The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis
Open accessAbstract
DNA methylation occurs in CG and non-CG sequence contexts. Non-CG methylation is abundant in plants and is mediated by CHROMOMETHYLASE (CMT) and DOMAINS REARRANGED METHYLTRANSFERASE (DRM) proteins; however, its roles remain poorly understood. Here we characterize the roles of non-CG methylation in Arabidopsis thaliana. We show that a poorly characterized methyltransferase, CMT2, is a functional methyltransferase in vitro and in vivo. CMT2 preferentially binds histone H3 Lys9 (H3K9) dimethylation and methylates non-CG cytosines that are regulated by H3K9 methylation. We revealed the contributions and redundancies between each non-CG methyltransferase in DNA methylation patterning and in regulating transcription. We also demonstrate extensive dependencies of small-RNA accumulation and H3K9 methylation patterning on non-CG methylation, suggesting self-reinforcing mechanisms between these epigenetic factors. The results suggest that non-CG methylation patterns are critical in shaping the landscapes of histone modification and small noncoding RNA.
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Cites
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
Human DNA methylomes at base resolution show widespread epigenomic differences
Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673
Establishing, maintaining and modifying DNA methylation patterns in plants and animals
Law, J. A., & Jacobsen, S. E. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2719 · Cited by 3,850
Self-citationControl of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase
Jackson, J. P., Lindroth, A. M., Cao, X., & Jacobsen, S. E. (2002) · Nature · doi:10.1038/nature731 · Cited by 1,251
Self-citationReduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis
Meissner, A. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki901 · Cited by 1,217
Zemach, A., Kim, M. Y., Hsieh, P.-H., Coleman-Derr, D., Eshed-Williams, L., Thao, K., Harmer, S. L., & Zilberman, D. (2013) · Cell · doi:10.1016/j.cell.2013.02.033 · Cited by 1,180
Dynamic changes in the human methylome during differentiation
Laurent, L., Wong, E., Li, G., Huynh, T., Tsirigos, A., Ong, C. T., Low, H. M., Kin Sung, K. W., Rigoutsos, I., Loring, J., et al. (2010) · Genome Research · doi:10.1101/gr.101907.109 · Cited by 1,041
Ramsahoye, B. H., Biniszkiewicz, D., Lyko, F., Clark, V., Bird, A. P., & Jaenisch, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5237 · Cited by 970
ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation
Zilberman, D., Cao, X., & Jacobsen, S. E. (2003) · Science · doi:10.1126/science.1079695 · Cited by 885
Self-citationComprehensive Analysis of Silencing Mutants Reveals Complex Regulation of the Arabidopsis Methylome
Stroud, H., Greenberg, M. V. C., Feng, S., Bernatavichute, Y. V., & Jacobsen, S. E. (2013) · Cell · doi:10.1016/j.cell.2012.10.054 · Cited by 873
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Cited by
Transgenerational epigenetic inheritance: myths and mechanisms
Heard, E., & Martienssen, R. A. (2014) · Cell · doi:10.1016/j.cell.2014.02.045 · Cited by 1,864
DNA methylation pathways and their crosstalk with histone methylation
Du, J., Johnson, L. M., Jacobsen, S. E., & Patel, D. J. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4043 · Cited by 1,000
Self-citationWidespread natural variation of DNA methylation within angiosperms
Niederhuth, C. E., Bewick, A. J., Ji, L., Alabady, M. S., Kim, K. D., Li, Q., Rohr, N. A., Rambani, A., Burke, J. M., Udall, J. A., et al. (2016) · Genome Biology · doi:10.1186/s13059-016-1059-0 · Cited by 566
The genetic and epigenetic landscape of the Arabidopsis centromeres
Naish, M., Alonge, M., Wlodzimierz, P., Tock, A. J., Abramson, B. W., Schmücker, A., Mandáková, T., Jamge, B., Lambing, C., Kuo, P., et al. (2021) · Science · doi:10.1126/science.abi7489 · Cited by 458
Gene body DNA methylation in plants
Bewick, A. J., & Schmitz, R. J. (2017) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2016.12.007 · Cited by 409
Metadata
- Authors
- Stroud, H., Do, T., Du, J., Zhong, X., Feng, S., Johnson, L., Patel, D. J., & Jacobsen, S. E.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2013-12-15
- Volume
- 21
- Issue
- 1
- Pages
- 64-72
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2016813268
- Cited by
- 907
- References
- 41
- FWCI
- 18.56
- Type
- journal article
- Language
- en
- Open access
- green
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