The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

Cited by (664)

Items 601–664 of 664

  1. Pentamethylquercetin inhibited the growth of hepatic ascitic tumor cell H22 by improving metabolic environment and aerobic glycolysis in monosodium glutamate-induced obese mice
    Wenqi Gao, Xiao Xiao · 2019 · Pharmacognosy Magazine
  2. Line-1 Retrotransposition and the Impact on Aging Rodent Skeletal Muscle Tissue
    Petey W. Mumford · 2019
  3. Dietary restriction in the epigenomic regulation of cardiovascular diseases
    Ken Shinmura · 2019 · Elsevier eBooks
  4. The antiviral mechanism and viral antagonism of host histone deacetylase 4 in influenza A virus infection
    Henry D. Galvin · 2020 · Otago University Research Archive (University of Otago)
  5. Sirtuins and the hallmarks of cancer
    Talita Helen Bombardelli Gomig, Tayana Schultz Jucoski, Érika Pereira Zambalde, Alexandre Luiz Korte de Azevedo, Daniela Fiori Gradia, Enilze M.S.F. Ribeiro · 2021 · Elsevier eBooks
  6. Sirtuin signaling in hematologic malignancies
    Ryan Austin Denu · 2021 · Elsevier eBooks
  7. Sirtuins as regulators and the regulated molecules of exosomes
    Qing Han, Yirui Cheng, Weiliang Xia · 2021 · Elsevier eBooks
  8. Live-Cell Imaging of Sirtuin Activity Using a One-Step Fluorescence Probe
    Mitsuyasu Kawaguchi, Hidehiko Nakagawa · 2021 · Methods in molecular biology
  9. Energy Metabolism and Epigenetics
    Scott J. Bultman · 2019 · Springer eBooks
  10. Introduction
    Shrestha Ghosh · 2019 · Springer theses
  11. Non-Small Cell Lung Cancer Utilizes SIRT6 to Initiate Tumorigenesis and Overcome Cellular Senescence
    Jaclyn D'Innocenzi · 2017
  12. Discussion
    Shrestha Ghosh · 2019 · Springer theses
  13. Papel do microRNA-33A e da proteína sirtuina 6 no metabolismo e progressão do câncer de cólon em camundongos submetidos ao treinamento físico aeróbico
    João Lucas Penteado Gomes · 2022
  14. Epigenetic modifications and regulations in gastrointestinal diseases
    Aditi Bhattacharya · 2023 · Elsevier eBooks
  15. Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma
    Elisa Gelli, Debora Soncini, Pamela Becherini, Claudia Martinuzzi, Katia Todoerti, Antonia Cagnetta, Sara Aquino, Fabio Guolo, Maurizio Miglino, Santina Bruzzone et al. · 2023 · Blood Advances
  16. Data from Low Glucose–Induced Overexpression of HOXC-AS3 Promotes Metabolic Reprogramming of Breast Cancer
    Wenjie Zhu, Xu Chen, Xiangyu Guo, Haiting Liu, Ranran Ma, Yawen Wang, Yahang Liang, Ying Sun, Mengqi Wang, Ruinan Zhao et al. · 2023
  17. Data from HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma
    Yixuan Li, Xiangyang Zhang, Shaoqi Zhu, Eden A. Dejene, Weiqun Peng, Antonia R. Sepulveda, Edward Seto · 2023
  18. eLife Assessment: Binding to nucleosome poises SIRT6 for histone H3 de-acetylation
    Tim Formosa · 2023 · eLife
  19. Binding to nucleosome poises human SIRT6 for histone H3 deacetylation
    Ekaterina Smirnova, Emmanuelle Bignon, Patrick Schultz, Gábor Pápai, Adam Ben Shem · 2023 · eLife
  20. Molecular dynamics simulation on the role of CL5D in accelerating the product dissociation of SIRT6
    Hao Rao, Ting Yang, Yue Wang, Junwen Fei, Lihua Bie, Jun Gao · 2025 · Physical Chemistry Chemical Physics
  21. The Role of NAD+-Dependent Signal Mechanisms in Cancer Development and Treatment
    Ting Lu, Zheng‐Hong Qin, Junchao Wu · 2025 · Springer eBooks
  22. A review on the role of SIRT6 in the prognosis of colorectal cancer
    Heba Hekal Mahmmoud, reham shehab ELnemr, Dalia Nabil Abdelhafez · 2025 · Fayoum University Medical Journal/Fayoum University Medical Journal
  23. The Role of Sirtuins in Bone Repair From the Perspective of Glucose Metabolism
    Yun Ding, Yu Gao, Jianjun Sun, Zhigang Cai · 2025 · International Journal of General Medicine
  24. Rare centenarian SIRT6 variants elevate SIRT6 protein levels and resist cellular senescence
    Jiping Yang, HyeRim Han, Xifan Wang, Yizhou Zhu, Haiqi Chen, Yousin Suh · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  25. Ursolic acid activates SIRT6 by enhancing enzyme-substrate interactions and promoting protein structural rearrangement
    Zohreh Tabatabaian Nimavard, Nuredin Bakhtiari, Fereshteh Taghavi, Sako Mirzaie, Farangis Ataei, Hamid Khaledi · 2025 · Biochimica et Biophysica Acta (BBA) - General Subjects
  26. SIRT6–GLUL axis: rewiring nitrogen metabolism in intrahepatic cholangiocarcinoma
    Huiping Zhou, Hui Li, Nan Wu, Diego Francesco Calvisi · 2025 · Gut
  27. Sirtuins as a Double-Edged Sword in Cancer: From Molecular Mechanisms to Therapeutic Opportunities
    Núria Sima, Laia Bosch‐Presegué, Alejandro Vaquero · 2014 · Springer eBooks
  28. Additional file 3 of Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth
    Zhang, Yizheng, Zhang, Chuchu, Li, Jiehan, Jiang, Meimei, Shuning Guo, Yang, Ge, Zhang, Lingling, Wang, Feng, Yi, Shiqi, Wang, Jiangang et al. · 2022 · Figshare
  29. Additional file 5 of Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth
    Zhang, Yizheng, Zhang, Chuchu, Li, Jiehan, Jiang, Meimei, Shuning Guo, Ge Yang, Zhang, Lingling, Wang, Feng, Shiqi Yi, Wang, Jiangang et al. · 2022 · Figshare
  30. Additional file 4 of Clinicopathological and prognostic value of SIRT6 in patients with solid tumors: a meta-analysis and TCGA data review
    Wu, Xiaojing, Wang, Shuyuan, Zhao, Xuanzhu, Lai, Sizhen, Yuan, Zhen, Zhan, Yixiang, Ni, Kemin, Zhaoce Liu, Liu, Lina, Ran Xin et al. · 2022 · Figshare
  31. Additional file 2 of Clinicopathological and prognostic value of SIRT6 in patients with solid tumors: a meta-analysis and TCGA data review
    Xiaojing Wu, Wang, Shuyuan, Zhao, Xuanzhu, Lai, Sizhen, Yuan, Zhen, Zhan, Yixiang, Ni, Kemin, Zhaoce Liu, Liu, Lina, Ran Xin et al. · 2022 · Figshare
  32. Additional file 7 of SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
    Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Vellone, Valerio G., Passalacqua, Mario, Andrea Benzi, Tommaso Bonfiglio, Reverberi, Daniele, Khalifa, Amr et al. · 2021 · Figshare
  33. Additional file 1 of Clinicopathological and prognostic value of SIRT6 in patients with solid tumors: a meta-analysis and TCGA data review
    Wu, Xiaojing, Wang, Shuyuan, Zhao, Xuanzhu, Lai, Sizhen, Yuan, Zhen, Zhan, Yixiang, Ni, Kemin, Zhaoce Liu, Liu, Lina, Ran Xin et al. · 2022 · Figshare
  34. Additional file 3 of Clinicopathological and prognostic value of SIRT6 in patients with solid tumors: a meta-analysis and TCGA data review
    Wu, Xiaojing, Wang, Shuyuan, Zhao, Xuanzhu, Lai, Sizhen, Yuan, Zhen, Zhan, Yixiang, Ni, Kemin, Zhaoce Liu, Liu, Lina, Xin, Ran et al. · 2022 · Figshare
  35. Additional file 2 of Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth
    Zhang, Yizheng, Zhang, Chuchu, Li, Jiehan, Jiang, Meimei, Shuning Guo, Yang, Ge, Zhang, Lingling, Wang, Feng, Yi, Shiqi, Wang, Jiangang et al. · 2022 · Figshare
  36. Additional file 1 of Identification of CPT2 as a prognostic biomarker by integrating the metabolism-associated gene signature in colorectal cancer
    Liu, Jiaxin, Li, Yimin, Xiao, Qing, Li, Yuanyuan, Peng, Yuqian, Yaqi Gan, Shu, Guang, Yi, Hanxi, Yin, Gang · 2022 · Figshare
  37. Additional file 4 of Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth
    Zhang, Yizheng, Zhang, Chuchu, Li, Jiehan, Jiang, Meimei, Shuning Guo, Yang, Ge, Zhang, Lingling, Wang, Feng, Shiqi Yi, Wang, Jiangang et al. · 2022 · Figshare
  38. Ubiquitin-Specific Protease 10: A New Target in Tumor Immune Escape
    Jingjing Huang, Ning Li, Jiangang Sun, Xiaojing Li · 2026 · Cancer Control
  39. SIRT6: From molecular functions to a potential therapeutic target in human disease
    Pratistha Singh, Jyotirmayee, Sana Ansari, Manvi Bansal, Supriya Barik, Malkhey Verma · 2026 · Gene Reports
  40. Pyrimidine and NAD salvage pathways : unexpected allies in the maintenance of genome stability
    Sandra Cunha Silveira · 2018 · theses.fr (ABES)
  41. Etude des modifications épigénétiques en fonction de l'agressivité du cancer sporadique du sein : l'implication de l'histone désacétylase SIRT1 dans la progression tumorale
    Khaldoun T Rifai · 2018 · theses.fr (ABES)
  42. Centenarian SIRT6 variants elevate SIRT6 protein and enhance cellular senescence resistance
    Yousin Suh, Jiping Yang, Xifan Wang, HyeRim Han, Yizhou Zhu, Lei Justan Zhang, Haiqi Chen, Paul D. Robbins · 2026 · Research Square
  43. Sirtuins in inflammation and autoimmunity
    Mirunalini Gobinath, Parikshit Roychowdhury, Sagarika Mukherjee, Mohd Aftab Siddiqui · 2026 · Elsevier eBooks
  44. Targeting Sirtuins in Thyroid Cancer: Mechanisms, Drug Development, and Emerging Roles in Tumor Immunity and Ferroptosis
    Ki Ju Cho, Ji Hyun Seo, Hayeong Kwon, Seung-Jun Lee, Young‐Sool Hah, Jung Je Park · 2026 · Cancers
  45. Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress
    Jonathan Gigas, Michael E. Meadow, Jing Guo, Catherine Lan, Eric C. Hillpot, John C. Martinez, Gregory Tombline, Philip M. Bellomio, Valeria Rivera-Almodóvar, Kevin A. Welle et al. · 2026 · GeroScience
  46. SIRT6 promotes a mesenchymal, invasive phenotype in melanoma
    Liz M. Garcia‐Peterson, Amelia M. Lemkuil, Mary Ann Ndiaye, Nihal Ahmad, Gagan Chhabra · 2026 · Journal of Dermato-Oncology
  47. Conserved Transcriptomic Signatures of Sirt6 Activity: A Cross-Species RNA-seq Meta-analysis
    A. Khanna, Roja Sharma, Samira Xhaferi, Ullas Kolthur-Seetharam, Peng Jiang, Jackson R. Taylor · 2026 · bioRxiv
  48. Targeting SIRT6: the design and therapeutic implications of activators and inhibitors
    Yuxin Shi, Xiaofan Han, Xinqi Li, Xue Li, Hao Fang, Xuben Hou · 2026 · Bioorganic & Medicinal Chemistry
  49. Deciphering the role of sirtuins in cancer immunoregulation through molecular cross-talk and docking-based interaction
    Aishwarya Saha, Sriparna De, Sreya Chattopadhyay, Sanjukta Dasgupta, Ankan Mitra · 2026 · Molecular Biology Reports
  50. Sirtuin inhibitors alter the food-by-temperature acclimation response to acute heat shock in Mytilus californianus
    Melissa May, R. Frank Fabela, Lars Tomanek · 2026 · Frontiers in Ecology and Evolution
  51. A systematic evaluation of SIRT6 as a transcriptomic biomarker of aging
    Ekaterina Kashuk, Anna Tarakanova, Alexandra Malygina, Nadezhda Kuzovkina, Anna Ponomareva, Debra Toiber, Ekaterina E. Khrameeva, D. Smirnov · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  52. Activator of Sirt6 exerts antitumor activity in pituitary neuroendocrine tumors
    Hong Yao, Beibei Fan, Chuanbao Li, Desheng Chen, Zhuoyi Tang, Jingwei Ye, Weiting Gu, Yijun Cheng, Hao Tang, Shaojian Lin et al. · 2026 · Endocrine
  53. A context-dependent framework for targeting NAD metabolism in cancer
    Leire Arrizabalaga, Laura Santambrogio, Guido Kroemer, Lorenzo Galluzzi, Aitziber Buqué · 2026 · Cell Metabolism
  54. BindingDB Entry 50045761: A FRET-based assay for screening SIRT6 modulators.
    BindingDB · 2016 · UC San Diego
  55. BindingDB Entry 50007852: Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD
    BindingDB · 2021 · UC San Diego
  56. BindingDB Entry 50046646: Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
    BindingDB · 2016 · UC San Diego
  57. BindingDB Entry 50019967: Design, synthesis, and pharmacological evaluations of pyrrolo[1,2-a]quinoxaline-based derivatives as potent and selective sirt6 activators.
    BindingDB · 2024 · UC San Diego
  58. BindingDB Entry 50001970: SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.
    BindingDB · 2020 · UC San Diego
  59. BindingDB Entry 50011050: Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.
    BindingDB · 2021 · UC San Diego
  60. BindingDB Entry 50009378: Allosteric Modulator Discovery: From Serendipity to Structure-Based Design.
    BindingDB · 2021 · UC San Diego
  61. BindingDB Entry 50044446: Discovery of novel and selective SIRT6 inhibitors.
    BindingDB · 2015 · UC San Diego
  62. BindingDB Entry 50018259: Emerging Therapeutic Potential of SIRT6 Modulators.
    BindingDB · 2024 · UC San Diego
  63. A metabolic–epigenetic pathway drives immune suppression in colorectal cancer
    Shweta Kumar, Raúl Mostoslavsky · 2026 · Nature Cancer
  64. Lactate charging of tRNAs “brakes” the ribosome
    Hyo Min Cho, Raúl Mostoslavsky · 2026 · Cell Metabolism