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Circulating Endocannabinoids and N-Acylethanolamines in Individuals with Cannabis Use Disorder—Preliminary Findings

Boachie, N., Gaudette, E. V., Bazinet, R. P., Lin, L., Tyndale, R. F., Mansouri, E., Huestis, M. A., Tong, J., Foll, B. L., Kish, S. J., et al. (2023) · Brain Sciences · doi:10.3390/brainsci13101375 · Cited by 22 · see citing works

Nasal Accumulation and Metabolism of Δ9-Tetrahydrocannabinol Following Aerosol (‘Vaping’) Administration in Adolescent Rats

Torrens, A., Ruiz, C., Martinez, M. X., Tagne, A. M., Roy, P., Grimes, D., Ahmed, F., Lallai, V., Inshishian, V., Bautista, M., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106600 · Cited by 14 · see citing works

NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice

Fotio, Y., Tagne, A. M., Squire, E., Lee, H.-L., Phillips, C. M., Chang, K., Ahmed, F., Greenberg, A. S., Villalta, S. A., Scarfone, V. M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46139-5 · Cited by 18 · see citing works

Sex Differences in Response-Contingent Cannabis Vapor Administration During Adolescence Mediate Enduring Effects on Behavioral Flexibility and Prefrontal Microglia Activation in Rats

Freels, T. G., Westbrook, S. R., Zamberletti, E., Kuyat, J. R., Wright, H. R., Malena, A. N., Melville, M. W., Brown, A. M., Glodosky, N. C., Ginder, D. E., et al. (2024) · Cannabis and Cannabinoid Research · doi:10.1089/can.2023.0014 · Cited by 18 · see citing works

Emerging Roles of Endocannabinoids as Key Lipid Mediators for a Successful Pregnancy

Rava, A., & Trezza, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065220 · Cited by 15 · see citing works

Enhancing axonal myelination in seniors: A review exploring the potential impact cannabis has on myelination in the aged brain

Murray, C. J., Vecchiarelli, H. A., & Tremblay, M. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1119552 · Cited by 12 · see citing works

Δ9-Tetrahydrocannabinol Alleviates Hyperalgesia in a Humanized Mouse Model of Sickle Cell Disease

Tagne, A. M., Fotio, Y., Gupta, K., & Piomelli, D. (2024) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.124.002285 · Cited by 11 · see citing works

Adolescent exposure to low-dose Δ9-tetrahydrocannabinol depletes the ovarian reserve in female mice

Lim, J., Lee, H.-L., Nguyen, J. K., Shin, J. H., Getze, S., Quach, C., Squire, E., Jung, K., Mahler, S. V., Mackie, K., et al. (2023) · Toxicological Sciences · doi:10.1093/toxsci/kfad027 · Cited by 9 · see citing works

Frequent low-impact exposure to THC during adolescence causes persistent sexually dimorphic alterations in the response to viral infection in mice

Lee, H.-L., Squire, E., Fotio, Y., Tagne, A. M., Lee, J., Yoon, J. J., Hong, Y., Kim, L. H., Jung, K., & Piomelli, D. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.107049 · Cited by 8 · see citing works

Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats

Martinez, M. X., Vera, V. A., Ruiz, C. M., Floresco, S., & Mahler, S. V. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06676-9 · Cited by 7 · see citing works

Post-weaning social isolation alters sociability in a sex-specific manner

Myers, T., Birmingham, E. A., Rhoads, B. T., McGrath, A. G., Miles, N. A., Schuldt, C. B., & Briand, L. A. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1444596 · Cited by 7 · see citing works

Sex differences in adolescent cannabis vapor self-administration mediate enduring effects on behavioral flexibility and prefrontal microglia activation in ratsPreprint

Freels, T. G., Westbrook, S. R., Wright, H. R., Kuyat, J. R., Zamberletti, E., Malena, A. N., Melville, M. W., Brown, A. M., Glodosky, N. C., Ginder, D. E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.21.524468 · Cited by 7 · see citing works

Potential roles for microglia in drug addiction: Adolescent neurodevelopment and beyond

Martinez, M. X., & Mahler, S. V. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578600 · Cited by 5 · see citing works

Cannabis use in youth is associated with chronic inflammation

Power, E., Mongan, D., Healy, C., Susai, S., Föcking, M., Zammit, S., Cannon, M., & Cotter, D. (2024) · Psychological Medicine · doi:10.1017/s0033291724002848 · Cited by 4 · see citing works

Perturbations of CB1 receptor signalling during adolescence impair cortical myelination in female rats

Zamberletti, E., Manenti, C., Prini, P., Gabaglio, M., Grimaldi, A., Pulze, L., Grassi, R., & Rubino, T. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107758 · Cited by 4 · see citing works

Overactivation of the Endocannabinoid System in Adolescence Disrupts Adult Adipose Organ Function in Mice

Jung, K., Lin, L., & Piomelli, D. (2024) · Cells · doi:10.3390/cells13050461 · Cited by 3 · see citing works

Lipopolysaccharide-induced endotoxaemia during adolescence promotes stress vulnerability in adult mice via deregulation of nuclear factor erythroid 2-related factor 2 in the medial prefrontal cortex

Chen, Y.-C., Huang, Y. H., Song, L., Tong, X., Li, J.-F., Lin, S., Chen, X., Zhang, J., Zhang, Z.-L., & Zeng, Q. (2023) · Psychopharmacology · doi:10.1007/s00213-022-06285-4 · Cited by 3 · see citing works

Divergent outcomes of delta 9 – tetrahydrocannabinol (THC) in adolescence on mesocortical dopamine and cognitive development in male and female mice

Capolicchio, T., Hernández, G., Shi, S. S. W., Dube, E., Estrada, K., Giroux, M., Nieman, B. J., Pausová, Z., & Flores, C. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06791-1 · Cited by 2 · see citing works

Targeting dysfunctional endocannabinoid signaling in a mouse model of Gulf War illness

Squire, E., Lee, H.-L., Jeong, W., Lee, S., Ravichandiran, V., Limoli, C. L., Piomelli, D., Parihar, V. K., & Jung, K. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110142 · Cited by 3 · see citing works

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Jung, K., Tagne, A. M., Avalos, H. C., D'Agosta, D., Katz, J., Lee, H.-L., & Piomelli, D. (2025) · Journal of Visualized Experiments · doi:10.3791/68358 · Cited by 1 · see citing works

Cannabis use, oral dysbiosis, and neurological disorders

Hazzard, A. A., McCrorey, M. K., Salman, T., Johnson, D. E., Luo, Z., Fu, X., Keegan, A. P., Benitez, A. M., Fitting, S., & Jiang, W. (2024) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2024-0012 · Cited by 1 · see citing works

Chronic Δ9‐tetrahydrocannabinol exposure during adolescence is associated with persistent behavioural tolerance in adult nonhuman primates

Razavi, Y., Kohut, S. J., Bergman, J., & Kangas, B. D. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70179 · Cited by 1 · see citing works

Interrogating the Impact of Δ9-Tetrahydrocannabinol Use During Adolescence: Microglia Lead the Way

Stella, N. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.09.006

Adolescent exposure to Δ9-tetrahydrocannabinol impairs testicular function in young adult male mice

Lim, J., Quach, C., Nguyen, J. K., Rizk, A., Getze, S., Jung, K., Mahler, S. V., Piomelli, D., & Luderer, U. (2025) · Toxicological Sciences · doi:10.1093/toxsci/kfaf035

Adolescence as a Window of Vulnerability to Cannabis Use: Insights from Animal Studies

Jung, K., Lee, H.-L., & Piomelli, D. (2025) · Springer eBooks · doi:10.1007/978-3-031-87990-6_11

Interactome and expression profile of class II transactivator (CIITA) in lipopolysaccharides mediated neuroinflammation: A combined network analysis and zebrafish model study

Nagasubramanian, K. (2025) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2025.100146

The how and why for multiple forms of hippocampal LTP

Gall, C. M., Le, A. A., & LYNCH, G. S. (2026) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2026.1855059

Persistent effects of adolescent THC on behavioral and neural responses to opioid drugs in male and female rats

Martinez, M. X., Ruiz, C. M., Perrone, C. R., Inshishian, V. C., Castillo, E., & Mahler, S. V. (2026) · Addiction Neuroscience · doi:10.1016/j.addicn.2026.100282

Antinociceptive interaction of Δ9-tetrahydrocannabinol and cannabidiol in a humanized mouse model of sickle cell disease

Tagne, A. M., Ajeigbe, O. F., Avalos, H. C., Galvani, F., Masri, S. A., Mireles, C., Gupta, K., & Piomelli, D. (2026) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2026.105037

Effects of Δ 9 -tetrahydrocannabinol on affiliative social behaviour: A systematic review of rodent studies

Ahmed, M., Pereira, C. F., Best, L. M., Mahmood, R., George, T. P., Foll, B. L., Boileau, I., & Kloiber, S. (2026) · Journal of Psychopharmacology · doi:10.1177/02698811261478615

A glial perspective on the neuropsychiatric effects of cannabis in adolescence and aging

Kawai, H., Kamiya, A., & Hasegawa, Y. (2026) · International Review of Psychiatry · doi:10.1080/09540261.2026.2742145

The endocannabinoid system and the ageing brain

Zimmer, A. (2026) · Nature reviews. Neuroscience · doi:10.1038/s41583-026-01085-7

Frequent Exposure to THC During Adolescence Disrupts Microglia Homeostasis and Disables Their Critical Functions in Young Adulthood

Jung, K., Lee, H.-L., Fotio, Y., Squire, E., & Piomelli, D. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.02.135

Cortical neuroinflammation contributes to long-term cognitive dysfunctions following adolescent delta-9-tetrahydrocannabinol treatment in female rats

Zamberletti, E., Gabaglio, M., Prini, P., Rubino, T., & Parolaro, D. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.09.021 · Cited by 114 · see citing works

Microglial cannabinoid receptor type 1 mediates social memory deficits produced by adolescent THC exposure and 16p11.2 duplicationPreprint

Hasegawa, Y., Kim, J., Ursini, G., Jouroukhin, Y., Zhu, X., Miyahara, Y., Xiong, F., Madireddy, S., Obayashi, M., Lutz, B., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.24.550212 · Cited by 1 · see citing works

Frequent low-impact exposure to THC during adolescence causes persistent sexually dimorphic alterations in the response to viral infection in mice

Lee, H.-L., Squire, E., Fotio, Y., Tagne, A. M., Lee, J., Yoon, J. J., Hong, Y., Kim, L. H., Jung, K., & Piomelli, D. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.107049 · Cited by 8 · see citing works

Exposure of Adolescent Mice to Delta-9-Tetrahydrocannabinol Induces Long-Lasting Modulation of Pro- and Anti-Inflammatory Cytokines in Hypothalamus and Hippocampus Similar to that Observed for Peripheral Macrophages

Moretti, S., Franchi, S., Castelli, M., Amodeo, G., Somaini, L., Panerai, A. E., & Sacerdote, P. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9592-2 · Cited by 32 · see citing works