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Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits
Open accessAbstract
Hunger is controlled by specialized neural circuits that translate homeostatic needs into motivated behaviors. These circuits are under chronic control by circulating signals of nutritional state, but their rapid dynamics on the timescale of behavior remain unknown. Here, we report optical recording of the natural activity of two key cell types that control food intake, AgRP and POMC neurons, in awake behaving mice. We find unexpectedly that the sensory detection of food is sufficient to rapidly reverse the activation state of these neurons induced by energy deficit. This rapid regulation is cell-type specific, modulated by food palatability and nutritional state, and occurs before any food is consumed. These data reveal that AgRP and POMC neurons receive real-time information about the availability of food in the external world, suggesting a primary role for these neurons in controlling appetitive behaviors such as foraging that promote the discovery of food.
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“However, AgRP activity is rapidly suppressed on sensory detection of food227,228,230, which, surprisingly, suggests that ongoing AgRP activity is dispensable for food consumption.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [230]
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“and the need to obtain food to alleviate the negative state of hunger (Chen et al., 2015, Sternson et al., 2013).”
From Dorsal raphe dopamine neurons represent the experience of social isolation (2016) · cites this paper as Chen et al., 2015
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“and inhibited by overfeeding and satiety signals [23–25].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [25]
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Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443
A pyramid approach to subpixel registration based on intensity
Thévenaz, P., Ruttimann, U. E., & Unser, M. A. (1998) · IEEE Transactions on Image Processing · doi:10.1109/83.650848 · Cited by 3,097
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Advanced methods of microscope control using μManager software
Edelstein, A., Tsuchida, M. A., Amodaj, N., Pinkard, H., Vale, R. D., & Stuurman, N. (2014) · Journal of Biological Methods · doi:10.14440/jbm.2014.36 · Cited by 1,927
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,924
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881
Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46229 · Cited by 1,578
Natural neural projection dynamics underlying social behavior
Gunaydin, L. A., Grosenick, L., Finkelstein, J. C., Kauvar, I. V., Fenno, L. E., Adhikari, A., Lammel, S., Mirzabekov, J. J., Airan, R. D., Zalocusky, K. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.017 · Cited by 1,389
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Dorsal raphe dopamine neurons represent the experience of social isolation
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Self-citation“Liking” and “wanting” in eating and food reward: Brain mechanisms and clinical implications
Morales, I., & Berridge, K. C. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113152 · Cited by 346
Three Pillars for the Neural Control of Appetite
Sternson, S. M., & Eiselt, A.-K. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-104948 · Cited by 345
Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism
García‐Cáceres, C., Balland, É., Prévot, V., Luquet, S. H., Woods, S. C., Koch, M., Horváth, T. L., Yi, C., Chowen, J. A., Verkhratsky, A., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0286-y · Cited by 343
Stamatakis, A. M., van Swieten, M. M. H., Basiri, M. L., Blair, G. A., Kantak, P. A., & Stuber, G. D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1202-15.2016 · Cited by 331
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Livneh, Y., Ramesh, R. N., Burgess, C. R., Levandowski, K. M., Madara, J. C., Fenselau, H., Goldey, G. J., Diaz, V. E., Jikomes, N., Resch, J. M., et al. (2017) · Nature · doi:10.1038/nature22375 · Cited by 316
Encoding of danger by parabrachial CGRP neurons
Campos, C., Bowen, A. J., Roman, C. W., & Palmiter, R. D. (2018) · Nature · doi:10.1038/nature25511 · Cited by 323
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Burnett, C. J., Li, C., Webber, E., Tsaousidou, E., Xue, S. Y., Brüning, J. C., & Krashes, M. J. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.032 · Cited by 305
Thirst neurons anticipate the homeostatic consequences of eating and drinking
Zimmerman, C. A., Lin, Y.-C., Leib, D. E., Guo, L., Huey, E. L., Daly, G. E., Chen, Y., & Knight, Z. A. (2016) · Nature · doi:10.1038/nature18950 · Cited by 283
Self-citationAgouti-related peptide neural circuits mediate adaptive behaviors in the starved state
Padilla, S. L., Qiu, J., Soden, M. E., Sanz, E., Nestor, C. C., Barker, F. D., Quintana, A., Zweifel, L. S., Rønnekleiv, O. K., Kelly, M. J., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4274 · Cited by 285
Mandelblat-Cerf, Y., Ramesh, R. N., Burgess, C. R., Patella, P., Yang, Z., Lowell, B. B., & Andermann, M. L. (2015) · eLife · doi:10.7554/elife.07122 · Cited by 290
Dynamics of Gut-Brain Communication Underlying Hunger
Beutler, L. R., Chen, Y., Ahn, J. S., Lin, Y.-C., Essner, R. A., & Knight, Z. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.043 · Cited by 289
Self-citationArcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus
Jaïs, A., & Brüning, J. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab025 · Cited by 298
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Steculorum, S. M., Ruud, J., Karakasilioti, I., Backes, H., Engström, L., Timper, K., Hess, M. E., Tsaousidou, E., Mauer, J., Vogt, M. C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.044 · Cited by 293
Neural mechanisms of social homeostasis
Matthews, G. A., & Tye, K. M. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14016 · Cited by 273
The melanocortin pathway and control of appetite-progress and therapeutic implications
Baldini, G., & Phelan, K. D. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0596 · Cited by 300
Allostasis: A brain-centered, predictive mode of physiological regulation
Schulkin, J., & Sterling, P. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.07.010 · Cited by 265
Parabrachial CGRP Neurons Control Meal Termination
Campos, C. A., Bowen, A. J., Schwartz, M. W., & Palmiter, R. D. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.006 · Cited by 262
Central amygdala circuits modulate food consumption through a positive-valence mechanism
Douglass, A. M., Kucukdereli, H., Ponserre, M., Marković, M., Gründemann, J., Strobel, C., Morales, P. L. A., Conzelmann, K., Lüthi, A., & Klein, R. (2017) · Nature Neuroscience · doi:10.1038/nn.4623 · Cited by 264
Neural Circuit Motifs in Valence Processing
Tye, K. M. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.001 · Cited by 268
Neuronal control of peripheral insulin sensitivity and glucose metabolism
Ruud, J., Steculorum, S. M., & Brüning, J. C. (2017) · Nature Communications · doi:10.1038/ncomms15259 · Cited by 245
The melanocortin pathway and energy homeostasis: From discovery to obesity therapy
Yeo, G. S. H., Chao, D. H. M., Siegert, A., Koerperich, Z. M., Ericson, M. D., Simonds, S. E., Larson, C. M., Luquet, S. H., Clarke, I. J., Sharma, S. D., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101206 · Cited by 254
Instant Clue: A Software Suite for Interactive Data Visualization and Analysis
Nolte, H., MacVicar, T., Tellkamp, F., & Krüger, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-31154-6 · Cited by 244
The emergence and influence of internal states
Flavell, S. W., Gogolla, N., Lovett-Barron, M., & Zelikowsky, M. (2022) · Neuron · doi:10.1016/j.neuron.2022.04.030 · Cited by 246
Adult Hippocampal Neurogenesis, Fear Generalization, and Stress
Besnard, A., & Sahay, A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.167 · Cited by 245
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Padilla, S. L., Qiu, J., Nestor, C. C., Zhang, C., Smith, A. W., Whiddon, B. B., Rønnekleiv, O. K., Kelly, M. J., & Palmiter, R. D. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1621065114 · Cited by 225
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Li, E., Shan, H., Chen, L., Long, A., Zhang, Y., Liu, Y., Jia, L., Wei, F., Han, J., Li, T., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.022 · Cited by 223
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Alhadeff, A. L., Su, Z., Hernandez, E., Klima, M. L., Phillips, S. Z., Holland, R. A., Guo, C., Hantman, A. W., De Jonghe, B. C., & Betley, J. N. (2018) · Cell · doi:10.1016/j.cell.2018.02.057 · Cited by 218
Nutritive, Post-ingestive Signals Are the Primary Regulators of AgRP Neuron Activity
Su, Z., Alhadeff, A. L., & Betley, J. N. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.036 · Cited by 216
Integrative neurocircuits that control metabolism and food intake
Brüning, J. C., & Fenselau, H. (2023) · Science · doi:10.1126/science.abl7398 · Cited by 214
Homeostasis Meets Motivation in the Battle to Control Food Intake
Ferrario, C. R., Labouèbe, G., Liu, S., Nieh, E. H., Routh, V. H., Xu, S., & O’Connor, E. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2338-16.2016 · Cited by 227
Dynamic GABAergic afferent modulation of AgRP neurons
Garfield, A. S., Shah, B. P., Burgess, C. R., Li, M. M., Li, C., Steger, J. S., Madara, J. C., Campbell, J. N., Kroeger, D., Scammell, T. E., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4392 · Cited by 211
The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease
Mazier, W., Saucisse, N., Gatta‐Cherifi, B., & Cota, D. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.07.007 · Cited by 214
Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks
González, J. A., Ιορδανίδου, Π., Strom, M., Adamantidis, A., & Burdakov, D. (2016) · Nature Communications · doi:10.1038/ncomms11395 · Cited by 192
Hunger neurons drive feeding through a sustained, positive reinforcement signal.
Chen, Y., Lin, Y.-C., Zimmerman, C. A., Essner, R. A., & Knight, Z. A. (2016) · eLife · doi:10.7554/elife.18640 · Cited by 196
Self-citationLi, M. M., Madara, J. C., Steger, J. S., Krashes, M. J., Balthasar, N., Campbell, J. N., Resch, J. M., Conley, N. J., Garfield, A. S., & Lowell, B. B. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.028 · Cited by 195
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Mazzone, C. M., Liang-Guallpa, J., Li, C., Wolcott, N. S., Boone, M. H., Southern, M., Kobzar, N. P., Salgado, I. D. A., Reddy, D., Sun, F., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0684-9 · Cited by 188
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Vohra, M. S., Benchoula, K., Serpell, C. J., & Wong, E. H. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174611 · Cited by 199
Hypothalamic detection of macronutrients via multiple gut-brain pathways
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Gabanyi, I., Lepousez, G., Wheeler, R., Prado, A. V., Nissant, A., Chevalier, G., Wagner, S., Moigneu, C., Dulauroy, S., Hicham, S., et al. (2022) · Science · doi:10.1126/science.abj3986 · Cited by 189
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Yapici, N., Cohn, R., Schusterreiter, C., Ruta, V., & Vosshall, L. B. (2016) · Cell · doi:10.1016/j.cell.2016.02.061 · Cited by 170
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The physiological control of eating: signals, neurons, and networks
Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168
Regulation of starvation-induced hyperactivity by insulin and glucagon signaling in adult Drosophila
Yu, Y., Huang, R., Ye, J., Zhang, V., Wu, C., Cheng, G., Jia, J., & Wang, L. (2016) · eLife · doi:10.7554/elife.15693 · Cited by 167
An appetite for life: brain regulation of hunger and satiety
Heisler, L. K., & Lam, D. D. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.09.002 · Cited by 166
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Lerner, T. N., Ye, L., & Deisseroth, K. (2016) · Cell · doi:10.1016/j.cell.2016.02.027 · Cited by 159
AgRP neurons: Regulators of feeding, energy expenditure, and behavior
Deem, J. D., Faber, C. L., & Morton, G. J. (2021) · FEBS Journal · doi:10.1111/febs.16176 · Cited by 171
Alcantara, I. C., Tapia, A. P. M., Aponte, Y., & Krashes, M. J. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00611-y · Cited by 155
Rapid, biphasic CRF neuronal responses encode positive and negative valence
Kim, J., Lee, S., Fang, Y., Shin, A., Park, S., Hashikawa, K., Bhat, S., Kim, D., Sohn, J., Lin, D., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0342-2 · Cited by 160
Reward Inhibits Paraventricular CRH Neurons to Relieve Stress
Yuan, Y., Wu, W., Chen, M., Cai, F., Fan, C., Shen, W., Sun, W., & Hu, J. (2019) · Current Biology · doi:10.1016/j.cub.2019.02.048 · Cited by 151
An excitatory ventral hippocampus to lateral septum circuit that suppresses feeding
Sweeney, P., & Yang, Y. (2015) · Nature Communications · doi:10.1038/ncomms10188 · Cited by 155
Li, C., Navarrete, J. S., Liang-Guallpa, J., Lü, C., Funderburk, S. C., Chang, R. B., Liberles, S. D., Olson, D. P., & Krashes, M. J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.016 · Cited by 147
Dopamine subsystems that track internal states
Grove, J. C. R., Gray, L. A., Medina, N. L. S., Sivakumar, N., Ahn, J. S., Corpuz, T. V., Berke, J. D., Kreitzer, A. C., & Knight, Z. A. (2022) · Nature · doi:10.1038/s41586-022-04954-0 · Cited by 148
Self-citationVentromedial Hypothalamus and the Generation of Aggression
Hashikawa, Y., Hashikawa, K., Falkner, A. L., & Lin, D. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00094 · Cited by 146
Reverse-translational identification of a cerebellar satiation network
Low, A. Y. T., Goldstein, N., Gaunt, J. R., Huang, K.-P., Zainolabidin, N., Yip, A. K. K., Carty, J. R. E., Choi, J. Y., Miller, A. M., Ho, H. S. T., et al. (2021) · Nature · doi:10.1038/s41586-021-04143-5 · Cited by 135
Alhadeff, A. L., Goldstein, N., Park, O., Klima, M. L., Vargas, A. P.-D., & Betley, J. N. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.050 · Cited by 133
Neural control of parental behaviors
Kohl, J., & Dulac, C. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.002 · Cited by 136
Periodic Remodeling in a Neural Circuit Governs Timing of Female Sexual Behavior
Inoue, S., Yang, R., Tantry, A., Davis, C.-H. O., Yang, T., Knoedler, J. R., Wei, Y., Adams, E. L., Thombare, S. S., Golf, S. R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.025 · Cited by 143
Neural Control and Modulation of Thirst, Sodium Appetite, and Hunger
Augustine, V., Lee, S., & Oka, Y. (2020) · Cell · doi:10.1016/j.cell.2019.11.040 · Cited by 135
Imaging large-scale cellular activity in spinal cord of freely behaving mice
Sekiguchi, K. J., Shekhtmeyster, P., Merten, K., Arena, A., Cook, D., Hoffman, E. A., Ngo, A., & Nimmerjahn, A. (2016) · Nature Communications · doi:10.1038/ncomms11450 · Cited by 134
Gamma oscillations organize top-down signalling to hypothalamus and enable food seeking
Carús-Cadavieco, M., Gorbati, M., Li, Y., Bender, F., van der Veldt, S., Kosse, C., Börgers, C., Lee, S. Y., Ramakrishnan, C., Hu, Y., et al. (2017) · Nature · doi:10.1038/nature21066 · Cited by 137
Xia, G., Han, Y., Meng, F., He, Y., Srisai, D., Farías, M., Dang, M., Palmiter, R. D., Xu, Y., & Wu, Q. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01053-w · Cited by 136
Homeostatic and non-homeostatic controls of feeding behavior: Distinct vs. common neural systems
Liu, C. M., & Kanoski, S. E. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.02.011 · Cited by 131
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Bayless, D. W., Yang, T., Mason, M. M., Susanto, A. A. T., Lobdell, A., & Shah, N. M. (2019) · Cell · doi:10.1016/j.cell.2018.12.041 · Cited by 131
Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
Brandt, C., Nolte, H., Henschke, S., Engström, L., Awazawa, M., Morgan, D. A., Gabel, P., Sprenger, H., Hess, M. E., Günther, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.015 · Cited by 133
Essner, R. A., Smith, A. G., Jamnik, A. A., Ryba, A. R., Trutner, Z. D., & Carter, M. E. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0798-17.2017 · Cited by 132
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Leib, D. E., Zimmerman, C. A., Poormoghaddam, A., Huey, E. L., Ahn, J. S., Lin, Y.-C., Tan, C. L., Chen, Y., & Knight, Z. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.041 · Cited by 128
Self-citationThanarajah, S. E., Backes, H., DiFeliceantonio, A. G., Albus, K., Cremer, A. L., Hanßen, R., Lippert, R. N., Cornely, O. A., Small, D. M., Brüning, J. C., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.006 · Cited by 143
Sustained NPY signaling enables AgRP neurons to drive feeding
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Self-citationVagal sensory neurons and gut-brain signaling
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A cholinergic basal forebrain feeding circuit modulates appetite suppression
Herman, A. M., Ortiz‐Guzman, J., Kochukov, M. Y., Herman, I., Quast, K. B., Patel, J. M., Tepe, B., Carlson, J. C., Ung, K., Selever, J., et al. (2016) · Nature · doi:10.1038/nature19789 · Cited by 122
The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation
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Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat
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Self-citationHabitual daily intake of a sweet and fatty snack modulates reward processing in humans
Thanarajah, S. E., DiFeliceantonio, A. G., Albus, K., Kuzmanovic, B., Rigoux, L., Iglesias, S., Hanßen, R., Schlamann, M., Cornely, O. A., Brüning, J. C., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.015 · Cited by 131
Hallschmid, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12934 · Cited by 113
Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding
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Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake
Ryan, P. J., Ross, S. I., Campos, C., Derkach, V. A., & Palmiter, R. D. (2017) · Nature Neuroscience · doi:10.1038/s41593-017-0014-z · Cited by 114
Campos, A., Port, J. D., & Acosta, A. J. (2022) · Brain Sciences · doi:10.3390/brainsci12040431 · Cited by 126
Mechanisms controlling hormone secretion in human gut and its relevance to metabolism
Martin, A. M., Sun, E. W. L., & Keating, D. J. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0399 · Cited by 117
Neuronal Networks in Hypertension
Guyenet, P. G., Stornetta, R. L., Souza, G. M. P. R., Abbott, S. B. G., & Brooks, V. L. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14521 · Cited by 110
Porniece, M., Cremer, A. L., Klemm, P., Steuernagel, L., Sundaram, S. M., Jaïs, A., Hausen, A. C., Tao, J., Secher, A., Pedersen, T. Å., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00499-0 · Cited by 109
Leptin-activated hypothalamic BNC2 neurons acutely suppress food intake
Tan, H. L., Yin, L., Tan, Y., Ivanov, J., Plucińska, K., Ilanges, A., Herb, B. R., Wang, P., Kosse, C., Cohen, P., et al. (2024) · Nature · doi:10.1038/s41586-024-08108-2 · Cited by 114
Multi-channel fiber photometry for population neuronal activity recording
Guo, Q., Zhou, J., Feng, Q., Lin, R., Gong, H., Luo, Q., Zeng, S., Luo, M., & Fu, L. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.003919 · Cited by 107
Profound and redundant functions of arcuate neurons in obesity development
Zhu, C., Jiang, Z., Xu, Y., Cai, Z., Jiang, Q., Xu, Y., Xue, M., Arenkiel, B. R., Wu, Q., Shu, G., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0229-2 · Cited by 106
Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits
Lau, B. K., Cota, D., Cristino, L., & Borgland, S. L. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.05.033 · Cited by 115
Higgs, S., Spetter, M. S., Thomas, J. M., Rotshtein, P., Lee, M. D., Hallschmid, M., & Dourish, C. T. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117736917 · Cited by 108
Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network
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Homeostatic regulation of food intake
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TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons
Gao, Y., Yao, T. S., Deng, Z., Sohn, J., Sun, J. M., Huang, Y., Kong, X., Yu, K.-J., Wang, R.-T., Chen, H., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.072 · Cited by 101
New Neuroscience of Homeostasis and Drives for Food, Water, and Salt
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Metadata
- Authors
- Chen, Y., Lin, Y.-C., Kuo, T.-W., & Knight, Z. A.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Knight, Zachary A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 160
- Issue
- 5
- Pages
- 829-841
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4373539
- OpenAlex
- W1971359921
- Cited by
- 660
- References
- 36
- Citations by year
- 2026: 43 · 2025: 84 · 2024: 57 · 2023: 48 · 2022: 62 · 2021: 76 · 2020: 52 · 2019: 65 · 2018: 54 · 2017: 53 · 2016: 47 · 2015: 19
- FWCI
- 31.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R00DK083531, U01DK089541, P30DK063720)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- food intake regulation, AgRP neurons, POMC neurons, arcuate nucleus, hunger, palatability, negative energy balance, appetitive behavior, foraging, neural circuits, nutritional status, awake behaving mice
- MeSH terms
- Animals, Appetitive Behavior, Eating, Feeding Behavior, Hunger, Hypothalamus, Neural Pathways, Neurons, Photometry, Pro-Opiomelanocortin, Mice, Agouti-Related Protein
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