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Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
Open accessAbstract
There is considerable heterogeneity in immunological parameters between individuals, but its sources are largely unknown. To assess the relative contribution of heritable versus non-heritable factors, we have performed a systems-level analysis of 210 healthy twins between 8 and 82 years of age. We measured 204 different parameters, including cell population frequencies, cytokine responses, and serum proteins, and found that 77% of these are dominated (>50% of variance) and 58% almost completely determined (>80% of variance) by non-heritable influences. In addition, some of these parameters become more variable with age, suggesting the cumulative influence of environmental exposure. Similarly, the serological responses to seasonal influenza vaccination are also determined largely by non-heritable factors, likely due to repeated exposure to different strains. Lastly, in MZ twins discordant for cytomegalovirus infection, more than half of all parameters are affected. These results highlight the largely reactive and adaptive nature of the immune system in healthy individuals.
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“However, monozygotic twins show age-related divergence of inflammatory biomarker levels, suggesting that the nonheritable influence on inflammation increases with time (118).”
From Connecting aging biology and inflammation in the omics era (2022) · cites this paper as [118]
In the citing paper
“a study of 210 healthy twins between 8 and 82 years old, which found that non-heritable factors are the strongest contributors to differences in chronic inflammation across individuals72 and that exposure to environmental factors, which have been collectively called the exposome, are the main drivers of SCI.”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [72]
In the citing paper
“Some studies have found that human CMV infection in older individuals is associated with increased cardiovascular and all-cause mortality, negative immune risk profile, inflammageing, and lower antibody responses to influenza125–129.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [128]
In the citing paper
“Previous work has shown that immune variation within the human population is driven primarily by environmental factors such as prior immune exposure, rather than genetic factors (Brodin et al., 2015).”
From Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans (2019) · cites this paper as Brodin et al., 2015
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Sparse inverse covariance estimation with the graphical lasso
Friedman, J., Hastie, T., & Tibshirani, R. (2008) · Biostatistics · doi:10.1093/biostatistics/kxm045 · Cited by 6,355
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways
Nair, R. P., Duffin, K. C., Helms, C., Ding, J., Stuart, P. E., Goldgar, D. E., Gudjonsson, J. E., Li, Y., Tejasvi, T., Feng, B., et al. (2009) · Nature Genetics · doi:10.1038/ng.311 · Cited by 1,433
Sylwester, A. W., Mitchell, B. L., Edgar, J. B., Taormina, C., Pelte, C., Ruchti, F., Sleath, P. R., Grabstein, K. H., Hosken, N. A., Kern, F., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050882 · Cited by 1,339 · cited 4×
“As an example, the lifelong need to control CMV seems to cause a broad shift in the magnitude and complexity of many cell subsets (Chidrawar et al., 2009; Wills et al., 2011), and 10% of all T cells in CMV+ individuals can be directed against this virus (Sylwester et al., 2005).”
BackgroundInfluentialPyogenic Bacterial Infections in Humans with MyD88 Deficiency
von Bernuth, H., Pïcard, C., Jin, Z., Sranujit, R. P., Xiao, H. Q., Ku, C., Chrabieh, M., Ben‐Mustapha, I., Ghandil, P., Çamcıoğlu, Y., et al. (2008) · Science · doi:10.1126/science.1158298 · Cited by 1,287
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
Querec, T. D., Akondy, R. S., Lee, E. K., Cao, W., Nakaya, H. I., Teuwen, D. E., Pirani, A. M., Gernert, K. M., Deng, J., Marzolf, B., et al. (2008) · Nature Immunology · doi:10.1038/ni.1688 · Cited by 1,123
Li, S., Rouphael, N., Duraisingham, S., Romero‐Steiner, S., Presnell, S., Davis, C. W., Schmidt, D. S., Johnson, S. E., Milton, A., Rajam, G., et al. (2013) · Nature Immunology · doi:10.1038/ni.2789 · Cited by 772
Analytic approaches to twin data using structural equation models
Rijsdijk, F. V. (2002) · Briefings in Bioinformatics · doi:10.1093/bib/3.2.119 · Cited by 761
Flagged first, then by citations
Research works printed but not linked: 2
- Francis, 1960, On the doctrine of original antigenic sin, Proc. Am. Philos. Soc., 104, 572
- Jablonski, 1922, A contribution to theheredity of refraction in human eyes, Arch. Augenheilk, 91, 308
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Interaction between unrelated viruses during in vivo co-infection to limit pathology and immunity
McAfee, M. S., Huynh, T. P., Johnson, J. L., Jacobs, B. L., & Blattman, J. N. (2015) · Virology · doi:10.1016/j.virol.2015.05.021 · Cited by 24
van der Geest, K. S. M., Lorencetti, P. G., Abdulahad, W. H., Horst, G., Huitema, M. G., Roozendaal, C., Kroesen, B., Brouwer, E., & Boots, A. M. H. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.12.009 · Cited by 24
van der Geest, K. S. M., Wang, Q., Eijsvogels, T. M. H., Koenen, H. J. P. M., Joosten, I., Brouwer, E., Hopman, M. T. E., Jacobs, J. F. M., & Boots, A. M. H. (2017) · Immunity & Ageing · doi:10.1186/s12979-017-0087-2 · Cited by 25
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Fernandes, S. B., Patil, N. D., Mériaux, S. B., Thérésine, M., Muller, C. P., Leenen, F. A. D., Elwenspoek, M. M. C., Zimmer, J., & Turner, J. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674532 · Cited by 23
Lindell, R. B., Zhang, D. “., Bush, J., Wallace, D. C., Rabinowitz, J. D., Lu, W., Wherry, E. J., Weiss, S. L., & Henrickson, S. E. (2022) · Shock · doi:10.1097/shk.0000000000001943 · Cited by 25
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Michaud, D. S., Houseman, E. A., Marsit, C. J., Nelson, H. H., Wiencke, J. K., & Kelsey, K. T. (2015) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-0681 · Cited by 23
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Falanga, Y. T., Frascoli, M., Kaymaz, Y., Forconi, C. S., Ong’echa, J. M., Bailey, J. A., Berg, L. J., & Moormann, A. M. (2017) · JCI Insight · doi:10.1172/jci.insight.93814 · Cited by 21
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Breznik, J. A., Huynh, A., Zhang, A., Bilaver, L., Bhakta, H., Stacey, H. D., Ang, J. C., Bramson, J. L., Nazy, I., Miller, M. S., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200369 · Cited by 23
Zhong, Z., Chen, M., Dai, S., Wang, Y., Yao, J., Shentu, H., Huang, J., Yu, C., Zhang, H., Wang, T., et al. (2023) · BMC Pediatrics · doi:10.1186/s12887-023-04396-1 · Cited by 22
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Meng, Z., Liu, T., Song, Y., Wang, Q., Xu, D., Jiang, J., Li, M., Qiao, J., Luo, X., Gu, J., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.12.017 · Cited by 22
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Faghfouri, A. H., Zarrin, R., Maleki, V., Payahoo, L., & Khajebishak, Y. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104619 · Cited by 23
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Ising, R., Weinhold, S., Bennstein, S. B., Zimmermann, A., Degistirici, Ö., Kögler, G., Meisel, R., Hengel, H., Timm, J., & Uhrberg, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010010 · Cited by 18
Orecchioni, M., Bordoni, V., Fuoco, C., Reina, G., Lin, H., Zoccheddu, M., Yılmazer, A., Zavan, B., Cesareni, G., Bedognetti, D., et al. (2020) · Small · doi:10.1002/smll.202000123 · Cited by 19
Enninga, E. A. L., Jang, J. S., Hur, B., Johnson, E. L., Wick, M. J., Sung, J., & Chakraborty, R. (2020) · American Journal of Reproductive Immunology · doi:10.1111/aji.13358 · Cited by 19
Maecker, H. T., Siebert, J., Rosenberg‐Hasson, Y., Koran, L. M., Ramalho, M., & Semelka, R. C. (2021) · Investigative Radiology · doi:10.1097/rli.0000000000000752 · Cited by 18
Self-citationImmune Profiling Mass Cytometry Assay Harmonization: Multicenter Experience from CIMAC-CIDC
Sahaf, B., Pichavant, M. R., Lee, B. H., Duault, C., Thrash, E. M., Davila, M., Fernandez, N., Millerchip, K. A., Bentebibel, S.-E., Haymaker, C., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-2052 · Cited by 18
Self-citationIndirect effects of cytomegalovirus infection: Implications for vaccine development
Moseley, P., Klenerman, P., & Kadambari, S. (2022) · Reviews in Medical Virology · doi:10.1002/rmv.2405 · Cited by 21
Greives, T. J., Dochtermann, N. A., & Stewart, E. C. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.11.015 · Cited by 18
Influenza vaccine response: future perspectives
Mameli, C., D’Auria, E., Erba, P., Nannini, P., & Zuccotti, G. (2017) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2018.1391786 · Cited by 18
Tomić, A., Tomic, I., Dekker, C. L., Maecker, H. T., & Davis, M. M. (2019) · Scientific Data · doi:10.1038/s41597-019-0213-4 · Cited by 19
Self-citationSchäfer, A., Sollet, Z. C., de Herve, M. G. D. G., Bühler, S., Ferrari‐Lacraz, S., Norman, P. J., Kichula, K. M., Farias, T. D. J., Masouridi‐Levrat, S., Mamez, A., et al. (2024) · Blood Advances · doi:10.1182/bloodadvances.2024013117 · Cited by 17
Franck, M., Daunizeau, C., Aronoff, J. E., Tanner, K., Trumble, B. C., Franceschi, C., Hertel, J., Fülöp, T., Lemoine, M., Gurven, M., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102880 · Cited by 18
Susiriwatananont, T., Eiamprapaporn, P., Roque, M. V., Farraye, F. A., Pearlman, A., & Chumsri, S. (2025) · Cells · doi:10.3390/cells14221779 · Cited by 19
Understanding immune variation for improved translational medicine
Duffy, D. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.06.005 · Cited by 18
Immunity to acute virus infections with advanced age
Nikolich‐Žugich, J., Bradshaw, C. M., Uhrlaub, J. L., & Watanabe, M. (2020) · Current Opinion in Virology · doi:10.1016/j.coviro.2020.09.007 · Cited by 19
Udovičić, I., Stanojević, I., Djordjevic, D., Zeba, S., Rondović, G., Abazovic, T., Lazic, S., Vojvodić, D., To, K., Abazović, D., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245815 · Cited by 19
Munks, M. W., Rott, K. H., Nesterenko, P. A., Smart, S. M., Williams, V., Tatum, A. M., Xu, G., Smith, T. A., Murray, S., & Hill, A. B. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1010351 · Cited by 17
Shaping immunity: The influence of natural selection on population immune diversity
Randolph, H. E., Aracena, K. A., Lin, Y., Mu, Z., & Barreiro, L. B. (2024) · Immunological Reviews · doi:10.1111/imr.13329 · Cited by 20
Evans, C., Mutasa, K., Rukobo, S., Govha, M., Mushayanembwa, P., Chasekwa, B., Majo, F. D., Tavengwa, N. V., Broad, J., Noble, C. C. A., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44166-2 · Cited by 17
Johnson, S., Seale, S., Gittelman, R. M., Rytlewski, J. A., Robins, H. S., & Fields, P. (2021) · PLoS ONE · doi:10.1371/journal.pone.0249484 · Cited by 18
Identification of the robust predictor for sepsis based on clustering analysis
Jang, J. Y., Yoo, G., Lee, T., Uh, Y., & Kim, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-06310-8 · Cited by 20
The Potential Harm of Cytomegalovirus Infection in Immunocompetent Critically Ill Children
Alyazidi, R. M., Murthy, S., Slyker, J. A., & Gantt, S. M. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00096 · Cited by 19
Dunsmore, G., Koleva, P. T., Sutton, R. T., Ambrosio, L., Huang, V., & Elahi, S. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i42.4787 · Cited by 17
New approaches to the study of immune responses in humans
Brodin, P. (2020) · Human Genetics · doi:10.1007/s00439-020-02129-3 · Cited by 22
Self-citationTransfer transcriptomic signatures for infectious diseases
di Iulio, J., Bartha, I., Spreafico, R., Virgin, H. W., & Telenti, A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2022486118 · Cited by 16
Lijing Lin, A., Curtin, J. A., Bakhsoliani, E., Hirsman, A. G., Howard, R., Tutino, M., Edwards, M. R., Prosperi, M., Simpson, A., Rattray, M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-16509-4 · Cited by 19
Dong, C., Miao, Y., Zhao, R. Z., Yang, M., Guo, A., Xue, Z., Li, T., Zhang, Q., Bao, Y., Shen, C., et al. (2022) · Advanced Science · doi:10.1002/advs.202204849 · Cited by 16
Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner
Papotto, P. H., Yılmaz, B., Pimenta, G. F., Mensurado, S., Cunha, C., Fiala, G. J., da Costa, D. G., Gonçalves‐Sousa, N., Chan, B. H. K., Blankenhaus, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112074 · Cited by 15
Metadata
- Authors
- Brodin, P., Jojic, V., Gao, T., Bhattacharya, S., Angel, C. J. L., Furman, D., Shen-Orr, S., Dekker, C. L., Swan, G. E., Butte, A. J., Maecker, H. T., & Davis, M. M.
- Affiliations
- Science for Life Laboratory (SE)
- University of North Carolina at Chapel Hill (US)
- Stanford Medicine (US)
- Technion – Israel Institute of Technology (IL)
- Lucile Packard Children's Hospital (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Davis, Mark M.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 160
- Issue
- 1-2
- Pages
- 37-47
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4302727
- OpenAlex
- W1978297432
- Cited by
- 1,065
- References
- 48
- Citations by year
- 2026: 67 · 2025: 82 · 2024: 93 · 2023: 84 · 2022: 85 · 2021: 115 · 2020: 106 · 2019: 102 · 2018: 109 · 2017: 96 · 2016: 80 · 2015: 45
- FWCI
- 75.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR001085)
- National Institute on Drug Abuse (R01DA011170, R01DA023063, DA011170, DA023063)
- National Institute of Allergy and Infectious Diseases (AI090019, U19AI090019, U19AI057229)
- National Institute of Environmental Health Sciences (R21ES022153, ES022153)
- National Center for Research Resources (UL1RR025744)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- monozygotic twins, cytokine response, serum proteins, environmental exposure, cytomegalovirus infection
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Blood Proteins, Child, Cytomegalovirus Infections, Humans, Immunity, Influenza Vaccines, Middle Aged, Twins, Dizygotic, Twins, Monozygotic, Cytokines, Young Adult
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