The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
Sebastián, Carlos, Zwaans, Bernadette M.M., Silberman, Dafne M., Gymrek, Melissa, Goren, Alon, Zhong, Lei, Ram, Oren, Truelove, Jessica, Guimaraes, Alexander R., Toiber, Debra, Cosentino, Claudia, Greenson, Joel K., MacDonald, Alasdair I., McGlynn, Liane, Maxwell, Fraser, Edwards, Joanne, Giacosa, Sofia, Guccione, Ernesto, Weissleder, Ralph, Bernstein, Bradley E., Regev, Aviv, Shiels, Paul G., Lombard, David B., Mostoslavsky, Raul·2012·Cell
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- Dietary restriction in the epigenomic regulation of cardiovascular diseasesKen Shinmura · 2019 · Elsevier eBooks
- The antiviral mechanism and viral antagonism of host histone deacetylase 4 in influenza A virus infectionHenry D. Galvin · 2020 · Otago University Research Archive (University of Otago)
- Sirtuins and the hallmarks of cancerTalita Helen Bombardelli Gomig, Tayana Schultz Jucoski, Érika Pereira Zambalde, Alexandre Luiz Korte de Azevedo, Daniela Fiori Gradia, Enilze M.S.F. Ribeiro · 2021 · Elsevier eBooks
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- Live-Cell Imaging of Sirtuin Activity Using a One-Step Fluorescence ProbeMitsuyasu Kawaguchi, Hidehiko Nakagawa · 2021 · Methods in molecular biology
- Energy Metabolism and EpigeneticsScott J. Bultman · 2019 · Springer eBooks
- IntroductionShrestha Ghosh · 2019 · Springer theses
- Non-Small Cell Lung Cancer Utilizes SIRT6 to Initiate Tumorigenesis and Overcome Cellular SenescenceJaclyn D'Innocenzi · 2017
- DiscussionShrestha Ghosh · 2019 · Springer theses
- Papel do microRNA-33A e da proteína sirtuina 6 no metabolismo e progressão do câncer de cólon em camundongos submetidos ao treinamento físico aeróbicoJoão Lucas Penteado Gomes · 2022
- Epigenetic modifications and regulations in gastrointestinal diseasesAditi Bhattacharya · 2023 · Elsevier eBooks
- Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myelomaElisa Gelli, Debora Soncini, Pamela Becherini, Claudia Martinuzzi, Katia Todoerti, Antonia Cagnetta, Sara Aquino, Fabio Guolo, Maurizio Miglino, Santina Bruzzone et al. · 2023 · Blood Advances
- Data from Low Glucose–Induced Overexpression of HOXC-AS3 Promotes Metabolic Reprogramming of Breast CancerWenjie Zhu, Xu Chen, Xiangyu Guo, Haiting Liu, Ranran Ma, Yawen Wang, Yahang Liang, Ying Sun, Mengqi Wang, Ruinan Zhao et al. · 2023
- Data from HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung AdenocarcinomaYixuan Li, Xiangyang Zhang, Shaoqi Zhu, Eden A. Dejene, Weiqun Peng, Antonia R. Sepulveda, Edward Seto · 2023
- eLife Assessment: Binding to nucleosome poises SIRT6 for histone H3 de-acetylationTim Formosa · 2023 · eLife
- Binding to nucleosome poises human SIRT6 for histone H3 deacetylationEkaterina Smirnova, Emmanuelle Bignon, Patrick Schultz, Gábor Pápai, Adam Ben Shem · 2023 · eLife
- Molecular dynamics simulation on the role of CL5D in accelerating the product dissociation of SIRT6Hao Rao, Ting Yang, Yue Wang, Junwen Fei, Lihua Bie, Jun Gao · 2025 · Physical Chemistry Chemical Physics
- The Role of NAD+-Dependent Signal Mechanisms in Cancer Development and TreatmentTing Lu, Zheng‐Hong Qin, Junchao Wu · 2025 · Springer eBooks
- A review on the role of SIRT6 in the prognosis of colorectal cancerHeba Hekal Mahmmoud, reham shehab ELnemr, Dalia Nabil Abdelhafez · 2025 · Fayoum University Medical Journal/Fayoum University Medical Journal
- The Role of Sirtuins in Bone Repair From the Perspective of Glucose MetabolismYun Ding, Yu Gao, Jianjun Sun, Zhigang Cai · 2025 · International Journal of General Medicine
- Rare centenarian SIRT6 variants elevate SIRT6 protein levels and resist cellular senescenceJiping Yang, HyeRim Han, Xifan Wang, Yizhou Zhu, Haiqi Chen, Yousin Suh · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Ursolic acid activates SIRT6 by enhancing enzyme-substrate interactions and promoting protein structural rearrangementZohreh Tabatabaian Nimavard, Nuredin Bakhtiari, Fereshteh Taghavi, Sako Mirzaie, Farangis Ataei, Hamid Khaledi · 2025 · Biochimica et Biophysica Acta (BBA) - General Subjects
- SIRT6–GLUL axis: rewiring nitrogen metabolism in intrahepatic cholangiocarcinomaHuiping Zhou, Hui Li, Nan Wu, Diego Francesco Calvisi · 2025 · Gut
- Sirtuins as a Double-Edged Sword in Cancer: From Molecular Mechanisms to Therapeutic OpportunitiesNúria Sima, Laia Bosch‐Presegué, Alejandro Vaquero · 2014 · Springer eBooks
- Additional file 3 of Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growthZhang, Yizheng, Zhang, Chuchu, Li, Jiehan, Jiang, Meimei, Shuning Guo, Yang, Ge, Zhang, Lingling, Wang, Feng, Yi, Shiqi, Wang, Jiangang et al. · 2022 · Figshare
- Additional file 5 of Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growthZhang, Yizheng, Zhang, Chuchu, Li, Jiehan, Jiang, Meimei, Shuning Guo, Ge Yang, Zhang, Lingling, Wang, Feng, Shiqi Yi, Wang, Jiangang et al. · 2022 · Figshare
- Additional file 4 of Clinicopathological and prognostic value of SIRT6 in patients with solid tumors: a meta-analysis and TCGA data reviewWu, Xiaojing, Wang, Shuyuan, Zhao, Xuanzhu, Lai, Sizhen, Yuan, Zhen, Zhan, Yixiang, Ni, Kemin, Zhaoce Liu, Liu, Lina, Ran Xin et al. · 2022 · Figshare
- Additional file 2 of Clinicopathological and prognostic value of SIRT6 in patients with solid tumors: a meta-analysis and TCGA data reviewXiaojing Wu, Wang, Shuyuan, Zhao, Xuanzhu, Lai, Sizhen, Yuan, Zhen, Zhan, Yixiang, Ni, Kemin, Zhaoce Liu, Liu, Lina, Ran Xin et al. · 2022 · Figshare
- Additional file 7 of SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in micePamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Vellone, Valerio G., Passalacqua, Mario, Andrea Benzi, Tommaso Bonfiglio, Reverberi, Daniele, Khalifa, Amr et al. · 2021 · Figshare
- Additional file 1 of Clinicopathological and prognostic value of SIRT6 in patients with solid tumors: a meta-analysis and TCGA data reviewWu, Xiaojing, Wang, Shuyuan, Zhao, Xuanzhu, Lai, Sizhen, Yuan, Zhen, Zhan, Yixiang, Ni, Kemin, Zhaoce Liu, Liu, Lina, Ran Xin et al. · 2022 · Figshare
- Additional file 3 of Clinicopathological and prognostic value of SIRT6 in patients with solid tumors: a meta-analysis and TCGA data reviewWu, Xiaojing, Wang, Shuyuan, Zhao, Xuanzhu, Lai, Sizhen, Yuan, Zhen, Zhan, Yixiang, Ni, Kemin, Zhaoce Liu, Liu, Lina, Xin, Ran et al. · 2022 · Figshare
- Additional file 2 of Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growthZhang, Yizheng, Zhang, Chuchu, Li, Jiehan, Jiang, Meimei, Shuning Guo, Yang, Ge, Zhang, Lingling, Wang, Feng, Yi, Shiqi, Wang, Jiangang et al. · 2022 · Figshare
- Additional file 1 of Identification of CPT2 as a prognostic biomarker by integrating the metabolism-associated gene signature in colorectal cancerLiu, Jiaxin, Li, Yimin, Xiao, Qing, Li, Yuanyuan, Peng, Yuqian, Yaqi Gan, Shu, Guang, Yi, Hanxi, Yin, Gang · 2022 · Figshare
- Additional file 4 of Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growthZhang, Yizheng, Zhang, Chuchu, Li, Jiehan, Jiang, Meimei, Shuning Guo, Yang, Ge, Zhang, Lingling, Wang, Feng, Shiqi Yi, Wang, Jiangang et al. · 2022 · Figshare
- Ubiquitin-Specific Protease 10: A New Target in Tumor Immune EscapeJingjing Huang, Ning Li, Jiangang Sun, Xiaojing Li · 2026 · Cancer Control
- SIRT6: From molecular functions to a potential therapeutic target in human diseasePratistha Singh, Jyotirmayee, Sana Ansari, Manvi Bansal, Supriya Barik, Malkhey Verma · 2026 · Gene Reports
- Pyrimidine and NAD salvage pathways : unexpected allies in the maintenance of genome stabilitySandra Cunha Silveira · 2018 · theses.fr (ABES)
- Etude des modifications épigénétiques en fonction de l'agressivité du cancer sporadique du sein : l'implication de l'histone désacétylase SIRT1 dans la progression tumoraleKhaldoun T Rifai · 2018 · theses.fr (ABES)
- Centenarian SIRT6 variants elevate SIRT6 protein and enhance cellular senescence resistanceYousin Suh, Jiping Yang, Xifan Wang, HyeRim Han, Yizhou Zhu, Lei Justan Zhang, Haiqi Chen, Paul D. Robbins · 2026 · Research Square
- Sirtuins in inflammation and autoimmunityMirunalini Gobinath, Parikshit Roychowdhury, Sagarika Mukherjee, Mohd Aftab Siddiqui · 2026 · Elsevier eBooks
- Targeting Sirtuins in Thyroid Cancer: Mechanisms, Drug Development, and Emerging Roles in Tumor Immunity and FerroptosisKi Ju Cho, Ji Hyun Seo, Hayeong Kwon, Seung-Jun Lee, Young‐Sool Hah, Jung Je Park · 2026 · Cancers
- Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stressJonathan Gigas, Michael E. Meadow, Jing Guo, Catherine Lan, Eric C. Hillpot, John C. Martinez, Gregory Tombline, Philip M. Bellomio, Valeria Rivera-Almodóvar, Kevin A. Welle et al. · 2026 · GeroScience
- SIRT6 promotes a mesenchymal, invasive phenotype in melanomaLiz M. Garcia‐Peterson, Amelia M. Lemkuil, Mary Ann Ndiaye, Nihal Ahmad, Gagan Chhabra · 2026 · Journal of Dermato-Oncology
- Conserved Transcriptomic Signatures of Sirt6 Activity: A Cross-Species RNA-seq Meta-analysisA. Khanna, Roja Sharma, Samira Xhaferi, Ullas Kolthur-Seetharam, Peng Jiang, Jackson R. Taylor · 2026 · bioRxiv
- Targeting SIRT6: the design and therapeutic implications of activators and inhibitorsYuxin Shi, Xiaofan Han, Xinqi Li, Xue Li, Hao Fang, Xuben Hou · 2026 · Bioorganic & Medicinal Chemistry
- Deciphering the role of sirtuins in cancer immunoregulation through molecular cross-talk and docking-based interactionAishwarya Saha, Sriparna De, Sreya Chattopadhyay, Sanjukta Dasgupta, Ankan Mitra · 2026 · Molecular Biology Reports
- Sirtuin inhibitors alter the food-by-temperature acclimation response to acute heat shock in Mytilus californianusMelissa May, R. Frank Fabela, Lars Tomanek · 2026 · Frontiers in Ecology and Evolution
- A systematic evaluation of SIRT6 as a transcriptomic biomarker of agingEkaterina Kashuk, Anna Tarakanova, Alexandra Malygina, Nadezhda Kuzovkina, Anna Ponomareva, Debra Toiber, Ekaterina E. Khrameeva, D. Smirnov · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Activator of Sirt6 exerts antitumor activity in pituitary neuroendocrine tumorsHong Yao, Beibei Fan, Chuanbao Li, Desheng Chen, Zhuoyi Tang, Jingwei Ye, Weiting Gu, Yijun Cheng, Hao Tang, Shaojian Lin et al. · 2026 · Endocrine
- A context-dependent framework for targeting NAD metabolism in cancerLeire Arrizabalaga, Laura Santambrogio, Guido Kroemer, Lorenzo Galluzzi, Aitziber Buqué · 2026 · Cell Metabolism
- BindingDB Entry 50045761: A FRET-based assay for screening SIRT6 modulators.BindingDB · 2016 · UC San Diego
- BindingDB Entry 50007852: Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NADBindingDB · 2021 · UC San Diego
- BindingDB Entry 50046646: Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.BindingDB · 2016 · UC San Diego
- BindingDB Entry 50019967: Design, synthesis, and pharmacological evaluations of pyrrolo[1,2-a]quinoxaline-based derivatives as potent and selective sirt6 activators.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50001970: SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.BindingDB · 2020 · UC San Diego
- BindingDB Entry 50011050: Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50009378: Allosteric Modulator Discovery: From Serendipity to Structure-Based Design.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50044446: Discovery of novel and selective SIRT6 inhibitors.BindingDB · 2015 · UC San Diego
- BindingDB Entry 50018259: Emerging Therapeutic Potential of SIRT6 Modulators.BindingDB · 2024 · UC San Diego
- A metabolic–epigenetic pathway drives immune suppression in colorectal cancerShweta Kumar, Raúl Mostoslavsky · 2026 · Nature Cancer
- Lactate charging of tRNAs “brakes” the ribosomeHyo Min Cho, Raúl Mostoslavsky · 2026 · Cell Metabolism