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The Histone Variant H2A.W Defines Heterochromatin and Promotes Chromatin Condensation in Arabidopsis
Open accessAbstract
Summary Histone variants play crucial roles in gene expression, genome integrity and chromosome segregation. However, to what extent histone variants control chromatin architecture remains largely unknown. We report genome-wide profiles of all four types of H2A variants in Arabidopsis and identify that the previously uncharacterized histone variant H2A.W specifically associates with heterochromatin. Genetic analyses show that H2A.W acts in synergy with the heterochromatic marks H3K9me2 and DNA methylation to maintain genome integrity. In vitro, H2A.W enhances chromatin condensation through a higher propensity to promote fiber-to-fiber interactions via its conserved C-terminal motif. In vivo, elimination of H2A.W causes decondensation of heterochromatin and conversely, ectopic expression of H2A.W promotes heterochromatin condensation. These results demonstrate that H2A.W plays critical roles in heterochromatin by promoting higher order chromatin condensation. Since motifs similar to the H2A.W C-terminal motif are present in other histone variants in other organisms, our findings impact our understanding of heterochromatin condensation in eukaryotes.
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Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Crystal structure of the nucleosome core particle at 2.8 Å resolution
Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J. (1997) · Nature · doi:10.1038/38444 · Cited by 9,466
Self-citationPhylogeny.fr: robust phylogenetic analysis for the non-specialist
Dereeper, A., Guignon, V., Blanc, G., Audic, S., Buffet, S., Chevenet, F., Dufayard, J.-F., Guindon, S., Lefort, V., Lescot, M., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn180 · Cited by 4,700
Establishing, maintaining and modifying DNA methylation patterns in plants and animals
Law, J. A., & Jacobsen, S. E. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2719 · Cited by 3,850
Self-citationLowary, P. T., & Widom, J. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1494 · Cited by 1,778
Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
Goldberg, A. D., Banaszynski, L. A., Noh, K.-M., Lewis, P. W., Elsaesser, S. J., Stadler, S., Dewell, S., Law, M., Guo, X., Li, X., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.003 · Cited by 1,280
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase
Jackson, J. P., Lindroth, A. M., Cao, X., & Jacobsen, S. E. (2002) · Nature · doi:10.1038/nature731 · Cited by 1,251
Self-citationZemach, A., Kim, M. Y., Hsieh, P.-H., Coleman-Derr, D., Eshed-Williams, L., Thao, K., Harmer, S. L., & Zilberman, D. (2013) · Cell · doi:10.1016/j.cell.2013.02.033 · Cited by 1,180
Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation
Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff, S., & Jacobsen, S. E. (2001) · Science · doi:10.1126/science.1059745 · Cited by 938
Self-citationNon-CG methylation patterns shape the epigenetic landscape in Arabidopsis
Stroud, H., Do, T., Du, J., Zhong, X., Feng, S., Johnson, L., Patel, D. J., & Jacobsen, S. E. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2735 · Cited by 907
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Metadata
- Authors
- Yelagandula, R., Stroud, H., Holec, S., Zhou, K., Feng, S., Zhong, X., Muthurajan, U. M., Nie, X., Kawashima, T., Groth, M., Luger, K., Jacobsen, S. E., & Berger, F.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 158
- Issue
- 1
- Pages
- 98-109
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1983671446
- Cited by
- 335
- References
- 68
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yelagandula, R., Stroud, H., Holec, S., Zhou, K., Feng, S., Zhong, X., Muthurajan, U. M., Nie, X., Kawashima, T., Groth, M., Luger, K., Jacobsen, S. E., & Berger, F. (2014). The Histone Variant H2A.W Defines Heterochromatin and Promotes Chromatin Condensation in Arabidopsis. Cell. https://doi.org/10.1016/j.cell.2014.06.006
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