The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation
Open accessAbstract
Summary NLRP3 is a key component of the macromolecular signaling complex called the inflammasome that promotes caspase 1-dependent production of IL-1β. The adapter ASC is necessary for NLRP3-dependent inflammasome function, but it is not known if ASC is a sufficient partner, and whether inflammasome formation occurs in the cytosol or in association with mitochondria is controversial. Here we show that the mitochondria-associated adapter molecule, MAVS, is required for optimal NLRP3 inflammasome activity. MAVS mediates recruitment of NLRP3 to mitochondria, promoting production of IL-1β and the pathophysiologic activity of the NLRP3 inflammasome in vivo. Our data support a more complex model of NLRP3 inflammasome activation than previously appreciated, with at least two adapters required for maximal function. Since MAVS is a mitochondria-associated molecule previously considered to be uniquely involved in type 1 interferon production, these findings also reveal unexpected polygamous involvement of PYD/CARD domain-containing adapters in innate immune signaling events.
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Cites
A role for mitochondria in nlrp3 inflammasome activation
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Cryopyrin activates the inflammasome in response to toxins and ATP
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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
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Cited by
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
Swanson, K. V., Deng, M., & Ting, J. P.-Y. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0165-0 · Cited by 4,884
The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation
Kelley, N., Jeltema, D., Duan, Y., & He, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133328 · Cited by 3,539
Activation and regulation of the inflammasomes
Latz, E., Xiao, T. S., & Stutz, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3452 · Cited by 2,884
Mechanism and Regulation of NLRP3 Inflammasome Activation
He, Y., Hara, H., & Núñez, G. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.09.002 · Cited by 2,759
Molecular mechanisms regulating NLRP3 inflammasome activation
Jo, E.-K., Kim, J. K., Shin, D.-M., & Sasakawa, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.95 · Cited by 1,378
Metadata
- Authors
- Subramanian, N., Natarajan, K., Clatworthy, M. R., Wang, Z., & Germain, R. N.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 153
- Issue
- 2
- Pages
- 348-361
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1997572777
- Cited by
- 678
- References
- 45
- FWCI
- 19.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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