Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

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Items 201–225 of 225

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4. Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer’s disease
   Jana, Arundhati, Wang, Xinge, Leasure, Joseph W., Magana, Lissette, Wang, Li, Kim, Young-Mee, Dodiya, Hemraj, Toth, Peter T., Sisodia, Sangram S., Rehman, Jalees · 2022 · Scientific Reports
5. Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease
   Pandey, Ravi S., Graham, Leah, Uyar, Asli, Preuss, Christoph, Howell, Gareth R., Carter, Gregory W. · 2019 · Molecular Neurodegeneration
6. Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease
   Huang, Yong, Wang, Minghui, Ni, Haofei, Zhang, Jinglong, Li, Aiqun, Hu, Bin, Junqueira Alves, Chrystian, Wahane, Shalaka, Rios de Anda, Mitzy, Ho, Lap et al. · 2024 · Nature Neuroscience
7. Alzheimer’s disease: rare variants with large effect sizes
   Del-Aguila, Jorge L, Koboldt, Daniel C, Black, Kathleen, Chasse, Rachel, Norton, Joanne, Wilson, Richard K, Cruchaga, Carlos · 2015 · Current Opinion in Genetics & Development
8. Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders
   Schadt, Eric E., Buchanan, Sean, Brennand, Kristen J., Merchant, Kalpana M. · 2014 · Frontiers in Pharmacology
9. Frequent Low-Dose Δ9-Tetrahydrocannabinol in Adolescence Disrupts Microglia Homeostasis and Disables Responses to Microbial Infection and Social Stress in Young Adulthood
   Lee, Hye-Lim, Jung, Kwang-Mook, Fotio, Yannick, Squire, Erica, Palese, Francesca, Lin, Lin, Torrens, Alexa, Ahmed, Faizy, Mabou Tagne, Alex, Ramirez, Jade et al. · 2022 · Biological Psychiatry
10. Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models
    Sekiya, Michiko, Wang, Minghui, Fujisaki, Naoki, Sakakibara, Yasufumi, Quan, Xiuming, Ehrlich, Michelle E., De Jager, Philip L., Bennett, David A., Schadt, Eric E., Gandy, Sam et al. · 2018 · Genome Medicine
11. Identification of novel diagnostic panel for mild cognitive impairment and Alzheimer’s disease: findings based on urine proteomics and machine learning
    Wang, Yuye, Sun, Yu, Wang, Yu, Jia, Shuhong, Qiao, Yanan, Zhou, Zhi, Shao, Wen, Zhang, Xiangfei, Guo, Jing, Zhang, Bin et al. · 2023 · Alzheimer's Research & Therapy
12. Distinct sex-specific DNA methylation differences in Alzheimer’s disease
    C. Silva, Tiago, Zhang, Wei, Young, Juan I., Gomez, Lissette, Schmidt, Michael A., Varma, Achintya, Chen, X. Steven, Martin, Eden R., Wang, Lily · 2022 · Alzheimer's Research & Therapy
13. Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer’s disease
    Gupta, Chirag, Xu, Jielin, Jin, Ting, Khullar, Saniya, Liu, Xiaoyu, Alatkar, Sayali, Cheng, Feixiong, Wang, Daifeng · 2022 · PLOS Computational Biology
14. Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice
    Nam, Kyong Nyon, Wolfe, Cody M., Fitz, Nicholas F., Letronne, Florent, Castranio, Emilie L., Mounier, Anais, Schug, Jonathan, Lefterov, Iliya, Koldamova, Radosveta · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
15. Alzheimer’s Disease (AD) Therapeutics—2: Beyond Amyloid—Re-Defining AD and Its Causality to Discover Effective Therapeutics
    Mullane, Kevin, Williams, Michael · 2018 · Biochemical Pharmacology
16. Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer’s Disease
    Higginbotham, Lenora, Dammer, Eric, Duong, Duc, Modeste, Erica, Montine, Thomas, Lah, James, Levey, Allan, Seyfried, Nicholas · 2019 · Proteomes
17. Deep belief network-based approach for detecting Alzheimer's disease using the multi-omics data
    Mahendran, Nivedhitha, Vincent P M, Durai Raj · 2023 · Computational and Structural Biotechnology Journal
18. Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer’s disease
    Fernández Zapata, Camila, Giacomello, Ginevra, Spruth, Eike J., Middeldorp, Jinte, Gallaccio, Gerardina, Dehlinger, Adeline, Dames, Claudia, Leman, Julia K. H., van Dijk, Roland E., Meisel, Andreas et al. · 2022 · Nature Communications
19. The effect of Abi3 locus deletion on the progression of Alzheimer’s disease-related pathologies
    Karahan, Hande, Smith, Daniel C., Kim, Byungwook, McCord, Brianne, Mantor, Jordan, John, Sutha K., Al-Amin, Md Mamun, Dabin, Luke C., Kim, Jungsu · 2023 · Frontiers in Immunology
20. Identification of potential lead compounds against BACE1 through in-silico screening of phytochemicals of Medhya rasayana plants for Alzheimer's disease management
    Nadh, Anuroopa G., Revikumar, Amjesh, Sudhakaran, P.R., Nair, Achuthsankar S. · 2022 · Computers in Biology and Medicine
21. Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
    Ibanez, Kristen R., McFarland, Karen N., Phillips, Jennifer, Allen, Mariet, Lessard, Christian B., Zobel, Lillian, De La Cruz, Elsa Gonzalez, Shah, Shivani, Vo, Quan, Wang, Xue et al. · 2022 · Alzheimer's Research & Therapy
22. Peroxisomal defects in microglial cells induce a disease-associated microglial signature
    Raas, Quentin, Tawbeh, Ali, Tahri-Joutey, Mounia, Gondcaille, Catherine, Keime, Céline, Kaiser, Romain, Trompier, Doriane, Nasser, Boubker, Leoni, Valerio, Bellanger, Emma et al. · 2023 · Frontiers in Molecular Neuroscience
23. Pathway Analysis Integrating Genome-Wide and Functional Data Identifies <i>PLCG2</i> as a Candidate Gene for Age-Related Macular Degeneration
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24. Mouse and human microglial phenotypes in Alzheimer’s disease are controlled by amyloid plaque phagocytosis through Hif1α
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25. Tuberous sclerosis complex‐1 (TSC1) contributes to selective neuronal vulnerability in Alzheimer's disease
    Adriaanse, Bryan A., Brady, Sinead, Wang, Minghui, Beard, Daniel J., Spencer, Jonathan I., Pansieri, Jonathan, Sutherland, Brad A., Esiri, Margaret M., Buchan, Alastair M., Cader, Zameel et al. · 2023 · Neuropathology and Applied Neurobiology