Cited by 2,049MicroRNA in disease regulationCancer-related molecular mechanisms researchCancer-related Molecular Pathways

MicroRNAs in cancer: biomarkers, functions and therapy

Open access
Hayes, Josie, Peruzzi, Pier Paolo, Lawler, Sean·2014·Trends in Molecular Medicine

Abstract

The emergence of microRNAs has been one of the defining developments in cancer biology over the past decade, and the explosion of knowledge in this area has brought forward new diagnostic and therapeutic opportunities. The importance of microRNAs in cancer has been underlined by the identification of alterations in microRNA target binding sites and the microRNA processing machinery in tumor cells. Clinical trials utilizing microRNA profiling for patient prognosis and clinical response are now underway, and the first microRNA mimic entered the clinic for cancer therapy in 2013. In this article we review the potential applications of microRNAs for the clinical assessment of patient outcome in cancer, as well as in cancer monitoring and therapy.

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Crossref · 10.1016/j.molmed.2014.06.005

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79 of 79 references verified0 citation errors · 0 not checkable

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Authors
Hayes, J., Peruzzi, P. P., & Lawler, S.
Affiliations
  • St James's University Hospital (GB)
  • The Ohio State University Wexner Medical Center (US)
  • Brigham and Women's Hospital (US)
Corresponding author
Lawler, Sean
Venue
Trends in Molecular Medicine
Publisher
Elsevier BV
Published
2014-08
Volume
20
Issue
8
Pages
460-469
ISSN
1471-4914 (ISSN-L)
OpenAlex
W1974254202
Cited by
2,049
References
79
Citations by year
2026: 61 · 2025: 78 · 2024: 103 · 2023: 130 · 2022: 186 · 2021: 244 · 2020: 290 · 2019: 273 · 2018: 235 · 2017: 203 · 2016: 140 · 2015: 91 · 2014: 12
FWCI
14.44
Type
journal article
Language
en
Open access
Locations
  • Trends in Molecular Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
microRNA, cancer, biomarkers, microRNA processing, miRNA expression profiling, prognosis, cancer therapy, miRNA mimics, cancer monitoring
MeSH terms
Animals, Humans, Neoplasms, Prognosis, Biomarkers, Tumor, Genetic Therapy, Gene Expression Regulation, Neoplastic, MicroRNAs, Gene Regulatory Networks

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