carlos, Zwaans, Bernadette M.M., Silberman, Dafne M., Gymrek, Melissa, Goren, Alon, Zhong, Lei, Ram, Oren, Truelove, Jessica +16 more·2012·Cell

DOI 10.1016/j.cell.2012.10.047

Cited by (664)

Items 101–200 of 664

Sirtuin 6: linking longevity with genome and epigenome stability
Anatoly Korotkov, Andrei Seluanov, Vera A. Gorbunova · 2021 · Trends in Cell Biology
SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer
Mei Ming, Weinong Han, Baozhong Zhao, Nagalingam Ravi Sundaresan, Chu‐Xia Deng, Mahesh P. Gupta, Yu‐Ying He · 2014 · Cancer Research
Metabolic and redox signaling in the retina
Thierry Léveillard, José‐Alain Sahel · 2016 · Cellular and Molecular Life Sciences
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells
Sara Iachettini, Daniela Trisciuoglio, Dante Rotili, Alessia Lucidi, Erica Salvati, Pasquale Zizza, Luca Di Leo, Donatella Del Bufalo, Maria Rosa Ciriolo, Carlo Leonetti et al. · 2018 · Cell Death and Disease
The roles of sirtuins family in cell metabolism during tumor development
Shunqin Zhu, Zhen Dong, Xiaoxue Ke, Jianbing Hou, Erhu Zhao, Kui Zhang, Feng Wang, Liqun Yang, Zhonghuai Xiang, Hongjuan Cui · 2018 · Seminars in Cancer Biology
A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways
Gomes, Ana P, Blenis, John · 2015 · Current Opinion in Biotechnology
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2
Tatsunori Nishimura, Asuka Nakata, Xiaoxi Chen, Kurumi Nishi, Makiko Meguro‐Horike, Soichiro Sasaki, Kenji Kita, Shin‐ichi Horike, Kaori Saitoh, Keiko Kato et al. · 2018 · Oncogene
SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein–Dependent Apoptotic Pathway
Long-Kuan Ran, Yong Chen, Zhenzhen Zhang, Na‐Na Tao, Ji‐Hua Ren, Li Zhou, Hua Tang, Xiang Chen, Ke Chen, Wanyu Li et al. · 2016 · Clinical Cancer Research
Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6
Justin W. Nicholatos, Adam B. Francisco, Carolyn Bender, Tiffany Yeh, Fraz Lugay, Jairo Salazar, Christin A. Glorioso, Sergiy Libert · 2018 · Acta Neuropathologica Communications
The role of SIRT1 in ocular aging
Tatsuya Mimura, Yuichi Kaji, Hidetaka Noma, Hideharu Funatsu, Shinseiro Okamoto · 2013 · Experimental Eye Research
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer
Umadevi Thirumurthi, Jia Shen, Weiya Xia, Adam M. LaBaff, Yongkun Wei, Chia‐Wei Li, Wei‐Chao Chang, Chung‐Hsuan Chen, Hui‐Kuan Lin, Dihua Yu et al. · 2014 · Science Signaling
Epigenetic mechanisms and the hallmarks of cancer: an intimate affair.
Nadine Darwiche · 2020 · PubMed Central
The role of HIF1α in renal cell carcinoma tumorigenesis
Lorraine J. Gudas, Leiping Fu, Denise R. Minton, Nigel Patrick Mongan, David M. Nanus · 2014 · Journal of Molecular Medicine
Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity
Alexander Rupert Moschen, Verena E. Wieser, Romana Raphaela Gerner, Alexandra Bichler, Barbara Enrich, Patrizia Lucia Moser, Christoph F. Ebenbichler, Susanne Kaser, Herbert Tilg · 2013 · Journal of Hepatology
Sirtuins' control of autophagy and mitophagy in cancer
Michele Aventaggiato, Enza Vernucci, Federica Barreca, Matteo Antonio Russo, Marco Tafani · 2020 · Pharmacology & Therapeutics
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases
Milena Vitiello, Alberto Zullo, Luigi Servillo, Francesco Paolo Mancini, Adriana Borriello, Alfonso Giovane, Fulvio Della Ragione, Nunzia D’Onofrio, Maria Luisa Balestrieri · 2016 · Ageing Research Reviews
Nutrient Sensing and the Oxidative Stress Response
Hanzhi Luo, Hou-Hsien Chiang, Makensie Louw, Albert Susanto, Danica Chen · 2017 · Trends in Endocrinology and Metabolism
Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging
Rui-Hong Wang, Tingrui Zhao, Kairong Cui, Gangqing Hu, Qiang Chen, Weiping Chen, Xin Wei Wang, Alejandro Soto–Gutiérrez, Keji Zhao, Chu‐Xia Deng · 2016 · Scientific Reports
SIRT2: Tumour suppressor or tumour promoter in operable breast cancer?
Liane M. McGlynn, Samer Zino, Alasdair Iain Macdonald, Jennifer Curle, Justice E. Reilly, Zahra M. A. Mohammed, Donald C. McMillan, Elizabeth Mallon, Anthony P. Payne, Joanne Edwards et al. · 2013 · European Journal of Cancer
Dietary Modulation of the Epigenome
Folami Ideraabdullah, Steven H. Zeisel · 2018 · Physiological Reviews
SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair
Tianyun Hou, Ziyang Cao, Jun Zhang, Ming Tang, Yuan Tian, Yinglu Li, Xiaopeng Lu, Yongcan Chen, Hui Wang, Fu‐Zheng Wei et al. · 2020 · Nucleic Acids Research
Accurate Measurement of Nicotinamide Adenine Dinucleotide (NAD+) with High-Performance Liquid Chromatography
Jun Yoshino, Shin‐ichiro Imai · 2013 · Methods in molecular biology
Intracellular Mono-ADP-Ribosylation in Signaling and Disease
Mareike Bütepage, Laura Eckei, Patricia Verheugd, Bernhard Lüscher · 2015 · Cells
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling
Thomas Strub, Flávia G. Ghiraldini, Saul Carcamo, Man Li, Aleksandra Wroblewska, Rajendra Singh, Matthew S. Goldberg, Dan Hasson, Zichen Wang, Stuart J. Gallagher et al. · 2018 · Nature Communications
Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators
Ewa Maria Kratz, Katarzyna Sołkiewicz, Adriana Kubis-Kubiak, Agnieszka Piwowar · 2021 · International Journal of Molecular Sciences
Emerging Therapeutic Potential of SIRT6 Modulators
Francesco Fiorentino, Antonello Mai, Dante Rotili · 2021 · Journal of Medicinal Chemistry
The complex role of SIRT6 in carcinogenesis
Batia Lerrer, Asaf A. Gertler, Haim Yosef Cohen · 2015 · Carcinogenesis
Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway
Lihong Bai, Gengpeng Lin, Longhua Sun, Yangli Liu, Xinyan Huang, Chuangjie Cao, Yubiao Guo, Canmao Xie · 2016 · Oncotarget
Sirtuin 6: a review of biological effects and potential therapeutic properties
Jade M. Beauharnois, Beatriz E. Bolívar, John T. Welch · 2013 · Molecular BioSystems
SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells
Xiaolin Zhong, Menghao Huang, Hyeong-Geug Kim, Yang Zhang, Kushan Chowdhury, Wenjie Cai, Romil Saxena, Robert F. Schwabe, Suthat Liangpunsakul, Xiaocheng Charlie Dong · 2020 · Cellular and Molecular Gastroenterology and Hepatology
Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer
Yashira L. Negrón Abril, Irma R. Fernandez, Jun Young Hong, Ying‐Ling Chiang, Dennis A. Kutateladze, Qingjie Zhao, Min Yang, Jing Hu, Sushabhan Sadhukhan, Bo Li et al. · 2021 · Oncogene
SIRT6 Regulates Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells Partially via Suppressing the Nuclear Factor-κB Signaling Pathway
Hualing Sun, Yanru Wu, Dongjie Fu, Yinchen Liu, Cui Huang · 2014 · Stem Cells
Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation
Muhannad Abu‐Remaileh, Rami I. Aqeilan · 2014 · Cell Death and Differentiation
Identifying the functional contribution of the defatty-acylase activity of SIRT6
Xiaoyu Zhang, Saba Khan, Hong Xiang Jiang, Marc A. Antonyak, Xiao Chen, Nicole A. Spiegelman, Jonathan H. Shrimp, Richard A. Cerione, Hening Lin · 2016 · Nature Chemical Biology
Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
Aranka Brockmueller, Saba Sameri, Alena Líšková, Kevin Zhai, Elizabeth Varghese, Samson Mathews Samuel, Dietrich Büsselberg, Peter Kubatka, Mehdi Shakibaei · 2021 · Cancers
SIRT6 is a key regulator of mitochondrial function in the brain
Dmitrii Smirnov, Ekaterina Eremenko, Daniel Stein, Shai Kaluski, Weronika Jasińska, Claudia Cosentino, Bárbara Martínez-Pastor, Yariv Brotman, Raúl Mostoslavsky, Ekaterina E. Khrameeva et al. · 2023 · Cell Death and Disease
E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells
Minghui Wu, Edward Seto, Jingsong Zhang · 2015 · Oncotarget
Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators
Mark A. Klein, John M. Denu · 2020 · Journal of Biological Chemistry
Molecular mechanisms of astragaloside‑IV in cancer therapy (Review)
Tianqi Chen, Peiying Yang, Yingjie Jia · 2021 · International Journal of Molecular Medicine
SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation
Xiaoyu Zhang, Nicole A. Spiegelman, Ornella D. Nelson, Hui Jing, Hening Lin · 2017 · eLife
CK2α/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients
Jun Sang Bae, See‐Hyoung Park, Urangoo Jamiyandorj, Kyoung Min Kim, Sang Jae Noh, Jung Ryul Kim, Hye Jeong Park, Keun Sang Kwon, Sung Hoo Jung, Ho Sung Park et al. · 2016 · American Journal Of Pathology
Build-UPS and break-downs: metabolism impacts on proteostasis and aging
Franziska Ottens, André Franz, Thorsten Hoppe · 2021 · Cell Death and Differentiation
Sirtuins and the Metabolic Hurdles in Cancer
Natalie J. German, Marcia C. Haigis · 2015 · Current Biology
SIRT6, a protein with many faces
Asaf A. Gertler, Haim Yosef Cohen · 2013 · Biogerontology
Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis
Sivan Elhanati, Rotem Ben‐Hamo, Yariv Kanfi, Alexander Varvak, Renana Glazz, Batia Lerrer, Sol Efroni, Haim Yosef Cohen · 2015 · Cell Reports
Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies
Yi Zhu, Jiaqi Liu, Joun Park, Priyamvada Rai, Rong Grace Zhai · 2019 · Pharmacology & Therapeutics
Identification of and molecular basis for sirt6 loss-of-function point mutations in cancer
Kugel, Sita, Feldman, Jessica L., Klein, Mark A., Silberman, Dafne M., Sebastián, Carlos, Mermel, Craig, Dobersch, Stephanie, Clark, Abbe R., Getz, Gad, Denu, John M. et al. · 2015 · Cell Reports
Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming
Bernadette M. M. Zwaans, David B. Lombard · 2014 · Disease Models & Mechanisms
Dysregulated glycolysis as an oncogenic event
Takumi Mikawa, Matilde Esther LLeonart, Akifumi Takaori‐Kondo, Nobuya Inagaki, Masayuki Yokode, Hiroshi Kondoh · 2015 · Cellular and Molecular Life Sciences
SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170
Sarallah Rezazadeh, David X. Yang, Gregory Tombline, Matthew A. Simon, S. P. Regan, Andrei Seluanov, Vera A. Gorbunova · 2019 · Nucleic Acids Research
The Two-Faced Role of SIRT6 in Cancer
Francesco Fiorentino, Vincenzo Carafa, Gregorio Favale, Lucia Altucci, Antonello Mai, Dante Rotili · 2021 · Cancers
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics
Giovanna Sociali, Lauretta Galeno, Marco Daniele Parenti, Alessia Grozio, Inga Bauer, Mario Passalacqua, Silvia Boero, Alessandra Donadini, Enrico Millo, Marta Bellotti et al. · 2015 · European Journal of Medicinal Chemistry
Sirtuins in Metabolic and Epigenetic Regulation of Stem Cells
Yi Fang, Shuang Tang, Xiaoling Li · 2019 · Trends in Endocrinology and Metabolism
Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
Minxian Qian, Zuojun Liu, Linyuan Peng, Xiaolong Tang, Fanbiao Meng, Ying Ao, Mingyan Zhou, Ming Wang, Xinyue Cao, Baoming Qin et al. · 2018 · eLife
Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures
Nicholas Alexander Graham, Aspram Minasyan, Anastasia Lomova, Ashley A. Cass, Nikolas G. Balanis, Michael Friedman, Shawna T. Chan, Sophie R. Zhao, Adrián Delgado, James L Go et al. · 2017 · Molecular Systems Biology
Are sirtuins markers of ovarian aging?
Jinjin Zhang, Fang Li, Zhiyong Lu, Jiaqiang Xiong, Meng Wu, Liangyan Shi, Aiyue Luo, Shixuan Wang · 2015 · Gene
The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells
Moran Choe, Jessica L. Brusgard, Saranya Chumsri, Lekhana Bhandary, Xianfeng Frank Zhao, Song Lu, Olga G. Goloubeva, Brian M. Polster, Gary M. Fiskum, Geoffrey D. Girnun et al. · 2015 · Journal of Cellular Biochemistry
Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism
Seung Min Jeong, Marcia C. Haigis · 2015 · Molecules and Cells
SIRT6 in Senescence and Aging-Related Cardiovascular Diseases
Xiao‐Kang Li, Lin Liu, Tian Xiang Li, Manling Liu, Yishi Wang, Heng Ma, Nan Mu, Haiyan Wang · 2021 · Frontiers in Cell and Developmental Biology
Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors
Bin He, Jing Hu, Xiaoyu Zhang, Hening Lin · 2014 · Organic & Biomolecular Chemistry
MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer
Jialin Shang, Shaobo Ning, Ying‐Yi Chen, Tianxiang Chen, Jian Zhang · 2020 · Acta Pharmacologica Sinica
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non‐small cell lung cancer
Yoko Azuma, Takehiko Yokobori, Akira Mogi, Bolag Altan, Toshiki Yajima, Takayuki Kosaka, Ryoichi Onozato, Ei Yamaki, Takayuki Asao, Masahiko Nishiyama et al. · 2015 · Journal of Surgical Oncology
Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal-regulated kinase signaling pathway
Zhigao Zhang, Chengyong Qin · 2013 · Molecular Medicine Reports
Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice
Zhiping Liu, Jiaojiao Wang, Xiaoyang Huang, Zhuoming Li, Peiqing Liu · 2016 · Translational research
Discovery of Novel PROTAC SIRT6 Degraders with Potent Efficacy against Hepatocellular Carcinoma
Jinbo Huang, Jiajie Su, Haiyu Wang, Jiayi Chen, Yuan Tian, Jun Zhang, Tingting Feng, Longjiang Di, Xiaopeng Lu, Hao Sheng et al. · 2024 · Journal of Medicinal Chemistry
Updates on the epigenetic roles of sirtuins
Tatsiana Kosciuk, Miao Wang, Jun Young Hong, Hening Lin · 2019 · Current Opinion in Chemical Biology
The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing
Jean‐Pierre Etchegaray, Lei Zhong, Catherine Li, Telmo Henriques, Eileen F. Ablondi, Tomoyoshi Nakadai, Capucine Van Rechem, Christina M. Ferrer, Kenneth N. Ross, Jee-Eun Choi et al. · 2019 · Molecular Cell
Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling
Juan Yang, Ying Li, Ya Zhang, Xiaosheng Fang, Na Chen, Xiangxiang Zhou, Xin Wang · 2020 · Journal of Experimental & Clinical Cancer Research
Sirtuins are crucial regulators of T cell metabolism and functions
Imène Hamaidi, Sungjune Kim · 2022 · Experimental & Molecular Medicine
Down-regulation of HDAC5 inhibits growth of human hepatocellular carcinoma by induction of apoptosis and cell cycle arrest
Jian Fan, Bin Lou, Wei Chen, Jie Zhang, Sha Lin, Feifei Lv, Yu Chen · 2014 · Tumor Biology
Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study
Dharmendra Kumar Yadav, Surendra Kumar, Saloni Saloni, Sanjeev Misra, Lalit Yadav, Mahesh Kumar Teli, Praveen Sharma, Sandeep Chaudhary, Naresh Kumar, Eun Ha Choi et al. · 2018 · Scientific Reports
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets
Rubayat Islam Khan, Saif Shahriar Rahman Nirzhor, Raushanara Akter · 2018 · Biomolecules
DNA repair as a shared hallmark in cancer and ageing
Thomas L. Clarke, Raúl Mostoslavsky · 2022 · Molecular Oncology
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Matthew A. Simon, Jiping Yang, Jonathan Gigas, Eric J. Earley, Eric C. Hillpot, Lei Justan Zhang, Maria Zagorulya, Greg Tombline, Michael B. Gilbert, Samantha L. Yuen et al. · 2022 · The EMBO Journal
SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapy
Yingjie Zhang, Liming Nie, Keqian Xu, Yang Fu, Juchang Zhong, Kongzhen Gu, Lingling Zhang · 2019 · Theranostics
Characterization of Histone Deacetylase Mechanisms in Cancer Development
Rihan Hai, Liuer He, Guang Shu, Gang Yin · 2021 · Frontiers in Oncology
SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity
Venkatraman Ravi, Aditi Jain, Danish Khan, Faiz Ahamed, Sneha Mishra, Malyasree Giri, Meena Inbaraj, Swati Krishna, Mohsen Sarikhani, Sangeeta Maity et al. · 2019 · Nucleic Acids Research
Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis
Linyuan Peng, Minxian Qian, Zuojun Liu, Xiaolong Tang, Jie Lena Sun, Yue Jiang, Shimin Sun, Xinyue Cao, Qiuxiang Pang, Baohua Liu · 2020 · Nucleic Acids Research
The sirtuin family in cancer
Luis Filipe Costa‐Machado, Pablo J. Fernández-Marcos · 2019 · Cell Cycle
FOXO3 Growth Inhibition of Colonic Cells Is Dependent on Intraepithelial Lipid Droplet Density
Wentao Qi, Philip S. Fitchev, Mona L. Cornwell, Jordan M. Greenberg, Maleen H. Cabe, Christopher R. Weber, Hemant K. Roy, Susan E. Crawford, Suzana D. Savkovic · 2013 · Journal of Biological Chemistry
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage
Angela Rizzo, Sara Iachettini, Erica Salvati, Pasquale Zizza, Carmen Maresca, Carmen D’Angelo, Delphine Benarroch, Angela Capolupo, Federica Del Gaudio, Sandro Cosconati et al. · 2016 · Nucleic Acids Research
Histone Deacetylases and Their Inhibitors in Cancer Epigenetics
Kelly N. Hassell · 2019 · Diseases
LncRNA HMMR-AS1 promotes proliferation and metastasis of lung adenocarcinoma by regulating MiR-138/sirt6 axis
Yong Cai, Zhaoying Sheng, Yun Chen, Jiying Wang · 2019 · Aging
Sirtuin-dependent clock control
Selma Masri · 2015 · Current Opinion in Clinical Nutrition & Metabolic Care
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas
Jung Ryul Kim, Young Jae Moon, Keun Sang Kwon, Jun Sang Bae, Sajeev Wagle, Taek Kyun Yu, Kyoung Min Kim, Ho Sung Park, Ju Hyung Lee, Woo Sung Moon et al. · 2013 · PLoS ONE
SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and suppression of JAK2/STAT3 signaling pathway activation
JUN FENG, Peng-Fei Yan, Hongyang Zhao, Fangcheng Zhang, Wohua Zhao, Min Feng · 2015 · Oncology Reports
SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway
Irene Santos‐Barriopedro, Laia Bosch‐Presegué, Anna Marazuela-Duque, Carolina de la Torre, Carlota Colomer, Berta N. Vázquez, Thomas Fuhrmann, Bárbara Martínez-Pastor, Wenfu Lu, Thomas W Braun et al. · 2018 · Nature Communications
Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis
Lindsay E. Wu, Ana P. Gomes, David A. Sinclair · 2014 · Cancer Cell
NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer
Szymon J. Szymura, Jacob Peter Zaemes, David F. Allison, Sheena H. Clift, Jaclyn D'Innocenzi, Lisa G. Gray, Brian D. McKenna, Benjamin B. Morris, Stefan Bekiranov, Robin D. LeGallo et al. · 2019 · Cell Communication and Signaling
Metabolic Dysregulations and Epigenetics: A Bidirectional Interplay that Drives Tumor Progression
Fabiana Crispo, Valentina Condelli, Silvia Lepore, Tiziana Notarangelo, Alessandro Sgambato, Franca Esposito, Francesca Maddalena, Matteo Landriscina · 2019 · Cells
The Bidirectional Relationship Between Cancer Epigenetics and Metabolism
Luke Izzo, Hayley C. Affronti, Kathryn E. Wellen · 2020 · Annual Review of Cancer Biology
Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy
Chen Chen, Zehua Wang, Yanru Qin · 2022 · Frontiers in Pharmacology
SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients
Liane M. McGlynn, Simon J. McCluney, Nigel Balfour Jamieson, Jackie Thomson, Alasdair Iain Macdonald, Karin A. Oien, Euan J. Dickson, C. Ross Carter, Colin J. McKay, Paul G. Shiels · 2015 · PLoS ONE
Histone Deacetylase Inhibitor RGFP109 Overcomes Temozolomide Resistance by Blocking NF-κB-Dependent Transcription in Glioblastoma Cell Lines
Zongyang Li, Qing-zhong Li, Lei Chen, Bao-dong Chen, Bo Wang, Xiejun Zhang, Wei-ping Li · 2016 · Neurochemical Research
Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer
Aikaterini F. Giannopoulou, Athanassios D. Velentzas, Eumorphia G. Konstantakou, Margaritis Avgeris, Stamatia A. Katarachia, Nikolaos C. Papandreou, Nikolaos Kalavros, Vassiliki Mpakou, Vassiliki A. Iconomidou, Ema Anastasiadou et al. · 2019 · International Journal of Molecular Sciences
An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality
Christina M. Ferrer, Marielle M. Alders, Alex Vincent Postma, Seonmi Park, Mark A. Klein, Murat Çetinbaş, Eva Pajkrt, Astrid Glas, Silvana van Koningsbruggen, Vincent M. Christoffels et al. · 2018 · Genes & Development
Anticancer Agents Targeted to Sirtuins
Tomohiro Kozako, Takayoshi Suzuki, Makoto Yoshimitsu, Naomichi Arima, Shin‐ichiro Honda, Shinji Soeda · 2014 · Molecules
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling
Liwen Wang, Weinan Guo, Jinyuan Ma, Wei Dai, Lin Liu, Sen Guo, Jiaxi Chen, Huina Wang, Yuqi Yang, Xiuli Yi et al. · 2017 · Autophagy
Sirtuin modulators: an updated patent review (2012 – 2014)
Paolo Mellini, Sérgio Valente, Antonello Mai · 2014 · Expert Opinion on Therapeutic Patents
The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression.
J Zhang, Yin Xj, Xu Cj, Ning Yx, M Chen, H Zhang, Chen Sf, L-Q Yao · 2015 · PubMed