The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Complementary Sequence-Mediated Exon Circularization
Open accessAbstract
Exon circularization has been identified from many loci in mammals, but the detailed mechanism of its biogenesis has remained elusive. By using genome-wide approaches and circular RNA recapitulation, we demonstrate that exon circularization is dependent on flanking intronic complementary sequences. Such sequences and their distribution exhibit rapid evolutionary changes, showing that exon circularization is evolutionarily dynamic. Strikingly, exon circularization efficiency can be regulated by competition between RNA pairing across flanking introns or within individual introns. Importantly, alternative formation of inverted repeated Alu pairs and the competition between them can lead to alternative circularization, resulting in multiple circular RNA transcripts produced from a single gene. Collectively, exon circularization mediated by complementary sequences in human introns and the potential to generate alternative circularization products extend the complexity of mammalian posttranscriptional regulation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“CircRNA is a highly stable single-stranded RNA with a covalently closed loop structure (Fig. 3), including a large category of non-coding RNAs generated by backsplicing in eukaryotic cells.218–220”
From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [218]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Natural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
Lorenz, R., Bernhart, S. H., Höner zu Siederdissen, C., Tafer, H., Flamm, C., Stadler, P. F., & Hofacker, I. L. (2011) · Algorithms for Molecular Biology · doi:10.1186/1748-7188-6-26 · Cited by 5,098
Circular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388
Statistics corner: A guide to appropriate use of correlation coefficient in medical research.
(2012) · Europe PMC (PubMed Central) · Cited by 4,239
Differential analysis of gene regulation at transcript resolution with RNA-seq
Trapnell, C., Hendrickson, D. G., Sauvageau, M., Goff, L., Rinn, J. L., & Pachter, L. (2013) · Nature Biotechnology · doi:10.1038/nbt.2450 · Cited by 3,492
Detecting and characterizing circular RNAs
Jeck, W. R., & Sharpless, N. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2890 · Cited by 2,710
Mechanisms of Alternative Pre-Messenger RNA Splicing
Black, D. L. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161720 · Cited by 2,704
Sanger, H. L., Klotz, G., Riesner, D., Gross, H. J., & Kleinschmidt, A. K. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.3852 · Cited by 2,296
Flagged first, then by citations
Cited by
Sorted by citations
Items 801–900 of 1,001
Emerging functions of circular RNA in the regulation of adipocyte metabolism and obesity
Zhang, Y., Tian, Z., Ye, H., Sun, X., Zhang, H., Sun, Y., Mao, Y., Yang, Z., & Li, M. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01062-w · Cited by 33
“Some introns on both sides of the circRNA exons contain intronic reverse complementary sequences (ICSs) [45], and these sequences are paired by base pairing to form a circular structure.”
BackgroundSelf-citationTao, T., Yuan, S., Liu, J., Shi, D., Peng, M., Li, C., & Wu, S. (2020) · Aging · doi:10.18632/aging.102816 · Cited by 31
“And the processing of circRNAs can affect the splicing of their precursor transcripts, leading to altered gene expression outcomes [36].”
BackgroundESRP1 controls biogenesis and function of a large abundant multiexon circRNA
Liu, D., Dredge, B. K., Bert, A. G., Pillman, K. A., Toubia, J., Guo, W., Dyakov, B. J. A., Migault, M., Conn, V. M., Conn, S. J., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad1138 · Cited by 30
“…principal mechanisms described to date for promoting backsplicing are base pairing between inverted Alu repeats in the introns flanking the back-spliced exons ( 37 ,38 ), potentially aided by binding of the splicing factor SFPQ ( 39 ), and looping mediated by a dimeric RNA binding protein ( 4 ).”
BackgroundCurrent advances in circular RNA detection and investigation methods: Are we running in circles?
Drulă, R., Braicu, C., & Berindan‐Neagoe, I. (2024) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1850 · Cited by 32
“Some circRNAs have been identified that retain the same sequence elements in the same order as the mRNAs from which they are derived (Zhang et al., 2014; Zheng et al., 2019).”
BackgroundFeng, X., Jiang, B., Zhai, S.-N., Liu, C., Wu, H., Zhu, B.-Q., Wei, M.-Y., Wei, J., Yang, L. C., & Chen, L. (2025) · Nature Biotechnology · doi:10.1038/s41587-025-02624-w · Cited by 40
“Of note, this cassette simultaneously produces ds-cRNA and egfp mRNA by backsplicing and splicing, respectively 29 ; thus, the translated EGFP was used as an internal marker to indicate the successful ds-cRNA production.”
InfluentialSelf-citationWebCircRNA: Classifying the Circular RNA Potential of Coding and Noncoding RNA
Pan, X., Xiong, K., Anthon, C., Hyttel, P., Freude, K., Jensen, L. J., & Gorodkin, J. (2018) · Genes · doi:10.3390/genes9110536 · Cited by 30
“This principle is used in circRNA detection programs such as CIRCexplorer [10] and find_circ [2].”
MethodCircMarker: a fast and accurate algorithm for circular RNA detection
Li, X., Chu, C., Pei, J., Măndoiu, I., & Wu, Y. (2018) · BMC Genomics · doi:10.1186/s12864-018-4926-0 · Cited by 30
“CIRCexplorer performs reads mapping using Bowtie and TopHat.”
MethodInfluentialCircular RNA Expression Profiles in Nasopharyngeal Carcinoma by Sequence Analysis
Yang, J., Gong, Y., Jiang, Q., Liu, L., Li, S., Zhou, Q., Huang, F., & Liu, Z. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00601 · Cited by 30
Profiling and Functional Analysis of Circular RNAs in Porcine Fast and Slow Muscles
Li, B., Yin, D., Li, P., Zhang, Z., Zhang, X., Li, H., Li, R., Hou, L., Liu, H., & Wu, W. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00322 · Cited by 30
Self-citationShang, F., Wang, Y., Ma, R., Di, Z., Wu, Z., Hai, E., Rong, Y., Pan, J., Liang, L., Wang, Z., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.678825 · Cited by 30
Self-citationSp1-Mediated circRNA circHipk2 Regulates Myogenesis by Targeting Ribosomal Protein Rpl7
Yan, J., Yang, Y., Fan, X., Tang, Y., & Tang, Z. (2021) · Genes · doi:10.3390/genes12050696 · Cited by 31
“For example, both the CAMSAP1 and CRKL locus could produce two major circRNA isoforms [62,63].”
BackgroundMethods to study circRNA-protein interactions
Ulshöfer, C. J., Pfafenrot, C., Bindereif, A., & Schneider, T. P. (2021) · Methods · doi:10.1016/j.ymeth.2021.04.014 · Cited by 31
Mitochondrial noncoding RNAs: new wine in an old bottle
Liang, H., Liu, J., Su, S., & Zhao, Q. (2021) · RNA Biology · doi:10.1080/15476286.2021.1935572 · Cited by 32
“circRNAs are endogenous biomolecules that are covalently closed at the 5 ́and 3 ́ ends and are mostly expressed from known protein-coding genes [38].”
BackgroundDahl, M., Husby, S., Eskelund, C. W., Besenbacher, S., Fjelstrup, S., Côme, C., Ek, S., Kolstad, A., Räty, R., Jerkeman, M., et al. (2021) · Leukemia · doi:10.1038/s41375-021-01311-4 · Cited by 33
Sayad, A., Najafi, S., Kashi, A. H., Hosseini, J., Akrami, S. M., Taheri, M. N., & Ghafouri‐Fard, S. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153720 · Cited by 30
Chen, Z., Huang, L., Wang, K., Zhang, L., Zhong, X., Yan, Z., Liu, B., & Zhu, P. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2038-5 · Cited by 30
“All circRNAs are generated from their parent pre-mRNAs, and grouped into extron circRNAs, intron circRNAs, and extron-intron circRNAs (Zhang et al., 2014). circRNAs play key roles in many biological processes, neuropsychiatric disorders, tumorigenesis and immunological responses (Piwecka et al.,…”
BackgroundInfluentialKong, Z., Lu, Y., Yang, Y., Chang, K. S., Lin, Y., Huang, Y., Wang, C., Zhang, L., Xu, W., Zhao, S., et al. (2023) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-22-0271 · Cited by 30
Inducible Expression of Eukaryotic Circular RNAs from Plasmids
Tatomer, D. C., Liang, D., & Wilusz, J. E. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7204-3_11 · Cited by 32
Circular RNAs and Plant Stress Responses
Litholdo, C. G., & da Fonseca, G. C. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_27 · Cited by 30
Computational approaches for circRNAs prediction andin silicocharacterization
Rebolledo, C., Silva, J. P., Saavedra, N., & Maracaja‐Coutinho, V. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad154 · Cited by 30
“CircComPara [64] integrates CIRCexplorer [40], CIRI [41] and find_circ [31] to improve the accuracy of circRNA prediction, and its recent version, CircComPara2 [57], integrates CIRI [41], find_circ [31], CIRCexplorer2 [56] (using multiple aligners such as STAR [33], BWA [34], Segemehl [45] or TopHat [65]), further enh…”
MethodResultInfluentialWang, H., Liang, Y., Zhang, T., Yu, X., Song, X., Chen, Y., Mao, Q., Xia, W., Chen, B., Xu, L., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01222-0 · Cited by 28
“These results suggest that EGFR-TKIs combined with IGF1Ri-treated cells exhibit DTP with activated autophagy, while EGFR-TKIs and cIGF1R combination treatment induce apoptosis and restrict autophagy.”
BackgroundSelf-citationCurrent RNA strategies in treating cardiovascular diseases
Chia, S. P. S., Pang, J. K. S., & Soh, B.-S. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.01.028 · Cited by 32
“66,67 To date, three classes of DNA base editors have been identi fi ed: adenine base editors (ABEs), cytosine base editors (CBEs), and glycosylase base editors (GBEs).”
Heydarnia, E., Dorostgou, Z., Hedayati, N., Mousavi, V., Yahyazadeh, S., Alimohammadi, M., Gheibi, M., Heidari, P., Igder, S., Mafi, A., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01494-0 · Cited by 30
“The production of circRNAs can be triggered by a set of regulatory factors or binding sites, called cis -acting elements [78].”
BackgroundDynamic conformation: Marching toward circular RNA function and application
Liu, C., Yang, L. C., & Chen, L. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.08.020 · Cited by 30
Self-citationCircular RNAs trigger nonsense-mediated mRNA decay
Boo, S. H., Shin, M.-K., Hwang, H. J., Hwang, H., Chang, S., Kim, T. S., Baek, D., & Kim, Y. K. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.11.022 · Cited by 31
Current research on circular RNAs associated with colorectal cancer
Wang, P., & He, X. (2017) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2017.1365168 · Cited by 29
A method to directly assay circRNA in real samples
Jiao, J., Gao, T., Shi, H., Sheng, A., Xiang, Y., Shu, Y., & Li, G. (2018) · Chemical Communications · doi:10.1039/c8cc08319c · Cited by 30
Zhang, J., Liu, R., Zhu, Y., Gong, J., Yin, S., Sun, P., Feng, H., Wang, Q., Zhao, S., Wang, Z., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030792 · Cited by 28
“A total of which 1526 circRNAs were predicted by CIRI2, 3410 circRNAs by CIRCexplorer, and 4564 circRNAs by find_circ; only 12 circRNAs were detected by all three algorithms (Figure S2) [5,44,45].”
Wu, Y., Xiao, H., Pi, J., Zhang, H., Pan, A., Pu, Y., Liang, Z., Shen, J., & Du, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29509 · Cited by 29
“The number of circRNAs produced from their source genes was analyzed, and the results showed that one gene could produce many circRNAs, which was consistent with the findings of Zhang and Tao (Yu et al., 2012; X. O. Zhang et al., 2014).”
ResultDistinct circular RNA expression profiles in pediatric ependymomas
Ahmadov, U., Bendikas, M. M., Ebbesen, K. K., Sehested, A. M., Kjems, J., Broholm, H., & Kristensen, L. S. (2020) · Brain Pathology · doi:10.1111/bpa.12922 · Cited by 30
Insights Into the Involvement of Circular RNAs in Autoimmune Diseases
Zhai, X., Zhang, Y., Xin, S., Cao, P., & Lu, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.622316 · Cited by 29
Self-citationRole of circular RNA expression in the pathological progression after spinal cord injury
Wang, W., Li, J., Li, J., Zhang, Z., Li, M.-X., Li, Q., Ma, H.-X., Yang, H., & Hou, X.-L. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.308100 · Cited by 28
“Targetscan (http://www.targetscan.org/) and miRanda (http://www.microrna.org/) (Zhang et al., 2014) software were used to predict miRNA target genes and miRNA/circRNA interactions.”
MethodScreening of cashmere fineness-related genes and their ceRNA network construction in cashmere goats
Hui, T., Zheng, Y., Chang, Y., Wang, Y., Bai, Z., Sun, J., Cai, W., Zhang, X., Bai, W., & Wang, Z. (2021) · Scientific Reports · doi:10.1038/s41598-021-01203-8 · Cited by 29
Self-citationLi, Y., Wang, F., Teng, P., Ku, L., Chen, L., Feng, Y., & Yao, B. (2022) · Genome biology · doi:10.1186/s13059-022-02621-1 · Cited by 27
“Recent studies also indicated that RNA adenosine to inosine (A-to-I) editing is located within the Alu sequence, interfering with inverted and repeated Alu pairs to influence circRNA biogenesis [13, 14].”
BackgroundSelf-citationJu, C., He, J., Wang, C., Sheng, J., Jia, J., Du, D., Li, H., Zhou, M., & He, F. (2022) · Biomarker Research · doi:10.1186/s40364-022-00388-y · Cited by 29
“RNA pairing across flanking introns facilitates circRNAs formation, while RNA pairing within individual intron restrains circRNAs formation [12].”
BackgroundThe long noncoding RNA regulation at the MYC locus
Xiang, J., Yang, L. C., & Chen, L. (2015) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.07.001 · Cited by 29
“Interestingly, recent studies have suggested that this locus also encodes circular RNAs, which are characterized by covalently closed loop structures without 50–30 polarity or polyadenylated tails [40 ,41].”
BackgroundSelf-citationAlkhathami, A. G., Sahib, A. S., Fayi, M. S. A., Fadhil, A. A., Jawad, M. A., Shafik, S. A., Sultan, S. J., Almulla, A. F., & Shen, M. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116007 · Cited by 28
Identification and characterization of circular RNAs in Ganoderma lucidum
Shao, J., Wang, L., Liu, X., Yang, M., Chen, H., Wu, B., & Liu, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-52932-w · Cited by 26
Guerra, B., Lima, J. E., Araujo, B., Torres, L. A. G. M. M., Santos, J. X., Machado, D., Cunha, E., Serrato, J., de Souza, J., Martins, J., et al. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.08.003 · Cited by 28
Song, Y., Bu, C., Chen, P., Liu, P., & Zhang, D. (2020) · Journal of Experimental Botany · doi:10.1093/jxb/eraa570 · Cited by 27
Lin, Z., Zhao, Y., Dai, F., Su, E., Li, F., & Yan, Y. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16251 · Cited by 28
Rickert, D., Bartl, J., Picard, D. J., Bernardi, F., Qin, N., Lovino, M., Puget, S., Meyer, F.-D., Koumba, I. M., Beez, T., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02306-2 · Cited by 28
Identification of the cross-strand chimeric RNAs generated by fusions of bi-directional transcripts
Wang, Y., Zou, Q., Li, F., Zhao, W., Xu, H., Zhang, W., Deng, H., & Yang, X. (2021) · Nature Communications · doi:10.1038/s41467-021-24910-2 · Cited by 30
circRNA : Regulatory factors and potential therapeutic targets in inflammatory dermatoses
Liu, R., Zhang, L., Zhao, X., Liu, J., Chang, W., Zhou, L., & Zhang, K. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17473 · Cited by 29
Mechanisms Controlling MicroRNA Expression in Tumor
Chen, S., Wang, Y., Li, D., Wang, H., Zhao, X., Yang, J., Chen, L., Guo, M., Zhao, J., Chen, C., et al. (2022) · Cells · doi:10.3390/cells11182852 · Cited by 28
Self-citationExosomal circRNAs: Novel biomarkers and therapeutic targets for gastrointestinal tumors
Wang, D., Li, R., Jiang, J., Qian, H., & Xu, W. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114053 · Cited by 29
Hoque, P., Romero, B., Akins, R. E., & Batish, M. (2023) · Cells · doi:10.3390/cells12242813 · Cited by 30
Xu, S., Xiao, S., Qiu, C., & Wang, Z. (2017) · Marine Genomics · doi:10.1016/j.margen.2016.12.004 · Cited by 28
Lu, G., Zhang, J., Liu, X., Liu, W., Cao, G., Lv, C., Zhang, X., Xu, P., Li, M., & Song, X. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14550 · Cited by 27
Self-citationCircular RNA in gastric cancer
Li, X., Yang, W., & Xu, J. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000908 · Cited by 28
“The perfectly matched complementary sequence can promote the expression of circRNA.([26,27])”
BackgroundTeng, M., Guo, J., Xu, X., Ci, X., Mo, Y., Kohen, Y., Ni, Z., Chen, S., Guo, W. Y., Bakht, M. K., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.03.027 · Cited by 30
“2,4 Due to the lack of poly(A) tail, circRNA is under-captured by common poly(dT) mRNA sequencing (mRNA-seq) and thus is omitted by many transcriptomic profiling studies.”
Deep Computational Circular RNA Analytics from RNA-seq Data
Jakobi, T., & Dieterich, C. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7562-4_2 · Cited by 27
YAP1 inhibits circRNA-000425 expression and thus promotes oncogenic activities of miR-17 and miR-106
Liu, Z., Huang, S., Cao, Y., Yao, Y., Li, J., Chen, J., Jiang, B., Yuan, X., Xiang, X., Xiong, J., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.163 · Cited by 27
EIciRNA‐mediated gene expression: tunability and bimodality
Hu, Q., & Zhou, T. (2018) · FEBS Letters · doi:10.1002/1873-3468.13253 · Cited by 27
Circular RNA in Liver: Health and Diseases
Song, M., Xia, L., Sun, M., Yang, C., & Wang, F. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_20 · Cited by 26
Awasthi, R., Singh, A. K., Mishra, G., Maurya, A., Chellappan, D. K., Gupta, G., Hansbro, P. M., & Dua, K. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_1 · Cited by 27
Circular RNAs as diagnostic biomarkers in gastric cancer: A meta-analysis review
Jiang, F., Hong, F., Shah, M. W., & Shen, X. (2019) · Pathology - Research and Practice · doi:10.1016/j.prp.2019.04.011 · Cited by 27
Li, L., Bu, D., & Zhao, Y. C. (2019) · FEBS Letters · doi:10.1002/1873-3468.13423 · Cited by 27
“Examples of such tools include MapSplice [2,18], find_circ [7], circRNA_finder [19], CIRCexplorer [3], segemehl [20], CIRI [21,22], DCC [23], UROBORUS [24], and acfs [25].”
BackgroundMethodAn Overview of Circular RNAs and Their Implications in Myotonic Dystrophy
Czubak, K., Sedehizadeh, S., Kozłowski, P., & Wojciechowska, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184385 · Cited by 27
“However, in silico analysis revealed that Alu elements, which are >300-nt long, are enriched in the introns flanking human exons that generate circRNAs [20,21,60], and almost 90% of circRNAs appeared to have complementary Alu elements in their flanking introns [5,21].”
BackgroundCircular RNAs and cancer: Opportunities and challenges
Solé, C., & Lawrie, C. H. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2020.02.008 · Cited by 27
Role of Circular RNAs in the Pathogenesis of Cardiovascular Disease
Li, B., Li, Y., Hu, L., Liu, Y., Zhou, Q., Wang, M., An, Y., & Li, P. (2020) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-019-09912-2 · Cited by 27
PCirc: random forest-based plant circRNA identification software
Yin, S., Tian, X., Zhang, J., Sun, P., & Li, G. (2021) · BMC Bioinformatics · doi:10.1186/s12859-020-03944-1 · Cited by 27
Decoding the complexity of circular RNAs in cardiovascular disease
Rai, A. K., Lee, B., Hebbard, C., Uchida, S., & Garikipati, V. N. S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105766 · Cited by 28
Song, X., Chen, B., Liang, Y., Li, Y., Zhang, H., Han, D., Wang, Y., Ye, F., Wang, L., Zhao, W., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01055-9 · Cited by 27
Exosomal circular RNAs: New player in breast cancer progression and therapeutic targets
Hussen, B. M., Mohamadtahr, S., Abdullah, S. R., Hidayat, H. J., Rasul, M. F., Faraj, G. S. H., Ghafouri‐Fard, S., Taheri, M. N., Khayamzadeh, M., & Jamali, E. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1126944 · Cited by 27
“EcircRNAs are primarily found in the cytoplasm and have one or more exons resulting from alternative splicing (Zhang et al., 2014).”
BackgroundThe recent advancements in circRNA research: From biogenesis to therapeutic interventions
Malviya, A., & Bhuyan, R. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154697 · Cited by 31
Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development
Agostino, S. D., Riccioli, A., Cesaris, P. D., Fontemaggi, G., Blandino, G., Filippini, A., & Fazi, F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00389 · Cited by 28
Pang, F., Zhang, M., Yang, X., Li, G., Zhu, S., Nie, X., Cao, R., Yang, X., Zhang, Z., Huang, H., et al. (2019) · PeerJ · doi:10.7717/peerj.6267 · Cited by 26
Genome-wide identification of circular RNAs in peanut (Arachis hypogaea L.)
Zhang, X., Ma, X., Ning, L., Li, Z., Zhao, K., Li, K., He, J., & Yin, D. (2019) · BMC Genomics · doi:10.1186/s12864-019-6020-7 · Cited by 26
“Various bioinformatics prediction tools, such as CIRCexplorer [20], CIRI [21], circRNA_finder [34], KNIFE [35], find_circ [3] and Segemehl [36], were developed to identify circRNAs in various species.”
BackgroundMethodInfluentialSelf-citationGuo, W., Zhang, B., Sun, C., Duan, H., Liu, W., Mu, K., Zhao, L., Li, H., Dong, Z., & Cui, Q. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4621 · Cited by 26
Zhi Yong, W. U., Zheng, M., Zhang, Y., Xie, M., Tian, S., Ding, T., Li, L., & Guan, Q. (2020) · Aging · doi:10.18632/aging.103603 · Cited by 26
“CircRNAs have important functions in many diseases, such as tumors, by upregulating target gene expression via microRNA (miRNA) sponge action [13].”
BackgroundSelf-citationCircPlant: An Integrated Tool for circRNA Detection and Functional Prediction in Plants
Zhang, P., Liu, Y., Chen, H., Meng, X., Xue, J., Chen, K., & Chen, M. (2020) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2020.10.001 · Cited by 28
Identification of Candidate Circular RNAs Underlying Intramuscular Fat Content in the Donkey
Li, B., Feng, C., Zhu, S., Zhang, J., Irwin, D. M., Zhang, X., Wang, Z., & Zhang, S. Y. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.587559 · Cited by 26
“Moreover, our results show that the identified circRNAs contain multiple exons, with most containing two or three exons, which is similar to the circRNAs in many other species (Zhang et al., 2014; Wei et al., 2017), suggesting many host preferentially produce two or three circRNAs in donkey.”
ResultSelf-citationPathogenic mechanisms and the potential clinical value of circFoxo3 in cancers
Zhang, L., Wang, Y., Zhang, Y., Zhao, Y., & Li, P. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.01.010 · Cited by 26
Self-citationRole of circular RNAs in colorectal tumor microenvironment
Ashraf, J. V., Nair, V. S., Saleh, R., & Elkord, E. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111351 · Cited by 26
Gomes‐Duarte, A., Bauer, S., Venø, M. T., Norwood, B. A., Henshall, D. C., Kjems, J., Rosenow, F., Vangoor, V. R., & Pasterkamp, R. J. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.627907 · Cited by 26
Circular RNAs as Novel Diagnostic Biomarkers and Therapeutic Targets in Kidney Disease
Yu, J., Xie, D., Huang, N., & Zhou, Q. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.714958 · Cited by 27
Javaran, V. J., Moffett, P., Lemoyne, P., Xu, D., Adkar‐Purushothama, C. R., & Fall, M. L. (2021) · Plants · doi:10.3390/plants10112355 · Cited by 26
Tsitsipatis, D., Mazan-Mamczarz, K., Si, Y., Herman, A. B., Yang, J., Guha, A., Piao, Y., Fan, J., Martindale, J. L., Munk, R. B., et al. (2022) · Aging · doi:10.18632/aging.204450 · Cited by 27
Zhang, S., Wang, C., Wang, Y., Zhang, H., Chen, X., Cheng, Y., Yuan, Y., Sha, J., Guo, X., & Cui, Y. (2023) · BMC Biology · doi:10.1186/s12915-023-01597-z · Cited by 28
Regulation of splicing and circularisation of RNA in epithelial mesenchymal plasticity
Neumann, D., Goodall, G. J., & Gregory, P. A. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.008 · Cited by 25
The novel roles of circular RNAs in metabolic organs
Zhang, Z., Guo, X., & Li, X. (2017) · Genes & Diseases · doi:10.1016/j.gendis.2017.12.002 · Cited by 26
Hsa_circ_0028502 and hsa_circ_0076251 are potential novel biomarkers for hepatocellular carcinoma
Jiang, Z., Shen, L., Wang, S., Wu, S., Hu, Y., Guo, J., & Fu, L. (2019) · Cancer Medicine · doi:10.1002/cam4.2584 · Cited by 26
Milward, E. A., Shahandeh, A., Heidari, M., Johnstone, D. M., Daneshi, N., & Hondermarck, H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.40029-5 · Cited by 32
Knockdown of Circular RNAs Using LNA-Modified Antisense Oligonucleotides
Løvendorf, M. B., Holm, A., Petri, A., Thrue, C. A., Uchida, S., Venø, M. T., & Kauppinen, S. (2022) · Nucleic Acid Therapeutics · doi:10.1089/nat.2022.0040 · Cited by 26
“As reported previously [8,61], most circRNAs in our liver cancer cell line data set were derived from protein-coding genes, and a large fraction (78.6”
InfluentialLi, Y., Ye, J., Xu, S., & Wang, J. (2023) · Discover Oncology · doi:10.1007/s12672-023-00686-3 · Cited by 27
“On the other hand, exonic circRNAs (ecircRNAs) and exon–intron circRNAs (EIciRNAs) can be formed by removing introns based on the pairing of complementary motifs in the transcripts [26].”
BackgroundWang, W., Liu, C., He, D., Shi, G., Song, P., Zhang, B., Tian, L., Wei, J., Jiang, Y., & Ma, L. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107189 · Cited by 28
Circular RNA expression profiles in the porcine liver of two distinct phenotype pig breeds
Huang, M., Shen, Y., Mao, H., Chen, L., Chen, J., Guo, X.-L., & Xu, N. (2017) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.17.0651 · Cited by 25
“Identification and annotation of circRNAs in liver tissue Specific alignments and corrections were applied to define putative circRNAs in the RNAseq reads [19].”
MethodSelf-citationIdentification of internal control genes for circular RNAs
Zhong, S., Zhou, S., Yang, S., Yu, X., Xu, H., Wang, J., Zhang, Q., Lv, M., & Feng, J. (2019) · Biotechnology Letters · doi:10.1007/s10529-019-02723-0 · Cited by 26
Huang, X., Cen, X. B., Sun, W., Xia, K., Yu, L.-Y., Liu, J., & Zhao, Z. (2019) · Europe PMC (PubMed Central) · Cited by 25
Disease‐Associated Circular RNAs: From Biology to Computational Identification
Tang, M., Kui, L., Lu, G., & Chen, W. (2020) · BioMed Research International · doi:10.1155/2020/6798590 · Cited by 25
“In human cells, the most common size is several hundred nucleotides spanning two or three exons [31, 44, 45].”
BackgroundThe mechanism and detection of alternative splicing events in circular RNAs
Li, X., Zhang, B., Li, F., Yu, K., & Bai, Y. (2020) · PeerJ · doi:10.7717/peerj.10032 · Cited by 25
Circular RNA in osteoarthritis: an updated insight into the pathophysiology and therapeutics.
Liu, D., Liang, Y., Yang, Y., He, M., Cai, Z., Xiao, W., & Li, Y. (2021) · Europe PMC (PubMed Central) · Cited by 25
Localization of RNAs in the nucleus: cis - and trans - regulation
Tong, C., & Yin, Y. (2021) · RNA Biology · doi:10.1080/15476286.2021.1894025 · Cited by 27
Wang, W., He, D., Chen, J., Zhang, Z., Wang, S., Jiang, Y., & Wei, J. (2021) · Aging · doi:10.18632/aging.203002 · Cited by 25
“org/) and CIRCexplorer was used to de novo assemble the mapped reads to circRNAs [22].”
MethodYe, Y., Feng, W., Zhang, J., Zhu, K., Huang, X., Pan, L., Su, J., Zheng, Y., Li, R., Deng, S., et al. (2021) · Genome Medicine · doi:10.1186/s13073-021-01002-w · Cited by 25
“CIRI2 [31, 37], CIRCexplorer2 [38], DCC [39], Find Circ [8], and MapSplice [40]) according to the suggested pa-”
InfluentialXu, C., Ai, K., Yi, L., Liu, W., Li, Y., Wang, Y., & Zhang, D. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04612-3 · Cited by 25
CircRNA-mediated regulation of brown adipose tissue adipogenesis
Liu, K., Liu, X., Deng, Y., Li, Z., & Tang, A. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.926024 · Cited by 25
Wang, X., Wang, G., Wu, Z., Dong, Y., Shi, Y., Yang, F., Chen, X., Wang, J., Du, S., Xu, H., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.12.012 · Cited by 25
Circular RNAs in glioma: Molecular functions and pathological implications
Tang, C., He, X., Jia, L., & Zhang, X. (2023) · Non-coding RNA Research · doi:10.1016/j.ncrna.2023.10.007 · Cited by 25
“The 5 ′ splice site is tightly connected to the 3 ′ splice site by regulatory elements in introns flanking back spliced exons to stimulate circRNA biogenesis [18,19].”
BackgroundSelf-citation
Metadata
- Authors
- Zhang, X.-O., Wang, H.-B., Zhang, Y., Lu, X., Chen, L.-L., & Yang, L.
- Affiliations
- Chinese Academy of Sciences (CN)
- Second Military Medical University (CN)
- Corresponding author
- Chen, Ling-Ling
- Yang, Li
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 159
- Issue
- 1
- Pages
- 134-147
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1981726010
- Cited by
- 1,999
- References
- 35
- Citations by year
- 2026: 70 · 2025: 117 · 2024: 200 · 2023: 183 · 2022: 254 · 2021: 280 · 2020: 245 · 2019: 212 · 2018: 176 · 2017: 121 · 2016: 74 · 2015: 54 · 2014: 9
- FWCI
- 35.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31271376, 2014CB964800, 31322018)
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- circular RNA, Alu elements, inverted repeats, post-transcriptional regulation, intron evolution, mammalian gene expression
- MeSH terms
- Animals, Base Sequence, Exons, Humans, Introns, Mammals, Molecular Sequence Data, Nucleic Acid Conformation, Genome, Human, Sequence Alignment, Alternative Splicing, Evolution, Molecular, Alu Elements, Embryonic Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
