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Complementary Sequence-Mediated Exon Circularization
Open accessAbstract
Exon circularization has been identified from many loci in mammals, but the detailed mechanism of its biogenesis has remained elusive. By using genome-wide approaches and circular RNA recapitulation, we demonstrate that exon circularization is dependent on flanking intronic complementary sequences. Such sequences and their distribution exhibit rapid evolutionary changes, showing that exon circularization is evolutionarily dynamic. Strikingly, exon circularization efficiency can be regulated by competition between RNA pairing across flanking introns or within individual introns. Importantly, alternative formation of inverted repeated Alu pairs and the competition between them can lead to alternative circularization, resulting in multiple circular RNA transcripts produced from a single gene. Collectively, exon circularization mediated by complementary sequences in human introns and the potential to generate alternative circularization products extend the complexity of mammalian posttranscriptional regulation.
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“CircRNA is a highly stable single-stranded RNA with a covalently closed loop structure (Fig. 3), including a large category of non-coding RNAs generated by backsplicing in eukaryotic cells.218–220”
From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [218]
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Genome-Wide circRNA Profiling from RNA-seq Data
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The role of circular RNAs in viral infection and related diseases
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eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells
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The Talented LncRNAs: Meshing into Transcriptional Regulatory Networks in Cancer
Segal, D., & Dostie, J. (2023) · Cancers · doi:10.3390/cancers15133433 · Cited by 39
“CircRNAs are produced by a non-canonical AS back-splicing process that occurs mostly at the middle exons of premRNAs [151].”
BackgroundSingle-Molecule Fluorescence In Situ Hybridization (FISH) of Circular RNA CDR1as
Kocks, C., Boltengagen, A., Piwecka, M., Rybak‐Wolf, A., & Rajewsky, N. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7562-4_7 · Cited by 38
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Evidence of Aberrant Immune Response by Endogenous Double‐Stranded RNAs: Attack from Within
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Sekar, S., Cuyugan, L., Adkins, J. R., Geiger, P. A., & Liang, W. S. (2018) · BMC Genomics · doi:10.1186/s12864-018-4670-5 · Cited by 36
“The down-sampled FASTQ files were then run through four different circRNA prediction algorithms—CIRCexplorer (v1.”
MethodInfluentialIdentification, characterization, and functional prediction of circular RNAs in maize
Yang, H., Li, X., Yan, Y., Duan, M., & Xu, J. (2020) · Molecular Genetics and Genomics · doi:10.1007/s00438-019-01638-9 · Cited by 35
The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells
Steen, N. V. D., Lyu, Y., Hitzler, A. K., Becker, A. C., Seiler, J., & Diederichs, S. (2020) · Cancers · doi:10.3390/cancers12051091 · Cited by 37
Circular RNAs in metabolism and metabolic disorders
Zeng, Y.-Z., Zheng, Z., Liu, F., & Yi, G. (2021) · Obesity Reviews · doi:10.1111/obr.13220 · Cited by 40
“As previously mentioned, several circRNAs modulate the activity of their parental gene by regulating the alternative splicing of primary gene transcripts.(117,118) The primary genes of hsa_circ_0017650 and hsa_circ_0136134 are inter-α-trypsin inhibitor heavy chain 5 (ITIH5) and lipoprotein lipase (LPL), respectively.”
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Qi, Y., Han, W., Chen, D., Zhao, J., Bai, L., Huang, F., Dai, Z., Li, G., Chen, C., Zhang, W., et al. (2021) · Theranostics · doi:10.7150/thno.56990 · Cited by 37
Function of Circular RNAs in Fish and Their Potential Application as Biomarkers
Rbbani, G., Nedoluzhko, A., Galindo‐Villegas, J., & Fernandes, J. M. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137119 · Cited by 35
The biogenesis, biological functions and modification of Circular RNAs
Liu, S., Guo, X., Shang, Q. J., & Gao, P. (2023) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2023.104861 · Cited by 37
The dynamic epitranscriptome: A to I editing modulates genetic information
Tajaddod, M., Jantsch, M. F., & Licht, K. (2015) · Chromosoma · doi:10.1007/s00412-015-0526-9 · Cited by 36
“Circular RNAs have been found associated with intronic Alu elements, which can promote the circularization process when flanking circular RNA precursors in an inverted orientation (Jeck et al. 2013; Liang and Wilusz 2014; Zhang et al. 2014).”
BackgroundRole of circular RNAs in cancer therapy resistance
Liu, W., Niu, J., Huo, Y., Zhang, L., Han, L., Zhang, N., & Yang, M. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02254-5 · Cited by 41
“In fact, only the testis-specific circRNA from the sex-determining region Y (Sry) was considered functional (in mouse testes) [22, 23].”
The expression profile and clinical application potential of hsa_circ_0000711 in colorectal cancer
Li, J., Ni, S., Zhou, C., & Ye, M. (2018) · Cancer Management and Research · doi:10.2147/cmar.s172388 · Cited by 35
“However, owing to the development of the next-generation RNA sequencing and bioinformatic analysis, researchers have discovered thousands of circRNAs and numerous studies have shed light on the biogenesis and function of circRNAs.(11,12) Emerging evidence has showed that circRNAs are involved in the progression of tum…”
Wang, M., Hou, J., Müller-McNicoll, M., Chen, W., & Schuman, E. M. (2019) · iScience · doi:10.1016/j.isci.2019.08.058 · Cited by 35
Zhang, P., Gao, K., Liang, Y., Su, F., Wang, F., & Li, Z. (2020) · Talanta · doi:10.1016/j.talanta.2020.121021 · Cited by 36
Genome-Wide Identification of Circular RNAs in Response to Low-Temperature Stress in Tomato Leaves
Yang, X., Liu, Y., Zhang, H., Wang, J., Zinta, G., Xie, S., Zhu, W., & Nie, W. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.591806 · Cited by 36
Circular RNAs: Promising Biomarkers for Age-related Diseases
Pan, Y., Wu, W., & Xiong, X. (2020) · Aging and Disease · doi:10.14336/ad.2020.0309 · Cited by 36
“, Quaking and MBL), or exon skipping [13, 17, 27, 32-34].”
BackgroundBiological roles and potential clinical values of circular RNAs in gastrointestinal malignancies
Tao, X., Shao, Y., Yan, J., Yang, L., Ye, Q., Wang, Q., Lu, R., & Guo, J. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0348 · Cited by 35
Self-citationSuster, I., & Feng, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136765 · Cited by 39
Plasma circRNAs as Biomarkers in Cancer
Zhou, Q., Ju, L., Ji, X., Cao, Y.-L., Shao, J., & Chen, L. (2021) · Cancer Management and Research · doi:10.2147/cmar.s330228 · Cited by 36
Self-citationCircular RNAs in prostate cancer: Biogenesis, biological functions, and clinical significance
Liu, X., Tong, Y., Ding, X., Peng, E., Yang, X., Liu, H., Ye, T., Wang, X., He, Y., Ye, Z., et al. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.10.017 · Cited by 35
Dorostgou, Z., Yadegar, N., Dorostgou, Z., Khorvash, F., & Vakili, O. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25094 · Cited by 35
Viral Circular RNAs and Their Possible Roles in Virus-Host Interaction
Zhang, X., Liang, Z., Wang, C., Shen, Z., Sun, S., Gong, C., & Hu, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.939768 · Cited by 35
Self-citationKhan, S. U., Khan, M. U., Khan, M. I., Fadahunsi, A. A., Khan, A. U., Gao, S., Bilal, M., & Li, F. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.085 · Cited by 35
Saleem, A., Khan, M. U., Zahid, T., Khurram, I., Ghani, M. U., Ullah, I., Munir, R., Călina, D. C., & Sharifi‐Rad, J. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09211-3 · Cited by 34
“In order to ensure that the acceptor and donor splice regions identified are compatible with canonical splice regions from specific gene annotation, the mapping sites of these reads are modified and realigned as required [32, 106, 107].”
Filippenkov, I. B., Sudarkina, O. Y., Limborska, S. A., & Dergunova, L. V. (2015) · RNA Biology · doi:10.1080/15476286.2015.1076611 · Cited by 34
“In this process, Alu repeats can play the role of repeated sequences.(12,24,27,28) Using ZKSCAN1, H1PK3 and EPHB4 as examples, it was discovered that the removal of Alu elements in flanking introns interrupted exon circularization.”
BackgroundMaternal Plasma DNA and RNA Sequencing for Prenatal Testing
Tamminga, S., van Maarle, M. C., Henneman, L., Oudejans, C. B. M., Cornel, M. C., & Sistermans, E. A. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2015.12.004 · Cited by 33
Circular RNAs roll into the regulatory network of plants
Li, Q., Zhang, Y., Chen, Y., & Yu, Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.061 · Cited by 35
Self-citationCircular RNAs and exosomes in cancer: a mysterious connection
Hou, J., Jiang, W., Zhu, L., Zhong, S., Zhang, H., Li, J., Zhou, S., Yang, S., He, Y., Wang, D., et al. (2018) · Clinical & Translational Oncology · doi:10.1007/s12094-018-1839-y · Cited by 34
Zeng, R., Zhou, J., Hu, C., & Zhang, J.-Z. (2018) · Planta · doi:10.1007/s00425-018-2857-2 · Cited by 33
“More recently, it has been shown that flanking intronic complementary sequences could lead to exon circularization in humans (Zhang et al. 2014).”
BackgroundIdentification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis
Xu, X., Jia, S., Dai, Y., Zhang, J., Li, X., Shi, J., Leng, J., & Lang, J. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.226070 · Cited by 34
CircRNAFisher: a systematic computational approach for de novo circular RNA identification
Jia, G., Wang, D.-L., Xue, M., Liu, Y., Pei, Y., Yang, Y., Xu, J.-M., Liang, Y., & Wang, P. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0063-1 · Cited by 34
Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets
Kaur, S., Mirza, A. H., & Pociot, F. (2018) · Non-Coding RNA · doi:10.3390/ncrna4040038 · Cited by 34
“A two-step mapping strategy was used as previously described [78] to identify circRNAs.”
BackgroundMethodCircular RNA expression profile in peripheral blood mononuclear cells from Crohn disease patients
Yin, J. J., Hu, T., Xu, L., Li, P., Li, M., Ye, Y., & Pang, Z. (2019) · Medicine · doi:10.1097/md.0000000000016072 · Cited by 33
Cocaine induces differential circular RNA expression in striatum
Bu, Q., Long, H., Shao, X., Gu, H., Kong, J., Luo, L., Liu, B., Guo, W., Wang, H., Tian, J., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0527-1 · Cited by 34
Self-citationWang, L., Zong, Z., Liu, Y., Guan, X., Chen, S., & Zhao, Y. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14736 · Cited by 34
Role of Circular RNAs in Cardiovascular Disease
Kishore, R., Garikipati, V. N. S., & González, C. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000841 · Cited by 35
Huang, L., Rong, Y., Tang, X., Yi, K., Wu, J., & Wang, F. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.625722 · Cited by 34
Garlapati, P., Ling, J., Chiao, P. J., & Fu, J. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02017-4 · Cited by 34
“The biogenesis of circRNAs is known to be highly regulated by intronic complementary sequences and splicing factors [2].”
BackgroundChen, F., Guo, L., Di, J., Li, M., Dong, D., & Pei, D. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.07.017 · Cited by 34
Du, Y., Liu, X., Zhang, S., Chen, S., Guan, X., Li, Q., Chen, X., & Zhao, Y. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00857-3 · Cited by 34
Screening circular RNAs with functional potential using the RfxCas13d/BSJ-gRNA system
Li, S., Wu, H., & Chen, L. (2022) · Nature Protocols · doi:10.1038/s41596-022-00715-5 · Cited by 33
“First PCR product 5 μl 15 μl 10 μM CRISPRi-seq-F2-(1-12) primer 2.”
MethodInfluentialSelf-citationCircRNA-miRNA-VEGFA: an important pathway to regulate cancer pathogenesis
Zhang, L., Zhang, Y., Li, X., Gao, H., Chen, X., & Li, P. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1049742 · Cited by 34
Self-citationRNA ‐based approaches for body fluid identification in forensic science
Lynch, C. R. H., & Fleming, R. I. (2020) · Wiley Interdisciplinary Reviews Forensic Science · doi:10.1002/wfs2.1407 · Cited by 36
Li, M., Sun, D., Song, N., Chen, X., Zhang, X., Zheng, W., Yu, Y., & Han, C. (2023) · Oncology Reports · doi:10.3892/or.2023.8599 · Cited by 42
“Functionally, they can play multiple roles in regulating alternative splicing and miRNA expression (68,69).”
BackgroundSelf-citationcircRNA-SFMBT2 orchestrates ERα activation to drive tamoxifen resistance in breast cancer cells
Li, Z., Li, Y., Han, D., Wang, X., Li, C., Chen, T., Li, W., Liang, Y., Luo, D., Chen, B., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06006-5 · Cited by 33
“Importantly, numerous unique circRNAs may be produced from a single gene, resulting in a far greater number of circRNAs than protein-coding genes in human cells [20].”
Advanced approaches of the use of circRNAs as a replacement for cancer therapy
Faraj, G. S. H., Hussen, B. M., Abdullah, S. R., Rasul, M. F., Hajiesmaeili, Y., Baniahmad, A., & Taheri, M. N. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.03.012 · Cited by 33
“In contrast, tumor-suppressing circRNAs may be expressed ectopically utilizing expression vectors with lengthy reverse complementary sequences that allow the enhanced sequence to circulate [161].”
BackgroundZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR
Li, Q., Yang, G., Ren, B., Liu, X., Tang, L., Shi, Q., Shan, G., & Wang, X. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.10.001 · Cited by 34
Zhang, P., Xu, H., Li, R., Wu, W., Chao, Z., Li, C., Xia, W., Wang, L., Yang, J., & Xu, Y. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.04.016 · Cited by 33
How RNA structure dictates the usage of a critical exon of spinal muscular atrophy gene
Singh, N. N., & Singh, R. N. (2019) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.07.004 · Cited by 31
“Presence of inverted Alu repeats results in formation of double stranded structures that are conducive for the generation of circRNAs through backsplicing [81,82].”
BackgroundCapelari, É. F., da Fonseca, G. C., Guzmán, F., & Margis, R. (2019) · Plants · doi:10.3390/plants8090302 · Cited by 34
“circRNAs have been implicated in: (i) regulation of RNA processing [22,38], (ii) transcription regulation [39], (iii) interaction with RNA binding proteins and ribonucleoproteins complexes [40,41], and (iv) acting as microRNA sponges, preventing miRNAs to bind their target mRNAs [12].”
BackgroundPotential diagnostic and therapeutic value of circular RNAs in cardiovascular diseases
Sun, J., Shi, Y., Cai, X., & Liu, J. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109604 · Cited by 33
Non-Coding RNAs: Novel Players in Insulin Resistance and Related Diseases
Formichi, C., Nigi, L., Grieco, G. E., Maccora, C., Fignani, D., Brusco, N., Licata, G., Sebastiani, G., & Dotta, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147716 · Cited by 34
“Circular RNAs CircRNAs are defined as covalently closed RNAs lacking of 3′ polyadenylation [83], highly conserved among species, firstly identified in yeast and in viruses [84,85].”
BackgroundCircular RNA repertoires are associated with evolutionarily young transposable elements
Gruhl, F., Janich, P., Kaessmann, H., & Gatfield, D. (2021) · eLife · doi:10.7554/elife.67991 · Cited by 32
“As pointed out above, TEs are relevant for circRNA formation because they can provide RVCs for the intramolecular base-pairing of nascent RNA molecules (Ivanov et al., 2015; Jeck et al., 2013; Zhang et al., 2014; Wilusz, 2015; Liang and Wilusz, 2014).”
BackgroundInfluentialTian, W., Zhang, B., Zhong, H., Nie, R., Ling, Y., Zhang, H., & Wu, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.761638 · Cited by 35
“Our study revealed that circRNAs shared a maximum number of two exons, following three exons, in chicken abdominal adipocytes, in agreement with a previous report which showed that most circRNAs comprised several exons, usually two or three (Zhang et al., 2014).”
ResultWu, Y., Xu, M., Feng, Z., Wu, H., Wu, J., Ha, X., Wu, Y., Chen, S., Xu, F., Wen, H., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04906-5 · Cited by 33
“To obtain reliable circRNA candidates, four different algorithms were employed to identify circRNAs, including find_circ [17], circRNA_finder [18], CIRI2 [19], and CIRCexplorer2 [20].”
MethodLuminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis
Tarrero, L. C., Ferrero, G., Miano, V., Intinis, C. D., Ricci, L., Arigoni, M., Riccardo, F., Annaratone, L., Castellano, I., Calogero, R., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24522 · Cited by 34
Zhang, L., Gao, H., Li, X., Yu, F., & Li, P. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5607 · Cited by 33
“There are three types of circRNAs produced by backs‑ plicing: i) Exonic circRNAs (ecRNAs) (33), ii) exon‑intron circRNAs (EIciRNAs) (34) and iii) circular intronic RNAs (ciRNAs) (33).”
BackgroundCao, S.-M., Wu, H., Yuan, G.-H., Pan, Y.-H., Zhang, J., Liu, Y.-X., Li, S., Xu, Y.-F., Wei, M.-Y., Yang, L. C., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.05.011 · Cited by 33
Self-citationVidal, A. F., Ribeiro-dos-Santos, A. M., Vinasco‐Sandoval, T., de Magalhães, L. L., Pinto, P., Anaissi, A. K. M., Demachki, S., de Assumpção, P. P., dos Santos, S. E. B., & Ribeiro‐dos‐Santos, Â. (2017) · Scientific Reports · doi:10.1038/s41598-017-15061-w · Cited by 32
Circular RNAs in Cardiovascular Diseases
Wang, L., Meng, X., Li, G., Zhou, Q., & Xiao, J. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_15 · Cited by 32
Dong, R., Ma, X.-K., Chen, L., & Yang, L. C. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8808-2_10 · Cited by 31
Self-citationMa, Y., Xu, Y., Zhang, J., & Zheng, L. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-020-00653-5 · Cited by 33
Exosomal circRNAs: Sorting Mechanisms, Roles and Clinical Applications in Tumors
Xu, Y., Kong, S., Qin, S., Shen, X., & Ju, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.581558 · Cited by 33
The Roles of CircRNAs in Regulating Muscle Development of Livestock Animals
Yang, Z., He, T., & Chen, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.619329 · Cited by 33
Ji, C., Wang, Y., Wei, X., Zhang, X., Cong, R., Yao, L., Qin, C., & Song, N.-H. (2021) · Human Reproduction · doi:10.1093/humrep/deab196 · Cited by 35
Self-citationCircular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer
Wang, S., Chao, F., Zhang, C., Han, D., Xu, G., & Chen, G. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.10.021 · Cited by 32
Wu, S., Huang, J., Li, Y., Liu, Z., & Zhao, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.802731 · Cited by 32
“CIRCExplorer2 (37) and CIRI (38) tools were used to identify circRNAs in this study.”
MethodLiu, H., Yan, Y., Lin, J., He, C., Yu, Z., Li, H., Zhou, Z., Wang, J., Wang, J., Mao, K., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.08.008 · Cited by 32
Circular RNAs in Alzheimer’s Disease: A New Perspective of Diagnostic and Therapeutic Targets
Vakili, O., Asili, P., Babaei, Z., Mirahmad, M., Keshavarzmotamed, A., Asemi, Z., & Mafi, A. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220829164211 · Cited by 34
Involvement of circRNAs in the Development of Heart Failure
Sygitowicz, G., & Sitkiewicz, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214129 · Cited by 32
Yuan, M., Zhang, X., Yue, F., Zhang, F., Jiang, S., Zhou, X., Lv, J., Zhang, Z., Sun, Y., Chen, Z., et al. (2023) · Advanced Science · doi:10.1002/advs.202205229 · Cited by 34
Self-citationComputational approaches and challenges in the analysis of circRNA data
Digby, B., Finn, S. P., & Broin, P. Ó. (2024) · BMC Genomics · doi:10.1186/s12864-024-10420-0 · Cited by 32
“Reverse complimentary matches in flanking non-coding cis regulatory elements (e.g ALU repeats) can form a hairpin structure that bring the downstream 5’ splice acceptor site in close proximity to the upstream 3’ acceptor site facilitating back-splicing [20, 46, 47] (Fig.”
BackgroundMethodCircRNA knockdown based on antisense strategies
Aquino‐Jarquín, G. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.104066 · Cited by 33
Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study
Galasso, M., Costantino, G., Pasquali, L., Minotti, L., Baldassari, F., Corrà, F., Agnoletto, C., & Volinia, S. (2016) · International Journal of Genomics · doi:10.1155/2016/4503840 · Cited by 31
“Briefly, CIRCexplorer was focused on the identification of junction reads from back-spliced exons and intron lariats (the terminal parts of all unmapped reads that are aligned independently to the genome) [19].”
Identification of Circular RNAs using RNA Sequencing
Sekar, S., Geiger, P. A., Cuyugan, L., Boyle, A., Serrano, G. E., Beach, T. G., & Liang, W. S. (2019) · Journal of Visualized Experiments · doi:10.3791/59981 · Cited by 34
CircRNA expression profiles in human visceral preadipocytes and adipocytes
Sun, W., Sun, X., Chu, W., Yu, S., Dong, F., & Xu, G. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10886 · Cited by 30
Matrix factorization with neural network for predicting circRNA-RBP interactions
Wang, Z., & Lei, X. (2020) · BMC Bioinformatics · doi:10.1186/s12859-020-3514-x · Cited by 31
The Role of Circular RNAs in Pancreatic Ductal Adenocarcinoma and Biliary-Tract Cancers
Limb, C., Liu, D., Venø, M. T., Rees, E., Krell, J., Bagwan, I., Giovannetti, E., Pandha, H., Strobel, O., Rockall, T., et al. (2020) · Cancers · doi:10.3390/cancers12113250 · Cited by 31
Circular RNA in tumor metastasis
Zhang, C., Ding, R., Sun, Y., Huo, S. T., He, A. T., Wen, C., Chen, H., Du, W. W., Lai, W., & Wang, H. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.01.032 · Cited by 31
“Molecular The This is an open access article under th necessary for the inchoate back-splicing mechanism to take place.(55) In 2003, two models were proposed for exonic circRNA formation: lariat-driven circularization and intron pairing-driven circularization.”
Self-citationCircular RNAs: new biomarkers of chemoresistance in cancer
Wang, J., Zhang, Y., Liu, L., Yang, T., & Song, J. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0312 · Cited by 31
Self-citationHuang, P., Li, F., Mo, Z., Geng, C., Wen, F., Zhang, C., Guo, J., Wu, S., Li, L., Brünner, N., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.669270 · Cited by 31
“CIRCexplorer software (27) uses back-spliced reads and NCBI RefSeq gene annotations as input to identify circRNA.”
MethodThe Role of N6-Methyladenosine Modified Circular RNA in Pathophysiological Processes
Tang, M., & Lv, Y. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.60131 · Cited by 32
“Another lariat-driven circRNA is ciRNA, whose formation processes depend on consensus RNA motifs near 5’ splice site and branchpoint [42].”
BackgroundCircHIPK3 Plays Vital Roles in Cardiovascular Disease
Zhang, L., Wang, Y., Yu, F., Li, X., Gao, H., & Li, P. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.733248 · Cited by 31
Min, X., Cai, M., Shao, T., Xu, Z., Liao, Z., Liu, D., Zhou, M., Wu, W., Zhou, Y., Mo, M., et al. (2021) · Aging Cell · doi:10.1111/acel.13529 · Cited by 33
“During backsplicing, a downstream splice- donor site is covalently linked to an upstream splice- acceptor site, resulting in the formation of exonic circRNAs or exon- intron circRNAs (Barrett et al., 2015; Li et al., 2015; Zhang et al., 2014).”
BackgroundPlant RNA-mediated gene regulatory network
Hajieghrari, B., & Farrokhi, N. (2021) · Genomics · doi:10.1016/j.ygeno.2021.12.020 · Cited by 32
Wu, D., Chen, T., Zhao, X., Huang, D., Huang, J., Huang, Y., Huang, Q., Liang, Z., Chen, C., Chen, M., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02336-y · Cited by 33
“One of the most common RNA circularization modes depends on the complementary pairing of intron flanks, and Alu elements play a vital function in this process [44].”
Background
Metadata
- Authors
- Zhang, X.-O., Wang, H.-B., Zhang, Y., Lu, X., Chen, L.-L., & Yang, L.
- Affiliations
- Chinese Academy of Sciences (CN)
- Second Military Medical University (CN)
- Corresponding author
- Chen, Ling-Ling
- Yang, Li
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 159
- Issue
- 1
- Pages
- 134-147
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1981726010
- Cited by
- 1,999
- References
- 35
- Citations by year
- 2026: 70 · 2025: 117 · 2024: 200 · 2023: 183 · 2022: 254 · 2021: 280 · 2020: 245 · 2019: 212 · 2018: 176 · 2017: 121 · 2016: 74 · 2015: 54 · 2014: 9
- FWCI
- 35.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31271376, 2014CB964800, 31322018)
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- circular RNA, Alu elements, inverted repeats, post-transcriptional regulation, intron evolution, mammalian gene expression
- MeSH terms
- Animals, Base Sequence, Exons, Humans, Introns, Mammals, Molecular Sequence Data, Nucleic Acid Conformation, Genome, Human, Sequence Alignment, Alternative Splicing, Evolution, Molecular, Alu Elements, Embryonic Stem Cells
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