A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

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Items 201–300 of 1,000

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2. Lipid accumulation and novel insight into vascular smooth muscle cells in atherosclerosis
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3. Regulation of cellular cholesterol distribution via non-vesicular lipid transport at ER-Golgi contact sites
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4. The culprit is the carrier, not the loads: cholesterol, triglycerides and apolipoprotein B in atherosclerosis and coronary heart disease
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5. Quantifying HDL proteins by mass spectrometry: how many proteins are there and what are their functions?
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6. Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish
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7. Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis
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8. Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases
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9. Structural basis of sterol binding and transport by a yeast StARkin domain
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10. Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature
    Bárbara Fuenzalida, Bastián Sobrevia, Claudette Cantin, Lorena Carvajal, Rocío Salsoso, Jaime Gutiérrez, Susana Contreras‐Duarte, Luis Sobrevía, Andrea Leiva · 2018 · Scientific Reports
11. Cholesterol Serum Levels and Use of Statins in Graves' Orbitopathy: A New Starting Point for the Therapy
    Giulia Lanzolla, Guia Maria Vannucchi, Ilaria Ionni, Irene Campi, Federica Sileo, Elisa Lazzaroni, Michele Marinò · 2020 · Frontiers in Endocrinology
12. Cholesterol – the devil you know; ceramide – the devil you don’t
    Trevor S. Tippetts, William L. Holland, Scott A. Summers · 2021 · Trends in Pharmacological Sciences
13. Current Understanding on the Role of Lipids in Macrophages and Associated Diseases
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14. Dual mechanisms of cholesterol-GPCR interactions that depend on membrane phospholipid composition
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15. Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase
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16. SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait
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17. EGF‐like and Other Disulfide‐rich Microdomains as Therapeutic Scaffolds
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18. Polygonatum sibiricum polysaccharides protect against obesity and non-alcoholic fatty liver disease in rats fed a high-fat diet
    Li Zeng, Fang-Wei Zhong, Zhi-Liang Chen, Geng-Xi Li, Qi Zhu · 2022 · Food Science and Human Wellness
19. Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver
    Seonghwan Hwang, Isamu Z. Hartman, Leona N. Calhoun, Kristina Garland, Gennipher A. Young, Matthew A. Mitsche, Jeffrey G. McDonald, Fang Xu, Luke J. Engelking, Russell A. DeBose‐Boyd · 2016 · Journal of Biological Chemistry
20. Membrane cholesterol mediates the cellular effects of monolayer graphene substrates
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21. Endogenous cholesterol ester hydroperoxides modulate cholesterol levels and inhibit cholesterol uptake in hepatocytes and macrophages
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22. Cideb controls sterol‐regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites
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23. Statin-Induced Chronic Cholesterol Depletion Switches GPCR Endocytosis and Trafficking: Insights from the Serotonin1A Receptor
    G. Aditya Kumar, Amitabha Chattopadhyay · 2019 · ACS Chemical Neuroscience
24. White tea and its active polyphenols lower cholesterol through reduction of very-low-density lipoprotein production and induction of LDLR expression
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25. Anti-tumor effects of mevalonate pathway inhibition in ovarian cancer
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26. Targeting cholesterol homeostasis in hematopoietic malignancies
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27. The administration of drugs inhibiting cholesterol/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice
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28. atherosclerosis: gone with the Wnt?
    Philippe Boucher, Rachel L. Matz, Jérôme Terrand · 2020 · Atherosclerosis
29. Overview: Lipid Metabolism in the Tumor Microenvironment
    Kaili Ma, Lianjun Zhang · 2021 · Advances in experimental medicine and biology
30. Dyslipidemia and Its Role in the Pathogenesis of Atherosclerotic Cardiovascular Disease: Implications for Evaluation and Targets for Treatment of Dyslipidemia Based on Recent Guidelines
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31. Lipid-based biomarkers for CVD, COPD, and aging – A translational perspective
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32. Clinical characterization and mutation spectrum of German patients with familial hypercholesterolemia
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33. Proprotein convertase subtilisin/kexin type 9 and lipid metabolism
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34. Data storytelling is not storytelling with data: A framework for storytelling in science communication and data journalism
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35. Hydroxylation site–specific and production-dependent effects of endogenous oxysterols on cholesterol homeostasis: Implications for SREBP-2 and LXR
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36. Theoretical framework and emerging challenges of lipid metabolism in cancer
    Qiuying Gu, Yuan Wang, Ping Yi, Chunming Cheng · 2024 · Seminars in Cancer Biology
37. The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR) Axis
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38. Research into cancer metabolomics: Towards a clinical metamorphosis
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39. A Diet-Sensitive BAF60a-Mediated Pathway Links Hepatic Bile Acid Metabolism to Cholesterol Absorption and Atherosclerosis
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40. The early years of lipoprotein research: from discovery to clinical application
    Patty W. Siri‐Tarino, Ronald M. Krauss · 2016 · Journal of Lipid Research
41. Microbial Reduction of Cholesterol to Coprostanol: An Old Concept and New Insights
    Aïcha Kriaa, Mélanie Bourgin, Héla Mkaouar, Amin Jablaoui, Nizar Akermi, Souha Soussou, Emmanuelle Maguin, Moez Rhimi · 2019 · Catalysts
42. Ginsenoside Rg3 Alleviates ox-LDL Induced Endothelial Dysfunction and Prevents Atherosclerosis in ApoE−/− Mice by Regulating PPARγ/FAK Signaling Pathway
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43. The biology of atherosclerosis comes full circle: lessons for conquering cardiovascular disease
    Peter Libby · 2021 · Nature Reviews Cardiology
44. Genetic testing for familial hypercholesterolemia: Impact on diagnosis, treatment and cardiovascular risk
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45. Drug treatment of chronic subdural hematoma
    Jinhao Huang, Chuang Gao, Jing‐fei Dong, Jianning Zhang, Rongcai Jiang · 2020 · Expert Opinion on Pharmacotherapy
46. Low-dose pollutant mixture triggers metabolic disturbances in female mice leading to common and specific features as compared to a high-fat diet
    Emmanuel Labaronne, Claudie Pinteur, Nathalie Véga, Sandra Pesenti, Benoit Julien, Emmanuelle Meugnier, Hubert Vidal, Danielle Naville, Brigitte Le Magueresse‐Battistoni · 2017 · The Journal of Nutritional Biochemistry
47. Organelle Communication at Membrane Contact Sites (MCS): From Curiosity to Center Stage in Cell Biology and Biomedical Research
    Thomas Simmen, Mitsuo Tagaya · 2017 · Advances in experimental medicine and biology
48. Simvastatin inhibits sonic hedgehog signaling and stemness features of pancreatic cancer
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49. Effects of statin exposure and lung cancer survival: A meta-analysis of observational studies
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50. Vesicular and non-vesicular lipid export from the ER to the secretory pathway
    Kouichi Funato, Howard Riezman, Manuel Muñiz · 2019 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
51. A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein
    Meredith H. Wilson, Sujith Rajan, Aidan Danoff, Richard Joseph White, Monica R. Hensley, Vanessa H. Quinlivan, Rosario Recacha, James H. Thierer, Frederick J. Tan, Elisabeth M. Busch‐Nentwich et al. · 2020 · PLoS Genetics
52. N6-methyladenosine modification and metabolic reprogramming of digestive system malignancies
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53. LDL-C: The Only Causal Risk Factor for ASCVD. Why Is It Still Overlooked and Underestimated?
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54. Manganese regulation of COPII condensation controls circulating lipid homeostasis
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55. Combination statin and chemotherapy inhibits proliferation and cytotoxicity of an aggressive natural killer cell leukemia
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56. Lysosome function in glomerular health and disease
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57. GRAMD1-mediated accessible cholesterol sensing and transport
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58. Keep recycling going: new approaches to reduce LDL-C
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59. Low-density Lipoprotein-Cholesterol Lowering Strategies for Prevention of Atherosclerotic Cardiovascular Disease: Focus on siRNA Treatment Targeting PCSK9 (Inclisiran)
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60. Cholesterol crystals and atherosclerotic plaque instability: Therapeutic potential of Eicosapentaenoic acid
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61. Macrophage polarisation and inflammatory mechanisms in atherosclerosis: Implications for prevention and treatment
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62. Cholesterol induces lipoprotein lipase expression in a tree shrew (Tupaia belangeri chinensis) model of non-alcoholic fatty liver disease
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63. Biofabricating atherosclerotic plaques: In vitro engineering of a three-dimensional human fibroatheroma model
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64. ANGPTL3 Inhibitors ― Their Role in Cardiovascular Disease Through Regulation of Lipid Metabolism ―
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65. Coordinate Regulation of Cholesterol and Bile Acid Metabolism by the Clock Modifier Nobiletin in Metabolically Challenged Old Mice
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66. Colesterol LDL y aterosclerosis: evidencias
    Carlos Guijarro, Juan Cosı́n-Sales · 2021 · Clínica e Investigación en Arteriosclerosis
67. Visualization of accessible cholesterol using a GRAM domain-based biosensor
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68. Genetically engineered livestock for biomedical models
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69. Cardiovascular disease in patients with genotyped familial hypercholesterolemia in Norway during 1994–2009, a registry study
    Liv J. Mundal, Marit Bragelien Veierød, Thomas Halvorsen, Kirsten Bjørklund Holven, Leiv Ose, Per Ole Iversen, Grethe Seppola Tell, Trond P. Leren, Kjetil Retterstøl · 2016 · European Journal of Preventive Cardiology
70. Muscle and statins: from toxicity to the nocebo effect
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71. Different mechanisms for selective transport of fatty acids using a single class of lipoprotein in Drosophila
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72. Structural and Functional Specialization of OSBP-Related Proteins
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73. Insensitivity to atorvastatin is associated with increased accumulation of intracellular lipid droplets and fatty acid metabolism in breast cancer cells
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74. The improvements of functional ingredients from marine foods in lipid metabolism
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75. Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics
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76. Unripe Rubus coreanus Miquel Extract Containing Ellagic Acid Regulates AMPK, SREBP-2, HMGCR, and INSIG-1 Signaling and Cholesterol Metabolism In Vitro and In Vivo
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77. Insights into incretin-based therapies for treatment of diabetic dyslipidemia
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78. Membrane cholesterol regulates endocytosis and trafficking of the serotonin1A receptor: Insights from acute cholesterol depletion
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79. Hyaluronan in pathophysiology of vascular diseases: specific roles in smooth muscle cells, endothelial cells, and macrophages
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80. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels
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81. Degradation and beyond
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82. New precision medicine avenues to the prevention of Alzheimer’s disease from insights into the structure and function of γ-secretases
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83. Statin therapy inhibits fatty acid synthase via dynamic protein modifications
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84. A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection
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85. Proprotein convertase subtilisn/kexin type 9 inhibitors and small interfering RNA therapy for cardiovascular risk reduction: A systematic review and meta-analysis
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86. Dual Targeting of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Histone Deacetylase as a Therapy for Colorectal Cancer
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87. Proteostatic Tactics in the Strategy of Sterol Regulation
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88. Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis
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89. Therapeutic FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis
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90. The effect of genetic variation in PCSK9 on the LDL-cholesterol response to statin therapy
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91. Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis
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92. Natural Product-Inspired Targeted Protein Degraders: Advances and Perspectives
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93. CSN6‐SPOP‐HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation
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94. Statin action enriches HDL3 in polyunsaturated phospholipids and plasmalogens and reduces LDL-derived phospholipid hydroperoxides in atherogenic mixed dyslipidemia
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95. Zinc mediates the SREBP-SCD axis to regulate lipid metabolism in Caenorhabditis elegans
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96. Chasing LDL cholesterol to the bottom — PCSK9 in perspective
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97. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
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98. β-Cell–Specific Deletion of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) Reductase Causes Overt Diabetes due to Reduction of β-Cell Mass and Impaired Insulin Secretion
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99. Functional Peroxisomes Are Essential for Efficient Cholesterol Sensing and Synthesis
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100. The Targeting of Native Proteins to the Endoplasmic Reticulum-Associated Degradation (ERAD) Pathway: An Expanding Repertoire of Regulated Substrates
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