The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment
Open accessAbstract
Summary Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner, yet little is known about their roles in lineage commitment. Here, we identified Braveheart (Bvht), a heart-associated lncRNA in mouse. Using multiple embryonic stem cell (ESC) differentiation strategies, we show that Bvht is required for progression of nascent mesoderm towards a cardiac fate. We find that Bvht is necessary for activation of a core cardiovascular gene network and functions upstream of MesP1 (mesoderm posterior 1), a master regulator of a common multipotent cardiovascular progenitor. We also show that Bvht interacts with SUZ12, a component of Polycomb Repressive Complex 2 (PRC2), during cardiomyocyte differentiation suggesting that Bvht mediates epigenetic regulation of cardiac commitment. Finally, we demonstrate a role for Bvht in maintaining cardiac fate in neonatal cardiomyocytes. Together, our work provides evidence for a long noncoding RNA with critical roles in the establishment of the cardiovascular lineage during mammalian development.
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Metadata
- Authors
- Klattenhoff, C. A., Scheuermann, J. C., Surface, L. E., Bradley, R. K., Fields, P. A., Steinhauser, M. L., Ding, H., Butty, V. L., Torrey, L., Haas, S., Abo, R., Tabebordbar, M., Lee, R. T., Burge, C. B., & Boyer, L. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 152
- Issue
- 3
- Pages
- 570-583
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2100982253
- Cited by
- 913
- References
- 82
- FWCI
- 44.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Klattenhoff, C. A., Scheuermann, J. C., Surface, L. E., Bradley, R. K., Fields, P. A., Steinhauser, M. L., Ding, H., Butty, V. L., Torrey, L., Haas, S., Abo, R., Tabebordbar, M., Lee, R. T., Burge, C. B., & Boyer, L. A. (2013). Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment. Cell. https://doi.org/10.1016/j.cell.2013.01.003
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