The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock
Open accessAbstract
Retinal photoreceptors entrain the circadian system to the solar day. This photic resetting involves cAMP response element binding protein (CREB)-mediated upregulation of Per genes within individual cells of the suprachiasmatic nuclei (SCN). Our detailed understanding of this pathway is poor, and it remains unclear why entrainment to a new time zone takes several days. By analyzing the light-regulated transcriptome of the SCN, we have identified a key role for salt inducible kinase 1 (SIK1) and CREB-regulated transcription coactivator 1 (CRTC1) in clock re-setting. An entrainment stimulus causes CRTC1 to coactivate CREB, inducing the expression of Per1 and Sik1. SIK1 then inhibits further shifts of the clock by phosphorylation and deactivation of CRTC1. Knockdown of Sik1 within the SCN results in increased behavioral phase shifts and rapid re-entrainment following experimental jet lag. Thus SIK1 provides negative feedback, acting to suppress the effects of light on the clock. This pathway provides a potential target for the regulation of circadian rhythms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation
Merico, D., Isserlin, R., Stueker, O., Emili, A., & Bader, G. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013984 · Cited by 2,235
Transplanted Suprachiasmatic Nucleus Determines Circadian Period
Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M. (1990) · Science · doi:10.1126/science.2305266 · Cited by 1,853
Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., et al. (2003) · Nature · doi:10.1038/nature01761 · Cited by 1,245
Self-citationSleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055
Self-citationA Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light
Albrecht, U., Sun, Z. S., Eichele, G., & Lee, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80495-x · Cited by 879
Real-time luminescence reporting of circadian gene expression in mammals
Yamazaki, S., & Takahashi, J. S. (2005) · Methods in Enzymology · doi:10.1016/s0076-6879(05)93012-7 · Cited by 200
Cited by
Generation of circadian rhythms in the suprachiasmatic nucleus
Hastings, M. H., Maywood, E. S., & Brancaccio, M. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0026-z · Cited by 1,065
Circadian time signatures of fitness and disease
Bass, J., & Lazar, M. A. (2016) · Science · doi:10.1126/science.aah4965 · Cited by 607
Circadian System and Glucose Metabolism: Implications for Physiology and Disease
Qian, J., & Scheer, F. A. J. L. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.03.005 · Cited by 365
Prenatal Androgen Exposure and Transgenerational Susceptibility to Polycystic Ovary Syndrome
Risal, S., Pei, Y., Lu, H., Manti, M., Fornes, R., Pui, H.-P., Zhao, Z., Massart, J., Ohlsson, C., Lindgren, E., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0666-1 · Cited by 356
Herzog, E. D., Hermanstyne, T., Smyllie, N. J., & Hastings, M. H. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027706 · Cited by 266
Metadata
- Authors
- Jagannath, A., Butler, R., Godinho, S. I. H., Couch, Y., Brown, L. A., Vasudevan, S. R., Flanagan, K. C., Anthony, D., Churchill, G. C., Wood, M. J. A., Steiner, G., Ebeling, M., Hossbach, M., Wettstein, J. G., Duffield, G. E., Gatti, S., Hankins, M. W., Foster, R. G., & Peirson, S. N.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 154
- Issue
- 5
- Pages
- 1100-1111
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2156902902
- Cited by
- 217
- References
- 8
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock. https://app.cochat.ai/papers/10.1016/j.cell.2013.08.004
- The paper
- Jagannath, A., Butler, R., Godinho, S. I. H., Couch, Y., Brown, L. A., Vasudevan, S. R., Flanagan, K. C., Anthony, D., Churchill, G. C., Wood, M. J. A., Steiner, G., Ebeling, M., Hossbach, M., Wettstein, J. G., Duffield, G. E., Gatti, S., Hankins, M. W., Foster, R. G., & Peirson, S. N. (2013). The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock. Cell. https://doi.org/10.1016/j.cell.2013.08.004
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
