The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Mechanical Feedback through E-Cadherin Promotes Direction Sensing during Collective Cell Migration
Open accessAbstract
Summary E-cadherin is a major homophilic cell-cell adhesion molecule that inhibits motility of individual cells on matrix. However its contribution to migration of cells through cell-rich tissues is less clear. We developed an in vivo sensor of mechanical tension across E-cadherin molecules, which we combined with cell-type-specific RNAi, photo-activatable Rac, and morphodynamic profiling, to interrogate how E-cadherin contributes to collective migration of cells between other cells. Using the Drosophila ovary as a model, we found that adhesion between border cells and their substrate, the nurse cells, functions in a positive feedback loop with Rac and actin assembly to stabilize forward-directed protrusion and directionally persistent movement. Adhesion between individual border cells communicates direction from the lead cell to the followers. Adhesion between motile cells and polar cells holds the cluster together and polarizes each individual cell. Thus, E-cadherin is an integral component of the guidance mechanisms that orchestrate collective chemotaxis in vivo.
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Cites
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Cited by
Mechanobiology of collective cell behaviours
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Metadata
- Authors
- Cai, D., Chen, S.-C., Prasad, M., He, L., Wang, X., Choesmel-Cadamuro, V., Sawyer, J. K., Danuser, G., & Montell, D. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 157
- Issue
- 5
- Pages
- 1146-1159
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2069202441
- Cited by
- 512
- References
- 45
- FWCI
- 25.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cai, D., Chen, S.-C., Prasad, M., He, L., Wang, X., Choesmel-Cadamuro, V., Sawyer, J. K., Danuser, G., & Montell, D. J. (2014). Mechanical Feedback through E-Cadherin Promotes Direction Sensing during Collective Cell Migration. Cell. https://doi.org/10.1016/j.cell.2014.03.045
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