Cited by 519Regulation of Appetite and ObesityMitochondrial Function and PathologyAutophagy in Disease and Therapy

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

Open access

Schneeberger, Marc, Dietrich, Marcelo O., Sebastián, David, Imbernón, Mónica, Castaño, Carlos, Garcia, Ainhoa, Esteban, Yaiza, Gonzalez-Franquesa, Alba, Rodríguez, Ignacio Castrillón, Bortolozzi, Analía, Garcia-Roves, Pablo M., Gomis, Ramon, Nogueiras, Ruben, Horvath, Tamas L., Zorzano, Antonio, Claret, Marc·2013·Cell

DOI 10.1016/j.cell.2013.09.003PMC PMC3839088

Open this paper in CoChat — free account

Abstract

Mitofusin 2 (MFN2) plays critical roles in both mitochondrial fusion and the establishment of mitochondria-endoplasmic reticulum (ER) interactions. Hypothalamic ER stress has emerged as a causative factor for the development of leptin resistance, but the underlying mechanisms are largely unknown. Here, we show that mitochondria-ER contacts in anorexigenic pro-opiomelanocortin (POMC) neurons in the hypothalamus are decreased in diet-induced obesity. POMC-specific ablation of Mfn2 resulted in loss of mitochondria-ER contacts, defective POMC processing, ER stress-induced leptin resistance, hyperphagia, reduced energy expenditure, and obesity. Pharmacological relieve of hypothalamic ER stress reversed these metabolic alterations. Our data establish MFN2 in POMC neurons as an essential regulator of systemic energy balance by fine-tuning the mitochondrial-ER axis homeostasis and function. This previously unrecognized role for MFN2 argues for a crucial involvement in mediating ER stress-induced leptin resistance.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cell.2013.09.003

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Mitochondrial Fission, Fusion, and Stress
Youle, R. J., & van der Bliek, A. M. (2012) · Science · doi:10.1126/science.1219855 · Cited by 3,674
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442
Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity
Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell · doi:10.1016/j.cell.2008.07.043 · Cited by 1,350
Endoplasmic reticulum-mitochondria contacts: Function of the junction
Rowland, A. A., & Voeltz, G. K. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3440 · Cited by 1,018
High-Resolution Respirometry: OXPHOS Protocols for Human Cells and Permeabilized Fibers from Small Biopsies of Human Muscle
Pesta, D. H., & Gnaiger, E. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-382-0_3 · Cited by 1,005
Mitochondrial fusion protects against neurodegeneration in the cerebellum
Chen, H., McCaffery, J. M., & Chan, D. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.026 · Cited by 924
Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance
Ozcan, L., Ergin, A. S., Lu, A., Chung, J., Sarkar, S., Nie, D., Myers, M. G., & Ozcan, U. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.004 · Cited by 875
Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism
Bach, D., Pich, S., Soriano, F. X., Vega, N., Baumgartner, B., Oriola, J., Daugaard, J. R., Lloberas, J., Camps, M., Zierath, J. R., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212754200 · Cited by 832
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis
Sebastián, D., Hernández-Alvarez, M. I., Segalés, J., Sorianello, E., Muñoz, J. P., Sala, D., Waget, A., Liesa, M., Paz, J. C., Gopalacharyulu, P., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108220109 · Cited by 673

Flagged first, then by citations

Show all 47 references

Sorted by citations

Items 201–300 of 519

Hypothalamic endoplasmic reticulum stress as a key mediator of obesity‐induced leptin resistance
Ye, Z., Liu, G., Guo, J., & Su, Z. (2018) · Obesity Reviews · doi:10.1111/obr.12673 · Cited by 54
Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation
Yuan, F., Jiang, H., Yin, H., Jiang, X., Jiao, F., Chen, S., Ying, H., Chen, Y., Zhai, Q., & Guo, F. (2020) · Nature Communications · doi:10.1038/s41467-020-16662-2 · Cited by 51
Endoplasmic reticulum stress in the pathogenesis of hypertension
Young, C. N. (2017) · Experimental Physiology · doi:10.1113/ep086274 · Cited by 51
A high-fat diet induces rapid changes in the mouse hypothalamic proteome
McLean, F. H., Campbell, F., Langston, R. F., Sergi, D., Resch, C., Grant, C., Morris, A. C., Mayer, C., & Williams, L. M. (2019) · Nutrition & Metabolism · doi:10.1186/s12986-019-0352-9 · Cited by 49
A Neural basis for Octanoic acid regulation of energy balance
Haynes, V. R., Michael, N. J., van den Top, M., Zhao, F., Brown, R. D., Souza, D. P. D., Dodd, G. T., Spanswick, D. C., & Watt, M. J. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.01.002 · Cited by 52
Role of Mitofusins and Mitophagy in Life or Death Decisions
Joaquim, M., & Escobar‐Henriques, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.572182 · Cited by 50
Saturated lipids decrease mitofusin 2 leading to endoplasmic reticulum stress activation and insulin resistance in hypothalamic cells
Diaz, B., Fuentes‐Mera, L., Tovar, A. R., Montiel, T., Massieu, L., Martı́nez-Rodrı́guez, H. G., & Camacho‐Morales, A. (2015) · Brain Research · doi:10.1016/j.brainres.2015.09.014 · Cited by 49
Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions
Kaneko, K., Xu, P., Cordonier, E. L., Chen, S. S., Ng, A., Xu, Y., Morozov, A., & Fukuda, M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.039 · Cited by 51
Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action
Filippi, B., Abraham, M. A., Silva, P. N., Rasti, M., LaPierre, M. P., Bauer, P. V., Rocheleau, J. V., & Lam, T. K. T. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.035 · Cited by 49
Leptin Signaling in the Control of Metabolism and Appetite: Lessons from Animal Models
Barrios-Correa, A. A., Estrada, J. A., & Contreras, I. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1185-0 · Cited by 54
Mitochondrial Dynamics and Liver Cancer
Hernández‐Álvarez, M. I., & Antonio Zorzano, A. (2021) · Cancers · doi:10.3390/cancers13112571 · Cited by 50
Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage
Sánchez‐Alegría, K., & Arias, C. (2022) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.386 · Cited by 48
The role of endoplasmic reticulum–mitochondria-associated membranes in diabetic kidney disease
Elwakiel, A., Mathew, A., & Isermann, B. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad190 · Cited by 49
Hypothalamic Dysfunction in Obesity and Metabolic Disorders
Carmo‐Silva, S., & Cavadas, C. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_4 · Cited by 53
Is mitochondrial morphology important for cellular physiology?
Wai, T. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.05.005 · Cited by 50
Mitochondria-associated membranes (MAMs): An emerging platform connecting energy and immune sensing to metabolic flexibility
Rieusset, J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.097 · Cited by 47
Bavachin Induces Apoptosis through Mitochondrial Regulated ER Stress Pathway in HepG2 Cells
Yang, Y. C., Tang, X., Hao, F., Ma, Z.-C., Wang, Y., Wang, L., & Gao, Y. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00672 · Cited by 48
Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia
Yao, T. S., Deng, Z., Gao, Y., Sun, J. M., Kong, X., Huang, Y., He, Z., Xu, Y., Chang, Y., Yu, K.-J., et al. (2016) · Diabetes · doi:10.2337/db16-0533 · Cited by 46
Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin
Huang, X., Zhou, X., Hu, X., Joshi, A. S., Guo, X., Zhu, Y., Chen, Q., Prinz, W. A., & Hu, J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708782114 · Cited by 52
Mitochondrial dynamics and metabolic homeostasis
Sebastián, D., & Antonio Zorzano, A. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.02.006 · Cited by 46
The partial inhibition of hypothalamic IRX3 exacerbates obesity
de Araújo, T. M., Razolli, D. S., Corrêa‐da‐Silva, F., Júnior, J. C. D. L., Gaspar, R. S., Sidarta-Oliveira, D., Victorio, S. C. D. S., Donato, J., Kim, Y., & Velloso, L. A. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.11.048 · Cited by 47
Progressive postnatal decline in leptin sensitivity of arcuate hypothalamic neurons in theMagel2-null mouse model of Prader–Willi syndrome
Pravdivyi, I., Ballanyi, K., Colmers, W. F., & Wevrick, R. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv159 · Cited by 47
Neuroprotective effects of leptin on cerebral ischemia through JAK2/STAT3/PGC-1-mediated mitochondrial function modulation
Zhang, W., Jin, Y., Wang, D., & Cui, J. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.01.002 · Cited by 43
Mitofusin 1 is required for oocyte growth and communication with follicular somatic cells
Carvalho, K. F., Machado, T. S., Garcia, B. M., Zangirolamo, A. F., Macabelli, C. H., Sugiyama, F. H. C., Grejo, M. P., Neto, J. D. A., Tostes, K., Ribeiro, F. K. S., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201901761r · Cited by 45
Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis
Folick, A., Koliwad, S. K., & Valdearcos, M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.668396 · Cited by 48
Recent Advances in the Cellular and Molecular Mechanisms of Hypothalamic Neuronal Glucose Detection
Fioramonti, X., Chrétien, C., Leloup, C., & Pénicaud, L. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00875 · Cited by 47
Downregulation of leptin receptor and kisspeptin/GPR54 in the murine hypothalamus contributes to male hypogonadism caused by high-fat diet-induced obesity
Zhai, L., Zhao, J., Zhu, Y., Liu, Q., Niu, W., Liu, C., & Wang, Y. (2018) · Endocrine · doi:10.1007/s12020-018-1646-9 · Cited by 44
TNFα selectively activates the IRE1α/XBP1 endoplasmic reticulum stress pathway in human airway smooth muscle cells
Yap, J. Q., Chen, X., Delmotte, P. F., & Sieck, G. C. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00212.2019 · Cited by 46
Mitochondrial Genetic Variants Identified to Be Associated with BMI in Adults
Flaquer, A., Baumbach, C., Kriebel, J., Meitinger, T., Peters, A., Waldenberger, M., Grallert, H., & Strauch, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105116 · Cited by 44
Astrocytic lipid metabolism determines susceptibility to diet-induced obesity
Varela, L., Kim, J. G., Fernández‐Tussy, P., Aryal, B. K., Liu, Z. W., Fernandez-Hernando, C. F., & Horváth, T. L. (2021) · Science Advances · doi:10.1126/sciadv.abj2814 · Cited by 44
Alpha-Melanocyte-Stimulating Hormone-Mediated Appetite Regulation in the Central Nervous System
Wu, Q., Chen, J., Hua, T., & Cai, J. (2023) · Neuroendocrinology · doi:10.1159/000530804 · Cited by 46
Mitochondrial Dynamics and Hypothalamic Regulation of Metabolism
Jin, S., & Diano, S. (2018) · Endocrinology · doi:10.1210/en.2018-00667 · Cited by 45
Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice
Trotta, M., Bello, E. P., Alsina, R., Tavella, M. B., Ferrán, J. L., Rubinstein, M., & Bumaschny, V. F. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.100985 · Cited by 45
Synergistic Exacerbation of Mitochondrial and Synaptic Dysfunction and Resultant Learning and Memory Deficit in a Mouse Model of Diabetic Alzheimer's Disease
Wang, Y., Wu, L., Li, J., Du, F., Zhong, C., Chen, J. X., & Yan, S. S. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140972 · Cited by 43
Cancer: Untethering Mitochondria from the Endoplasmic Reticulum?
Herrera-Cruz, M. S., & Simmen, T. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00105 · Cited by 45
MFN2 Plays a Distinct Role from MFN1 in Regulating Spermatogonial Differentiation
Chen, W., Sun, Y. W., Sun, Q., Zhang, J., Jiang, M., Chang, C.-W., Huang, X., Wang, C., Wang, P., Zhang, Z., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.03.024 · Cited by 42
Leptin-induced mitochondrial fusion mediates hepatic lipid accumulation
Hsu, W.-H., Lee, B. H., & Pan, T.-M. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.120 · Cited by 42
Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions
Saito, K., Davis, K., Morgan, D. A., Toth, B. A., Jiang, J., Singh, U., Berglund, E. D., Grobe, J. L., Rahmouni, K., & Cui, H. (2019) · Diabetes · doi:10.2337/db18-1167 · Cited by 42
Regulation of Mitochondria-Associated Membranes (MAMs) by NO/sGC/PKG Participates in the Control of Hepatic Insulin Response
Bassot, A., Chauvin, M., Bendridi, N., Ji-Cao, J., Vial, G., Monnier, L., Bartosch, B., Alves, A., Cottet‐Rousselle, C., Gouriou, Y., et al. (2019) · Cells · doi:10.3390/cells8111319 · Cited by 46
Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease
Garrido‐Maraver, J., Loh, S. H. Y., & Martins, L. M. (2019) · Biology Open · doi:10.1242/bio.047530 · Cited by 41
Chemical Modulation of Mitochondria–Endoplasmic Reticulum Contact Sites
Rebelo, A. P. M., Bello, F. D., Knedlík, T., Kaar, N., Volpin, F., Shin, S. H., & Giacomello, M. (2020) · Cells · doi:10.3390/cells9071637 · Cited by 41
Brain JNK and metabolic disease
Nogueiras, R., & Sabio, G. (2020) · Diabetologia · doi:10.1007/s00125-020-05327-w · Cited by 42
The Complex Interplay between Imbalanced Mitochondrial Dynamics and Metabolic Disorders in Type 2 Diabetes
Huynh, T. V., Rethi, L., Rethi, L., Chen, C., Chen, Y., & Kao, Y. (2023) · Cells · doi:10.3390/cells12091223 · Cited by 42
Behind melanocortin antagonist overexpression in the zebrafish brain: A behavioral and transcriptomic approach
Guillot, R., Cortés, R., Navarro, S., Mischitelli, M., García-Herranz, V., Sánchez, E., Cal, L., Navarro, J. C., Míguez, J. M., Afanasyev, S., et al. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.04.011 · Cited by 39
Hypothalamic Mitochondrial Dysfunction as a Target in Obesity and Metabolic Disease
Cuñarro, J., Casado, S., Lugilde, J., & Tovar, S. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00283 · Cited by 41
Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity
Timper, K., Paeger, L., Sánchez-Lasheras, C., Varela, L., Jaïs, A., Nolte, H., Vogt, M. C., Hausen, A. C., Heilinger, C., Evers, N., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.034 · Cited by 41
Mitochondria-Associated Membranes (MAMs): A Novel Therapeutic Target for Treating Metabolic Syndrome
Yang, M., Li, C., & Sun, L. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200212100644 · Cited by 43
Morphological control of mitochondrial bioenergetics
Yoon, Y. (2015) · Frontiers in bioscience · doi:10.2741/4306 · Cited by 41
ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure
Xiao, Y., Deng, Y., Yuan, F., Xia, T., Liu, H., Li, Z., Liu, Z., Ying, H., Liu, Y., Zhai, Q., et al. (2017) · Diabetes · doi:10.2337/db16-1546 · Cited by 40
Interplay between the brain and adipose tissue: a metabolic conversation
Díaz‐Castro, F., Morselli, E., & Claret, M. (2024) · EMBO Reports · doi:10.1038/s44319-024-00321-4 · Cited by 44
POMC Neurons Dysfunction in Diet-induced Metabolic Disease: Hallmark or Mechanism of Disease?
Quarta, C., Fioramonti, X., & Cota, D. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.031 · Cited by 41
Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway
Liu, Y. F., Wen, D., Gao, J., Xie, B., Yu, H., Shen, Q., Zhang, J., Jing, W.-W., Cong, B., & Ma, C. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.06.005 · Cited by 40
Drp1 is required for AgRP neuronal activity and feeding
Jin, S., Yoon, N. A., Liu, Z.-W., Song, J. E., Horvath, T. L., Kim, J. D., & Diano, S. (2021) · eLife · doi:10.7554/elife.64351 · Cited by 39
Mitochondrial Fission Governed by Drp1 Regulates Exogenous Fatty Acid Usage and Storage in Hela Cells
Song, J.-E., Alves, T. C., Stutz, B., Šestan-Peša, M., Kilian, N., Jin, S., Diano, S., Kibbey, R. G., & Horváth, T. L. (2021) · Metabolites · doi:10.3390/metabo11050322 · Cited by 37
Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
Ramírez, S., Haddad-Tóvolli, R., Radosevic, M., Toledo, M., Pané, A., Alcolea, D. A., Ribas, V., Milà‐Guasch, M., Pozo, M., Obri, A., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.023 · Cited by 42
A cellular and molecular basis of leptin resistance
Tan, B., Hedbacker, K., Kelly, L., Zhang, Z., Moura‐Assis, A., Luo, J., Rabinowitz, J. D., & Friedman, J. M. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.01.001 · Cited by 45
Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins
Gong, T., Torres, D. J., Berry, M. J., & Pitts, M. W. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.038 · Cited by 38
Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia
Nobis, S., Goichon, A., Achamrah, N., Guérin, C., Azhar, S., Chan, P., Morin, A., Bôle‐Feysot, C., do-Rego, J.-C., Vaudry, D., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25548-9 · Cited by 38
Acquired disorders of mitochondrial metabolism and dynamics in pulmonary arterial hypertension
Breault, N. M., Wu, D., Dasgupta, A., Chen, K., & Archer, S. L. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1105565 · Cited by 38
Mitofusin 2 regulates the oocytes development and quality by modulating meiosis and mitochondrial function
Liu, Q., Kang, L., Wang, L.-J., Zhang, L., & Xiang, W.-P. (2016) · Scientific Reports · doi:10.1038/srep30561 · Cited by 32
Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver
Henschke, S., Nolte, H., Magoley, J., Kleele, T., Brandt, C., Hausen, A. C., Wunderlich, C. M., Bauder, C. A., Aschauer, P., Manley, S., et al. (2024) · Science · doi:10.1126/science.adk1005 · Cited by 37
Maternal transmission of mitochondrial diseases
Chiaratti, M. R., Macabelli, C. H., Neto, J. D. A., Grejo, M. P., Pandey, A. K., Perecin, F., & del Collado, M. (2020) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2019-0095 · Cited by 37
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion
Thorens, B. (2024) · Physiological Reviews · doi:10.1152/physrev.00038.2023 · Cited by 37
Dissociation of mitochondrial from sarcoplasmic reticular stress in Drosophila cardiomyopathy induced by molecularly distinct mitochondrial fusion defects
Bhandari, P., Song, M., & Dorn, G. W. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.12.018 · Cited by 34
MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress
Nagashima, S., Takeda, K., Ohno, N., Ishido, S., Aoki, M., Saitoh, Y., Takada, T., Tokuyama, T., Sugiura, A., Fukuda, T., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201900308 · Cited by 34
Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation
Chiurazzi, M., Maro, M. D., Cozzolino, M., & Colantuoni, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103450 · Cited by 33
Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function
Ghosal, S., Gebara, E., Ramos‐Fernández, E., Chioino, A., Grosse, J., de Suduiraut, I. G., Zanoletti, O., Schneider, B. L., Antonio Zorzano, A., Astori, S., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112776 · Cited by 33
The Mechanism of Leptin Resistance in Obesity and Therapeutic Perspective
Engin, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_16 · Cited by 42
Mouse Stbd1 is N-myristoylated and affects ER–mitochondria association and mitochondrial morphology
Demetriadou, A., Morales‐Sanfrutos, J., Nearchou, M., Baba, O., Kyriacou, K. C., Tate, E. W., Drousiotou, A., & Petrou, P. (2017) · Journal of Cell Science · doi:10.1242/jcs.195263 · Cited by 35
Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice
Braga, R. R., Crisol, B., Brícola, R. S., Sant’Ana, M. R., Nakandakari, S. C. B. R., COSTA, S. O., Prada, P. O., da Silva, A. S. R., de Moura, L. P., Pauli, J. R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-82352-8 · Cited by 31
Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis
Schneeberger, M., Gómez-Valadés, A. G., Altirriba, J., Sebastián, D., Ramírez, S., García, A., Esteban, Y., Drougard, A., Ferrés‐Coy, A., Bortolozzi, A. A., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.041 · Cited by 34
(Neuro)degenerated Mitochondria-ER contacts
Mario, A. D., Quintana–Cabrera, R., Martinvalet, D., & Giacomello, M. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.056 · Cited by 35
PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons
Wang, L., Sui, L., Panigrahi, S. K., Meece, K., Xin, Y., Kim, J., Gromada, J., Doege, C. A., Wardlaw, S. L., Egli, D. M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.12.021 · Cited by 33
Resveratrol reduces the apoptosis induced by cigarette smoke extract by upregulating MFN2
Song, C., Luo, B., & Gong, L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175009 · Cited by 32
Mitochondria-associated endoplasmic reticulum membranes in the heart
Wu, S., & Zou, M. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.12.018 · Cited by 33
Interfaces between mitochondrial dynamics and disease
Mishra, P. (2016) · Cell Calcium · doi:10.1016/j.ceca.2016.05.004 · Cited by 32
Orexin A attenuates palmitic acid-induced hypothalamic cell death
Duffy, C. M., Nixon, J. P., & Butterick, T. A. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.07.003 · Cited by 31
Proteomic profiling of mitochondria: what does it tell us about the ageing brain?
Ingram, T. L., & Chakrabarti, L. (2016) · Aging · doi:10.18632/aging.101131 · Cited by 33
Mitochondrial and autophagic alterations in skin fibroblasts from Parkinson disease patients with Parkin mutations
González‐Casacuberta, I., Juárez‐Flores, D. L., Ezquerra, M., Fucho, R., Catalán‐García, M., Guitart‐Mampel, M., Tobías, E., García‐Ruiz, C., Fernández-Checa, J. C., Tolosa, E. S., et al. (2019) · Aging · doi:10.18632/aging.102014 · Cited by 33
Apoptotic signals at the endoplasmic reticulum-mitochondria interface
Giamogante, F., Poggio, E., Barazzuol, L., Covallero, A., & Calí, T. (2021) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2021.02.007 · Cited by 30
Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity
Jayashankar, V., Selwan, E. M., Hancock, S. E., Verlande, A., Goodson, M. O., Eckenstein, K. H., Milinkeviciute, G., Hoover, B., Chen, B., Fleischman, A. G., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202013086 · Cited by 31
Mitofusin 2: A link between mitochondrial function and substrate metabolism?
Emery, J., & Ortiz, R. M. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.09.003 · Cited by 34
Hypothalamic microinflammation
Cai, D., & Khor, S. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820683-6.00023-3 · Cited by 33
The Potential of Small Molecules to Modulate the Mitochondria–Endoplasmic Reticulum Interplay in Alzheimer’s Disease
Dentoni, G., Castro‐Aldrete, L., Naia, L., & Ankarcrona, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.920228 · Cited by 32
SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity
Deng, Y., Xiao, Y., Yuan, F., Liu, Y., Jiang, X., Deng, J., Fejes‐Tóth, G., Náray‐Fejes‐Tóth, A., Chen, S., Chen, Y., et al. (2018) · Diabetes · doi:10.2337/db17-1069 · Cited by 32
Advances in mitochondria-centered mechanism behind the roles of androgens and androgen receptor in the regulation of glucose and lipid metabolism
Yin, L., Qi, S., & Zhu, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1267170 · Cited by 35
Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system
Asgari, R., Caceres-Valdiviezo, M., Wu, S., Hamel, L., Humber, B. E., Agarwal, S. M., Fletcher, P. J., Fulton, S., Hahn, M., & Pereira, S. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102078 · Cited by 35
Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q10 Deficiency
Romero–Moya, D., Santos‐Ocaña, C., Castaño, J., Garrabou, G., Rodríguez‐Gómez, J. A., Ruiz-Bonilla, V., Bueno, C., González‐Rodríguez, P., Giorgetti, A., Perdiguero, E., et al. (2017) · Stem Cells · doi:10.1002/stem.2634 · Cited by 31
Neuronal Signal Transduction-Involved Genes in Pig Hypothalamus Affect Feed Efficiency as Revealed by Transcriptome Analysis
Hou, Y., Hu, M., Zhou, H., Li, C., Li, X., Liu, X., Zhao, Y., & Zhao, S. (2018) · BioMed Research International · doi:10.1155/2018/5862571 · Cited by 30
Mechanisms Mediating the Actions of Fatty Acids in the Hypothalamus
Dragano, N. R. V., Monfort‐Pires, M., & Velloso, L. A. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.10.012 · Cited by 31
UPRmt and coordinated UPRER in type 2 diabetes
Kang, Z., Chen, F., Wu, W., Liu, R. R., Chen, T., & Xu, F. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.974083 · Cited by 29
The Effects of Maternal Obesity on Porcine Placental Efficiency and Proteome
Li, J.-W., Hu, J., Wei, M., Guo, Y., & Yan, P. (2019) · Animals · doi:10.3390/ani9080546 · Cited by 29
Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism
Haigh, J., New, L. E., & Filippi, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.580879 · Cited by 30
Mitochondria‐Associated Endoplasmic Reticulum Membranes: Inextricably Linked with Autophagy Process
Ji, C., Zhang, Z., Li, Z., She, X., Wang, X., Li, B., Xu, X., Song, D., & Zhang, D. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7086807 · Cited by 32
Hypoxemia-induced leptin secretion: a mechanism for the control of food intake in diseased fish
MacDonald, L. E., Alderman, S. L., Kramer, S., Woo, P. T. K., & Bernier, N. J. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0615 · Cited by 30
Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms
Engel, D. F., Bóbbo, V. C. D., Solon, C., Nogueira, G. A. S., Moura‐Assis, A., Mendes, N. F., Zanesco, A. M., Papangelis, A., Ulven, T., & Velloso, L. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68110-2 · Cited by 29
Inflammation-Induced Protein Unfolding in Airway Smooth Muscle Triggers a Homeostatic Response in Mitochondria
Dasgupta, D., Delmotte, P. F., & Sieck, G. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010363 · Cited by 29
ER–Mitochondria Contacts and Insulin Resistance Modulation through Exercise Intervention
Sun, Y., & Ding, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249587 · Cited by 27
Hypothalamic Lipids: Key Regulators of Whole Body Energy Balance
González‐García, I., Fernø, J., Diéguez, C., Nogueiras, R., & López, M. (2016) · Neuroendocrinology · doi:10.1159/000448432 · Cited by 30
Obesity-induced hepatic steatosis is mediated by endoplasmic reticulum stress in the subfornical organ of the brain
Horwath, J. A., Hurr, C., Butler, S. D., Guruju, M. R., Cassell, M. D., Mark, A. L., Davisson, R. L., & Young, C. N. (2017) · JCI Insight · doi:10.1172/jci.insight.90170 · Cited by 28

Authors: Schneeberger, M., Dietrich, M. O., Sebastián, D., Imbernón, M., Castaño, C., Garcia, A., Esteban, Y., Gonzalez-Franquesa, A., Rodríguez, I. C., Bortolozzi, A., Garcia-Roves, P. M., Gomis, R., Nogueiras, R., Horvath, T. L., Zorzano, A., & Claret, M.
Affiliations: Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
Universidade Federal do Rio Grande do Sul (BR)
Universidade de Santiago de Compostela (ES)
Corresponding author: Claret, Marc
ORCID: Schneeberger, Marc
Dietrich, Marcelo O.
Sebastián, David
Imbernón, Mónica
Castaño, Carlos
Esteban, Yaiza
Claret, Marc
Venue: Cell
Publisher: Elsevier BV
Published: 2013-09
Volume: 155
Issue: 1
Pages: 172-187
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2013.09.003
PMC: PMC3839088
OpenAlex: W1972621040
Cited by: 519
References: 47
Citations by year: 2026: 18 · 2025: 22 · 2024: 28 · 2023: 31 · 2022: 32 · 2021: 41 · 2020: 52 · 2019: 53 · 2018: 52 · 2017: 72 · 2016: 48 · 2015: 28 · 2014: 36 · 2013: 4
FWCI: 20.91
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 390 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
RUNA. Repositorio Institucional del Sergas (Servicio Gallego de Salud (SERGAS)) (submittedVersion, other-oa)
Funders: National Institutes of Health (DP1OD006850)
National Institute on Aging (R01AG040236)
National Institute of Diabetes and Digestive and Kidney Diseases (DP1DK098058, DP1 DK006850)
National Institute of Neurological Disorders and Stroke (P01NS062686)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitofusin 2, proopiomelanocortin neurons, hypothalamus, endoplasmic reticulum stress, leptin resistance, diet-induced obesity, mitochondrial fusion, energy balance, hyperphagia, energy expenditure, POMC processing
MeSH terms: Animals, Hypothalamus, Mice, Inbred C57BL, Neurons, Obesity, Pro-Opiomelanocortin, GTP Phosphohydrolases, Leptin, Mice, Endoplasmic Reticulum Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks