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Cited by 414

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

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Leprivier, Gabriel, Remke, Marc, Rotblat, Barak, Dubuc, Adrian, Mateo, Abigail-Rachele F., Kool, Marcel, Agnihotri, Sameer, El-Naggar, Amal, Yu, Bin, Prakash Somasekharan, Syam, Faubert, Brandon, Bridon, Gaëlle, Tognon, Cristina E., Mathers, Joan, Thomas, Ryan, Li, Amy, Barokas, Adi, Kwok, Brian, Bowden, Mary, Smith, Stephanie, Wu, Xiaochong, Korshunov, Andrey, Hielscher, Thomas, Northcott, Paul A., Galpin, Jason D., Ahern, Christopher A., Wang, Ye, McCabe, Martin G., Collins, V. Peter, Jones, Russell G., Pollak, Michael, Delattre, Olivier, Gleave, Martin E., Jan, Eric, Pfister, Stefan M., Proud, Christopher G., Derry, W. Brent, Taylor, Michael D., Sorensen, Poul H.·2013·Cell
DOI 10.1016/j.cell.2013.04.055
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Abstract

SUMMARY Metabolic adaptation is essential for cell survival during nutrient deprivation. We report that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking translation elongation. Tumor cells exploit this pathway to adapt to nutrient deprivation by reactivating the AMPK-eEF2K axis. Adaptation of transformed cells to nutrient withdrawal is severely compromised in cells lacking eEF2K. Moreover, eEF2K knockdown restored sensitivity to acute nutrient deprivation in highly resistant human tumor cell lines. In vivo, overexpression of eEF2K rendered murine tumors remarkably resistant to caloric restriction. Expression of eEF2K strongly correlated with overall survival in human medulloblastoma and glioblastoma multiforme. Finally, C. elegans strains deficient in efk-1, the eEF2K ortholog, were severely compromised in their response to nutrient depletion. Our data highlight a conserved role for eEF2K in protecting cells from nutrient deprivation and in conferring tumor cell adaptation to metabolic stress.

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Authors
Leprivier, G., Remke, M., Rotblat, B., Dubuc, A., Mateo, A.-R. F., Kool, M., Agnihotri, S., El-Naggar, A., Yu, B., Prakash Somasekharan, S., Faubert, B., Bridon, G., Tognon, C. E., Mathers, J., Thomas, R., Li, A., Barokas, A., Kwok, B., Bowden, M., Smith, S., Wu, X., Korshunov, A., Hielscher, T., Northcott, P. A., Galpin, J. D., Ahern, C. A., Wang, Y., McCabe, M. G., Collins, V. P., Jones, R. G., Pollak, M., Delattre, O., Gleave, M. E., Jan, E., Pfister, S. M., Proud, C. G., Derry, W. B., Taylor, M. D., & Sorensen, P. H.
Venue
Cell
Publisher
Elsevier BV
Published
2013-05
Volume
153
Issue
5
Pages
1064-1079
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2013.04.055
OpenAlex
W2106404376
Cited by
414
References
52
FWCI
16.68
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation. https://app.cochat.ai/papers/10.1016/j.cell.2013.04.055
The paper
Leprivier, G., Remke, M., Rotblat, B., Dubuc, A., Mateo, A.-R. F., Kool, M., Agnihotri, S., El-Naggar, A., Yu, B., Prakash Somasekharan, S., Faubert, B., Bridon, G., Tognon, C. E., Mathers, J., Thomas, R., Li, A., Barokas, A., Kwok, B., Bowden, M., . . . Sorensen, P. H. (2013). The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation. Cell. https://doi.org/10.1016/j.cell.2013.04.055

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.