The DOI matches its Crossref record; 112 of the 115 references it cites were found in a registry or an index.
A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
Open accessAbstract
One-fourth of all deaths in industrialized countries result from coronary heart disease. A century of research has revealed the essential causative agent: cholesterol-carrying low-density lipoprotein (LDL). LDL is controlled by specific receptors (LDLRs) in liver that remove it from blood. Mutations that eliminate LDLRs raise LDL and cause heart attacks in childhood, whereas mutations that raise LDLRs reduce LDL and diminish heart attacks. If we are to eliminate coronary disease, lowering LDL should be the primary goal. Effective means to achieve this goal are currently available. The key questions are: who to treat, when to treat, and how long to treat.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The receptors for LDL (LDLR) and transferrin receptor (TFR) are both endocytosed from the cell surface via clathrin-coated vesicles and transported through intracellular recycling pathways (14, 15, 16, 17, 18, 19, 20).”
From The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes (2022) · cites this paper as [14]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“LDLR plays a crucial role in the uptake of LDL-C from the circulation by hepatocytes 1,2,7 .”
From Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover (2026) · cites this paper as [1]
The cited source says what the claim attributes to it.
In the citing paper
“The regulation of LDLR trafficking and turnover is essential for maintaining cholesterol homeostasis and remains a major focus of therapeutic strategies for CVD 1,2,7 .”
From Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover (2026) · cites this paper as [1]
The cited source says what the claim attributes to it.
In the citing paper
“Elevated LDL-C levels are linked to an increased risk of ASCVD,4,5”
From Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation (2025) · cites this paper as [5]
In the citing paper
“Unlike common diseases, the clarity of causation for Mendelian disorders usually simplifies the task of generating models (including human cells and organoids or rodents) to connect genotype to organismal phenotype; these have led to many critical insights into the biology of health and disease in humans98,99.”
From A brief history of human disease genetics (2020) · cites this paper as [98]
In the citing paper
“These data suggest that lifelong lower levels of plasma LDL cholesterol are much more effective than late LDL reductions induced by statins in preventing coronary heart disease (31).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [31]
In the citing paper
“Hypercholesterolemia is one of the key risk factors in promoting atherosclerosis, which is the underlying cause of approximately 90% of cases of myocardial infarction, 60% of strokes, most cases of chronic heart failure, peripheral arterial disease, and vascular dementia (31).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [31]
In the citing paper
“An example is the J-shaped association between alcohol consumption and cardiovascular disease; there is now consensus that this apparent protective effect of moderate levels of consumption is artefactual, as discussed above.130”
From Mendelian randomization (2022) · cites this paper as [130]
In the citing paper
“For example, a large-effect genetic variant influencing alcohol consumption that has been of considerable value in MR studies of the effects of alcohol75,130 is only prevalent in East Asian populations.”
From Mendelian randomization (2022) · cites this paper as [130]
In the citing paper
“Mutations in LDLR cause familial hypercholesterolemia (FH), characterized by elevated levels of plasma LDL-C and increased risk of coronary heart disease (1).”
From Identification of amino acid residues in the MT-loop of MT1-MMP critical for its ability to cleave low-density lipoprotein receptor (2022) · cites this paper as [1]
In the citing paper
“Statins block cholesterol synthesis by suppressing HMG-CoA reductase91”
From EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis (2025) · cites this paper as [91]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
OLSSON, A. G., McMurray, J. J. V., Thorgeirsson, G., Spaulding, C. M., Slattery, J., Pyörälà, K., Færgeman, O., Wright, R. S., Berg, K. M., Wilhelmsen, L., et al. (1994) · The Lancet · Cited by 8,467
Sacks, F. M., Pfeffer, M. A., Moye, L. A., Rouleau, J. L., Rutherford, J. D., Cole, T. G., Brown, L., Warnica, J. W., Arnold, J. M. O., Wun, C.-C., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610033351401 · Cited by 7,439
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
Self-citation(1998) · New England Journal of Medicine · doi:10.1056/nejm199811053391902 · Cited by 5,261
High density lipoprotein as a protective factor against coronary heart disease
Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B., & Dawber, T. R. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90874-9 · Cited by 5,059
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
Self-citationSREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Self-citationProgress and challenges in translating the biology of atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2011) · Nature · doi:10.1038/nature10146 · Cited by 4,010
Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834
Self-citation
Flagged first, then by citations
3 of the 115 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Anitschkow, 1913, Ueber experimentelle cholesterinsteatose und ihre bedeutung für die entstehung einiger pathologischer prozesse, Zentralbl. Allg. Pathol. Anat., 24, 1
- Goldstein, 1982, Lipoprotein receptors: Genetic defense against atherosclerosis, Clin. Res., 30, 417
Cited by
Sorted by citations
Items 601–700 of 1,000
Yan, G., Qin, Z., Liu, A., Huang, Z., Wang, X., Zhang, S., Xie, X., Huang, X., Chen, J., Li, Y., et al. (2024) · Food & Function · doi:10.1039/d4fo02312a · Cited by 10
Maidman, S. D., Hegele, R. A., & Rosenson, R. S. (2024) · Current Atherosclerosis Reports · doi:10.1007/s11883-024-01258-8 · Cited by 13
Lin, C., Xia, M., Dai, Y., Huang, Q., Sun, Z., Zhang, G., Luo, R., Peng, Q., Li, J., Wang, X., et al. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100810 · Cited by 11
Singh, S. A., Miyosawa, K., & Aikawa, M. (2015) · Expert Review of Proteomics · doi:10.1586/14789450.2015.1078731 · Cited by 10
Hypocholesterolaemia and mortality in patients with coronary artery disease
Ndrepepa, G., Holdenrieder, S., Cassese, S., Xhepa, E., Fusaro, M., & Kastrati, A. (2019) · European Journal of Clinical Investigation · doi:10.1111/eci.13194 · Cited by 10
Anti-Apo B-100 Autoantibody is a Marker of Unstable Coronary Plaque
Imai, M., Kawamura, M., Kochi, I., Matsuoka, T., Kihara, S., & Yamamoto, H. (2020) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.58784 · Cited by 10
Dietary Cholesterol Metabolite Regulation of Tissue Immune Cell Development and Function
Frascoli, M., Reboldi, A., & Kang, J. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200273 · Cited by 10
Bitto, N., Ghigliazza, G., Lavorato, S., Caputo, C., & Mura, V. L. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12030934 · Cited by 11
Mokgalaboni, K., Phoswa, W. N., Yates, S., Lebelo, S. L., Madiba, S., & Modjadji, P. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20095668 · Cited by 9
Sarkar, P., & Chattopadhyay, A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00472 · Cited by 11
Novel regulators of plasma lipid levels
Loaiza, N., Oldoni, F., & Kuivenhoven, J. A. (2017) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000416 · Cited by 10
Fuenzalida, B., Kallol, S., Lüthi, M., Albrecht, C., & Leiva, A. (2021) · Placenta · doi:10.1016/j.placenta.2021.01.019 · Cited by 10
Dandan, M., Han, J., Mann, S. A., Kim, R., Mohammed, H., Nyangau, E., & Hellerstein, M. K. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316764 · Cited by 10
Langslet, G., Holven, K. B., & Bogsrud, M. P. (2021) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwab228 · Cited by 9
Antitumor Activity of Simvastatin in Preclinical Models of Mantle Cell Lymphoma
Santos, J. C., Profitós-Pelejà, N., Ribeiro, M. L., & Roué, G. (2022) · Cancers · doi:10.3390/cancers14225601 · Cited by 10
Manganese therapy for dyslipidemia and plaque reversal in murine models
Wang, Y., Feng, X., Zhou, W., Huang, R., Hu, Y., Hui, H., Tian, J., Wang, X., & Chen, X. (2023) · Life Metabolism · doi:10.1093/lifemeta/load040 · Cited by 10
Memory T cells delay the progression of atherosclerosis via AMPK signaling pathway
Peng, L., Cao, Y., Zhao, S., Huang, Y., Yang, K., & Huang, W. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.11.20 · Cited by 10
Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation
Toyota, Y., YOSHIOKA, H., Sagimori, I., Hashimoto, Y., & Ohgane, K. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115576 · Cited by 12
Quantitation of F-actin in cytoskeletal reorganization: Context, methodology and implications
Sahu, S. S., Sarkar, P., & Chattopadhyay, A. (2024) · Methods · doi:10.1016/j.ymeth.2024.07.009 · Cited by 10
Gao, Y., Jiang, Q., Liang, W., Zhang, C., Zhang, K., & Zhang, Z. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.137332 · Cited by 9
CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis
Wu, L., Wang, J., Wang, Y., Yang, J., Yao, Y., Wang, Y., Huang, D., Hu, Y., Xu, X., Wang, R., et al. (2026) · Nature · doi:10.1038/s41586-026-10161-y · Cited by 18
Arias‐Alpizar, G., Papadopoulou, P., Ríos, X., Pulagam, K. R., Moradi, M., Pattipeiluhu, R., Bussmann, J., Sommerdijk, N. A. J. M., Llop, J., Kros, A., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202202709 · Cited by 8
Bouwens, E., Vanmaele, A., Hoeks, S. E., Verhagen, H. J. M., Fioole, B., Moelker, A. D., Raa, S. T., Hussain, B., Oliveira‐Pinto, J., Gonçalves, F. B., et al. (2023) · Vascular Medicine · doi:10.1177/1358863x231181159 · Cited by 10
Apple, S. J., Clark, R. E., Daich, J., González, M. L., Ostfeld, R. J., Toth, P. P., Bittner, V., Martin, S. S., Rana, J. S., Nasir, K., et al. (2023) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2412350 · Cited by 10
Lee, K.-J., Lee, Y.-M., Yang, S.-B., Lee, J. H., Kim, H. R., Lim, J.-H., & Park, J. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.07.008 · Cited by 10
Triglycerides: the past, the present, and the future
Braunwald, E. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae515 · Cited by 10
Marcuzzi, A., Piscianz, E., Valencic, E., Monasta, L., Brumatti, L. V., & Tommasini, A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160921277 · Cited by 9
Leiva, A., Contreras‐Duarte, S., Amigo, L., Sepúlveda, E., Borić, M. P., Quiñones, V., Busso, D., & Rigotti, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184280 · Cited by 9
Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment
Morinaga, T., Yamaguchi, N., Nakayama, Y., Tagawa, M., & Yamaguchi, N. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061811 · Cited by 8
Kim, G. H., Baek, H. K., Lee, J. S., Kim, S., & Yi, S. S. (2019) · Journal of Food Science · doi:10.1111/1750-3841.14454 · Cited by 9
Functional analysis of six uncharacterised mutations in LDLR gene
Gomez, A., Colombo, R., Pontoglio, A., Helman, L., Kaeser, L., Giunta, G. A., Parolín, M. L., Toscanini, U. F., & Cuniberti, L. A. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.10.013 · Cited by 9
Off–On Squalene Epoxidase-Specific Fluorescent Probe for Fast Imaging in Living Cells
Zang, T., Wang, S.-D., Su, S., Gao, M., Chen, Q., Liang, C., Jing, J., Zhang, R., & Zhang, X. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c03168 · Cited by 9
Centrality of Myeloid-Lineage Phagocytes in Particle-Triggered Inflammation and Autoimmunity
Favor, O. K., Pestka, J. J., Bates, M. A., & Lee, K. S. S. (2021) · Frontiers in Toxicology · doi:10.3389/ftox.2021.777768 · Cited by 9
Jia, X., Qi, Y., Zheng, R., Lin, L., Hu, C., Zhu, Y., Cao, Q., Wu, X., Qi, H., Wei, R., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.906396 · Cited by 9
Effect of Coffee on the Bioavailability of Sterols
Pires, C. L., Silva, I. M. V., Coimbra, M. A., Moreno, M. J., & Coreta-Gomes, F. M. (2022) · Foods · doi:10.3390/foods11192935 · Cited by 9
LDL-Cholesterol Increases the Transcytosis of Molecules through Endothelial Monolayers
Magalhães, A., Matias, I., Palmela, I., Brito, M. A., & Dias, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163988 · Cited by 10
Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus
Brénachot, X., Gautier, T., Nédélec, E., Deckert, V., Laderrière, A., Nuzzaci, D., Rigault, C., Lemoine, A., Pénicaud, L., Lagrost, L., et al. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00245 · Cited by 9
Jasim, S., Sheikha, G. M. A., Abuzaid, H., Al‐Qirim, T. M., Shattat, G. F., Sabbah, D. A., Ala, S. A., Aboumair, M. S., Sweidan, K., & Bkhaitan, M. M. (2018) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c18-00346 · Cited by 9
Brandts, J., & Müller‐Wieland, D. (2019) · Current Atherosclerosis Reports · doi:10.1007/s11883-019-0802-x · Cited by 9
Christensen, J. J., Ulven, S. M., Thoresen, M., Westerman, K. E., Holven, K. B., & Andersen, L. F. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.06.018 · Cited by 9
A New Approach to an Old Problem
Cranley, J. J., & MacRae, C. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.310941 · Cited by 9
Rada, M., Krzywoń, L., Kapelanski‐Lamoureux, A., Petrillo, S. K., Reynolds, A. R., Lazaris, A., Seidah, N. G., & Metrakos, P. P. (2022) · medRxiv · doi:10.1101/2022.10.16.22281153 · Cited by 9
Rimpelová, S., Kolář, M., Strnad, H., Ruml, T., Vítek, L., & Gbelcová, H. (2021) · Molecules · doi:10.3390/molecules26123528 · Cited by 8
Vitamin D3 suppresses the cholesterol homeostasis pathway in patient‐derived glioma cell lines
Yuan, R., Zhang, W., You, Y., Cui, G., Gao, Z., Wang, X., & Chen, J. (2023) · FEBS Open Bio · doi:10.1002/2211-5463.13679 · Cited by 8
Protective Effects of High-Density Lipoprotein on Cancer Risk: Focus on Multiple Myeloma
Allegra, A., Murdaca, G., Mirabile, G., & Gangemi, S. (2024) · Biomedicines · doi:10.3390/biomedicines12030514 · Cited by 8
Therapeutic Effects of Amaranth: Analysis of the Antidiabetic Potential of the Plant
Herrera, A. C., Zamudio, F. V., & Campos, M. R. S. (2024) · Journal of Medicinal Food · doi:10.1089/jmf.2022.0159 · Cited by 9
Systems genetics of metabolic health in the BXD mouse genetic reference population
Li, X., Morel, J., Masi, A. D., Lalou, A., Sulc, J., Benegiamo, G., Poisson, J., Liu, Y. J., von Alvensleben, G., Maxime, N., et al. (2024) · Cell Systems · doi:10.1016/j.cels.2024.05.006 · Cited by 9
Arcay, R. M., Barceló‐Nicolau, M., Suárez-Bode, L., Martín, L., Reigada, R., Höring, M., Liebisch, G., Garrido, C., Cabot, G., Vílchez, H., et al. (2024) · mBio · doi:10.1128/mbio.01347-24 · Cited by 8
Sun, Y., Fu, Z., & Ma, Z. (2024) · Animals · doi:10.3390/ani14213090 · Cited by 8
In Silico Tools to Score and Predict Cholesterol–Protein Interactions
Nguyen, A., & Ondrus, A. E. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01885 · Cited by 8
Approved Steroidal Drugs (2000–2025): A Medicinal Chemistry Perspective
Zhu, J., Luo, G., & Xiang, H. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03005 · Cited by 8
Genetics for the Identification of Lipid Targets Beyond PCSK9
Wang, L. R., & Hegele, R. A. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.11.003 · Cited by 8
Lu, Y. U., Miyamoto, T., Takeuchi, H., TSUNODA, F., Tanaka, N., & Shiozawa, T. (2023) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2023.026067 · Cited by 8
Lipid profile screening and ASCVD prevention
Figorilli, F., Mannarino, M. R., Sahebkar, A., & Pirro, M. (2023) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2023.2218087 · Cited by 8
Effects of Ellagic Acid on Glucose and Lipid Metabolism: A Systematic Review and Meta‐Analysis
Wang, X., Zhou, X., & Zhang, X. (2024) · Journal of Nutrition and Metabolism · doi:10.1155/2024/5558665 · Cited by 8
Yelamanchili, D., Gillard, B. K., Gotto, A. M., Cainzos‐Achirica, M., Nasir, K., Remaley, A. T., Rosales, C., & Pownall, H. J. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100707 · Cited by 8
Zhao, S., Giles, C., Huynh, K., Kettunen, J., Järvelin, M., Kähönen, M. A. P., Viikari, J., Lehtimäki, T. J., Raitakari, O. T., Meikle, P. J., et al. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c03229 · Cited by 8
Gong, X., Cui, H., Bian, Y., Li, Y., Wang, Y., Peng, Y., Wen, W., Li, K., Wang, H., Zhang, Z.-Y., et al. (2021) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2021.06.003 · Cited by 8
Shrivastava, S. K., Sarkar, P., Preira, P., Salomé, L., & Chattopadhyay, A. (2022) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.2c03941 · Cited by 8
The role of natural products as PCSK9 modulators: A review
Khayatan, D., Zare, K., Khanahmadi, M., Momtaz, S., Butler, A. E., Jamialahmadi, T., Almahmeed, W. A., Abdolghaffari, A. H., & Sahebkar, A. (2024) · Phytotherapy Research · doi:10.1002/ptr.8260 · Cited by 8
Rondini, E. A., Duniec‐Dmuchowski, Z., Cukovic, D., Dombkowski, A. A., & Kocarek, T. A. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.233312 · Cited by 8
Cohen, D. E. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.11.011 · Cited by 8
Lovastatin exerts protective effects on endothelial cells via upregulation of PTK2B
Chu, W., Guan, L., Huang, D., Ren, Y., & Zhou, Y. W. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3547 · Cited by 8
Rada, M., Reynolds, A. R., Lazaris, A., Seidah, N. G., & Metrakos, P. P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.29.542731 · Cited by 8
Wu, L., Wang, J., Wang, Y., Yang, J., Yao, Y., Huang, D., Hu, Y., Xu, X., Wang, R., Du, W., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.07.596575 · Cited by 8
Chen, M. (2021) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj_119_21 · Cited by 7
Zhu, W., Huang, P., Li, R., Ran, J., Dai, W., Tang, Y., Lian, P., Ding, C., & Huang, X. (2024) · The FASEB Journal · doi:10.1096/fj.202301748r · Cited by 8
Lu, J., Zhang, H., Chen, B., Yang, Y., Cui, J., Xu, W., Song, L., Yang, H., He, W., Zhang, Y., et al. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003199 · Cited by 7
van Wouw, S. A. E., Loix, M., Ottenhoff, R., Kingma, J., Jongejan, A., Bogie, J. F. J., Hoekstra, M., & Zelcer, N. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119163 · Cited by 9
Oxylipins in Atherosclerosis: Their Role in Inflammation, Diagnosis, and Therapeutic Perspectives
Chistyakov, D. V., Chistyakov, V. V., & Sergeeva, M. G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110577 · Cited by 9
Dang, B.-T. N., Pham, K., Nguyen, A.-H., Park, J., Kwon, T. K., Kang, J., Jeong, J., & Yook, S. (2025) · Biomaterials Research · doi:10.34133/bmr.0289 · Cited by 7
The pathophysiology of excess plasma-free cholesterol
Gillard, B. K., Rosales, C., Gotto, A. M., & Pownall, H. J. (2023) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000899 · Cited by 7
Cholesterol and Cytokines: Molecular Links to Atherosclerosis and Carcinogenesis
Suryan, V., & Chandra, N. C. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01383-w · Cited by 7
Chao, T.-H., Lin, T., Cheng, C., Wu, Y., Ueng, K., Wu, Y., Lin, W.-W., Leu, H.-B., Cheng, H., Huang, C., et al. (2024) · PubMed Central · doi:10.6515/acs.202409_40(5).20240724a · Cited by 7
D’Arcy, B. M., Swingle, M. R., Schambeau, L., Pannell, L. K., Prakash, A., & Honkanen, R. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-42046-8 · Cited by 7
Yamasaki, S., Tomihara, T., Kimura, G., Ueno, Y., Ketema, R. M., Sato, S., Mukai, Y., Sikder, M. T., Kurasaki, M., Hosokawa, T., et al. (2019) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2019.1639638 · Cited by 9
Target discovery using biobanks and human genetics
Hicks, M. A., Hou, C., Iranmehr, A., Marosi, K., & Kirkness, E. F. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.09.014 · Cited by 7
Wang, Y., Ouyang, Q.-G., Huang, W.-L., Huang, H.-L., Zhuang, X.-L., Lin, Q., & Zeng, D.-L. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s241022 · Cited by 7
O’Rahilly, S. (2020) · Diabetes · doi:10.2337/dbi19-0037 · Cited by 7
Dyslipidemia: Current Perspectives and Implications for Clinical Practice
Majanović, S. K., Cvijanović, O., Detel, D., Jovanović, G. K., Bakula, M., Rahelić, D., Čaljkušić‐Mance, T., Šoić-Vranić, T., & Cvek, S. Z. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.98386 · Cited by 9
Primary Prevention of CVD with Aspirin: Benefits vs Risks
Weisman (2021) · The Journal of Family Practice · doi:10.12788/jfp.0222 · Cited by 7
Chang, X., Zhao, Y., Qin, S., Wang, H., Wang, B., Zhai, L., Liu, B., Gu, H.-M., & Zhang, D. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.764024 · Cited by 7
LDL Cholesterol—How Low Can We Go?
Tobert, J. A. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2022.01.005 · Cited by 8
A stepwise approach to prescribing novel lipid-lowering medications
Kakavand, H., Aghakouchakzadeh, M., Shahi, A., Virani, S. S., Dixon, D. L., Tassell, B. W. V., & Talasaz, A. H. (2022) · Journal of clinical lipidology · doi:10.1016/j.jacl.2022.10.003 · Cited by 7
Mensink, F. B., Los, J., ten Cate, T. J. F., Oemrawsingh, R. M., Brouwer, M. A., Messaoudi, S. E., van Royen, N., Cornel, J. H., Riksen, N. P., & van Geuns, R. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1061346 · Cited by 7
Ahmad, W. A. W., Rosman, A., Bavanandan, S., Mohamed, M., Kader, M. A. S. A., Muthusamy, T. S., Cardiology, C. V. S., Lam, K. H., Kasim, S. S., Hoo, F. K., et al. (2023) · Malaysian Journal of Medical Sciences · doi:10.21315/mjms2023.30.1.6 · Cited by 7
LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes
Ding, J., Nguyen, A. T., Lohman, K., Hensley, M. T., Parker, D., Hou, L., Taylor, J. R., Voora, D., Sawyer, J. K., Boudyguina, E. Y., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci173278 · Cited by 7
Herencia, J. A. C., Rueda, M. S., Bru, A. P., Escribano, F. M., García, I. P., Ródenas, L. M. A., Bernardo, D. C., Divisón, J. A., & Gil-Guillén, V. F. (2018) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2017.10.003 · Cited by 7
Yu, Q., Wang, F., Meng, X., Gong, Y., Wang, Y., Xu, C., & Wang, S. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9239 · Cited by 7
Baum, S. J., Wade, R. L., Xiang, P., Arellano, J., Olmos, C. C., Nunna, S., Chen, C., Carter, C. M., & Desai, N. R. (2019) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s216606 · Cited by 7
Merolle, L., Marraccini, C., Latorrata, A., Quartieri, E., Farioli, D., Scarano, L., Fasano, T., Bergamini, S., Bellei, E., Monari, E., et al. (2020) · Journal of Clinical Apheresis · doi:10.1002/jca.21770 · Cited by 7
Efficacy and Safety of Naproxen for Acute Pain
Weisman, S. R. (2020) · The Journal of Family Practice · doi:10.12788/jfp.0064 · Cited by 8
Low-carbohydrate diets increase LDL-cholesterol, and thereby indicate increased risk of CVD
Mansoor, N., Vinknes, K. J., Veierød, M. B., & Retterstøl, K. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001343 · Cited by 8
Statins, PCSK9 inhibitors and cholesterol homeostasis: a view from within the hepatocyte
Sniderman, A. D., Kiss, R. S., Reid, T., Thanassoulis, G., & Watts, G. F. (2017) · Clinical Science · doi:10.1042/cs20160872 · Cited by 7
Ahmad, P., Shah, A., Waiz, M., Chaturvedi, C. P., Alvi, S. S., & Khan, M. S. (2024) · Phytotherapy Research · doi:10.1002/ptr.8323 · Cited by 6
Liang, L., Peng, F., Wang, L., Lin, C., & Chi, H. (2025) · Medicine · doi:10.1097/md.0000000000041493 · Cited by 6
SREBP2 as a central player in cancer progression: potential for targeted therapeutics
Chen, R., Chen, T., Li, X., Yu, J., Lin, M., Wen, S., Zhang, M., Chen, J., Yi, B., Zhong, H., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1535691 · Cited by 6
Fresnedo, O., Lopez-Gomez, J. A., Ceniceros, C., Larrinaga, G., Saiz, A., Mosteiro, L., Navarro-Imaz, H., & Rueda, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-09664-x · Cited by 6
Site-1 protease–mediated cholesterol metabolism is essential for lymphatic development in mice
Kondo, Y., Jiang, Y., Geng, X., Song, J., Simeroth, S., McDaniel, J. M., Yu, P., Srinivasan, R. S., & Xia, L. (2025) · JCI Insight · doi:10.1172/jci.insight.188637 · Cited by 6
Almalki, S. G., Alsaweed, M., Albadrani, H. M., Alqurashi, Y. E., Bazuhair, M. A., Ahmed, H. H., Ahmad, P., Alfahed, A., Othaim, A. A., & Iqbal, D. (2023) · Journal of Taibah University for Science · doi:10.1080/16583655.2023.2297456 · Cited by 6
Metadata
- Authors
- Goldstein, J. L., & Brown, M. S.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Goldstein, Joseph L.
- Brown, Michael S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 161
- Issue
- 1
- Pages
- 161-172
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4525717
- OpenAlex
- W2160347316
- Cited by
- 1,233
- References
- 115
- Citations by year
- 2026: 101 · 2025: 134 · 2024: 117 · 2023: 121 · 2022: 136 · 2021: 150 · 2020: 116 · 2019: 105 · 2018: 87 · 2017: 84 · 2016: 61 · 2015: 19
- FWCI
- 16.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Regeneron Pharmaceuticals
- National Heart, Lung, and Blood Institute (HL-20948, P01HL020948)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- cholesterol, coronary artery disease, low-density lipoprotein, LDL receptor, LDLR mutations, familial hypercholesterolemia, statins, lipid-lowering therapy, atherosclerosis
- MeSH terms
- Animals, Cardiovascular Diseases, Cholesterol, Coronary Vessels, Dietary Fats, Humans, Receptors, LDL, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Plaque, Atherosclerotic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
