The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance
Open accessAbstract
Mitofusin 2 (MFN2) plays critical roles in both mitochondrial fusion and the establishment of mitochondria-endoplasmic reticulum (ER) interactions. Hypothalamic ER stress has emerged as a causative factor for the development of leptin resistance, but the underlying mechanisms are largely unknown. Here, we show that mitochondria-ER contacts in anorexigenic pro-opiomelanocortin (POMC) neurons in the hypothalamus are decreased in diet-induced obesity. POMC-specific ablation of Mfn2 resulted in loss of mitochondria-ER contacts, defective POMC processing, ER stress-induced leptin resistance, hyperphagia, reduced energy expenditure, and obesity. Pharmacological relieve of hypothalamic ER stress reversed these metabolic alterations. Our data establish MFN2 in POMC neurons as an essential regulator of systemic energy balance by fine-tuning the mitochondrial-ER axis homeostasis and function. This previously unrecognized role for MFN2 argues for a crucial involvement in mediating ER stress-induced leptin resistance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, the depletion of Mfn2 in the anorexigenic POMC neurons causes severe obesity and leptin resistance probably by affecting ER-stress (Schneeberger et al., 2013).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Schneeberger et al., 2013
In the citing paper
“the depletion of Mfn2 in the anorexigenic POMC neurons causes severe obesity and leptin resistance probably by affecting ER-stress (Schneeberger et al., 2013).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Schneeberger et al., 2013
In the citing paper
“Defective mitochondrial dynamics and mitochondrial-ER communication in hypothalamic POMC and AgRP neurons might actually modify feeding behavior and whole-body energy homeostasis (Dietrich et al, 2013; Schneeberger et al, 2013).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Schneeberger et al, 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mitochondrial Fission, Fusion, and Stress
Youle, R. J., & van der Bliek, A. M. (2012) · Science · doi:10.1126/science.1219855 · Cited by 3,674
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442
Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity
Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell · doi:10.1016/j.cell.2008.07.043 · Cited by 1,350
Endoplasmic reticulum-mitochondria contacts: Function of the junction
Rowland, A. A., & Voeltz, G. K. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3440 · Cited by 1,018
Pesta, D. H., & Gnaiger, E. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-382-0_3 · Cited by 1,005
Mitochondrial fusion protects against neurodegeneration in the cerebellum
Chen, H., McCaffery, J. M., & Chan, D. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.026 · Cited by 924
Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance
Ozcan, L., Ergin, A. S., Lu, A., Chung, J., Sarkar, S., Nie, D., Myers, M. G., & Ozcan, U. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.004 · Cited by 875
Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism
Bach, D., Pich, S., Soriano, F. X., Vega, N., Baumgartner, B., Oriola, J., Daugaard, J. R., Lloberas, J., Camps, M., Zierath, J. R., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212754200 · Cited by 832
Sebastián, D., Hernández-Alvarez, M. I., Segalés, J., Sorianello, E., Muñoz, J. P., Sala, D., Waget, A., Liesa, M., Paz, J. C., Gopalacharyulu, P., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108220109 · Cited by 673
Flagged first, then by citations
Cited by
Sorted by citations
The cell biology of mitochondrial membrane dynamics
Giacomello, M., Pyakurel, A., Glytsou, C., & Scorrano, L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0210-7 · Cited by 1,550
Mitochondrial ROS Signaling in Organismal Homeostasis
Shadel, G. S., & Horvath, T. L. (2015) · Cell · doi:10.1016/j.cell.2015.10.001 · Cited by 1,353
Mitochondrial Dynamics and Metabolic Regulation
Wai, T., & Langer, T. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.12.001 · Cited by 1,354
The machineries, regulation and cellular functions of mitochondrial calcium
Giorgi, C., Marchi, S., & Pinton, P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0052-8 · Cited by 941
Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
Timper, K., & Brüning, J. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.026609 · Cited by 851
Arruda, A. P., Pers, B. M., Parlakgül, G., Güney, E., Inouye, K., & Hotamışlıgil, G. S. (2014) · Nature Medicine · doi:10.1038/nm.3735 · Cited by 741
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
Hetz, C., & Mollereau, B. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3689 · Cited by 684
Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death
Marchi, S., Patergnani, S., Missiroli, S., Morciano, G., Rimessi, A., Wieckowski, M. R., Giorgi, C., & Pinton, P. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.05.003 · Cited by 727
Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits
Chen, Y., Lin, Y.-C., Kuo, T.-W., & Knight, Z. A. (2015) · Cell · doi:10.1016/j.cell.2015.01.033 · Cited by 660
Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
Eisner, V., Picard, M., & Hajnóczky, G. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0133-0 · Cited by 622
An energetic view of stress: Focus on mitochondria
Picard, M. A., McEwen, B. S., Epel, E. S., & Sandi, C. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.01.001 · Cited by 584
Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether
Naon, D., Zaninello, M., Giacomello, M., Varanita, T., Grespi, F., Lakshminaranayan, S., Serafini, A., Semenzato, M., Herkenne, S., Hernández-Alvarez, M. I., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606786113 · Cited by 521
Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability
García‐Cáceres, C., Quarta, C., Varela, L., Gao, Y., Gruber, T., Legutko, B., Jastroch, M., Johansson, P., Ninkovic, J., Yi, C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.028 · Cited by 533
Mitofusins, from Mitochondria to Metabolism
Schrepfer, E., & Scorrano, L. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.02.022 · Cited by 504
Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
Kleinridders, A., Cai, W., Cappellucci, L., Ghazarian, A., Collins, W. R., Vienberg, S. G., Pothos, E. N., & Kahn, C. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500877112 · Cited by 486
Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK
de Morentin, P. B. M., González‐García, I., Martins, L., Lage, R., Fernández-Mallo, D., Martínez‐Sánchez, N., Ruíz-Pino, F., Liu, J. T., Morgan, D. A., Pinilla, L., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.031 · Cited by 455
The coming of age of the mitochondria–ER contact: a matter of thickness
Giacomello, M., & Pellegrini, L. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.52 · Cited by 471
Hypothalamic POMC neurons promote cannabinoid-induced feeding
Koch, M., Varela, L., Kim, J. G., Kim, J. D., Hernández-Nuño, F., Simonds, S. E., Castorena, C. M., Vianna, C. R., Elmquist, J. K., Morozov, Y. M., et al. (2015) · Nature · doi:10.1038/nature14260 · Cited by 457
The Mitochondrial Basis of Aging and Age-Related Disorders
Srivastava, S. (2017) · Genes · doi:10.3390/genes8120398 · Cited by 446
Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Hernández‐Álvarez, M. I., Sebastián, D., Vives, S., Ivanova, S., Bartoccioni, P., Kakimoto, P. A., Plana, N., Veiga, S. R., Hernandez, V. A., Vasconcelos, N., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.010 · Cited by 407
Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling
Weir, H. J., Yao, P., Huynh, F. K., Escoubas, C. C., Goncalves, R. L., Burkewitz, K., Laboy, R., Hirschey, M. D., & Mair, W. B. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.024 · Cited by 372
Mollica, M. P., Raso, G. M., Cavaliere, G., Trinchese, G., Filippo, C. D., Aceto, S., Prisco, M., Pirozzi, C., Guida, F., Lama, A., et al. (2017) · Diabetes · doi:10.2337/db16-0924 · Cited by 369
Mitofusin 2: from functions to disease
Filadi, R., Pendin, D., & Pizzo, P. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0023-6 · Cited by 373
Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function
Rambold, A. S., & Pearce, E. L. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.08.006 · Cited by 357
Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism
García‐Cáceres, C., Balland, É., Prévot, V., Luquet, S. H., Woods, S. C., Koch, M., Horváth, T. L., Yi, C., Chowen, J. A., Verkhratsky, A., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0286-y · Cited by 343
A guide to understanding endoplasmic reticulum stress in metabolic disorders
Lemmer, I. L., Willemsen, N., Hilal, N., & Bartelt, A. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101169 · Cited by 334
Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses
Carreras‐Sureda, A., Pihán, P., & Hetz, C. A. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.08.004 · Cited by 331
Mechanisms of mitochondrial respiratory adaptation
Bennett, C. F., Latorre‐Muro, P., & Puigserver, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00506-6 · Cited by 322
Dietrich, M. O., Liu, Z.-W., & Horvath, T. L. (2013) · Cell · doi:10.1016/j.cell.2013.09.004 · Cited by 306
Self-citationThe UPR ER : Sensor and Coordinator of Organismal Homeostasis
Frakes, A. E., & Dillin, A. G. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.031 · Cited by 302
Mfn2 is critical for brown adipose tissue thermogenic function
Boutant, M., Kulkarni, S. S., Joffraud, M., Ratajczak, J., Valera‐Alberni, M., Combe, R., Antonio Zorzano, A., & Cantó, C. (2017) · The EMBO Journal · doi:10.15252/embj.201694914 · Cited by 309
Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging
Sebastián, D., Palacı́n, M., & Antonio Zorzano, A. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.01.003 · Cited by 292
Leptin signalling pathways in hypothalamic neurons
Kwon, O., Kim, K. W., & Kim, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2133-1 · Cited by 306
Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus
Jaïs, A., & Brüning, J. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab025 · Cited by 298
The melanocortin pathway and control of appetite-progress and therapeutic implications
Baldini, G., & Phelan, K. D. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0596 · Cited by 300
The brain as an insulin-sensitive metabolic organ
Milstein, J. L., & Ferris, H. A. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101234 · Cited by 274
Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis
Williams, K. W., Liu, T., Kong, X., Fukuda, M., Deng, Y., Berglund, E. D., Deng, Z., Gao, Y., Liu, T., Sohn, J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.002 · Cited by 258
Rieusset, J. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0416-1 · Cited by 248
Structure, function, and regulation of mitofusin‐2 in health and disease
Chandhok, G., Lazarou, M., & Neumann, B. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12378 · Cited by 263
Cieri, D., Vicario, M., Giacomello, M., Vallese, F., Filadi, R., Wagner, T., Pozzan, T., Pizzo, P., Scorrano, L., Brini, M., et al. (2017) · Cell Death and Differentiation · doi:10.1038/s41418-017-0033-z · Cited by 255
Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors
Yang, L., Qi, Y., & Yang, Y. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.002 · Cited by 248
Xia, M., Zhang, Y., Jin, K., Lu, Z., Zeng, Z., & Xiong, W. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0289-8 · Cited by 249
Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance
Contreras, C., González‐García, I., Martínez‐Sánchez, N., Seoane‐Collazo, P., Jacas, J., Morgan, D. A., Serra, D., Gallego, R., González, F., Casals, N., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.057 · Cited by 244
Filadi, R., Theurey, P., & Pizzo, P. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.01.003 · Cited by 247
Martínez‐Sánchez, N., Seoane‐Collazo, P., Contreras, C., Varela, L., Villarroya, J., Rial‐Pensado, E., Buqué, X., Aurrekoetxea, I., Delgado, T. C., Vázquez‐Martínez, R., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.014 · Cited by 238
Pathak, T., & Trebak, M. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.07.001 · Cited by 227
Therapeutic potential of targeting mitochondrial dynamics in cancer
Rodrigues, T., & Ferraz, L. S. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114282 · Cited by 226
The Diabetes Susceptibility Gene Clec16a Regulates Mitophagy
Soleimanpour, S. A., Gupta, A., Bakay, M., Ferrari, A. M., Groff, D. N., Fadista, J., Spruce, L. A., Kushner, J. A., Groop, L., Seeholzer, S. H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.016 · Cited by 211
Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice
Lee, J., Liu, J., Feng, X., Hernández, M. A. S., Mucka, P., Ibi, D., Choi, J. W., & Özcan, U. (2016) · Nature Medicine · doi:10.1038/nm.4145 · Cited by 215
Mitochondrial division and fusion in metabolism
Roy, M., Reddy, P. H., Iijima, M., & Sesaki, H. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.02.001 · Cited by 215
Yang, Z., Yu, G.-L., Zhu, X., Peng, T., & Lv, Y.-C. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.01.005 · Cited by 209
Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network
Vincent, A. E., White, K., Davey, T., Philips, J., Ogden, R. T., Lawless, C., Warren, C., Hall, M. G., Ng, Y. S., Falkous, G., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.010 · Cited by 195
Diet impact on mitochondrial bioenergetics and dynamics
Putti, R., Sica, R., Migliaccio, V., & Lionetti, L. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00109 · Cited by 192
Tur, J., Pereira‐Lopes, S., Vico, T., Marín, E., Muñoz, J. P., Hernández‐Álvarez, M. I., Cardona, P.-J., Antonio Zorzano, A., Lloberas, J., & Celada, A. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108079 · Cited by 198
Hall, C. E., Yao, Z., Choi, M., Tyzack, G. E., Serio, A., Luisier, R., Harley, J., Preza, E., Arber, C., Crisp, S. J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.024 · Cited by 179
Dysregulated Mitochondrial Dynamics and Metabolism in Obesity, Diabetes, and Cancer
Dai, W., & Jiang, L. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00570 · Cited by 186
Hypothalamic-autonomic control of energy homeostasis
Seoane‐Collazo, P., Fernø, J., González, F., Diéguez, C., Leis, R., Nogueiras, R., & López, M. (2015) · Endocrine · doi:10.1007/s12020-015-0658-y · Cited by 189
Danese, A., Patergnani, S., Bonora, M., Wieckowski, M. R., Previati, M., Giorgi, C., & Pinton, P. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.01.003 · Cited by 192
Mitochondrial function in development and disease
Rossmann, M. P., Dubois, S. M., Agarwal, S., & Zon, L. I. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048912 · Cited by 200
AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity
Vohra, M. S., Benchoula, K., Serpell, C. J., & Wong, E. H. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174611 · Cited by 199
Celardo, I., Costa, A. C., Lehmann, S., Jones, C., Wood, N. W., Mencacci, N. E., Mallucci, G. R., Loh, S. H. Y., & Martins, L. M. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.173 · Cited by 183
Mechanisms Orchestrating Mitochondrial Dynamics for Energy Homeostasis
Yu, S. B., & Pekkurnaz, G. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.07.027 · Cited by 184
Mitochondrial Fission in Human Diseases
Serasinghe, M. N., & Chipuk, J. E. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_38 · Cited by 186
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
Chung, K., Hsu, C., Fan, L.-C., Huang, Z., Bhatia, D., Chen, Y., Hisata, S., Cho, S. J., Nakahira, K., Imamura, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11327-1 · Cited by 179
At the right distance: ER-mitochondria juxtaposition in cell life and death
Naon, D., & Scorrano, L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.05.011 · Cited by 178
Role of Mitochondrial Dysfunction in Hypertension and Obesity
Lahera, V., de las Heras, N., López-Farré, A., Manucha, W., & Ferder, L. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0710-9 · Cited by 176
The Good and the Bad of Mitochondrial Breakups
Sprenger, H., & Langer, T. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.08.003 · Cited by 179
The Leptin Receptor Complex: Heavier Than Expected?
Wauman, J., Zabeau, L., & Tavernier, J. H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00030 · Cited by 185
Metabolic implications of organelle–mitochondria communication
Gordaliza‐Alaguero, I., Cantó, C., & Antonio Zorzano, A. (2019) · EMBO Reports · doi:10.15252/embr.201947928 · Cited by 177
POMC Neurons: From Birth to Death
Toda, C., Santoro, A. N., Kim, J. D., & Diano, S. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034110 · Cited by 175
Hypothalamic innate immune reaction in obesity
Kälin, S., Heppner, F. L., Bechmann, I., Prinz, M., Tschöp, M. H., & Yi, C.-X. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.48 · Cited by 167
Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset
Li, Y.-J., Cao, Y.-L., Feng, J.-X., Qi, Y., Meng, S., Yang, J., Zhong, Y.-T., Kang, S., Chen, X., Lan, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12912-0 · Cited by 182
Mitochondrial dynamics in the central regulation of metabolism
Nasrallah, C. M., & Horváth, T. L. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.160 · Cited by 176
Mitochondria-Associated Membranes Response to Nutrient Availability and Role in Metabolic Diseases
Theurey, P., & Rieusset, J. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.09.002 · Cited by 170
Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes
Novials, A., Montané, J., & Cadavez, L. (2014) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s37649 · Cited by 164
Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
Naón, D., Hernández‐Álvarez, M. I., Shinjo, S., Wieczór, M., Ivanova, S., de Brito, O. M., Quintana, A., Hidalgo, J., Palacı́n, M., Aparicio, P., et al. (2023) · Science · doi:10.1126/science.adh9351 · Cited by 165
Insulin Resistance and Mitochondrial Dysfunction
González-Franquesa, A., & Patti, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_25 · Cited by 160
Tipping the metabolic scales towards increased longevity in mammals
Riera, C. E., & Dillin, A. (2015) · Nature Cell Biology · doi:10.1038/ncb3107 · Cited by 153
Ramírez, S., Gómez-Valadés, A. G., Schneeberger, M., Varela, L., Haddad-Tóvolli, R., Altirriba, J., Noguera, E., Drougard, A., Flores‐Martínez, Á., Imbernón, M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.010 · Cited by 157
Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling
Göbel, J., Engelhardt, E., Pelzer, P., Sakthivelu, V., Jahn, H. M., Jevtic, M., Folz‐Donahue, K., Kukat, C., Schauss, A. C., Frese, C. K., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.03.005 · Cited by 160
ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis
Jao, T., Nangaku, M., Wu, C.-H., Sugahara, M., Saito, H., Maekawa, H., Ishimoto, Y., Aoe, M., Inoue, T., Tanaka, T., et al. (2019) · Kidney International · doi:10.1016/j.kint.2018.09.023 · Cited by 148
Mitochondrial response to nutrient availability and its role in metabolic disease
Gao, A. W., Cantó, C., & Houtkooper, R. H. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303782 · Cited by 148
Impaired Mitochondrial Dynamics and Bioenergetics in Diabetic Skeletal Muscle
Liu, R., Jin, P., LiqunYu, Wang, Y., Han, L., Shi, T., & Li, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092810 · Cited by 146
Gebara, E., Zanoletti, O., Ghosal, S., Grosse, J., Schneider, B. L., Knott, G. W., Astori, S., & Sandi, C. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.003 · Cited by 152
Hebert-Chatelain, E., Reguero, L., Puente, N., Lutz, B., Chaouloff, F., Rossignol, R., Piazza, P.-V., Benard, G., Grandes, P., & Marsicano, G. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.03.007 · Cited by 151
Moltedo, O., Remondelli, P., & Amodio, G. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00172 · Cited by 147
Marchi, S., Bittremieux, M., Missiroli, S., Morganti, C., Patergnani, S., Sbano, L., Rimessi, A., Kerkhofs, M., Parys, J. B., Bultynck, G., et al. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4567-7_4 · Cited by 142
“Hypothalamic Microinflammation” Paradigm in Aging and Metabolic Diseases
Cai, D., & Khor, S. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.021 · Cited by 138
PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding
Jais, A., Paeger, L., Sotelo-Hitschfeld, T., Bremser, S., Prinzensteiner, M., Klemm, P., Mykytiuk, V., Widdershooven, P. J. M., Vesting, A. J., Grzelka, K., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.022 · Cited by 129
Wang, T., McDonald, C., Petrenko, N. B., Leblanc, M., Wang, T., Giguère, V., Evans, R. M., Patel, V. V., & Pei, L. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01156-14 · Cited by 134
Mendizabal‐Zubiaga, J., Melser, S., Bénard, G., Ramos, A., Reguero, L., Arrabal, S., Elezgarai, I., Gerrikagoitia, I., Suárez, J., de Fonseca, F. R., et al. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00476 · Cited by 137
Metabolic signaling functions of ER–mitochondria contact sites: role in metabolic diseases
Tubbs, E., & Rieusset, J. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0189 · Cited by 130
Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration
Öztürk, Z., O’Kane, C. J., & Pérez-Moreno, J. J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00048 · Cited by 136
Miret‐Casals, L., Sebastián, D., Brea, J. M., Rico-Leo, E. M., Palacín, M., Fernández‐Salguero, P. M., Loza, M. I., Alberício, F., & Antonio Zorzano, A. (2017) · Cell chemical biology · doi:10.1016/j.chembiol.2017.12.001 · Cited by 132
Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings
Morciano, G., Marchi, S., Morganti, C., Sbano, L., Bittremieux, M., Kerkhofs, M., Corricelli, M., Danese, A., Karkucińska‐Więckowska, A., Wieckowski, M. R., et al. (2018) · Neoplasia · doi:10.1016/j.neo.2018.03.005 · Cited by 136
Sustained NPY signaling enables AgRP neurons to drive feeding
Chen, Y., Essner, R. A., Kosar, S., Miller, O. H., Lin, Y.-C., Mesgarzadeh, S., & Knight, Z. A. (2019) · eLife · doi:10.7554/elife.46348 · Cited by 128
The role of mitochondria-associated membranes in cellular homeostasis and diseases
Perrone, M., Caroccia, N., Genovese, I., Missiroli, S., Modesti, L., Pedriali, G., Vezzani, B., Vitto, V. A. M., Antenori, M., Lebiedzińska, M., et al. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.11.002 · Cited by 132
Mitochondrial Morphofunction in Mammalian Cells
Bulthuis, E. P., Adjobo-Hermans, M. J. W., Willems, P. H. G. M., & Koopman, W. J. H. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7534 · Cited by 133
Mitochondrial UCP2 in the central regulation of metabolism
Toda, C., & Diano, S. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.02.006 · Cited by 130
STAT3 phosphorylation in central leptin resistance
Liu, H., Du, T., Li, C., & Yang, G. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00569-w · Cited by 130
Metadata
- Authors
- Schneeberger, M., Dietrich, M. O., Sebastián, D., Imbernón, M., Castaño, C., Garcia, A., Esteban, Y., Gonzalez-Franquesa, A., Rodríguez, I. C., Bortolozzi, A., Garcia-Roves, P. M., Gomis, R., Nogueiras, R., Horvath, T. L., Zorzano, A., & Claret, M.
- Affiliations
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade de Santiago de Compostela (ES)
- Corresponding author
- Claret, Marc
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 155
- Issue
- 1
- Pages
- 172-187
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3839088
- OpenAlex
- W1972621040
- Cited by
- 519
- References
- 47
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 28 · 2023: 31 · 2022: 32 · 2021: 41 · 2020: 52 · 2019: 53 · 2018: 52 · 2017: 72 · 2016: 48 · 2015: 28 · 2014: 36 · 2013: 4
- FWCI
- 20.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- RUNA. Repositorio Institucional del Sergas (Servicio Gallego de Salud (SERGAS)) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (DP1OD006850)
- National Institute on Aging (R01AG040236)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP1DK098058, DP1 DK006850)
- National Institute of Neurological Disorders and Stroke (P01NS062686)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitofusin 2, proopiomelanocortin neurons, hypothalamus, endoplasmic reticulum stress, leptin resistance, diet-induced obesity, mitochondrial fusion, energy balance, hyperphagia, energy expenditure, POMC processing
- MeSH terms
- Animals, Hypothalamus, Mice, Inbred C57BL, Neurons, Obesity, Pro-Opiomelanocortin, GTP Phosphohydrolases, Leptin, Mice, Endoplasmic Reticulum Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review