APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p
Open accessAbstract
The abnormal autophagy is associated with a variety of cardiovascular diseases. Long noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how lncRNAs operate in the regulation of autophagy in the heart is unclear. Here we report that a long noncoding RNA, named autophagy promoting factor (APF), can regulate autophagic cell death by targeting miR-188-3p and ATG7. The results show that miR-188-3p suppresses autophagy and myocardial infarction by targeting ATG7. Further, we find that APF lncRNA regulates miR-188-3p, and thus affects ATG7 expression, autophagic cell death and myocardial infarction. Our present study reveals a novel regulating model of autophagic programme, which comprises APF, miR-188-3p and ATG7 in the heart. Modulation of their levels may serve as potential targets and diagnostic tools for novel therapeutic strategies of myocardial infarction and heart failure. ATG7 promotes cardiomyocyte autophagy but the molecular mechanism of its regulation is unknown. Here, Wang et al.identify a long non-coding RNA dubbed autophagy promoting factor (APF) that binds and inhibits miR-188-3p, which in turn acts on ATG7, to regulate cardiac autophagy.
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lncRNA APF is implicated in myocardial infarction pathogenesis by indirectly promoting ATG7 expression.
“Finally, the long non-coding RNA autophagy-promoting factor (APF) has been implicated in the pathogenesis of myocardial infarction owing to its ability to indirectly promote the expression of ATG7 [850].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [850]
AAV-mediated deletion of Atg7 with Mir188-3p reduces size of myocardial infarction/area.
“| IRI | AAV‐mediated deletion of Atg7 with Mir188‐3p) | Reduced size of myocardial infarction/area | Wang et al (2015) |”
From Autophagy in major human diseases (2021) · cites this paper as Wang et al (2015)
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- Authors
- Wang, K., Liu, C.-Y., Zhou, L.-Y., Wang, J.-X., Wang, M., Zhao, B., Zhao, W.-K., Xu, S.-J., Fan, L.-H., Zhang, X.-J., Feng, C., Wang, C.-Q., Zhao, Y.-F., & Li, P.-F.
- Affiliations
- Qingdao University (CN)
- Chinese Academy of Sciences (CN)
- Venue
- Nature Communications
- Published
- 2015-04-10
- Volume
- 6
- Issue
- 1
- Pages
- 6779-6779
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2080503329
- Cited by
- 473
- References
- 61
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 18 · 2023: 22 · 2022: 41 · 2021: 66 · 2020: 71 · 2019: 83 · 2018: 65 · 2017: 47 · 2016: 31 · 2015: 5
- FWCI
- 38.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Natural Science Foundation of China (81230005, 81470522, 81270160)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- long non-coding RNA, miR-188-3p, ATG7, autophagic cell death, myocardial infarction, cardiomyocyte autophagy, microRNA sponging, heart failure, cardiac gene regulation
- MeSH terms
- Autophagy-Related Protein 7, Animals, Autophagy, Base Sequence, Gene Expression Regulation, Heart Failure, Male, Mice, Inbred C57BL, Microtubule-Associated Proteins, Molecular Sequence Data, Myocardial Infarction, Oligonucleotides, Signal Transduction, Apoptosis, Myocytes, Cardiac, MicroRNAs, Mice, Primary Cell Culture, RNA, Long Noncoding
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