Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer’s disease
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Myeloid cells are suggested as an important player in Alzheimer´s disease (AD). However, its continuum of phenotypic and functional changes across different body compartments and their use as a biomarker in AD remains elusive. Here, we perform multiple state-of-the-art analyses to phenotypically and metabolically characterize immune cells between peripheral blood (n = 117), cerebrospinal fluid (CSF, n = 117), choroid plexus (CP, n = 13) and brain parenchyma (n = 13). We find that CSF cells increase expression of markers involved in inflammation, phagocytosis, and metabolism. Changes in phenotype of myeloid cells from AD patients are more pronounced in CP and brain parenchyma and upon in vitro stimulation, suggesting that AD-myeloid cells are more vulnerable to environmental changes. Our findings underscore the importance of myeloid cells in AD and the detailed characterization across body compartments may serve as a resource for future studies focusing on the assessment of these cells as biomarkers in AD.
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Postmortem AD brain tissues show extensive monocyte infiltration into the brain parenchyma, where monocytes cluster around amyloid-β plaques.
“End point analyses of postmortem AD brain tissues show extensive monocyte infiltration into the brain parenchyma of patients with AD, where they cluster around amyloid-β (Aβ) plaques (13, 14).”
From Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems (2025) · cites this paper as [14]
The Results section on the choroid plexus and brain parenchyma reports infiltrating macrophages in postmortem AD grey frontal matter, but it does not establish extensive monocyte infiltration: it found no difference in cell-cluster abundance between AD and controls. The passages do not report monocytes clustering around Aβ plaques. (LLM, conf=0.87)
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Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works
ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking
Wilkerson, M. D., & Hayes, D. N. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq170 · Cited by 5,645 · see citing works
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
Dubois, B., Feldman, H. H., Jacova, C., Hampel, H., Molinuevo, J. L., Blennow, K., DeKosky, S. T., Gauthier, S., Selkoe, D., Bateman, R., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70090-0 · Cited by 3,321 · see citing works
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
Benilova, I., Karran, E., & De Strooper, B. (2012) · Nature Neuroscience · doi:10.1038/nn.3028 · Cited by 1,962 · see citing works
FlowSOM: Using self‐organizing maps for visualization and interpretation of cytometry data
Gassen, S. V., Callebaut, B., van Helden, M. J. G., Lambrecht, B. N., Demeester, P. M. A., Dhaene, T., & Saeys, Y. (2015) · Cytometry Part A · doi:10.1002/cyto.a.22625 · Cited by 1,930 · see citing works
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Zhang, B., Gaiteri, C., Bodea, L.-G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.030 · Cited by 1,657 · see citing works
Microglia Biology: One Century of Evolving Concepts
Prinz, M., Jung, S., & Priller, J. (2019) · Cell · doi:10.1016/j.cell.2019.08.053 · Cited by 1,525 · see citing works
Self-citationNLRP3 inflammasome activation drives tau pathology
Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., et al. (2019) · Nature · doi:10.1038/s41586-019-1769-z · Cited by 1,487 · see citing works
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Prinz, M., & Priller, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3722 · Cited by 1,329 · see citing works
Self-citationAn environment-dependent transcriptional network specifies human microglia identity
Gosselin, D., Skola, D., Coufal, N. G., Holtman, I. R., Schlachetzki, J. C. M., Sajti, E., Jaeger, B. N., O’Connor, C., Fitzpatrick, C., Pasillas, M. P., et al. (2017) · Science · doi:10.1126/science.aal3222 · Cited by 1,220 · see citing works
Van Hove, H., Martens, L., Scheyltjens, I., De Vlaminck, K., Pombo Antunes, A. R., De Prijck, S., Vandamme, N., De Schepper, S., Van Isterdael, G., Scott, C. L., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0393-4 · Cited by 1,160 · see citing works
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease
Gate, D., Saligrama, N., Leventhal, O., Yang, A. C., Unger, M. S., Middeldorp, J., Chen, K., Lehallier, B., Channappa, D., De Los Santos, M. B., et al. (2020) · Nature · doi:10.1038/s41586-019-1895-7 · Cited by 992 · see citing works
Self-citationTREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
Wang, Y., Ulland, T. K., Ulrich, J. D., Song, W., Tzaferis, J. A., Hole, J. T., Yuan, P., Mahan, T. E., Shi, Y., Gilfillan, S., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151948 · Cited by 840 · see citing works
Revisiting the Mechanisms of CNS Immune Privilege
Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682 · see citing works
The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?
Abbott, N. J., Pizzo, M. E., Preston, J. E., Janigro, D., & Thorne, R. G. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1812-4 · Cited by 593 · see citing works
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
Initiative, T. A. D. N., Bradshaw, E. M., Chibnik, L. B., Keenan, B. T., Ottoboni, L., Raj, T., Tang, A., Rosenkrantz, L. L., Imboywa, S., Lee, M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3435 · Cited by 570 · see citing works
Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes
Raj, T., Rothamel, K., Mostafavi, S., Ye, C., Lee, M. N., Replogle, J. M., Feng, T., Lee, M., Asinovski, N., Frohlich, I., et al. (2014) · Science · doi:10.1126/science.1249547 · Cited by 506 · see citing works
CyTOF workflow: Differential discovery in high-throughput high-dimensional cytometry datasets
Nowicka, M., Krieg, C., Crowell, H. L., Weber, L. M., Hartmann, F. J., Guglietta, S., Becher, B., Levesque, M. P., & Robinson, M. D. (2017) · F1000Research · doi:10.12688/f1000research.11622.3 · Cited by 483 · see citing works
Immunometabolism at the interface between macrophages and pathogens
Russell, D. G., Huang, L., & VanderVen, B. C. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0124-9 · Cited by 461 · see citing works
NBB-Psy, Böttcher, C., Schlickeiser, S., Sneeboer, M. A. M., Kunkel, D., Knop, A., Paza, E., Fidzinski, P., Kraus, L., Snijders, G. J. L., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0290-2 · Cited by 436 · see citing works
Self-citationCompensation of Signal Spillover in Suspension and Imaging Mass Cytometry
Chevrier, S., Crowell, H. L., Zanotelli, V. R., Engler, S., Robinson, M. D., & Bodenmiller, B. (2018) · Cell Systems · doi:10.1016/j.cels.2018.02.010 · Cited by 407 · see citing works
Hawkes, C. A., & McLaurin, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805453106 · Cited by 397 · see citing works
TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease
Griciuc, A., Patel, S., Federico, A. N., Choi, S. H., Innes, B. J., Oram, M. K., Cereghetti, G., McGinty, D., Anselmo, A., Sadreyev, R. I., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.06.010 · Cited by 378 · see citing works
Mildner, A., Schlevogt, B., Kierdorf, K., Böttcher, C., Erny, D., Kummer, M. P., Quinn, M., Brück, W., Bechmann, I., Heneka, M. T., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6209-10.2011 · Cited by 351 · see citing works
Self-citationCerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status
Piccio, L., Deming, Y., Del-Águila, J. L., Ghezzi, L., Holtzman, D. M., Fagan, A. M., Fenoglio, C., Galimberti, D., Borroni, B., & Cruchaga, C. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1533-5 · Cited by 337 · see citing works
Piccio, L. M., Buonsanti, C., Cella, M., Tassi, I., Schmidt, R. E., Fenoglio, C., Rinker, J. R., Naismith, R. T., Panina‐Bordignon, P., Passini, N., et al. (2008) · Brain · doi:10.1093/brain/awn217 · Cited by 308 · see citing works
Mildner, A., Huang, H., Radke, J., Stenzel, W., & Priller, J. (2017) · Glia · doi:10.1002/glia.23097 · Cited by 301 · see citing works
Self-citationThe <i>MS4A</i> gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
Deming, Y., Filipello, F., Cignarella, F., Cantoni, C., Hsu, S., Mikesell, R., Li, Z., Del-Aguila, J. L., Dube, U., Farias, F. G., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau2291 · Cited by 271 · see citing works
diffcyt: Differential discovery in high-dimensional cytometry via high-resolution clustering
Weber, L. M., Nowicka, M., Soneson, C., & Robinson, M. D. (2019) · Communications Biology · doi:10.1038/s42003-019-0415-5 · Cited by 262 · see citing works
CNS-specific T cells shape brain function via the choroid plexus
Baruch, K., & Schwartz, M. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.04.002 · Cited by 195 · see citing works
Neuroinflammatory phenotype in early Alzheimer's disease
Sudduth, T. L., Schmitt, F. A., Nelson, P. T., & Wilcock, D. M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.09.012 · Cited by 194 · see citing works
β-amyloid, microglia, and the inflammasome in Alzheimer’s disease
Gold, M., & El Khoury, J. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0518-0 · Cited by 187 · see citing works
P2Y12 receptors: structure and function
Cattaneo, M. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12952 · Cited by 185 · see citing works
Dystrophic microglia in late‐onset Alzheimer's disease
Streit, W. J., Khoshbouei, H., & Bechmann, I. (2020) · Glia · doi:10.1002/glia.23782 · Cited by 152 · see citing works
Mattiola, I., Tomay, F., Pizzol, M. D., Silva-Gomes, R., Savino, B., Gulić, T., Doni, A., Lonardi, S., Boutet, M., Nerviani, A., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0417-y · Cited by 137 · see citing works
Grassivaro, F., Menon, R., Acquaviva, M., Ottoboni, L., Ruffini, F., Bergamaschi, A., Muzio, L., Farina, C., & Martino, G. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1523-19.2019 · Cited by 127 · see citing works
Farhadian, S., Mehta, S. S., Zografou, C., Robertson, K., Price, R. W., Pappalardo, J. L., Chiarella, J., Hafler, D. A., & Spudich, S. (2018) · JCI Insight · doi:10.1172/jci.insight.121718 · Cited by 118 · see citing works
Zaghi, J., Goldenson, B., Inayathullah, M., Lossinsky, A. S., Masoumi, A., Avagyan, H., Mahanian, M., Bernas, M. J., Weinand, M. E., Rosenthal, M. J., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-008-0481-0 · Cited by 115 · see citing works
Single-cell RNA-seq analysis of human CSF microglia and myeloid cells in neuroinflammation
Esaulova, E., Cantoni, C., Shchukina, I., Zaitsev, K., Bucelli, R. C., Wu, G. F., Artyomov, M. N., Cross, A. H., & Edelson, B. T. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000732 · Cited by 101 · see citing works
Ott, B. R., Jones, R. N., Daiello, L. A., de la Monte, S. M., Stopa, E. G., Johanson, C. E., Denby, C., & Grammas, P. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00245 · Cited by 91 · see citing works
The Potential Role of Chemokines in Alzheimer’s Disease Pathogenesis
Azizi, G., Hossein‐Khannazer, N., & Mirshafiey, A. (2014) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317513518651 · Cited by 89 · see citing works
Carrillo, M. C., Dean, R. A., Nicolas, F., Miller, D. S., Berman, R., Khachaturian, Z. S., Bain, L. J., Schindler, R. J., & Knopman, D. S. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.05.1762 · Cited by 61 · see citing works
Böttcher, C., van der Poel, M., Fernández-Zapata, C., Schlickeiser, S., Leman, J. K. H., Hsiao, C.-C., Mizee, M. R., Adelia, Vincenten, M. C. J., Kunkel, D., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01010-8 · Cited by 58 · see citing works
Self-citationSingle-cell peripheral immunoprofiling of Alzheimer’s and Parkinson’s diseases
Phongpreecha, T., Fernandez, R., Mrdjen, D., Culos, A., Gajera, C. R., Wawro, A. M., Stanley, N., Gaudilliere, B. L., Poston, K. L., Aghaeepour, N., et al. (2020) · Science Advances · doi:10.1126/sciadv.abd5575 · Cited by 51 · see citing works
Böttcher, C., Fernández‐Zapata, C., Schlickeiser, S., Kunkel, D., Schulz, A. R., Mei, H. E., Weidinger, C., Gieß, R. M., Asseyer, S., Siegmund, B., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-55852-x · Cited by 49 · see citing works
Self-citationOstendorf, L., Dittert, P., Biesen, R., Duchow, A. S., Stiglbauer, V., Ruprecht, K., Bellmann–Strobl, J., Seelow, D., Stenzel, W., Niesner, R. A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-89786-0 · Cited by 32 · see citing works
Self-citationKhoonrit, P., Mirdogan, A., Dehlinger, A., Mekboonsonglarp, W., Likhitwitayawuid, K., Priller, J., Böttcher, C., & Sritularak, B. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238509 · Cited by 30 · see citing works
Self-citationAngel, A., Volkman, R., Royal, T. G., & Offen, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031144 · Cited by 29 · see citing works
Purinergic P2Y12 Receptor Activation in Eosinophils and the Schistosomal Host Response
Muniz, V. S., Baptista-dos-Reis, R., Benjamim, C. F., dos Santos, H. A. M., Pyrrho, A. S., Strauch, M. A., Melo, P. A., Vicentino, A. R. R., Juliana, S.-P., Bandeira‐Melo, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139805 · Cited by 28 · see citing works
Neuroinflammation: No Rose by Any Other Name
Graeber, M. B. (2014) · Brain Pathology · doi:10.1111/bpa.12192 · Cited by 27 · see citing works
Monocytes exposed to plasma from patients with Alzheimer’s disease undergo metabolic reprogramming
Wolfe, H. E., Mela, V., Minogue, A. M., Miller, A., McGuigan, C., Williams, L., Lohan, D., LAWLOR, B. A., & Lynch, M. A. (2019) · Neuroscience Research · doi:10.1016/j.neures.2019.01.001 · Cited by 6 · see citing works
Giacomello, G., Böttcher, C., & Parr, M. K. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101715 · Cited by 4 · see citing works
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- [51]Gate D Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer´s disease Nature 2020 577 399 404 10.1038/s41586-019-1895-7 31915375 PMC7445078 · DOI · Paper page
Cited by
Sorted by citations
Muñoz-Castro, C., Mejias-Ortega, M., Sanchez-Mejias, E., Navarro, V., Trujillo-Estrada, L., Jimenez, S., Garcia-Leon, J. A., Fernandez-Valenzuela, J. J., Sanchez-Mico, M. V., Romero-Molina, C., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01530-z · Cited by 66 · see citing works
Immunomodulatory Effects of New Phenanthrene Derivatives from Dendrobium crumenatum
Kongkatitham, V., Dehlinger, A., Wang, M., Poldorn, P., Weidinger, C., Letizia, M., Chaotham, C., Otto, C., Ruprecht, K., Paul, F., et al. (2023) · Journal of Natural Products · doi:10.1021/acs.jnatprod.3c00107 · Cited by 16 · see citing works
Self-citationLorenzini, L., Zanella, L., Sannia, M., Baldassarro, V. A., Moretti, M., Cescatti, M., Quadalti, C., Baldi, S., Bartolucci, G., Gloria, L. D., et al. (2024) · Alzheimer's Research & Therapy · doi:10.1186/s13195-024-01471-2 · Cited by 15 · see citing works
A year in review: brain barriers and brain fluids research in 2022
Keep, R. F., Jones, H. C., Hamilton, M. G., & Drewes, L. R. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00429-0 · Cited by 14 · see citing works
Merchak, A. R., Bolen, M. L., Tansey, M. G., & Menees, K. B. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00476 · Cited by 12 · see citing works
Tian, C., Ao, Z., Cerneckis, J., Cai, H., Chen, L., Niu, H., Takayama, K., Kim, J., Shi, Y., Gu, M., et al. (2025) · Science Advances · doi:10.1126/sciadv.adu2708 · Cited by 9 · see citing works
“End point analyses of postmortem AD brain tissues show extensive monocyte infiltration into the brain parenchyma of patients with AD, where they cluster around amyloid-β (A β ) plaques ( 13 , 14 ).”
Giacomello, G., Otto, C., Priller, J., Ruprecht, K., Böttcher, C., & Parr, M. K. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45010051 · Cited by 8 · see citing works
Self-citationSingle-cell peripheral immunoprofiling of Lewy body and Parkinson’s disease in a multi-site cohort
Phongpreecha, T., Mathi, K., Cholerton, B., Fox, E. J., Sigal, N., Espinosa, C. A., Reincke, S. M., Chung, P., Hwang, L.-J., Gajera, C. R., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00748-2 · Cited by 8 · see citing works
Single-cell transcriptomics for immune profiling of cerebrospinal fluid in neurological diseases
Ramos-Vicente, D., Monterosso, P., de Fàbregues, O., Roch, G., Vila, M., & Bové, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1599303 · Cited by 8 · see citing works
Wang, M., Otto, C., Fernández‐Zapata, C., Dehlinger, A., Gallaccio, G., Diekmann, L., Niederschweiberer, M. A., Schindler, P., Körtvelyessy, P., Kunkel, D., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112383 · Cited by 7 · see citing works
Self-citationSubasinghe, K., Berry, R., Rowe, M., Winters, A., Yang, S., & Phillips, N. (2025) · BIO-PROTOCOL · doi:10.21769/bioprotoc.5327 · Cited by 5 · see citing works
Wang, M., Dehlinger, A., Fernández‐Zapata, C., Golan, M., Gallaccio, G., Sander, L. E., Schlickeiser, S., Kunkel, D., Schmitz‐Hübsch, T., Sawitzki, B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43553-z · Cited by 5 · see citing works
Self-citationTian, C., Ao, Z., Cerneckis, J., Cai, H., Chen, L., Niu, H., Takayama, K., Kim, J., Shi, Y., Gu, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.16.638539 · Cited by 3 · see citing works
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Liu, X., Liu, Y., Yao, L., Chen, Y., & Ye, Y. (2025) · Polymer · doi:10.1016/j.polymer.2025.129040 · Cited by 2 · see citing works
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Wilcox, D. R., Rudmann, E. A., Ye, E. M., Noori, A., Magdamo, C., Jain, A., Alabsi, H. S., Foy, B. H., Triant, V. A., Robbins, G. K., et al. (2023) · AIDS · doi:10.1097/qad.0000000000003595 · Cited by 2 · see citing works
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Fernández‐Zapata, C., Otto, C., Gallaccio, G., Chen, Q., Wang, M., Uluvar, B., Teves, M., Samol, C., Buthut, M., Boesl, F., et al. (2025) · medRxiv · doi:10.1101/2025.01.02.24319302 · Cited by 2 · see citing works
Self-citationPiccolino, I., Iannuzzi, F., Lionetti, L., Mazzonello, B., Barreca, V., Banaj, N., Arezzini, V., Piras, F., & Bossù, P. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1664164 · Cited by 1 · see citing works
Gallaccio, G., Wang, M., Schlickeiser, S., Kunkel, D., Böttcher, C., & Fernández‐Zapata, C. (2024) · STAR Protocols · doi:10.1016/j.xpro.2024.103038 · Cited by 1 · see citing works
Self-citationCharacterization of human immune cell subpopulations in cerebrospinal fluid using mass cytometry. v2Preprint
Gallaccio, G., Wang, M., Schlickeiser, S., Kunkel, D., Böttcher, C., & Fernández‐Zapata, C. (2024) · doi:10.17504/protocols.io.36wgqjp4ovk5/v2
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Merchak, A. R., Menees, K. B., Bolen, M. L., & Tansey, M. G. (2024) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.14
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Consentino, M., Valdebenito, S., & Eugenín, E. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_14
Lorenzini, L., Zanella, L., Sannia, M., Baldassarro, V. A., Moretti, M., Cescatti, M., Quadalti, C., Baldi, S., Bartolucci, G., Gloria, L. D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26723867
Muñoz‐Castro, C., Mejias‐Ortega, M., Sánchez‐Mejías, E., Navarro, V., Trujillo‐Estrada, L., Jiménez, S., León, J. A. G., Fernandez-Valenzuela, J. J., Sanchez-Mico, M. V., Romero‐Molina, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26571967
Phongpreecha, T., Mathi, K., Cholerton, B., Fox, E. J., Sigal, N., Espinosa, C. A., Reincke, S. M., Chung, P., Hwang, L.-J., Gajera, C. R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26461788
Xiang, X., Li, T., Feng, Z., Yang, J., Gong, Z., Wang, L., Wang, L., & Zhang, W. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71201
- Authors
- Fernández Zapata, C., Giacomello, G., Spruth, E. J., Middeldorp, J., Gallaccio, G., Dehlinger, A., Dames, C., Leman, J. K. H., van Dijk, R. E., Meisel, A., Schlickeiser, S., Kunkel, D., Hol, E. M., Paul, F., Parr, M. K., Priller, J., & Böttcher, C.
- Affiliations
- Freie Universität Berlin (DE)
- German Center for Neurodegenerative Diseases (DE)
- Utrecht University (NL)
- Max Delbrück Center (DE)
- Charité – Universitätsmedizin Berlin (DE)
- Humboldt-Universität zu Berlin (DE)
- Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
- Corresponding author
- Priller, Josef
- Böttcher, Chotima
- ORCID
- Venue
- Nature Communications
- Published
- 2022-11-23
- Volume
- 13
- Issue
- 1
- Pages
- 7210-7210
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC9684147
- OpenAlex
- W4309908757
- Cited by
- 27
- References
- 56
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 11 · 2023: 6 · 2022: 1
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- edoc Publication server (Humboldt University of Berlin) (submittedVersion, cc-by)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- DZNE Pub (submittedVersion, cc-by)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
- Refubium (Universitätsbibliothek der Freien Universität Berlin) (submittedVersion, cc-by)
- Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver (cc-by)
- edoc Publication server (Humboldt University of Berlin) (cc-by)
- Funders
- Deutsche Forschungsgemeinschaft (CRC/TRR 167, 259373024, TRR 167)
- Fondation Leducq (19CVD01)
- ZonMw (733050107)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, myeloid cells, cerebrospinal fluid, choroid plexus, brain parenchyma, peripheral blood, immune cell phenotypes, inflammation, phagocytosis, cellular metabolism, biomarkers, compartmentalization
- MeSH terms
- Alzheimer Disease, Choroid Plexus, Humans, Phenotype, Biomarkers, Myeloid Cells, Myeloid Progenitor Cells
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