Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

NMRPipe: A multidimensional spectral processing system based on UNIX pipes

Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., & Bax, A. (1995) · Journal of Biomolecular NMR · doi:10.1007/bf00197809 · Cited by 15,961

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

Cox, J., & Mann, M. (2008) · Nature Biotechnology · doi:10.1038/nbt.1511 · Cited by 14,855

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262

Universal sample preparation method for proteome analysis

Wiśniewski, J. R., Zougman, A., Nagaraj, N., & Mann, M. (2009) · Nature Methods · doi:10.1038/nmeth.1322 · Cited by 8,352

Global quantification of mammalian gene expression control

Schwanhäusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W., & Selbach, M. (2011) · Nature · doi:10.1038/nature10098 · Cited by 6,566 · cited 2×

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836

SWISS-MODEL: an automated protein homology-modeling server

Schwede, T. F. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg520 · Cited by 5,592

Participation of p53 protein in the cellular response to DNA damage.

Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science · doi:10.1126/science.1210597 · Cited by 3,451

The CCPN data model for NMR spectroscopy: Development of a software pipeline

Vranken, W., Boucher, W., Stevens, T. J., Fogh, R. H., Pajon, A., Llinás, M., Ulrich, E. L., Markley, J. L., Ionides, J., & Laue, E. D. (2005) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.20449 · Cited by 3,222

Spatiotemporal and global profiling of DNA–protein interactions enables discovery of low-affinity transcription factors

Guo, A., Yan, K., Hu, H., Zhai, L., Hu, T., Su, H., Chi, Y., Zha, J., Xu, Y., Zhao, D., et al. (2023) · Nature Chemistry · doi:10.1038/s41557-023-01196-z · Cited by 35

TET Proteins and 5-Methylcytosine Oxidation in the Immune SystemPreprint

Tsagaratou, A., & Rao, A. (2013) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2013.78.020248 · Cited by 36

DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38

de Dieuleveult, M., & Miotto, B. (2018) · Epigenetics Insights · doi:10.1177/2516865718811117 · Cited by 34

GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cellsPreprint

Schüle, K. M., Leichsenring, M., Andreani, T., Vastolo, V., Mallick, M., Musheev, M. U., Karaulanov, E., & Niehrs, C. (2019) · Genes & Development · doi:10.1101/gad.325696.119 · Cited by 36

Genome-Wide Mapping of 5mC and 5hmC Identified Differentially Modified Genomic Regions in Late-Onset Severe Preeclampsia: A Pilot Study

Zhu, L., Lyu, R., Kong, L., Cheng, H., Lan, F., & Li, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134119 · Cited by 36

The Contribution of Mass Spectrometry-Based Proteomics to Understanding Epigenetics

Noberini, R., Sigismondo, G., & Bonaldi, T. (2015) · Epigenomics · doi:10.2217/epi.15.108 · Cited by 36

TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis

Mahfoudhi, E., Talhaoui, I., Cabagnols, X., Della-Valle, V., Secardin, L., Rameau, P., Bernard, O., Ishchenko, A. A., Abbès, S., Vainchenker, W., et al. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.031 · Cited by 38

The Elusive Role of 5′-Hydroxymethylcytosine

Szyf, M. (2016) · Epigenomics · doi:10.2217/epi-2016-0076 · Cited by 34

Single-Cell Chromatin Accessibility Analysis Reveals the Epigenetic Basis and Signature Transcription Factors for the Molecular Subtypes of Colorectal Cancers

Liu, Z., Hu, Y., Xie, H., Chen, K., Wen, L., Fu, W., Zhou, X., & Tang, F. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-1445 · Cited by 32

Advancing Small‐Molecule‐Based Chemical Biology with Next‐Generation Sequencing Technologies

Chandran, A., Kizaki, S., Bando, T., Pandian, G. N., & Sugiyama, H. (2014) · ChemBioChem · doi:10.1002/cbic.201402556 · Cited by 38

Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication

Shibutani, T., Ito, S., Toda, M., Kanao, R., Collins, L. B., Shibata, M., Urabe, M., Koseki, H., Masuda, Y., Swenberg, J. A., et al. (2014) · Scientific Reports · doi:10.1038/srep05220 · Cited by 33

Application of a low cost array-based technique — TAB-Array — for quantifying and mapping both 5mC and 5hmC at single base resolution in human pluripotent stem cells

Nazor, K. L., Boland, M. J., Bibikova, M. V., Klotzle, B., Yu, M., Glenn-Pratola, V., Schell, J. P., Coleman, R. L., Cabral-da-Silva, M. C., Schmidt, U., et al. (2014) · Genomics · doi:10.1016/j.ygeno.2014.08.014 · Cited by 33

Epigenetic regulation of cognition: A circumscribed review of the field

Grigorenko, E. L., Kornilov, S. A., & Naumova, O. Y. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000857 · Cited by 34

Characterization of TET and IDH gene expression in chronic lymphocytic leukemia: comparison with normal B cells and prognostic significance

Damme, M. V., Crompot, E., Meuleman, N., Maerevoet, M., Mineur, P., Bron, D., Lagneaux, L., & Stamatopoulos, B. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0298-y · Cited by 33

Complete Profiling of Methyl-CpG-Binding Domains for Combinations of Cytosine Modifications at CpG Dinucleotides Reveals Differential Read-out in Normal and Rett-Associated States

Buchmuller, B. C., Kosel, B., & Summerer, D. (2020) · Scientific Reports · doi:10.1038/s41598-020-61030-1 · Cited by 32

Mammalian DNA methylome dynamics: mechanisms, functions and new frontiers

Wei, A., & Wu, H. (2022) · Development · doi:10.1242/dev.182683 · Cited by 33

Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea

Chávez, L., Huang, Y., Luong, K., Agarwal, S., Iyer, L. M., Pastor, W. A., Hench, V. K., Frazier‐Bowers, S. A., Korol, E., Liu, S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419513111 · Cited by 33

Cytosine modifications in neurodevelopment and diseases

Yao, B., & Jin, P. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1433-y · Cited by 33

A chemical probe targets DNA 5-formylcytosine sites and inhibits TDG excision, polymerases bypass, and gene expression

Xu, L., Chen, Y.-C., Nakajima, S., Chong, J. P. C., Wang, L., Lan, L., Zhang, C., & Wang, D. (2013) · Chemical Science · doi:10.1039/c3sc51849c · Cited by 33

Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT)

Lai, M., Liang, L., Chen, J., Qiu, N., Ge, S., Ji, S., Shi, T., Zhen, B., Liu, M., Ding, C., et al. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.057448 · Cited by 33

TET-TDG active DNA demethylation at CpG and non-CpG sites

DeNizio, J. E., Dow, B. J., Serrano, J. C., Ghanty, U., Drohat, A. C., & Kohli, R. M. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.166877 · Cited by 32

Base-resolution profiling of active DNA demethylation using MAB-seq and caMAB-seq

Wu, H., Wu, X., & Zhang, Y. (2016) · Nature Protocols · doi:10.1038/nprot.2016.069 · Cited by 35

Alternative roles for oxidized mCs and TETs

Cimmino, L., & Aifantis, I. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.11.003 · Cited by 35

The effect of paternal methyl-group donor intake on offspring DNA methylation and birth weight

Pauwels, S., Truijen, I., Ghosh, M., Duca, R. C., Langie, S. A. S., Bekaert, B., Freson, K., Huybrechts, I., Koppen, G., Devlieger, R., et al. (2017) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174417000046 · Cited by 34

Transformation of 5-Carboxylcytosine to Cytosine Through C–C Bond Cleavage in Human Cells Constitutes a Novel Pathway for DNA Demethylation

Yang, F., Xie, N., Tao, W.-B., Ding, J.-H., You, X., Ma, C.-J., Zhang, X., Yi, C., Zhou, X., Yuan, B., et al. (2020) · CCS Chemistry · doi:10.31635/ccschem.020.202000286 · Cited by 35

Active turnover of genomic methylcytosine in pluripotent cells

Spada, F., Schiffers, S., Kirchner, A., Zhang, Y., Arista, G., Kosmatchev, O., Korytiaková, E., Rahimoff, R., Ebert, C., & Carell, T. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0621-y · Cited by 32

TETology: Epigenetic Mastermind in Action

Seethy, A. A., Pethusamy, K., Chattopadhyay, I., Sah, R., Chopra, A., Dhar, R., & Karmakar, S. (2021) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-021-03537-5 · Cited by 31

Lymphoid-specific helicase in epigenetics, DNA repair and cancer

Chen, X., Li, Y., Rubio, K., Bi, D., Li, Y., Tang, Q., Mao, C., Liu, S., Xiao, D., Barreto, G., et al. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01543-2 · Cited by 32

Whole-genome profiling of DNA methylation and hydroxymethylation identifies distinct regulatory programs among innate lymphocytes

Peng, V., Xing, X., Bando, J. K., Tršan, T., Luccia, B. D., Collins, P. L., Li, D., Wang, W.-L., Lee, H. J., Oltz, E. M., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01164-8 · Cited by 33

Nutritional Epigenetic Regulators in the Field of Cancer

Schnekenburger, M., & Diederich, M. F. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800206-3.00018-5 · Cited by 35

Loss of 5-hydroxymethylcytosine and intratumoral heterogeneity as an epigenomic hallmark of glioblastoma

Kraus, T. F. J., Kolck, G., Greiner, A., Schierl, K., Guibourt, V., & Kretzschmar, H. A. (2015) · Tumor Biology · doi:10.1007/s13277-015-3606-9 · Cited by 32

Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice

Skarpengland, T., Holm, S., Scheffler, K., Gregersen, I., Dahl, T. B., Suganthan, R., Segers, F. M., Østlie, I., Otten, J. J. T., Luna, L., et al. (2016) · Scientific Reports · doi:10.1038/srep28337 · Cited by 32

MeCP2 regulates Tet1-catalyzed demethylation, CTCF binding, and learning-dependent alternative splicing of the BDNF gene in Turtle

Zheng, Z., Ambigapathy, G., & Keifer, J. (2017) · eLife · doi:10.7554/elife.25384 · Cited by 31

A protein architecture guided screen for modification dependent restriction endonucleases

Lutz, T., Flodman, K., Copelas, A., Czapinska, H., Mabuchi, M. Y., Fomenkov, A. I., He, X., Bochtler, M., & Xu, S.-Y. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz755 · Cited by 27

Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns

Adam, S., Bräcker, J., Klingel, V., Osteresch, B., Radde, N. E., Brockmeyer, J., Bashtrykov, P., & Jeltsch, A. (2022) · Communications Biology · doi:10.1038/s42003-022-03033-4 · Cited by 30

Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis

Joshi, K., Zhang, L., Breslin, P., Kini, A. R., & Zhang, J. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02496-x · Cited by 31

Vitamin C enhances substantially formation of 5-hydroxymethyluracil in cellular DNA

Modrzejewska, M., Gawroński, M., Skonieczna, M., Zarakowska, E., Starczak, M., Foksiński, M., Rzeszowska‐Wolny, J., Gackowski, D., & Oliński, R. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.535 · Cited by 30

Loss of 5hmC identifies a new type of aberrant DNA hypermethylation in glioma

Fernández, A. F., Bayón, G. F., Sierra, M., Urdinguio, R. G., Toraño, E. G., García, M. G., Carella, A., López, V., Santamarina‐Ojeda, P., Pérez, R. F., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy214 · Cited by 33

Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11

Tough, D. F., Lewis, H. D., Rioja, I., Lindon, M. J., & Prinjha, R. K. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12848 · Cited by 30

Dissecting the behavior and function of MBD3 in DNA methylation homeostasis by single-molecule spectroscopy and microscopy

Cui, Y., & Irudayaraj, J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv098 · Cited by 30

Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase

Liu, Y., Duong, W., Krawczyk, C., Bretschneider, N., Borbély, G., Varshney, M., Zinser, C., Schär, P., & Rüegg, J. (2016) · Epigenetics & Chromatin · doi:10.1186/s13072-016-0055-7 · Cited by 30

5-Methylcytosine and Its Derivatives

Yuan, B. (2014) · Advances in clinical chemistry · doi:10.1016/bs.acc.2014.09.003 · Cited by 30

DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells

Hainer, S. J., McCannell, K. N., Yu, J., Ee, L.-S., Zhu, L. J., Rando, O. J., & Fazzio, T. G. (2016) · eLife · doi:10.7554/elife.21964 · Cited by 32

Insights into the Biochemistry, Evolution, and Biotechnological Applications of the Ten-Eleven Translocation (TET) Enzymes

Parker, M. J., Weigele, P., & Saleh, L. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b01185 · Cited by 29

Quantifying propagation of DNA methylation and hydroxymethylation with iDEMS

Stewart-Morgan, K. R., Requena, C. E., Flury, V., Du, Q., Heckhausen, Z., Hájková, P., & Groth, A. (2023) · Nature Cell Biology · doi:10.1038/s41556-022-01048-x · Cited by 31

Crystal structure of the 5hmC specific endonuclease PvuRts1I

Kazrani, A. A., Kowalska, M., Czapinska, H., & Bochtler, M. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku186 · Cited by 30

Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity

Lu, H., Bhoopatiraju, S., Wang, H., Schmitz, N. P., Wang, X., Freeman, M. J., Forster, C. L., Verneris, M. R., Linden, M. A., & Hallstrom, T. C. (2016) · Oncotarget · doi:10.18632/oncotarget.12583 · Cited by 30

DNA Hypomethylation in Intragenic and Intergenic Enhancer Chromatin of Muscle-Specific Genes Usually Correlates with their Expression.

Ehrlich, K. C., Paterson, H. L., Lacey, M. R., & Ehrlich, M. (2016) · Europe PMC (PubMed Central) · Cited by 28

Protein and DNA Modifications: Evolutionary Imprints of Bacterial Biochemical Diversification and Geochemistry on the Provenance of Eukaryotic EpigeneticsPreprint

Aravind, L., Burroughs, A. M., Zhang, D., & Iyer, L. M. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016063 · Cited by 30

5-Hydroxymethylcytosine, the “Sixth Base”, during brain development and ageing

Kraus, T. F. J., Guibourt, V., & Kretzschmar, H. A. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1346-4 · Cited by 29

Epigenetic Modifiers in Normal and Malignant Hematopoiesis

Haladyna, J. N., Yamauchi, T., Neff, T., & Bernt, K. M. (2015) · Epigenomics · doi:10.2217/epi.14.88 · Cited by 30

RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications

Xu, L., Wang, W., Chong, J. P. C., Shin, J. H., Xu, J., & Wang, D. (2015) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2015.1087960 · Cited by 28

5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma

Barazeghi, E., Gill, A. J., Sidhu, S. B., Norlén, O., Dina, R. E., Palazzo, F. F., Hellman, P., Stalberg, P. L. H., & Westin, G. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0197-2 · Cited by 29

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage

Gilmore, J. M., Sardiu, M. E., Groppe, B. D., Thornton, J. L., Liu, X., Dayebgadoh, G., Banks, C. A. S., Slaughter, B. D., Unruh, J. R., Workman, J. L., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155492 · Cited by 29

Profiling of oxBS-450K 5-hydroxymethylcytosine in human placenta and brain reveals enrichment at imprinted loci

Mora, J. R. H., Sánchez-Delgado, M., Petazzi, P., Morán, S., Esteller, M., Iglesias‐Platas, I., & Monk, D. (2017) · Epigenetics · doi:10.1080/15592294.2017.1344803 · Cited by 29

Age-related epigenome-wide DNA methylation and hydroxymethylation in longitudinal mouse blood

Kochmanski, J. J., Marchlewicz, E. H., Cavalcante, R. G., Sartor, M. A., & Dolinoy, D. C. (2018) · Epigenetics · doi:10.1080/15592294.2018.1507198 · Cited by 30

Structural insights into methylated DNA recognition by the C-terminal zinc fingers of the DNA reader protein ZBTB38

Hudson, N. O., Whitby, F. G., & Buck‐Koehntop, B. A. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005147 · Cited by 28

ZBTB2 reads unmethylated CpG island promoters and regulates embryonic stem cell differentiation

Karemaker, I. D., & Vermeulen, M. (2018) · EMBO Reports · doi:10.15252/embr.201744993 · Cited by 28

Epigenetic Mechanisms of Learning and Memory

Stefanelli, G., Walters, B. J., Ramzan, F., Narkaj, K., Tao, C. S., & Zovkic, I. B. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-804078-2.00015-5 · Cited by 31

Genetic Characterization of Ten-Eleven-Translocation Methylcytosine Dioxygenase Alterations in Human Glioma

Kraus, T. F. J., Greiner, A., Steinmaurer, M., Dietinger, V., Guibourt, V., & Kretzschmar, H. A. (2015) · Journal of Cancer · doi:10.7150/jca.12010 · Cited by 29

5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation

Uribe‐Lewis, S., Carroll, T., Menon, S., Nicholson, A. M., Manasterski, P. J., Winton, D. J., Buczacki, S. J. A., & Murrell, A. (2020) · Scientific Reports · doi:10.1038/s41598-019-57214-z · Cited by 27

Flanking sequence preference modulates de novo DNA methylation in the mouse genome

Mallona, I., Ilie, I. M., Karemaker, I. D., Butz, S., Manzo, M., Caflisch, A., & Baubec, T. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1168 · Cited by 33

Epi‐miRNAs : Modern mediators of methylation status in human cancers

Papadimitriou, M., Panoutsopoulou, K., Pilala, K., Scorilas, A., & Avgeris, M. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1735 · Cited by 29

Mammalian DNA demethylation

Schomacher, L. (2013) · Epigenetics · doi:10.4161/epi.24977 · Cited by 28

Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging

Occean, J. R., Yang, N., Sun, Y., Dawkins, M. S., Munk, R. B., Belair, C., Dar, S. A., Anerillas, C., Wang, L., Shi, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50725-y · Cited by 30

Chromatin regulators of neural development

Tyssowski, K. M., Kishi, Y., & Gotoh, Y. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.008 · Cited by 27

Enzymatic DNA oxidation: mechanisms and biological significance

Xu, G., & Walsh, C. P. (2014) · BMB Reports · doi:10.5483/bmbrep.2014.47.11.223 · Cited by 27

The expanding scope and impact of epigenetic cytosine modifications

Liu, M. Y., DeNizio, J. E., Schutsky, E. K., & Kohli, R. M. (2016) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2016.05.029 · Cited by 28

Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease

Kweon, S.-M., Zhu, B., Chen, Y., Aravind, L., Xu, S.-Y., & Feldman, D. E. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.055 · Cited by 26

Genome-wide antagonism between 5-hydroxymethylcytosine and DNA methylation in the adult mouse brain

Guo, J. U., Szulwach, K. E., Su, Y., Li, Y., Yao, B., Xu, Z., Shin, J. H., Xie, B., Gao, Y., Ming, G., et al. (2014) · Frontiers in Biology · doi:10.1007/s11515-014-1295-1 · Cited by 28

5-Hydroxymethylcytosine in E-box motifs ACAT|GTG and ACAC|GTG increases DNA-binding of the B-HLH transcription factor TCF4

Khund-Sayeed, S., He, X., Holzberg, T. R., Wang, J., Rajagopal, D., Upadhyay, S., Durell, S. R., Mukherjee, S., Weirauch, M. T., Rose, R. B., et al. (2016) · Integrative Biology · doi:10.1039/c6ib00079g · Cited by 27

MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer

Cui, J., Duan, B., Zhao, X., Chen, Y., Sun, S., Deng, W., Zhang, Y., Du, J., Chen, Y., & Gu, L. (2016) · Tumor Biology · doi:10.1007/s13277-016-5237-1 · Cited by 28

Distinctive Klf4 mutants determine preference for DNA methylation status

Hashimoto, H., Wang, D., Steves, A. N., Jin, P., Blumenthal, R., Zhang, X., & Cheng, X. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw774 · Cited by 27

TET-Catalyzed 5-Carboxylcytosine Promotes CTCF Binding to Suboptimal Sequences Genome-Wide

Nanan, K. K., Sturgill, D. M., Prigge, M. F., Thénoz, M., Dillman, A., Mandler, M. D., & Oberdoerffer, S. (2018) · iScience · doi:10.1016/j.isci.2019.07.041 · Cited by 29

DNA Methylation in the Adaptive Response to Exercise

Bittel, A. J., & Chen, Y.-W. (2024) · Sports Medicine · doi:10.1007/s40279-024-02011-6 · Cited by 30

Epigenetic modifications in DNA could mimic oxidative DNA damage: A double-edged sword

Ito, S., & Kuraoka, I. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.04.013 · Cited by 26

A rapid mass spectrometric method for the measurement of catalytic activity of ten-eleven translocation enzymes

Sudhamalla, B., Dey, D., Breski, M., & Islam, K. (2017) · Analytical Biochemistry · doi:10.1016/j.ab.2017.06.011 · Cited by 26

Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK

Wang, N., Bao, H., Chen, L., Liu, Y., Li, Y., Wu, B., & Huang, H. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz744 · Cited by 25

Dissecting TET2 Regulatory Networks in Blood Differentiation and Cancer

Lazarenkov, A., & Sardina, J. L. (2022) · Cancers · doi:10.3390/cancers14030830 · Cited by 26

Targeted DNA demethylation in human cells by fusion of a plant 5-methylcytosine DNA glycosylase to a sequence-specific DNA binding domain

Parrilla-Doblas, J. T., Ariza, R. R., & Roldán‐Arjona, T. (2017) · Epigenetics · doi:10.1080/15592294.2017.1294306 · Cited by 26

Multifaceted Targeting of the Chromatin Mediates Gonadotropin-Releasing Hormone Effects on Gene Expression in the Gonadotrope

Melamed, P., Haj, M., Yosefzon, Y., Rudnizky, S., Wijeweera, A., Pnueli, L., & Kaplan, A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00058 · Cited by 25

Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients

Lagos, C., Carvajal, P., Castro, I., Jara, D., González, S., Aguilera, S., Barrera, M., Quest, A. F. G., Bahamondes, V., Molina, C., et al. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.06.002 · Cited by 25

Stress Marks on the Genome: Use or Lose?

Bokhari, B. T., & Sharma, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020364 · Cited by 26

Detection of DNA Modifications by Sequence-Specific Transcription Factors

Yang, J., Zhang, X., Blumenthal, R., & Cheng, X. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.09.013 · Cited by 29

Emerging epigenetic therapeutics for myeloid leukemia: modulating demethylase activity with ascorbate

Das, A. B., Smith-Díaz, C. C., & Vissers, M. C. M. (2020) · Haematologica · doi:10.3324/haematol.2020.259283 · Cited by 25

Cytosine modifications in the honey bee (Apis mellifera) worker genome

Rasmussen, E. M. K., & Amdam, G. V. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00008 · Cited by 28

5-Formylcytosine-induced DNA–peptide cross-links reduce transcription efficiency, but do not cause transcription errors in human cells

Ji, S., Park, D., Kropachev, K. Y., Kolbanovskiy, M., Fu, I., Broyde, S. B., Essawy, M. M., Geacintov, N. E., & Tretyakova, N. Y. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009834 · Cited by 25

Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency

Mulholland, C. B., Traube, F. R., Ugur, E., Parsa, E., Eckl, E.-M., Schönung, M., Modic, M., Bartoschek, M. D., Stolz, P., Ryan, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-68600-3 · Cited by 24

Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition

Lax, E., Carmo, S. D., Enuka, Y., Sapozhnikov, D. M., Welikovitch, L. A., Mahmood, N., Rabbani, S. A., Wang, L., Britt, J. P., Hancock, W. W., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02561-9 · Cited by 25

The Carboxy-Terminal Domain of ROS1 Is Essential for 5-Methylcytosine DNA Glycosylase Activity

Hong, S., Hashimoto, H., Kow, Y. W., Zhang, X., & Cheng, X. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.09.010 · Cited by 26

Genomics meets proteomics: identifying the culprits in disease

Stunnenberg, H. G., & Hubner, N. C. (2013) · Human Genetics · doi:10.1007/s00439-013-1376-2 · Cited by 26

Real-time dynamics of methyl-CpG-binding domain protein 3 and its role in DNA demethylation by fluorescence correlation spectroscopy

Cui, Y., Cho, I.-H., Chowdhury, B., & Irudayaraj, J. (2013) · Epigenetics · doi:10.4161/epi.25958 · Cited by 25

Functions of TET Proteins in Hematopoietic Transformation

Han, J., An, J., & Ko, M. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.0294 · Cited by 26

Analysis of KLF4 regulated genes in cancer cells reveals a role of DNA methylation in promoter- enhancer interactions

Oyinlade, O., Wei, S., Kammers, K., Liu, S., Wang, S., Ma, D., Huang, Z., Qian, J. X., Zhu, H., Wan, J., et al. (2018) · Epigenetics · doi:10.1080/15592294.2018.1504592 · Cited by 24

Cys2His2 Zinc Finger Methyl-CpG Binding Proteins: Getting a Handle on Methylated DNA

Hodges, A. J., Hudson, N. O., & Buck‐Koehntop, B. A. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.09.012 · Cited by 25

Precise genomic mapping of 5-hydroxymethylcytosine via covalent tether-directed sequencing

Gibas, P., Narmontė, M., Staševskij, Z., Gordevičius, J., Klimašauskas, S., & Kriukienė, E. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000684 · Cited by 24

The Role of 2-Oxoglutarate Dependent Dioxygenases in Gliomas and Glioblastomas: A Review of Epigenetic Reprogramming and Hypoxic Response

Crake, R., Burgess, E. R., Royds, J. A., Phillips, E., Vissers, M. C. M., & Dachs, G. U. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.619300 · Cited by 24

Hydroxymethylation profile of cell-free DNA is a biomarker for early colorectal cancer

Walker, N. J., Rashid, M., Yu, S., Bignell, H., Lumby, C. K., Livi, C. M., Howell, K., Morley, D. J., Morganella, S., Barrell, D. G., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-20975-1 · Cited by 24

Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expression

Liang, D., Yan, R., Long, X., Ji, D., Song, B., Wang, M., Zhang, F., Cheng, X., Sun, F., Zhu, R., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01475-y · Cited by 25

5-Hydroxymethylcytosine-Mediated DNA Demethylation in Stem Cells and Development

Sun, W., Guan, M., & Li, X. (2014) · Stem Cells and Development · doi:10.1089/scd.2013.0428 · Cited by 25

Are there specific readers of oxidized 5‐methylcytosine bases?

Song, J., & Pfeifer, G. P. (2016) · BioEssays · doi:10.1002/bies.201600126 · Cited by 36

Protein Interactions at Oxidized 5-Methylcytosine Bases

Pfeifer, G. P., Szabó, P. E., & Song, J. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.07.039 · Cited by 49

Role and regulation of TET-mediated \nDNA modifications in gene expression

Müller, U. (2014) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)

Role and regulation of TET-mediated DNA modifications in gene expression

Müller, U. (2014) · doi:10.5282/edoc.17823

A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation

Iurlaro, M., Ficz, G., Oxley, D., Raiber, E., Bachman, M., Booth, M. J., Andrews, S., Balasubramanian, S., & Reik, W. (2013) · Genome biology · doi:10.1186/gb-2013-14-10-r119 · Cited by 321