The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
Sebastián, Carlos, Zwaans, Bernadette M.M., Silberman, Dafne M., Gymrek, Melissa, Goren, Alon, Zhong, Lei, Ram, Oren, Truelove, Jessica +16 more·2012·Cell
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- Prognostic role of SIRT6 in gastrointestinal cancers: a meta-analysisLi Shi, Ying Wang, Timothy Bonney Oppong, Xiaoli Fu, Haiyan Yang, Yadong Wang · 2020 · Open Medicine
- RETRACTED ARTICLE: MicroRNA-572/hMOF/Sirt6 regulates the progression of ovarian cancerMingbo Cai, Zhenhua Hu, Liping Han, Ruixia Guo · 2020 · Cell Cycle · Retracted
- Interweaving Tumor Heterogeneity into the Cancer Epigenetic/Metabolic AxisJia Yu Leung, Kimberly Chia, Derrick Sek Tong Ong, Reshma Taneja · 2019 · Antioxidants and Redox Signaling
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- Protein Acetylation as an Integral Part of Metabolism in Cancer Development and ProgressionMiroslava Čuperlović‐Culf, Adrian S. Culf · 2014
- Inhibition of Sirt6 suppresses tumor growth by inducing G1/S phase arrest in renal cancer cells.Yu Ding, Sisi Wu, Yuwei Huo, Xuemei Chen, Li Chai, Yan Wang, Xiangxiu Wang, Guonian Zhu, Wei Jiang · 2019 · Europe PMC (PubMed Central)
- Strong Involvement of Classical Histone Deacetylases and Mechanistically Distinct Sirtuins in Bellicose CancersShabir Ahmad Ganai · 2020 · Springer eBooks
- Correction: Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia CellsYoshitaka Sunami, Marito Araki, Yumi Hironaka, Soji Morishita, Masaki Kobayashi, Ei Leen Liew, Yoko Edahiro, Miyuki Tsutsui, Akimichi Ohsaka, Norio Komatsu · 2013 · PLoS ONE
- Binding to nucleosome poises SIRT6 for histone H3 de-acetylationEkaterina Smirnova, Emmanuelle Bignon, Patrick Schultz, Gábor Pápai, Adam Ben Shem · 2023 · eLife
- Nuclear SIRT6 depletion activates LINE1-cGAS-STING pathway to induce PASMCs senescence in hypoxic pulmonary hypertensionMeng Wang, Meiling Zhang, Jian Chen, Yan Wang, Junming Zhang, Yuwen Dai, Chenfei Zhao, Yukun Gan, Limin Liu, Zhichao Li · 2026 · Cellular Signalling
- Subtype-specific sirtuin expression signatures link mitochondrial–epigenetic networks to breast cancer survivalZoltan I. Ungvari, Otília Menyhárt, Alberto Ocana, Andrea Lehoczki, Mónika Fekete, Giampaolo Bianchini, Balázs Győrffy · 2026 · GeroScience
- Deciphering the role of SIRT6 in suppressing the AMPK-mTOR-TFEB axis: regulation of autophagy activation in HCCCong Shan Li, Hua Jin, Ruoyu Meng, Seung-Woo Baek, Seong‐Hun Kim, Ok Hee Chai, Byung Hyun Park, Na Rae Lee, Soo Mi Kim, Soo Mi Kim · 2026 · Cancer Gene Therapy
- SIRT6 suppresses colon cancer growth by inducing apoptosis and autophagy through transcriptionally down-regulating SurvivinNannan Liu, Yanqiu Li, Guang Luo, Meimei Jiang, Chun Liu, Yingjie Zhang, Lingling Zhang · 2024 · Mitochondrion
- Regulation of Stem Cell Function by NAD +Yufan Feng, Huixian Qiu, Danica Chen · 2025 · Physiology
- Low Rap1-interacting factor 1 and sirtuin 6 expression predict poor outcome in radiotherapy-treated Hodgkin lymphoma patientsHamid Bur, Kirsi‐Maria Haapasaari, Taina M. Turpeenniemi-Hujanen, Outi M. Kuittinen, Päivi Auvinen, Katja Marin, Ylermi Soini, Peeter Karihtala · 2017 · Leukemia & lymphoma/Leukemia and lymphoma
- MiR-363 suppresses the tumor growth of natural killer/T-cell lymphoma via the SIRT6/PI3K/AKT axisBei Xu, Lian Jiang, Jia-Li Cui, Xiu-Li Zhu, Yajie Bai, Jian Chen, Yuqiao Diao · 2022 · Annals of Translational Medicine
- Metabolic Changes and Their CharacterizationNoor-ul Ain, Hira Gull · 2020 · Springer eBooks
- Sirtuins and cellular metabolism in cancersZhen Dong, Hongjuan Cui · 2021 · Elsevier eBooks
- Une vision élargie des modèles explicatifs de la biologie des cancersJean Bénard, Christian‐Jacques Larsen · 2013 · Bulletin du Cancer
- [Dacron and polytetrafluoroethylene aorto-bifemoral grafts].Lazar B Davidovic, Slobodan I. Lotina, Dusan M. Kostic, Ilija Cinara, Slobodan D. Cvetkovic, P L Stojanović, L B Velimirović, Dragan M. Markovic, Siniša Pejkić, G Pavlović · 1997 · PubMed
- Sirtuin 6 regulates the proliferation and survival of clear cell renal cell carcinoma cells via B‑cell lymphoma 2Jun An, Jieping Yang, Yang Yao, Kaining Lu, Zhiqiang Zhao, Meng Yu, Yuyan Zhu · 2021 · Oncology Letters
- Cibler le métabolisme tumoral : efficacité et perspectivesJulien Hadoux, Christophe Massard · 2013 · ONCOLOGIE
- AgingDudley W. Lamming · 2014 · Elsevier eBooks
- Expression analysis and biological regulation of silencing regulatory protein 6 (SIRT6) in cutaneous squamous cell carcinomaSai Chen, Hongxia Chen, Xu Wang, Dongmei Zhang, Li Zhang, Jiawei Cheng, Qi Zhang, Zhixiang Hua, Xu Miao, Jian Shi · 2024 · Anais Brasileiros de Dermatologia
- Research progress on sirtuin family genes in colorectal cancerTong Liu, Tianhua Wu, Lijun Luo, Wei Li, Minglin Zhang · 2025 · Frontiers in Oncology
- Metabolic and epigenetic interplay in HSPC specification: A balance between extrinsic and intrinsic cuesMaria Kalogeraki, Vincent Rondeau, Zeina Abou Nader, Marion Espéli, Karl Balabanian · 2026 · iScience
- Mechanisms of the Antiproliferative Effects of SIRT6 Inhibition in Melanoma: A Multi-Omics AnalysisKarla B. Anaya Aldrete, Durdana Waseem, Liz M. Garcia‐Peterson, Mary Ann Ndiaye, Jeong Ha Nam, Nihal Ahmad · 2026 · Cancers
- A Novel Prognostic Model of Hepatocellular Carcinoma per Two NAD+ Metabolic Synthesis-Associated GenesLuo Dai, Shiliu Lu, Linfeng Mao, Mingbei Zhong, Gangping Feng, Songqing He, Guandou Yuan · 2024 · International Journal of Molecular Sciences
- Sirtuins and metabolic regulation: food and supplementationSérgio Henrique Sousa Santos, Victor Hugo Dantas Guimarães, Janaína Ribeiro Oliveira, Luiz Fernando de Rezende · 2021 · Elsevier eBooks
- Metabolic regulation in urological tumors: Interplay with epigenetics and epitranscriptomicsVera Miranda‐Gonçalves, Catarina Guimarães‐Teixeira, Rui Henrique, Cármen Jerónimo · 2021 · Elsevier eBooks
- Stress Responses as Master Keys to Epigenomic Changes in Transcriptome and Metabolome for Cancer Etiology and TherapeuticsAtanu Mondal, Apoorva Bhattacharya, Vipin Singh, Shruti Pandita, Albino Bacolla, RAJ KUMAR PANDITA, John A. Tainer, Kenneth S. Ramos, Tej K. Pandita, Chandrima Das · 2021 · Molecular and Cellular Biology
- Molecular characterization and expression pattern analysis of Sirtuin family genes in the eastern honeybee, Apis ceranaQiang Ma, Sheng Chen, Zhengang Ma, Du-Fu Li, Xiaoqun Dang, Jin-Shan Xu, Zeyang Zhou · 2024 · Discover Life
- Interaction Between Cellular Metabolic States and Chromatin DynamicsSamantha J Linder, Raúl Mostoslavsky · 2016 · Elsevier eBooks
- Sirtuins and AgingCarles Cantó, Riekelt H. Houtkooper · 2016 · Springer eBooks
- Remission is good - relapse is badPaul S. Gaynon · 2017 · Haematologica
- Sirtuins and next generation hallmarks of cancer: cellular energetics and tumor promoting inflammationRobert Kleszcz, Wanda Baer‐Dubowska · 2021 · Elsevier eBooks
- The correlation of serum sirt6 with clinical outcome and prognosis in patients with gastric cancerDanyang Li, Cheng Cao · 2022 · Medicine
- The Controversy Around Sirtuins and Their Functions in AgingYu Sun, Weiwei Dang · 2016 · Elsevier eBooks
- Multitasking Roles of the Mammalian Deacetylase SIRT6Sylvana Hassanieh, Raúl Mostoslavsky · 2018 · Elsevier eBooks
- Recent Advances in Chromatin Mechanisms Controlling Pancreatic CarcinogenesisThomas P. Hank, Andrew Scott Liss · 2018 · Epigenomes
- The bifunctional roles of sirtuins and their therapeutic potential in cancerYeuan Ting Lee, Yi Jer Tan, Pei Yi Mok, Ayappa V. Subramaniam, Chern Ein Oon · 2021 · Elsevier eBooks
- Sirtuins, healthspan, and longevity in mammalsSurinder Kumar, William Giblin, David B. Lombard · 2021 · Elsevier eBooks
- Binding to nucleosome poises human SIRT6 for histone H3 deacetylationEkaterina Smirnova, Emmanuelle Bignon, Patrick Schultz, Gábor Pápai, Adam Ben Shem · 2023 · eLife
- Binding to nucleosome poises human SIRT6 for histone H3 deacetylationEkaterina Smirnova, Emmanuelle Bignon, Patrick Schultz, Gábor Pápai, Adam Ben Shem · 2024 · eLife
- The Prognostic and Clinicopathological Roles of Sirtuin-6 in Various Cancers: A Meta-AnalysisTing Jing, Xiaofeng Yang, Yanhao He · 2023 · Matrix Science Medica
- Redox‐Guided Metabolic Control in Cancer: Integration of the Reactive Oxygen Species–AMP‐Activated Protein Kinase–Sirtuin Axis in Tumour Adaptation and TherapyFathe Singh · 2026 · Journal of Biochemical and Molecular Toxicology
- Phylogenetic analysis and detection of positive selection in the SIRT gene family across vertebratesQiuxi Zhou, Xiongtao Yang, Da Li, Jing Li, Ling Peng, Wenwu He · 2025 · Scientific Reports
- GCIP and SIRT6 cooperatively suppress ITGAV gene expression by modulating c-myc transcription abilityYi‐Ching Huang, Tien-Ming Yuan, Bang‐Hung Liu, Ruei‐Yue Liang, Kai‐Li Liu, Show‐Mei Chuang · 2025 · Journal of Biological Chemistry
- Sirtuin 6 mediates the therapeutic effect of endometrial regenerative cell-derived exosomes in alleviation of acute transplant rejection by weakening c-myc-dependent glutaminolysisTong Liu, Chenglu Sun, Xu Liu, Pengyu Zhao, Bo Shao, Yini Xu, Yiyi Xiao, Hongda Wang, Qiang Chen, Guangmei Yang et al. · 2025 · Frontiers in Cell and Developmental Biology
- Histidine and tyrosine residues are targets for SIRT6 ADP-ribosylation activityJ.G.M. Rack, Evgeniia A. Prokhorova, R. Lauro, Anna Georgina Kopasz, Domagoj Baretić, Roberto Raggiaschi, Jovana Mutabdzija, Dmitri V. Filippov, Gyula Timinszky, Orsolya Leidecker et al. · 2026 · Open Biology
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- SIRT6 Activation Improves Intervertebral Disc Health in the Aging SpinePranay L. Ramteke, Bahiyah Watson, Sanjana Jagannath, Sarah Elizabeth Bell, Mallory Toci, Olivia K. Ottone, Qinglin Wu, Oliver Abinader, Ramkrishna Mitra, John A. Collins et al. · 2026 · Aging Cell
- Diverse Roles for SIRT6 in Mammalian Healthspan and LongevityBernadette M. M. Zwaans, William Giblin, David B. Lombard · 2016 · Springer eBooks
- Carcinogenic Compounds, 2-nitrofluorene and Clonidine Can Modulate the Level of Sirtuin mRNAs Expression in Human Adipose Tissue-derived Stem CellsJiyoun Lee, Chae-yeong Lee, Young-Ho Kwon, Ho-Chan Kim, Hyun Kim · 2014 · Korean Journal of Physical Anthropology
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- Mammalian Sirtuins, Cellular Energy Regulation, and Metabolism, and CarcinogenesisAthanassios Vassilopoulos, Rui-Hong Wang, David R. Gius · 2018 · Elsevier eBooks
- Aberrant Epigenomic Regulatory Networks in Multiple Myeloma and Strategies for Their Targeted ReversalSamrat Roy Choudhury, Brian A. Walker · 2019 · RNA technologies
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