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Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits
Open accessAbstract
Hunger is controlled by specialized neural circuits that translate homeostatic needs into motivated behaviors. These circuits are under chronic control by circulating signals of nutritional state, but their rapid dynamics on the timescale of behavior remain unknown. Here, we report optical recording of the natural activity of two key cell types that control food intake, AgRP and POMC neurons, in awake behaving mice. We find unexpectedly that the sensory detection of food is sufficient to rapidly reverse the activation state of these neurons induced by energy deficit. This rapid regulation is cell-type specific, modulated by food palatability and nutritional state, and occurs before any food is consumed. These data reveal that AgRP and POMC neurons receive real-time information about the availability of food in the external world, suggesting a primary role for these neurons in controlling appetitive behaviors such as foraging that promote the discovery of food.
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“However, AgRP activity is rapidly suppressed on sensory detection of food227,228,230, which, surprisingly, suggests that ongoing AgRP activity is dispensable for food consumption.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [230]
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“and the need to obtain food to alleviate the negative state of hunger (Chen et al., 2015, Sternson et al., 2013).”
From Dorsal raphe dopamine neurons represent the experience of social isolation (2016) · cites this paper as Chen et al., 2015
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“and inhibited by overfeeding and satiety signals [23–25].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [25]
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Metadata
- Authors
- Chen, Y., Lin, Y.-C., Kuo, T.-W., & Knight, Z. A.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Knight, Zachary A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 160
- Issue
- 5
- Pages
- 829-841
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4373539
- OpenAlex
- W1971359921
- Cited by
- 660
- References
- 36
- Citations by year
- 2026: 43 · 2025: 84 · 2024: 57 · 2023: 48 · 2022: 62 · 2021: 76 · 2020: 52 · 2019: 65 · 2018: 54 · 2017: 53 · 2016: 47 · 2015: 19
- FWCI
- 31.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R00DK083531, U01DK089541, P30DK063720)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- food intake regulation, AgRP neurons, POMC neurons, arcuate nucleus, hunger, palatability, negative energy balance, appetitive behavior, foraging, neural circuits, nutritional status, awake behaving mice
- MeSH terms
- Animals, Appetitive Behavior, Eating, Feeding Behavior, Hunger, Hypothalamus, Neural Pathways, Neurons, Photometry, Pro-Opiomelanocortin, Mice, Agouti-Related Protein
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