MicroRNAs in cancer: biomarkers, functions and therapy
Open accessAbstract
The emergence of microRNAs has been one of the defining developments in cancer biology over the past decade, and the explosion of knowledge in this area has brought forward new diagnostic and therapeutic opportunities. The importance of microRNAs in cancer has been underlined by the identification of alterations in microRNA target binding sites and the microRNA processing machinery in tumor cells. Clinical trials utilizing microRNA profiling for patient prognosis and clinical response are now underway, and the first microRNA mimic entered the clinic for cancer therapy in 2013. In this article we review the potential applications of microRNAs for the clinical assessment of patient outcome in cancer, as well as in cancer monitoring and therapy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
1 retracted
HMGA2 functions as a competing endogenous RNA to promote lung cancer progression
Kumar, M. S., Armenteros-Monterroso, E., East, P., Chakravorty, P., Matthews, N., Winslow, M. M., & Downward, J. (2013) · Nature · doi:10.1038/nature12785 · Cited by 253 · see citing works
RetractedHallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,497 · see citing works
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990 · see citing works
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969 · see citing works
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672 · see citing works
miRBase: tools for microRNA genomics
Griffiths‐Jones, S., Saini, H. K., van Dongen, S., & Enright, A. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm952 · Cited by 4,349 · see citing works
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 4,269 · see citing works
Treatment of HCV Infection by Targeting MicroRNA
Janssen, H. L. A., Reesink, H. W., Lawitz, E., Zeuzem, S., Rodriguez‐Torres, M., Patel, K., van der Meer, A. J., Patick, A. K., Chen, A. P., Zhou, Y., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1209026 · Cited by 2,206 · see citing works
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells
Ebert, M. S., Neilson, J. R., & Sharp, P. A. (2007) · Nature Methods · doi:10.1038/nmeth1079 · Cited by 1,845 · see citing works
Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps
Chi, S. W., Zang, J. B., Mele, A., & Darnell, R. B. (2009) · Nature · doi:10.1038/nature08170 · Cited by 1,791 · see citing works
Roles for MicroRNAs in Conferring Robustness to Biological Processes
Ebert, M. S., & Sharp, P. A. (2012) · Cell · doi:10.1016/j.cell.2012.04.005 · Cited by 1,564 · see citing works
Clinical relevance of circulating cell-free microRNAs in cancer
Schwarzenbach, H., Nishida, N., Călin, G. A., & Pantel, K. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.5 · Cited by 1,091 · see citing works
Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs
Tay, Y., Kats, L. M., Salmena, L., Weiss, D., Tan, S. M., Ala, U., Karreth, F. A., Poliseno, L., Provero, P., Cunto, F. D., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.029 · Cited by 1,011 · see citing works
MicroRNAs accurately identify cancer tissue origin
Rosenfeld, N., Aharonov, R., Meiri, E., Rosenwald, S., Spector, Y., Zepeniuk, M., Benjamin, H., Shabes, N., Tabak, S., Levy, A., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1392 · Cited by 971 · see citing works
MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy
Kasinski, A. L., & Slack, F. J. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3166 · Cited by 934 · see citing works
Circular RNA and miR-7 in Cancer
Hansen, T. B., Kjems, J. K., & Damgaard, C. K. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1568 · Cited by 921 · see citing works
Blood Cell Origin of Circulating MicroRNAs: A Cautionary Note for Cancer Biomarker Studies
Pritchard, C. C., Kroh, E., Wood, B., Arroyo, J. D., Dougherty, K. J., Miyaji, M. M., Tait, J. F., & Tewari, M. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0370 · Cited by 879 · see citing works
miR-34 – a microRNA replacement therapy is headed to the clinic
Bader, A. (2012) · Front. Gene. · doi:10.3389/fgene.2012.00120 · Cited by 728 · see citing works
TarBase: A comprehensive database of experimentally supported animal microRNA targets
Sethupathy, P., CORDA, B., & Hatzigeorgiou, A. G. (2005) · RNA · doi:10.1261/rna.2239606 · Cited by 719 · see citing works
Sumazin, P., Yang, X., Chiu, H., Chung, W., Iyer, A. P., Llobet‐Navàs, D., Rajbhandari, P., Bansal, M., Guarnieri, P., Silva, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.041 · Cited by 692 · see citing works
Kong, W. W., Yang, H., He, L., Zhao, J., Coppola, D., Dalton, W. S., & Cheng, J. Q. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00941-08 · Cited by 689 · see citing works
Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34
Wiggins, J. F., Ruffino, L., Kelnar, K., Omotola, M., Patrawala, L., Brown, D., & Bader, A. G. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0655 · Cited by 679 · see citing works
Chin, L. J., Ratner, E., Leng, S., Zhai, R., Nallur, S. V., Babar, I., Müller, R., Straka, E., Su, L., Burki, E. A., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2129 · Cited by 634 · see citing works
MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
Garzon, R., Volinia, S., Liu, C., Fernandez-Cymering, C., Palumbo, T., Pichiorri, F., Fabbri, M., Coombes, K. R., Alder, H., Nakamura, T., et al. (2008) · Blood · doi:10.1182/blood-2007-07-098749 · Cited by 631 · see citing works
Silencing of microRNA families by seed-targeting tiny LNAs
Obad, S., dos Santos, C. O., Petri, A., Heidenblad, M., Broom, O. J., Ruse, C. I., Fu, C., Lindow, M., Stenvang, J., Straarup, E. M., et al. (2011) · Nature Genetics · doi:10.1038/ng.786 · Cited by 627 · see citing works
A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells
Png, K. J., Halberg, N., Yoshida, M., & Tavazoie, S. F. (2011) · Nature · doi:10.1038/nature10661 · Cited by 531 · see citing works
Song, S. J., Poliseno, L., Song, M. S., Ala, U., Webster, K. A., Ng, C., Beringer, G., Brikbak, N. J., Yuan, X., Cantley, L. C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.026 · Cited by 491 · see citing works
First microRNA mimic enters clinic
Bouchie, A. J. (2013) · Nature Biotechnology · doi:10.1038/nbt0713-577 · Cited by 471 · see citing works
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition
Kim, N. H., Kim, H. S., Li, X.-Y., Lee, I., Choi, H.-S., Kang, S. E., Cha, S. Y., Ryu, J. K., Yoon, D., Fearon, E. R., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201103097 · Cited by 432 · see citing works
Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing
Auyeung, V. C., Ulitsky, I., McGeary, S. E., & Bartel, D. P. (2013) · Cell · doi:10.1016/j.cell.2013.01.031 · Cited by 427 · see citing works
The shaping and functional consequences of the microRNA landscape in breast cancer
Dvinge, H., Git, A., Gräf, S., Salmon‐Divon, M., Curtis, C. N., Sottoriva, A., Zhao, Y., Hirst, M., Armisen, J., Miska, E. A., et al. (2013) · Nature · doi:10.1038/nature12108 · Cited by 393 · see citing works
Miravirsen (SPC3649) can inhibit the biogenesis of miR-122
Gebert, L. F. R., Rebhan, M. A. E., Crivelli, S. E. M., Denzler, R., Stoffel, M., & Hall, J. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt852 · Cited by 367 · see citing works
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2
Shen, J., Xia, W., Khotskaya, Y. B., Huo, L., Nakanishi, K., Lim, S., Du, Y., Wang, Y., Chang, W., Chen, C., et al. (2013) · Nature · doi:10.1038/nature12080 · Cited by 358 · see citing works
ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing
Ota, H., Sakurai, M., Gupta, R., Valente, L., Wulff, B., Ariyoshi, K., Iizasa, H., Davuluri, R. V., & Nishikura, K. (2013) · Cell · doi:10.1016/j.cell.2013.03.024 · Cited by 357 · see citing works
A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells
Melo, S. A., Moutinho, C., Ropero, S., Calin, G. A., Rossi, S., Spizzo, R., Fernández, A. F., Dávalos, V., Villanueva, A., Montoya, G., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.09.007 · Cited by 347 · see citing works
A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool
Manterola, L., Guruceaga, E., Pérez‐Larraya, J. G., González-Huarriz, M., Jáuregui, P., Tejada, S., Díez-Valle, R., Segura, V., Samprón, N., Barrena, C., et al. (2014) · Neuro-Oncology · doi:10.1093/neuonc/not218 · Cited by 347 · see citing works
SNPs in human miRNA genes affect biogenesis and function
Sun, G., Yan, J., Noltner, K., Feng, J., Li, H., Sarkis, D. A., Sommer, S. S., & Rossi, J. J. (2009) · RNA · doi:10.1261/rna.1560209 · Cited by 333 · see citing works
MicroRNA-21: A novel therapeutic target in human cancer
Pan, X., Wang, Z.-X., & Wang, R. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.10.12.14252 · Cited by 322 · see citing works
MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells
Hwang, W., Jiang, J., Yang, S.-H., Huang, T. S., Lan, H., Teng, H., Yang, C.-Y., Tsai, Y., Lin, C.-H., Wang, H., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2910 · Cited by 303 · see citing works
Control of metastatic progression by microRNA regulatory networks
Pencheva, N., & Tavazoie, S. F. (2013) · Nature Cell Biology · doi:10.1038/ncb2769 · Cited by 295 · see citing works
The Loop Position of shRNAs and Pre-miRNAs Is Critical for the Accuracy of Dicer Processing In Vivo
Gu, S., Jin, L., Zhang, Y., Huang, Y., Zhang, F., Valdmanis, P. N., & Kay, M. A. (2012) · Cell · doi:10.1016/j.cell.2012.09.042 · Cited by 279 · see citing works
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)
Mavrakis, K. J., der Meulen, J. V., Wolfe, A. L., Liu, X., Mets, E., Taghon, T., Khan, A. A., Setty, M. N., Rondou, P., Vandenberghe, P., et al. (2011) · Nature Genetics · doi:10.1038/ng.858 · Cited by 262 · see citing works
Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain
Boudreau, R. L., Jiang, P., Gilmore, B. L., Spengler, R. M., Tirabassi, R., Nelson, J. A., Ross, C. A., Xing, Y., & Davidson, B. L. (2014) · Neuron · doi:10.1016/j.neuron.2013.10.062 · Cited by 217 · see citing works
MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer
Andorfer, C. A., Necela, B. M., Thompson, E. A., & Perez, E. A. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.01.006 · Cited by 214 · see citing works
Clinical Outcome Prediction by MicroRNAs in Human Cancer: A Systematic Review
Nair, V. S., Maeda, L. S., & Ioannidis, J. P. A. (2012) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djs027 · Cited by 213 · see citing works
Choudhury, Y., Tay, F. C., Lam, D. H., Sandanaraj, E., Tang, C., Ang, B.-T., & Wang, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62925 · Cited by 209 · see citing works
microRNA-451: A conditional switch controlling glioma cell proliferation and migration
Godlewski, J. A., Bronisz, A., Nowicki, M. O., Chiocca, E. A., & Lawler, S. E. (2010) · Cell Cycle · doi:10.4161/cc.9.14.12248 · Cited by 203 · see citing works
Self-citationA Developmental Taxonomy of Glioblastoma Defined and Maintained by MicroRNAs
Kim, T., Huang, W., Park, R. W., Park, P. J., & Johnson, M. D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4117 · Cited by 191 · see citing works
MicroRNA-138 suppresses epithelial–mesenchymal transition in squamous cell carcinoma cell lines
Liu, X., Wang, C., Chen, Z., Jin, Y., Wang, Y., Kolokythas, A., Dai, Y., & Zhou, X. C. (2011) · Biochemical Journal · doi:10.1042/bj20111006 · Cited by 181 · see citing works
Liu, C., Kelnar, K., Vlassov, A. V., Brown, D., Wang, J., & Tang, D. G. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3864 · Cited by 179 · see citing works
MicroRNAs and the cancer phenotype: profiling, signatures and clinical implications
Stahlhut, C. E., & Slack, F. J. (2013) · Genome Medicine · doi:10.1186/gm516 · Cited by 174 · see citing works
Wynendaele, J., Böhnke, A., Leucci, E., Nielsen, S. J., Lambertz, I., Hammer, S., Sbrzesny, N., Kubitza, D., Wolf, A. A., Gradhand, E., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0527 · Cited by 171 · see citing works
The validity of circulating microRNAs in oncology: Five years of challenges and contradictions
Jarry, J., Schadendorf, D., Greenwood, C. M. T., Spatz, A., & van Kempen, L. C. L. T. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.02.009 · Cited by 163 · see citing works
Human RNA Methyltransferase BCDIN3D Regulates MicroRNA Processing
Xhemalçe, B., Robson, S. C., & Kouzarides, T. (2012) · Cell · doi:10.1016/j.cell.2012.08.041 · Cited by 153 · see citing works
Method for microRNA isolation from clinical serum samples
Li, Y., & Kowdley, K. V. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2012.09.007 · Cited by 133 · see citing works
Liu, M. X., Siu, M. K. Y., Liu, S. S., Yam, J. W. P., Ngan, H., & Chan, D. W. (2013) · Oncotarget · doi:10.18632/oncotarget.1458 · Cited by 132 · see citing works
Xiao, F.-M., Bai, Y., Chen, Z., Li, Y., Luo, L., Huang, J., Yang, J., Liao, H., & Guo, L. (2014) · European Journal of Cancer · doi:10.1016/j.ejca.2014.01.024 · Cited by 127 · see citing works
Wang, Y., Gu, J. H., Roth, J. A., Hildebrandt, M. A. T., Lippman, S. M., Ye, Y., Minna, J. D., & Wu, X. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3273 · Cited by 82 · see citing works
Wu, Y., Xiao, Y., Ding, X., Zhuo, Y., Ren, P., Zhou, C., & Zhou, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029043 · Cited by 79 · see citing works
B-cell malignancies in microRNA Eμ-miR-17∼92 transgenic mice
Sandhu, S. K., Fassan, M., Volinia, S., Lovat, F., Balatti, V., Pekarsky, Y., & Croce, C. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315365110 · Cited by 75 · see citing works
Quantification of Therapeutic miRNA Mimics in Whole Blood from Nonhuman Primates
Kelnar, K., Peltier, H. J., Leatherbury, N., Stoudemire, J., & Bader, A. G. (2014) · Analytical Chemistry · doi:10.1021/ac403044t · Cited by 70 · see citing works
A core microRNA signature associated with inducers of the epithelial‐to‐mesenchymal transition
Díaz‐Martín, J., Díaz‐López, A., Moreno‐Bueno, G., Castilla, M. Á., Rosa-Rosa, J. M., Cano, A., & Palacios, J. (2013) · The Journal of Pathology · doi:10.1002/path.4289 · Cited by 69 · see citing works
DNA-Damage-Induced Nuclear Export of Precursor MicroRNAs Is Regulated by the ATM-AKT Pathway
Wan, G., Zhang, X., Langley, R. R., Liu, Y., Hu, X., Han, C., Peng, G., Ellis, L. M., Jones, S. N., & Lu, X. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.038 · Cited by 69 · see citing works
Farazi, T., ten Hoeve, J. T., Brown, M. A., Mihailović, A., Horlings, H., van de Vijver, M., Tuschl, T., & Wessels, L. (2014) · Genome Biology · doi:10.1186/gb-2014-15-1-r9 · Cited by 68 · see citing works
MicroRNA control of epithelial‐mesenchymal transition in cancer stem cells
Hao, J., Zhang, Y., Deng, M., Ye, R., Zhao, S., Wang, Y., Li, J., & Zhao, Z. (2014) · International Journal of Cancer · doi:10.1002/ijc.28761 · Cited by 68 · see citing works
Farazi, T. A., Brown, M., Morozov, P. S., ten Hoeve, J. J., Ben‐Dov, I. Z., Hovestadt, V., Hafner, M., Renwick, N. M., Mihailović, A., Wessels, L. F. A., et al. (2012) · Methods · doi:10.1016/j.ymeth.2012.07.020 · Cited by 61 · see citing works
p53 Is Positively Regulated by miR-542-3p
Wang, Y., Huang, J., Castellà, M., Huntsman, D. D., & Taniguchi, T. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1706 · Cited by 60 · see citing works
Pardini, B., Rosa, F., Barone, E., Gaetano, C. D., Slyšková, J., Novotný, J. P., Levý, M., Garritano, S., Vodičková, Ľ., Büchler, T., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0314 · Cited by 58 · see citing works
The LCS6 polymorphism in the binding site of let-7 microRNA to the KRAS 3′-untranslated region
Sebio, A., Paré, L., Páez, D., Salazar, J., González, A., Sala, N., del Río, E., Martín-Richard, M., Tobeña, M., Barnadas, A., et al. (2013) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e32835d9b0b · Cited by 56 · see citing works
miRNA-451: A putative predictor marker of Imatinib therapy response in chronic myeloid leukemia
Scholl, V., Hassan, R., & Zalcberg, I. R. (2011) · Leukemia Research · doi:10.1016/j.leukres.2011.08.023 · Cited by 49 · see citing works
Repression of Dicer is associated with invasive phenotype and chemoresistance in ovarian cancer
Kuang, Y., Cai, J., Li, D., HAN, Q., Cao, J., & Wang, Z. (2013) · Oncology Letters · doi:10.3892/ol.2013.1158 · Cited by 46 · see citing works
A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions
Lerner, R. G., & Petritsch, C. K. (2014) · Nature Cell Biology · doi:10.1038/ncb2924 · Cited by 43 · see citing works
Integrative Analysis of Somatic Mutations Altering MicroRNA Targeting in Cancer Genomes
Ziebarth, J. D., Bhattacharya, A., & Cui, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047137 · Cited by 42 · see citing works
A miR-SNP of the XPO5 gene is associated with advanced non-small-cell lung cancer
Guo, Z., Ding, Li, Wang, & Li (2013) · OncoTargets and Therapy · doi:10.2147/ott.s48284 · Cited by 32 · see citing works
Hu, C.-W., Tseng, C.-W., Chien, C.-W., Huang, H., Ku, W., Lee, S., Chen, Y., & Juan, H. (2013) · Journal of Proteome Research · doi:10.1021/pr400302w · Cited by 24 · see citing works
WHO classification of myeloid neoplasms and leukemia
Wandt, H., Haferlach, T., Thiede, C., & Ehninger, G. (2010) · Blood · doi:10.1182/blood-2009-10-249664 · Cited by 20 · see citing works
The Many Functions of MicroRNAs in Glioblastoma
Chiocca, E. A., & Lawler, S. E. (2010) · World Neurosurgery · doi:10.1016/j.wneu.2010.06.047 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287 · see citing works
LncRNA-mediated regulation of cell signaling in cancer
Peng, W.-X., Koirala, P., & Mo, Y.-Y. (2017) · Oncogene · doi:10.1038/onc.2017.184 · Cited by 1,649 · see citing works
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis
Condrat, C. E., Thompson, D. C., Barbu, M. G., Bugnar, O. L., Boboc, A. E., Crețoiu, D., Suciu, N., Creţoiu, S. M., & Voinea, S. C. (2020) · Cells · doi:10.3390/cells9020276 · Cited by 1,357 · see citing works
Hammond, S. M. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.05.001 · Cited by 1,291 · see citing works
siRNA versus miRNA as therapeutics for gene silencing
Lam, J. K. W., Chow, M. Y. T., Zhang, Y., & Leung, S. W. S. (2015) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2015.23 · Cited by 1,081 · see citing works
Progress and prospects of early detection in lung cancer
Knight, S., Crosbie, P. A. J., Balata, H., Chudziak, J., Hussell, T., & Dive, C. (2017) · Open Biology · doi:10.1098/rsob.170070 · Cited by 945 · see citing works
Circular RNAs are miRNA sponges and can be used as a new class of biomarker
Kulcheski, F. R., Christoff, A. P., & Margis, R. (2016) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2016.09.011 · Cited by 739 · see citing works
Aptamer-Based Detection of Circulating Targets for Precision Medicine
Wu, L., Wang, Y., Xu, X., Liu, Y., Lin, B., Zhang, M., Zhang, J., Wan, S., Yang, C. J., & Tan, W. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01140 · Cited by 704 · see citing works
A network-biology perspective of microRNA function and dysfunction in cancer
Bracken, C. P., Scott, H. S., & Goodall, G. J. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.134 · Cited by 668 · see citing works
Reddy, K. B. (2015) · Cancer Cell International · doi:10.1186/s12935-015-0185-1 · Cited by 620 · see citing works
Recent advances in biosensor development for the detection of cancer biomarkers
Jayanthi, V. S. P. K. S. A., Das, A. B., & Saxena, U. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.12.014 · Cited by 569 · see citing works
Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
Zhang, H., Dai, Z., Wu, W., Wang, Z., Zhang, N., Zhang, L., Zeng, W., Liu, Z., & Cheng, Q. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01987-7 · Cited by 543 · see citing works
N6-methyladenosine links RNA metabolism to cancer progression
Dai, D., Wang, H., Zhu, L., Jin, H., & Wang, X. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0129-x · Cited by 466 · see citing works
Data Normalization Strategies for MicroRNA Quantification
Schwarzenbach, H., da Silva, A. M., Calin, G., & Pantel, K. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2015.239459 · Cited by 426 · see citing works
MicroRNA in lung cancer: role, mechanisms, pathways and therapeutic relevance
Iqbal, M. A., Arora, S., Prakasam, G., Călin, G. A., & Syed, M. A. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.07.003 · Cited by 449 · see citing works
MicroRNA: A signature for cancer progression
Hussen, B. M., Hidayat, H. J., Salihi, A. B., Sabir, D. K., Taheri, M. N., & Ghafouri‐Fard, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111528 · Cited by 407 · see citing works
RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges
Yu, A., Choi, Y. H., & Tu, M. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019554 · Cited by 405 · see citing works
Stress granules, P-bodies and cancer
Anderson, P., Kedersha, N., & Ivanov, P. V. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.11.009 · Cited by 396 · see citing works
Trials and Tribulations of MicroRNA Therapeutics
Seyhan, A. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031469 · Cited by 381 · see citing works
Vienberg, S. G., Geiger, J., Madsen, S., & Dalgaard, L. T. (2016) · Acta Physiologica · doi:10.1111/apha.12681 · Cited by 375 · see citing works
Sholley, M. M., Ferguson, G. P., Seibel, H. R., Montour, J. L., & Wilson, J. D. (1984) · PubMed · Cited by 332 · see citing works
RNAi-Based Therapeutics and Novel RNA Bioengineering Technologies
Traber, G. M., & Yu, A. (2022) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.122.001234 · Cited by 301 · see citing works
Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies
Khan, A. S., Ahmed, E. I., Elareer, N. R., Junejo, K., Steinhoff, M. S., & Shahab Uddin, M. S. (2019) · Cells · doi:10.3390/cells8080840 · Cited by 296 · see citing works
Chen, G., Shi, Y., Liu, M., & Sun, J. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0204-3 · Cited by 291 · see citing works
Noncoding RNAs in cancer therapy resistance and targeted drug development
Wang, W., Han, C., Sun, Y., Chen, T.-Q., & Chen, Y. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0748-z · Cited by 266 · see citing works
Emerging roles of lncRNAs in the post-transcriptional regulation in cancer
He, R., Luo, D., & Mo, Y. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.01.003 · Cited by 258 · see citing works
MicroRNA-based therapeutics in central nervous system injuries
Sun, P., Liu, D., Jickling, G. C., Sharp, F. R., & Yin, K. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18773871 · Cited by 256 · see citing works
Rodríguez, M., Bajo-Santos, C., Hessvik, N. P., Lorenz, S., Fromm, B., Berge, V., Sandvig, K., Linē, A., & Llorente, A. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0726-4 · Cited by 253 · see citing works
Honegger, A., Schilling, D., Bastian, S., Sponagel, J., Kuryshev, V., Sültmann, H., Scheffner, M., Hoppe‐Seyler, K., & Hoppe‐Seyler, F. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004712 · Cited by 250 · see citing works
Challenges identifying efficacious miRNA therapeutics for cancer
Segal, M., & Slack, F. J. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1765770 · Cited by 244 · see citing works
Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy
Roy, S., Bag, A. K., Singh, R. K., Talmadge, J. E., Batra, S. K., & Datta, K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01228 · Cited by 237 · see citing works
Overview upon miR-21 in lung cancer: focus on NSCLC
Bica, C., Cojocneanu, R., Magdo, L., Ráduly, L., Gulei, D., & Berindan‐Neagoe, I. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2877-x · Cited by 235 · see citing works
Liu, C., Liu, R., Zhang, D., Deng, Q., Liu, B., Chao, H., Rycaj, K., Takata, Y., Lin, K., Lu, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14270 · Cited by 229 · see citing works
MicroRNA in cancer therapy: breakthroughs and challenges in early clinical applications
Martino, M. T. D., Tagliaferri, P., & Tassone, P. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03391-x · Cited by 228 · see citing works
Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression
Fan, C., Li, Y., Lan, T., Wang, W., Long, Y., & Yu, S. Y. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2021.11.006 · Cited by 227 · see citing works
Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages
Asgarpour, K., Shojaei, Z., Amiri, F., Ai, J., Mahjoubin‐Tehran, M., Ghasemi, F., Arefnezhad, R., Hamblin, M. R., & Mirzaei, H. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00650-6 · Cited by 221 · see citing works
Mahmoudi, T., de la Guárdia, M., & Baradaran, B. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.115842 · Cited by 220 · see citing works
Integrative methods for analyzing big data in precision medicine
Gligorijević, V., Malod‐Dognin, N., & Pržulj, N. (2015) · PROTEOMICS · doi:10.1002/pmic.201500396 · Cited by 216 · see citing works
cGAS–STING and Cancer: Dichotomous Roles in Tumor Immunity and Development
Ng, K. W., Marshall, E. A., Bell, J. C., & Lam, W. L. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.07.013 · Cited by 215 · see citing works
Abbastabar, M., Kheyrollah, M., Azizian, K., Bagherlou, N., Tehrani, S. S., Maniati, M., & Karimian, A. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.07.008 · Cited by 214 · see citing works
Single-cell sequencing of the small-RNA transcriptome
Faridani, O. R., Abdullayev, I., Hagemann-Jensen, M., Schell, J. P., Lanner, F., & Sandberg, R. (2016) · Nature Biotechnology · doi:10.1038/nbt.3701 · Cited by 219 · see citing works
Zhang, M., Wang, H., Wang, H., Wang, F., & Li, Z. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c00686 · Cited by 210 · see citing works
Long non-coding RNA CASC2 suppresses malignancy in human gliomas by miR-21
Wang, P., Liu, Y., Yao, Y., Li, Z., Li, Z., Ma, J., & Xue, Y. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.11.011 · Cited by 209 · see citing works
Luo, Z., Rong, Z., Zhang, J., Zhu, Z., Yu, Z., Li, T., Fu, Z., Qiu, Z., & Huang, C. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01203-8 · Cited by 205 · see citing works
Cao, D., Li, L., & Chan, W. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060842 · Cited by 203 · see citing works
Circular RNAs: A novel type of non-coding RNA and their potential implications in antiviral immunity
Wang, M., Yu, F., Wu, W., Zhang, Y., Chang, W., Ponnusamy, M., Wang, K., & Li, P. (2017) · International Journal of Biological Sciences · doi:10.7150/ijbs.22531 · Cited by 203 · see citing works
Zhang, W. C., Chin, T. M., Yang, H. H., Nga, M. E., Lunny, D. P., Lim, E. K. H., Sun, L., Pang, Y. H., Leow, Y. N., Malusay, S. R. Y., et al. (2016) · Nature Communications · doi:10.1038/ncomms11702 · Cited by 201 · see citing works
Circulating miRNA analysis for cancer diagnostics and therapy
Valihrach, L., Androvic, P., & Kubista, M. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.10.002 · Cited by 199 · see citing works
Phosphatidylserine: A cancer cell targeting biomarker
Sharma, B., & Kanwar, S. S. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.08.012 · Cited by 198 · see citing works
Advanced liquid biopsy technologies for circulating biomarker detection
Soda, N., Rehm, B. H. A., Sonar, P. M., Nguyen, N., & Shiddiky, M. J. A. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb01490j · Cited by 198 · see citing works
Li, Y., Zeng, C., Hu, J., Pan, Y., Shan, Y., Liu, B., & Li, J. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0632-2 · Cited by 197 · see citing works
MiRNAs: Biology, Biogenesis, their Web-based Tools, and Databases
Tafrihi, M., & Hasheminasabgorji, E. (2018) · MicroRNA · doi:10.2174/2211536607666180827111633 · Cited by 196 · see citing works
Gong, H., Hu, X., Zeng, R., Li, Y., Xu, J., Li, M., & Tang, D. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.132307 · Cited by 196 · see citing works
Autophagy: A novel mechanism of chemoresistance in cancers
Li, X., Zhou, Y., Li, Y., Yang, L., Ma, Y., Peng, X., Yang, S., Liu, J., & Li, H. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109415 · Cited by 195 · see citing works
Piwi-interacting RNAs in cancer: emerging functions and clinical utility
Ng, K. W., Anderson, C., Marshall, E. A., Minatel, B. C., Enfield, K. S. S., Saprunoff, H., Lam, W. L., & Martínez, V. D. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0491-9 · Cited by 194 · see citing works
Circulating Cell-Free Nucleic Acids: Main Characteristics and Clinical Application
Szilágyi, M., Pös, O., Márton, É., Buglyó, G., Soltész, B., Keserű, J. S., Penyige, A., Szemes, T., & Nagy, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186827 · Cited by 193 · see citing works
Arif, K. M. T., Elliott, E. K., Haupt, L. M., & Griffiths, L. R. (2020) · Cancers · doi:10.3390/cancers12102922 · Cited by 193 · see citing works
microRNAs: New prognostic, diagnostic, and therapeutic biomarkers in cervical cancer
Nahand, J. S., Taghizadeh‐boroujeni, S., Karimzadeh, M. R., Borran, S., Pourhanifeh, M. H., Moghoofei, M., Bokharaei‐Salim, F., Karampoor, S., Jafari, A. H., Asemi, Z., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28457 · Cited by 188 · see citing works
Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance
Raghunath, A., Sundarraj, K., Arfuso, F., Sethi, G., & Perumal, E. (2018) · Cancers · doi:10.3390/cancers10120481 · Cited by 184 · see citing works
MicroRNAs as potential diagnostic and prognostic biomarkers in melanoma
Mirzaei, H., Gholamin, S., Shahidsales, S., Sahebkar, A., Jaafari, M. R., Mirzaei, H. R., Hassanian, S. M., & Avan, A. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.10.009 · Cited by 183 · see citing works
Yang, H., Zhang, H., Ge, S., Ning, T., Bai, M., Li, J., Li, S., Sun, W., Deng, T., Zhang, L., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.07.023 · Cited by 182 · see citing works
RetractedQing, M., Chen, S. L., Sun, Z., Fan, Y., Luo, H. Q., & Li, N. B. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c00805 · Cited by 182 · see citing works
Satoh, J., Kino, Y., & Niida, S. (2015) · Biomarker Insights · doi:10.4137/bmi.s25132 · Cited by 181 · see citing works
sRNAbench and sRNAtoolbox 2019: intuitive fast small RNA profiling and differential expression
Aparicio‐Puerta, E., Lebrón, R., Rueda, A., Gómez‐Martín, C., Giannoukakos, S., Jáspez, D., Medina, J. M., Zubković, A., Jurak, I., Fromm, B., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz415 · Cited by 174 · see citing works
Cancer and Embolic Stroke of Undetermined Source
Navi, B. B., Kasner, S. E., Elkind, M. S. V., Cushman, M., Bang, O. Y., & DeAngelis, L. M. (2021) · Stroke · doi:10.1161/strokeaha.120.032002 · Cited by 174 · see citing works
Lai, X., Eberhardt, M., Schmitz, U., & Vera, J. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz638 · Cited by 169 · see citing works
miRNA dysregulation is an emerging modulator of genomic instability
Cardoso, A. P. F., Banerjee, M., Nail, A. N., Lykoudi, A., & States, J. C. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.004 · Cited by 169 · see citing works
Yin, H., Xiong, G., Guo, S., Xu, C., Xu, R., Guo, P., & Shu, D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.04.018 · Cited by 166 · see citing works
Huan, T., Chen, G., Liu, C., Bhattacharya, A., Rong, J., Chen, B. H., Seshadri, S. S., Tanrıverdi, K., Freedman, J. E., Larson, M. G., et al. (2017) · Aging Cell · doi:10.1111/acel.12687 · Cited by 165 · see citing works
Decreased levels of serum exosomal miR‐638 predict poor prognosis in hepatocellular carcinoma
Shi, M., Jiang, Y., Yang, L., Yan, S., Wang, Y., & Lu, X. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26650 · Cited by 161 · see citing works
Khalighfard, S., Alizadeh, A. M., Irani, S., & Omranipour, R. (2018) · Scientific Reports · doi:10.1038/s41598-018-36321-3 · Cited by 161 · see citing works
MicroRNAs as potential biomarkers for the diagnosis of glioma: A systematic review and meta‐analysis
Zhou, Q., Liu, J., Quan, J., Liu, W., Tan, H., & Li, W. (2018) · Cancer Science · doi:10.1111/cas.13714 · Cited by 160 · see citing works
Kurozumi, S., Yamaguchi, Y., Kurosumi, M., Ohira, M., Matsumoto, H., & Horiguchi, J. (2016) · Journal of Human Genetics · doi:10.1038/jhg.2016.89 · Cited by 158 · see citing works
Clinical significance of microRNAs in chronic and acute human leukemia
Yeh, C., Moles, R., & Nicot, C. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0518-2 · Cited by 153 · see citing works
Mutual regulation of microRNAs and DNA methylation in human cancers
Wang, S., Wu, W., & Claret, F. X. (2017) · Epigenetics · doi:10.1080/15592294.2016.1273308 · Cited by 153 · see citing works
Koo, K. M., Carrascosa, L. G., Shiddiky, M. J. A., & Trau, M. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04795 · Cited by 152 · see citing works
Li, B., Wang, W., Li, Z., Chen, Z., Zhi, X., Xu, J., Li, Q., Wang, L., Huang, X., Wang, L., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.09.035 · Cited by 151 · see citing works
Non-coding RNAs in endometriosis: a narrative review
Panir, K., Schjenken, J. E., Robertson, S. A., & Hull, M. L. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy014 · Cited by 151 · see citing works
Yang, Y., Ding, L., Hu, Q., Xia, J., Sun, J., Wang, X., Xiong, H., Gurbani, D., Li, L., Liu, Y., et al. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0710-z · Cited by 150 · see citing works
Editorial focus: understanding off-target effects as the key to successful RNAi therapy
Bartoszewski, R., & Sikorski, A. F. (2019) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-019-0196-3 · Cited by 150 · see citing works
New Insight into microRNA Functions in Cancer: Oncogene–microRNA–Tumor Suppressor Gene Network
Zhou, K., Liu, M., & Cao, Y. (2017) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2017.00046 · Cited by 146 · see citing works
Epigenetic regulation mechanisms of microRNA expression
Morales, S., Monzó, M., & Navarro, A. (2017) · BioMolecular Concepts · doi:10.1515/bmc-2017-0024 · Cited by 145 · see citing works
Nanoarchitecture Frameworks for Electrochemical miRNA Detection
Masud, M. K., Umer, M., Hossain, M. S. A., Yamauchi, Y., Nguyen, N., & Shiddiky, M. J. A. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.11.012 · Cited by 144 · see citing works
Yue, C., Chen, J., Li, L., Li, L., Chen, J., & Guo, Y.-M. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01731-7 · Cited by 143 · see citing works
The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications
Zheng, H., Zhan, Y., Liu, S., Lu, J., Luo, J., Feng, J., & Fan, S. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0901-5 · Cited by 140 · see citing works
LncRNAs with miRNAs in regulation of gastric, liver, and colorectal cancers: updates in recent years
Tam, C., Wong, J. H., Tsui, S. K., Zuo, T., Chan, T., & Ng, T. B. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09837-5 · Cited by 139 · see citing works
The Untranslated Regions of mRNAs in Cancer
Schuster, S. L., & Hsieh, A. C. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.02.011 · Cited by 138 · see citing works
Ren, Y., Wang, R., Weng, S., Xu, H., Zhang, Y., Chen, S., Liu, S., Ba, Y., Zhou, Z., Luo, P., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01831-w · Cited by 138 · see citing works
Micrornas in prostate cancer: an overview
Vanacore, D., Boccellino, M., Rossetti, S., Cavaliere, C., D’Aniello, C., Franco, R. D., Romano, F. J., Montanari, M., Mantia, E. L., Piscitelli, R., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16933 · Cited by 136 · see citing works
Koppers‐Lalic, D., Hackenberg, M., de Menezes, R., Mišovic, B., Wąchalska, M., Geldof, A. A., Zini, N., de Reijke, T. M., Wurdinger, T. D., Vis, A. N., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8124 · Cited by 135 · see citing works
Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members
Cui, J., & Placzek, W. J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010308 · Cited by 135 · see citing works
Chin, L. K., Son, T., Hong, J., Liu, A. Q., Skog, J., Castro, C. M., Weissleder, R., Lee, H., & Im, H. (2020) · ACS Nano · doi:10.1021/acsnano.0c07581 · Cited by 135 · see citing works
Emerging landscape of circular RNAs in lung cancer
Hu, W., Bi, Z., Chen, Z., Liu, C., Li, L., Zhang, F., Zhou, Q. Y., Zhu, W., Song, Y., Zhan, B.-T., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.04.006 · Cited by 134 · see citing works
Kang, L., Mao, J., Tao, Y., Song, B., Ma, W., Lü, Y., Zhao, L., Li, J., Yang, B., & Li, L. (2015) · Cancer Science · doi:10.1111/cas.12656 · Cited by 132 · see citing works
RetractedYee, D., Shah, K., Coles, M. C., Sharp, T. V., & Lagos, D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.809053 · Cited by 132 · see citing works
Müller, S., Bley, N., Glaß, M., Busch, B., Rousseau, V., Misiak, D., Fuchs, T., Lederer, M., & Hüttelmaier, S. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky229 · Cited by 131 · see citing works
Yamada, Y., Arai, T., Kojima, S., Sugawara, S., Kato, M., Okato, A., Yamazaki, K., Naya, Y., Ichikawa, T., & Seki, N. (2018) · Cancer Science · doi:10.1111/cas.13722 · Cited by 130 · see citing works
The mini-driver model of polygenic cancer evolution
Castro-Giner, F., Ratcliffe, P. J., & Tomlinson, I. P. M. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3999 · Cited by 129 · see citing works
Cancer Biomarkers Discovery and Validation: State of the Art, Problems and Future Perspectives
Mordente, A., Meucci, E., Martorana, G. E., & Silvestrini, A. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-7215-0_2 · Cited by 129 · see citing works
Predicting tumor cell line response to drug pairs with deep learning
Xia, F., Shukla, M. P., Brettin, T. S., García–Cardona, C., Cohn, J. D., Allen, J., Maslov, S., Holbeck, S. L., Doroshow, J. H., Evrard, Y. A., et al. (2018) · BMC Bioinformatics · doi:10.1186/s12859-018-2509-3 · Cited by 128 · see citing works
- Authors
- Hayes, J., Peruzzi, P. P., & Lawler, S.
- Affiliations
- St James's University Hospital (GB)
- The Ohio State University Wexner Medical Center (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Lawler, Sean
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 20
- Issue
- 8
- Pages
- 460-469
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W1974254202
- Cited by
- 2,049
- References
- 79
- Citations by year
- 2026: 61 · 2025: 78 · 2024: 103 · 2023: 130 · 2022: 186 · 2021: 244 · 2020: 290 · 2019: 273 · 2018: 235 · 2017: 203 · 2016: 140 · 2015: 91 · 2014: 12
- FWCI
- 14.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- microRNA, cancer, biomarkers, microRNA processing, miRNA expression profiling, prognosis, cancer therapy, miRNA mimics, cancer monitoring
- MeSH terms
- Animals, Humans, Neoplasms, Prognosis, Biomarkers, Tumor, Genetic Therapy, Gene Expression Regulation, Neoplastic, MicroRNAs, Gene Regulatory Networks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review