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Cited by 269

The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.

Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man

Open access
Jais, Alexander, Einwallner, Elisa, Sharif, Omar, Gossens, Klaus, Lu, Tess Tsai-Hsiu, Soyal, Selma M., Medgyesi, David, Neureiter, Daniel, Paier-Pourani, Jamile, Dalgaard, Kevin, Duvigneau, J. Catharina, Lindroos-Christensen, Josefine, Zapf, Thea-Christin, Amann, Sabine, Saluzzo, Simona, Jantscher, Florian, Stiedl, Patricia, Todoric, Jelena, Martins, Rui, Oberkofler, Hannes, Müller, Simone, Hauser-Kronberger, Cornelia, Kenner, Lukas, Casanova, Emilio, Sutterlüty-Fall, Hedwig, Bilban, Martin, Miller, Karl, Kozlov, Andrey V., Krempler, Franz, Knapp, Sylvia, Lumeng, Carey N., Patsch, Wolfgang, Wagner, Oswald, Pospisilik, J. Andrew, Esterbauer, Harald·2014·Cell
DOI 10.1016/j.cell.2014.04.043
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Abstract

SUMMARY Obesity and diabetes affect more than half a billion individuals worldwide. Interestingly, the two conditions do not always coincide and the molecular determinants of “healthy” versus “unhealthy” obesity remain ill-defined. Chronic metabolic inflammation (metaflammation) is believed to be pivotal. Here, we tested a hypothesized anti-inflammatory role for heme oxygenase-1 (HO-1) in the development of metabolic disease. Surprisingly, in matched biopsies from “healthy” versus insulin-resistant obese subjects we find HO-1 to be among the strongest positive predictors of metabolic disease in humans. We find that hepatocyte and macrophage conditional HO-1 deletion in mice evokes resistance to diet-induced insulin resistance and inflammation, dramatically reducing secondary disease such as steatosis and liver toxicity. Intriguingly, cellular assays show that HO-1 defines prestimulation thresholds for inflammatory skewing and NF-κB amplification in macrophages and for insulin signaling in hepatocytes. These findings identify HO-1 inhibition as a potential therapeutic strategy for metabolic disease.

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Metadata

Authors
Jais, A., Einwallner, E., Sharif, O., Gossens, K., Lu, T. T.-H., Soyal, S. M., Medgyesi, D., Neureiter, D., Paier-Pourani, J., Dalgaard, K., Duvigneau, J. C., Lindroos-Christensen, J., Zapf, T.-C., Amann, S., Saluzzo, S., Jantscher, F., Stiedl, P., Todoric, J., Martins, R., Oberkofler, H., Müller, S., Hauser-Kronberger, C., Kenner, L., Casanova, E., Sutterlüty-Fall, H., Bilban, M., Miller, K., Kozlov, A. V., Krempler, F., Knapp, S., Lumeng, C. N., Patsch, W., Wagner, O., Pospisilik, J. A., & Esterbauer, H.
Venue
Cell
Publisher
Elsevier BV
Published
2014-07
Volume
158
Issue
1
Pages
25-40
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2014.04.043
OpenAlex
W2009521826
Cited by
269
References
80
FWCI
12.78
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man. https://app.cochat.ai/papers/10.1016/j.cell.2014.04.043
The paper
Jais, A., Einwallner, E., Sharif, O., Gossens, K., Lu, T. T.-H., Soyal, S. M., Medgyesi, D., Neureiter, D., Paier-Pourani, J., Dalgaard, K., Duvigneau, J. C., Lindroos-Christensen, J., Zapf, T.-C., Amann, S., Saluzzo, S., Jantscher, F., Stiedl, P., Todoric, J., Martins, R., . . . Esterbauer, H. (2014). Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man. Cell. https://doi.org/10.1016/j.cell.2014.04.043

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.