The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling
Open accessAbstract
SUMMARY Tumor cells metastasize to distant organs through genetic and epigenetic alterations, including changes in microRNA (miR) expression. Here we find miR-22 triggers epithelial-mesenchymal transition (EMT), enhances invasiveness and promotes metastasis in mouse xenografts. In a conditional mammary gland-specific transgenic (TG) mouse model, we show that miR-22 enhances mammary gland side-branching, expands the stem cell compartment, and promotes tumor development. Critically, miR-22 promotes aggressive metastatic disease in MMTV-miR-22 TG mice, as well as compound MMTV-neu or -PyVT-miR-22 TG mice. We demonstrate that miR-22 exerts its metastatic potential by silencing anti-metastatic miR-200 through direct targeting of the TET (Ten eleven translocation) family of methylcytocine dioxygenases, thereby inhibiting demethylation of the mir-200 promoter. Finally, we show that miR-22 overexpression correlates with poor clinical outcomes and silencing of the TET-miR-200 axis in patients. Taken together, our findings implicate miR-22 as a crucial epigenetic modifier and promoter of EMT and breast cancer stemness towards metastasis.
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Cites
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Cited by
MicroRNAs in cancer: biomarkers, functions and therapy
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TET-mediated active DNA demethylation: mechanism, function and beyond
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Role of TET enzymes in DNA methylation, development, and cancer
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“Distributions of 5fC and 5caC were determined by antibody (5fC/5caC DIP) (Shen et al., 2013) or chemical tagging (fC-Seal) (Song et al., 2013a) methods.”
InfluentialMetabolic requirements for the maintenance of self-renewing stem cells
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Metadata
- Authors
- Song, S. J., Poliseno, L., Song, M. S., Ala, U., Webster, K., Ng, C., Beringer, G., Brikbak, N. J., Yuan, X., Cantley, L. C., Richardson, A. L., & Pandolfi, P. P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 154
- Issue
- 2
- Pages
- 311-324
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1977846137
- Cited by
- 491
- References
- 10
- FWCI
- 19.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Song, S. J., Poliseno, L., Song, M. S., Ala, U., Webster, K., Ng, C., Beringer, G., Brikbak, N. J., Yuan, X., Cantley, L. C., Richardson, A. L., & Pandolfi, P. P. (2013). MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling. Cell. https://doi.org/10.1016/j.cell.2013.06.026
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
