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Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity
Open accessAbstract
Adipose tissue hypoxia and inflammation have been causally implicated in obesity-induced insulin resistance. Here, we report that, early in the course of high-fat diet (HFD) feeding and obesity, adipocyte respiration becomes uncoupled, leading to increased oxygen consumption and a state of relative adipocyte hypoxia. These events are sufficient to trigger HIF-1α induction, setting off the chronic adipose tissue inflammatory response characteristic of obesity. At the molecular level, these events involve saturated fatty acid stimulation of the adenine nucleotide translocase 2 (ANT2), an inner mitochondrial membrane protein, which leads to the uncoupled respiratory state. Genetic or pharmacologic inhibition of either ANT2 or HIF-1α can prevent or reverse these pathophysiologic events, restoring a state of insulin sensitivity and glucose tolerance. These results reveal the sequential series of events in obesity-induced inflammation and insulin resistance.
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“In insulin responsive tissues, sustained HIF-1 activation promotes a shift toward glycolytic metabolism, alters mitochondrial function, and contributes to insulin resistance by disrupting normal oxidative metabolism and redox balance [236,237].”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [236]
Experimental — accuracy not yet measuredIn the citing paper
“Adipocytes respond by inducing glycolysis and angiogenesis in an attempt to alleviate the hypoxia (3).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [3]
In the citing paper
“For example, VEGF is upregulated in AT of mice fed a HFD for three days, but there are reports of both enhanced and reduced VEGF expression in chronic obesity (3,13,43,44), suggesting that sprouting angiogenesis is activated early and may or may not persist.”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [3]
In the citing paper
“In contrast, HIF-2α attenuates HFD-induced inflammation (3).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [3]
In the citing paper
“Within three days of HFF, rapid adipocyte hypertrophy along with mitochondrial uncoupling increase the demand for oxygen and reduce oxygen availability (3).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [3]
In the citing paper
“Although HIF-1α and HIF-2α pathways can interact, HIF-1α signaling dominates in obesity, playing a causative role in early AT dysfunction (3).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [3]
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Cites
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693
Self-citationAdipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
Hosogai, N., Fukuhara, A., Oshima, K., Miyata, Y., Tanaka, S., Segawa, K., Furukawa, S., Tochino, Y., Komuro, R., Matsuda, M., et al. (2007) · Diabetes · doi:10.2337/db06-0911 · Cited by 1,257 · cited 1×
“, 2009), and recent evidence suggests that this can cause adipose tissue dysfunction in obesity (Hosogai et al., 2007).”
Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism
Cao, H., Gerhold, K. A., Mayers, J. R., Wiest, M. M., Watkins, S. M., & Hotamışlıgil, G. S. (2008) · Cell · doi:10.1016/j.cell.2008.07.048 · Cited by 1,174
Self-citationHe, W., Barak, Y., Hevener, A. L., Olson, P., Liao, D., Le, J., Nelson, M. C., Ong, E. S., Olefsky, J. M., & Evans, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536828100 · Cited by 978
Self-citationInflammation and Lipid Signaling in the Etiology of Insulin Resistance
Glass, C. K., & Olefsky, J. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.001 · Cited by 956
Self-citationSplanchnic lipolysis in human obesity
Nielsen, S., Guo, Z., Johnson, C. M., Hensrud, D. D., & Jensen, M. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21047 · Cited by 933
Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue
Halberg, N., Khan, T., Trujillo, M. E., Wernstedt-Asterholm, I., Attie, A. D., Sherwani, S., Wang, Z. V., Landskroner-Eiger, S., Dineen, S., Magalang, U. J., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00192-09 · Cited by 896
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 593
Immunometabolism in obesity: Understanding the beneficial and detrimental roles of inflammation
Lee, Y. S. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003620 · Cited by 11
Self-citationRegulatory T cells in cancer and inflammation
Yang, H., Zhang, H., Xia, N., & Cheng, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02584-w · Cited by 8
Das, S. S., Kar, A., Rajkumar, S., Lee, S. H., Alvarez, M., Pietiläinen, K. H., & Pajukanta, P. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319358 · Cited by 8
Xu, T., He, P., namWangdu, S., Xu, C., Hou, B., Ma, P., Wang, Z., Zhang, L., Du, G., ring, T., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117254 · Cited by 8
Rapid downregulation of DICER is a hallmark of adipose tissue upon high-fat diet feeding
Madsen, S., Peluso, A. A., Yonamine, C. Y., Ingerslev, L. R., Dall, M., Petersen, P. S. S., Plucińska, K., Pradas-Juni, M., Moreno‐Justicia, R., González-Franquesa, A., et al. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112413 · Cited by 8
Folie, S., Radlinger, B., Goebel, G., Salzmann, K., Staudacher, G., Ress, C., Tilg, H., & Kaser, S. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108837 · Cited by 9
Role of Epicardial Adipose Tissue in Triggering and Maintaining Atrial Fibrillation
Wang, W., Tian, Y., Wang, W., Yin, H., Yin, D., & Tian, Y. (2022) · Cardiovascular Innovations and Applications · doi:10.15212/cvia.2022.0012 · Cited by 8
Distinct hypoxic regulation of preadipocyte factor-1 (Pref-1) in preadipocytes and mature adipocytes
Moon, Y., Lee, S., Park, B., & Park, H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.11.008 · Cited by 8
Qin, T., He, Z., Hassan, H. M., Wang, Q., Shi, L., Yu, Y., Zhou, Y., Zhang, W., & Yuan, Z. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156219 · Cited by 7
Liu, J., Jiang, Y., Liu, T., Chen, C., Chui, L., Cui, A., Zhang, X., Wang, X., Wang, Y., Yang, C., et al. (2025) · BMC Biology · doi:10.1186/s12915-025-02211-0 · Cited by 9
Cascaded diffusion-driven self-reinforced adhesive hydrogels for hydrophobic tissue closure
Xie, W., Tian, Z., Xue, R., Duan, X., Yuan, Z., Wan, Z., Su, X., Feng, Y., Jiang, Y., Wang, H., et al. (2025) · Composites Part B Engineering · doi:10.1016/j.compositesb.2025.112580 · Cited by 8
Kaur, S., Ghosh, A., J, S., Kaur, G., Singh, G., Pandey, P., Kumar, A., Seem, K., Bhardwaj, R., & Riar, A. (2025) · Food Chemistry Advances · doi:10.1016/j.focha.2025.101066 · Cited by 7
Impact of intestinal microenvironments in obesity and bariatric surgery on shaping macrophages
Leyderman, M., Wilmore, J. R., Shope, T. R., Cooney, R. N., & Urao, N. (2023) · Immunometabolism · doi:10.1097/in9.0000000000000033 · Cited by 8
Liu, D., Wang, T., Zhao, X., Chen, J., Yang, T., Shen, Y., & Zhou, Y. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231219115 · Cited by 7
Ding, F., Zheng, P., Fang, H., Luo, Y., Yan, X., Chen, H., & Yan, Y. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1742 · Cited by 7
Komanetsky, S. M., Hedrick, V., Sobreira, T. J. P., Aryal, U. K., Kim, S. Q., & Kim, K. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.06.009 · Cited by 7
Zhang, P., Li, L., Sun, H., Zhang, Y., Zhang, G., Zhang, T., & Zeng, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.575695 · Cited by 7
Cellular and Molecular Players in the Interplay between Adipose Tissue and Breast Cancer
Reggiani, F., Falvo, P., & Bertolini, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031359 · Cited by 7
Future Directions in Research in Transcriptomics in the Healing of Diabetic Foot Ulcers
Sumpio, B. J., Li, Z., Wang, E., Mezghani, I., Theocharidis, G., & Veves, A. (2022) · Advances in Therapy · doi:10.1007/s12325-022-02348-2 · Cited by 7
Cimini, F. A., Barchetta, I., Ceccarelli, V., Chiappetta, C., Biasio, A., Bertoccini, L., Sentinelli, F., Leonetti, F., Silecchia, G., Cristofano, C. D., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.589188 · Cited by 7
The hypoxia response and nutritional peptides
Kietzmann, T., & Mäkelä, V. H. (2021) · Peptides · doi:10.1016/j.peptides.2021.170507 · Cited by 8
Lee, M., Hwang, J., Park, S. E., Jung, S., & Jo, K. J. (2022) · Journal of Korean Medical Science · doi:10.3346/jkms.2022.37.e246 · Cited by 7
Hypoxia-inducible factors: new strategies for treatment of obesity-induced metabolic diseases
Choe, S. S., & Kim, J. B. (2020) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2019-136428 · Cited by 7
Self-citationAlzubi, A., & Monk, J. M. (2024) · Biomedicines · doi:10.3390/biomedicines12112621 · Cited by 6
Liao, Y., Wang, M., Qin, F., Liu, C., & Chen, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1571480 · Cited by 6
Fatty acids promote uncoupled respiration via ATP/ADP carriers in white adipocytes
Ahmadian, M., Aksu, A. M., Dhillon, P., Zerbel, Z. J., Kelemen, Y., Gbayisomore, O., Gómez-Banoy, N., Chen, S. J., & Reilly, S. M. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01467-2 · Cited by 7
Sharma, P., Victoria, V. S. S., Kumar, P. P., Karmakar, S., Swetha, M., & Reddy, A. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110472 · Cited by 6
Pan, T., Yang, B., Yao, S., Wang, R., & Zhu, Y. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122802 · Cited by 5
Seki, M., Miwa, A., Ohsaka, F., Karatsu, Y., Tsuruta, T., Hino, S., Morita, T., & Sonoyama, K. (2022) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2021-061 · Cited by 6
IRE1α: from the function to the potential therapeutic target in atherosclerosis
Zhou, Z., Wu, L., Liu, Y., Tang, M.-Y., Tang, J., Deng, Y.-Q., Liu, L., Nie, B.-B., Zou, Z.-K., & Huang, L. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04780-6 · Cited by 6
Khoo, J. J. C., Hagemeyer, C. E., Henstridge, D. C., Kumble, S., Wang, T., Xu, R., Gani, L. U., King, T., Soh, S.-B., Puar, T. H. K., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0254619 · Cited by 6
Ishizu, T., Eichin, D., Padzik, A., Tuominen, S., Grenman, R. A., Salmi, M., Grönroos, T. J., & Tuomela, J. M. (2021) · BMC Cancer · doi:10.1186/s12885-021-08357-8 · Cited by 6
YANG, C.-Q., XU, J.-H., YAN, D.-D., LIU, B.-L., LIU, K., & HUANG, F. (2017) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(17)30095-x · Cited by 14
HIF-1α Regulates the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease
Liu, Q., Liu, H., Yi, Z., Yang, Z., & Wen, S. (2025) · Digestion · doi:10.1159/000548503 · Cited by 5
Myricetin attenuates hypoxia-induced inflammation in human adipocytes
Geiger, K. D., Muendlein, A., Leiherer, A., Gaenger, S., Brandtner, E. M., Wabitsch, M., Fraunberger, P., Drexel, H., & Heinzle, C. F. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08865-9 · Cited by 5
Zhu, C., Huang, Z., Zhou, H., Han, X., Li, L., & Yin, N. (2025) · Biofabrication · doi:10.1088/1758-5090/adb2e7 · Cited by 7
The interplay between circadian rhythms and aging: molecular mechanisms and therapeutic strategies
Dhaka, P., Neha, N., Kumar, R., Hossain, C. M., & Parvez, S. (2025) · Biogerontology · doi:10.1007/s10522-025-10301-3 · Cited by 6
Wang, F., Liu, Y., Li, Y., Xu, Y., Zhao, J., Yang, B., Tang, D., Zhang, C., He, Z., Ming, D., et al. (2024) · Environmental Toxicology · doi:10.1002/tox.24382 · Cited by 5
Huang, C., Wang, C.-H., Yeh, H., Tsai, H., Yang, C.-W., Li, T., Su, C., Yang, Y., Lin, H., & Hou, M. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.10.006 · Cited by 5
Shi, H., Li, Y., Ji, W., Lin, Z., Cai, W., Chen, T., Yuan, B., Niu, X., Li, H., Shu, W., et al. (2018) · Obesity · doi:10.1002/oby.22191 · Cited by 5
Remodeling of white adipose tissue microenvironment against obesity by phytochemicals
Ke, S., Hu, Q., Zhu, G., Li, L., Sun, X., Cheng, H., Li, L., Yao, Y., & Li, H. (2023) · Phytotherapy Research · doi:10.1002/ptr.7758 · Cited by 5
Borel, A., Tamisier, R., Böhme, P., Priou, P., Avignon, A., Benhamou, P., Hanaire, H. P., Pépin, J., Kessler, L., Valensi, P. E., et al. (2018) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(18)30110-x · Cited by 5
Borel, A., Tamisier, R., Böhme, P., Priou, P., Avignon, A., Benhamou, P., Hanaire, H. P., Pépin, J., Kessler, L., Valensi, P. E., et al. (2018) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2018.10.001 · Cited by 6
Expression of human and mouse adenine nucleotide translocase (ANT) isoform genes in adipogenesis
Gavaldà‐Navarro, A., Domingo, P., Viñas, O., & Mampel, T. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.03.015 · Cited by 5
Kim, E. R., Fan, S., Akhmedov, D., Sun, K., Lim, H., O'Brien, W. G., Xu, Y., Mangieri, L. R., Zhu, Y., Lee, C.-C., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.93367 · Cited by 5
Data on biochemical indexes of HFD-fed mice treatment with metformin or resveratrol
Zhao, W., Li, A., Feng, X., Hou, T., Liu, K., Liu, B., & Zhang, N. (2016) · Data in Brief · doi:10.1016/j.dib.2016.07.049 · Cited by 5
Runthala, A., Vulichi, S. R., Kosanam, S., Pasupula, R., Ramakrishna, K., Sutradhar, M., & Narayan, K. P. (2025) · Scientific Reports · doi:10.1038/s41598-025-95439-3 · Cited by 4
Hypoxia-inducible factors link inflammation and lipid metabolism in atherosclerotic macrophages
Park, K. S., Ko, Y. J., & Choi, J.-H. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1765661 · Cited by 5
Reytor-González, C., Sarno, G., Montalván, M., Verde, L., Annunziata, G., Barrea, L., Muscogiuri, G., & Simancas‐Racines, D. (2026) · Nutrients · doi:10.3390/nu18040685 · Cited by 4
Destabilization of HIF-1a by Diabetes, Oxidative Stress, Obesity and Other Related Disorders
Karavasilis, A., Καρκαλούσος, Π., Trapali, M., Fountzoula, C., & Karikas, G. A. (2023) · Journal of Diabetes Mellitus · doi:10.4236/jdm.2023.132012 · Cited by 4
Feng, T., & Ou, Q. (2024) · Sleep research. · doi:10.1002/slp2.10 · Cited by 4
Park, D., An, C., & Yu, J. (2024) · La radiologia medica · doi:10.1007/s11547-024-01888-7 · Cited by 4
Zafar, U. (2020) · Springer eBooks · doi:10.1007/978-3-030-53370-0_23 · Cited by 4
Milenković, J., Djordjevic, B., Stojanović, D. R., Dunjić, O., & Petrovski, V. (2022) · Acta Medica Medianae · doi:10.5633/amm.2022.0208 · Cited by 4
The Heterogeneity of White Adipose Tissue
Luong, Q. V., & Lee, K. Y. (2018) · InTech eBooks · doi:10.5772/intechopen.76898 · Cited by 5
Reduced oxygen consumption by fat cells improves metabolic defects
Joffin, N., & Scherer, P. E. (2018) · Nature · doi:10.1038/d41586-018-07248-6 · Cited by 4
Anti-inflammatory and Anti-infectious Dietary Paradigms May Be Crucial for Visceral Weight Reduction
Chen, D., Zhang, M.-L., Shi, Z., Li, C., Wang, Q., Song, J., Xu, Q., Li, H., & Zeng, Q.-P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00422 · Cited by 4
Kumar, V., & Kumar, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89779-2.00011-9 · Cited by 4
A Chronic Inflammatory Inductive Condition in the Nursing Profession: A Scoping Review
Vitale, E. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220516163936 · Cited by 4
Albanna, A., Ibrahim, D. A., Shamsher, A., Al-Shawia, M. A. A., & Halboup, A. M. (2025) · Journal of Experimental Pharmacology · doi:10.2147/jep.s522053 · Cited by 3
CCL26 and CXCL12 preserve insulin-sensitizing macrophages in subcutaneous adipose tissue in obesity
Jeelani, I., da Cunha, F. F., Rohm, T. V., Nasamran, C. A., Wang, L., Moon, J.-S., Prakash, S., Oswari, J., Isaac, R., Murphy, C., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116450 · Cited by 3
Self-citationElian, V., Popovici, V., Nicolescu, M. I., Nicolescu, A. M., Aurelian, S. M., & Ozon, E. A. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47110929 · Cited by 3
Morawitz, K. H., & Gross, J. C. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1804905 · Cited by 3
Yang, C., Xu, Z., He, S.-T., Zheng, G.-J., Wang, J., Zang, F., Hu, J.-Q., Wang, Y., Zhang, W.-Y., Gao, C.-F., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01124-z · Cited by 3
Teng, Y., Bian, W., Li, Q., Eyk, J. E. V., Yan, X., & Zhang, S. Y. (2026) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2026-0043 · Cited by 3
2,4-Dinitrophenol Downregulates Genes for Diabetes and Fatty Liver in Obese Mice
Gao, Q., Jiang, H., Liao, T., & Zeng, Q.-P. (2015) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2015.39007 · Cited by 3
Zhou, N., Zheng, W., Peng, L., Gao, S., Shi, Y., Cao, M., Xu, Y., Sun, B., & Li, X. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad710 · Cited by 4
Depot-Biased ROS: A Middleman in Adipose-Driven Cardiovascular Disease
Bakkar, N. Z., Osman, S. T., AlZaim, I., & EL‐Yazbi, A. F. (2024) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-031-62131-4_3 · Cited by 3
Huang, Y., Zeng, M., Yang, M., Zheng, X., Jin, L., Zhang, R., Wu, Y., Li, F., Yang, B., & Liu, J. (2025) · Journal of Diabetes · doi:10.1111/1753-0407.70125 · Cited by 3
Liu, M., Li, H., Zhang, J., Zhong, Y., Huang, C., Zhu, L., Hu, Z., Xu, Y.-J., Zhao, S., & Pan, W. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70892 · Cited by 3
Narenmandula, N., Hongmei, Ding, X., Li, K., Hashentuya, Yang, D., Wendurige, Yang, R. X., Dandan, Y., Tana, et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.863532 · Cited by 3
Zheng, X., Ma, J., Hu, M., Long, J., Wei, Q., & Ren, W. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.986567 · Cited by 3
Zhang, F., Aquino, G. V., Dabi, A., Nugent, W. H., Song, B. K., & Bruce, E. D. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.12.034 · Cited by 3
HIF inhibition: Current strategies and clinical challenges
Więch-Walów, A., Bartoszewska, S., Barton, A., Czechowicz, P., Dudzik, J., Wielockx, B., Collawn, J. F., & Bartoszewski, R. (2026) · Redox biology · doi:10.1016/j.redox.2026.104220 · Cited by 3
“In insulin responsive tissues, sustained HIF-1 activation promotes a shift toward glycolytic metabolism, alters mitochondrial function, and contributes to insulin resistance by disrupting normal oxidative metabolism and redox balance [236,237].”
Inhibition of the mTORC1 pathway alleviates adipose tissue fibrosis
Gong, S., Li, C., Leng, Q., Liu, C., Zhu, Y., Zhang, H., & Li, X. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e21526 · Cited by 2
Cui, Y., Yang, K., Guo, C., Xia, Z., Jiang, B., Xue, Y., Song, B., Hu, W., Zhang, M., Wei, Y., et al. (2024) · Nitric Oxide · doi:10.1016/j.niox.2024.10.001 · Cited by 2
Zarychta, J., Kowalczyk, A., Słowik, K., Przywara, D., Petniak, A., Kondracka, A., Wójtowicz‐Marzec, M., Słyk-Gulewska, P., Kwaśniewska, A., Kocki, J., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011042 · Cited by 2
Chronic inflammation in case of obesity-associated diseases
Kim, O. T., Дадаева, В. А., NURULLINA, G. I., & Drapkina, O. M. (2025) · Russian Journal of Preventive Medicine · doi:10.17116/profmed202528011115 · Cited by 2
Ultrasound Responsive Nanotherapeutics for Multimodal Reprogramming of Obese Fat
Zheng, L., Leoi, M. W. N., Than, A., Leow, M. K., Shabbir, A., Li, D., & Chen, P. (2025) · ACS Nano Medicine · doi:10.1021/acsnanomed.5c00047 · Cited by 2
Hydrogen Sulfide in Adipose Tissue Biology
Katsouda, A., & Papapetropoulos, A. (2025) · Handbook of experimental pharmacology · doi:10.1007/164_2025_759 · Cited by 2
Cheng, C., Chen, J., Wu, Y., Song, Y., Xu, J., Xu, Y., & Zheng, L. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157902 · Cited by 2
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Self-citationGao, C., Yin, J., Hu, T., Liu, S., Zhao, X., Ding, H., Lin, X., & Fang, L. (2023) · Clinical Cardiology · doi:10.1002/clc.24151 · Cited by 1
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Yang, X., Wang, Q., Nie, H., Wang, M., Wang, Y., Li, S., Liu, Q., & Liu, G. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2568972 · Cited by 1
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Metadata
- Authors
- Lee, Y. S., Kim, J.-W., Osborne, O., Oh, D. Y., Sasik, R., Schenk, S., Chen, A., Chung, H., Murphy, A., Watkins, S. M., Quehenberger, O., Johnson, R. S., & Olefsky, J. M.
- Affiliations
- University of California San Diego (US)
- University of Cambridge (GB)
- Corresponding author
- Johnson, Randall S.
- Olefsky, Jerrold M.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 157
- Issue
- 6
- Pages
- 1339-1352
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4114226
- OpenAlex
- W2023289992
- Cited by
- 598
- References
- 51
- Citations by year
- 2026: 45 · 2025: 51 · 2024: 59 · 2023: 64 · 2022: 65 · 2021: 70 · 2020: 57 · 2019: 37 · 2018: 39 · 2017: 39 · 2016: 34 · 2015: 27 · 2014: 11
- FWCI
- 27.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging
- Wellcome Trust
- National Institutes of Health (DK-074868, P01-DK054441, DK-063491, DK-033651)
- National Institute of Child Health and Human Development (R01AG043120, R24HD050837)
- American Diabetes Association
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- HIF-1α, adipose tissue hypoxia, adipose tissue inflammation, insulin resistance, obesity, high-fat diet, uncoupled respiration, ANT2, saturated fatty acids, mitochondrial respiration, glucose tolerance
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Animals, Fatty Acids, Inflammation, Insulin Resistance, Nitric Oxide, Obesity, Oxygen, Cell Hypoxia, Adipocytes, Mice, Knockout, Lactic Acid, Adenine Nucleotide Translocator 2, Mice, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1, alpha Subunit, Diet, High-Fat
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