Cited by 472TGF-β signaling in diseasesCancer Cells and MetastasisDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma

Open access

Oshimori, Naoki, Oristian, Daniel, Fuchs, Elaine·2015·Cell

DOI 10.1016/j.cell.2015.01.043PMC PMC4509607

Open this paper in CoChat — free account Open PDF

Abstract

Subsets of long-lived, tumor-initiating stem cells often escape cancer therapies. However, sources and mechanisms that generate tumor heterogeneity and drug-resistant cell population are still unfolding. Here, we devise a functional reporter system to lineage trace and/or genetic ablate signaling in TGF-β-activated squamous cell carcinoma stem cells (SCC-SCs). Dissecting TGF-β's impact on malignant progression, we demonstrate that TGF-β concentrating near tumor-vasculature generates heterogeneity in TGF-β signaling at tumor-stroma interface and bestows slower-cycling properties to neighboring SCC-SCs. While non-responding progenies proliferate faster and accelerate tumor growth, TGF-β-responding progenies invade, aberrantly differentiate, and affect gene expression. Intriguingly, TGF-β-responding SCC-SCs show increased protection against anti-cancer drugs, but slower-cycling alone does not confer survival. Rather, TGF-β transcriptionally activates p21, which stabilizes NRF2, thereby markedly enhancing glutathione metabolism and diminishing effectiveness of anti-cancer therapeutics. Together, these findings establish a surprising non-genetic paradigm for TGF-β signaling in fueling heterogeneity in SCC-SCs, tumor characteristics, and drug resistance.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cell.2015.01.043

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
Trapnell, C., Roberts, A., Goff, L. A., Pertea, G. M., Kim, D., Kelley, D. R., Pimentel, H., Salzberg, S. L., Rinn, J. L., & Pachter, L. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.016 · Cited by 12,145
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
The resurgence of platinum-based cancer chemotherapy
Kèlland, L. R. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2167 · Cited by 4,733
Modulation of oxidative stress as an anticancer strategy
Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4002 · Cited by 3,579
TGFβ signalling in context
Massagué, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3434 · Cited by 3,239
Clonal evolution in cancer
Greaves, M., & Maley, C. C. (2012) · Nature · doi:10.1038/nature10762 · Cited by 3,162
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555

Flagged first, then by citations

Show all 52 references

Sorted by citations

Items 401–472 of 472

2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells
El‐Gazzar, A., Noppen, S., Thomas, J., Dehaen, W., Balzarini, J. M., & Liekens, S. (2017) · Oncotarget · doi:10.18632/oncotarget.23501 · Cited by 2
Transforming Growth Factor Beta (TGF-β) Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC)
Kudinov, A. E., & Beck, T. N. (2018) · Current cancer research · doi:10.1007/978-3-319-78762-6_4 · Cited by 2
The progress in the study of reprogramming to acquire the features of stem cells in iPSCs and cancers
Saito, S., Wuputra, K., Kato, K., & Yokoyama, K. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822231-7.00002-3 · Cited by 2
Diverse temporal and spatial mechanisms work, partially through Stanniocalcin-1, V-ATPase and senescence, to activate the extracellular ATP-mediated drug resistance in human cancer cells
Zhang, H., Song, J., Ward, R. A., Han, Y., Hunt, A., Shriwas, P., Steed, A., Edwards, C., Cao, Y., Co, M., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1276092 · Cited by 2
Pulmonary papillary squamous cell carcinoma: a population-based analysis of incidence, treatment, and prognosis
Yuan, Q., Sun, N., Meng, Z., & Chen, X. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.09.71 · Cited by 2
FAST1 Predicts Poor Survival of Renal Carcinoma and Promotes Its Progression Through the TGF-β/Smad Pathway
Tao, T., Fu, X., Hu, L., Yang, X., Sun, P., & Sun, F. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s288847 · Cited by 2
CANCER STEM CELLS
Ghosh, D. S., Durga Prasad, T. S., Chourasia, R. K., & Mahmood, A. A. R. (2023) · International Journal of Trends in OncoScience · doi:10.22376/ijtos.2023.1.4.1-12 · Cited by 2
Prognostic factors of metastatic testicular non-seminomatous germ cell tumors after chemotherapy
Liao, T.-Y., Liaw, C., Chuang, C., Chang, Y., Hsu, C., Peng, M., & Chang, J. W. (2018) · Journal of Cancer Research and Practice · doi:10.1016/j.jcrpr.2018.03.003 · Cited by 2
Hybrid cancer stem cells utilise vascular tracks for collective streaming invasion in a metastasis-on-a-chip devicePreprint
Scemama, A., Lunetto, S., Tailor, A., Ciò, S. D., Ambler, L., Coetzee, A. S., Cottom, H., Khurram, S. A., Gautrot, J. E., & Biddle, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.02.573897 · Cited by 2
T-ChroNet: Time-aware chromatin network reconstruction to detect dynamic regulatory programs in longitudinal epigenetic dataset
Giovenale, S. D., Lischio, O., Cortile, C., Corleone, G., Fanciulli, M., Bonchi, F., & Barozzi, I. (2026) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqag034 · Cited by 1
Loss of the tumor suppressor p53 generates a signaling gradient that drives epithelial clonal expansion
Gan, Q., Li, W., Lex, R. K., Ying, Z., & Beronja, S. (2026) · Science · doi:10.1126/science.aed3065 · Cited by 1
Stem Cells and Cancer
Davis, M. L., Gassner, K., Barrueco, R. R., & Llobet‐Navàs, D. (2018) · Springer eBooks · doi:10.1007/978-3-319-90695-9_12 · Cited by 1
Therapeutic Approaches Targeting Cancer Stem Cells
Mukai, S. (2023) · Biochemistry · doi:10.5772/intechopen.108963 · Cited by 1
Lymph Vessels Associate with Cancer Stem Cells from Initiation to Malignant Stages of Squamous Cell Carcinoma
Cazzola, A., Lozano, D. C., Menne, D. H., Pedrera, R. D., Liu, J., Peña-Jiménez, D., Fontenete, S., Halin, C., & Pérez‐Moreno, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713615 · Cited by 1
Cancer stem cell–derived exosomes: what is known to date
Bhasin, N., Dabral, P., Selvendiran, K., & Anbalagan, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-13212-4.00028-3 · Cited by 1
The Response of Cancer Cell Populations to Therapies
Lindsay, D., Garvey, C. M., Mumenthaler, S. M., & Foo, J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804310-3.00010-7 · Cited by 1
A Cancer Stem Cell Perspective on Minimal Residual Disease in Solid Malignancies
van der Heijden, M., & Vermeulen, L. (2019) · Resistance to targeted anti-cancer therapeutics · doi:10.1007/978-3-030-16624-3_2 · Cited by 2
Regulation of ROS in Skin Stem Cells for Cancer Therapeutics
Najeeb, S., Suresh, S., Raga, S. S., Binumon, T. M., & Panicker, S. P. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_220 · Cited by 1
Significant antitumour effect of an antibody against TMEM180, a new cancer-specific moleculePreprint
Yasunaga, M., Saijou, S., Hanaoka, S., Anzai, T., Tsumura, R., & Matsumura, Y. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/397844 · Cited by 1
NRF2-dependent metabolic reprogramming is required for tumor recurrence following oncogene inhibitionPreprint
Fox, D. B., Lupo, R., Noteware, L. C., Newcomb, R., Liu, J., Locasale, J. W., Hirschey, M. D., & Alvarez, J. V. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/513994 · Cited by 1
Wnt-mediated interactions of tumor-initiating cells with a macrophage niche drive skin tumor formationPreprint
Fontenete, S., Christensen, J., Martínez-Silgado, A., Zarzuela, E., Muñoz, J., Megı́as, D., Castellana, D., Loewe, R. P., & Pérez‐Moreno, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.17.209338 · Cited by 1
Intra-epithelial non-canonical Activin A signalling safeguards prostate progenitor quiescencePreprint
Cambuli, F., Foletto, V., Alaimo, A., Felice, D. D., Gandolfi, F., Palumbieri, M. D., Zaffagni, M., Genovesi, S., Lorenzoni, M., Celotti, M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.05.433921 · Cited by 1
Tissue-Resident Alveolar Macrophages Control the Timing of Breast Cancer Metastatic Outgrowth in the LungPreprint
Dalla, E., Papanicolaou, M., Park, M., Hou, R., Sun, D., Forrest, A. R. R., Barth, N. D., Casanova-Acebes, M., Entenberg, D. R., Mérad, M., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4453789 · Cited by 1
Oncogenic RAS drives rapid onset cellular plasticity and elicits a tumour-promoting neutrophil response at the inception of preneoplastic developmentPreprint
Elliot, A. M., Bravo, I. R., Johansson, J. A., Hutton, E., Cunningham, R., Myllymäki, H., Chang, K.-M., Beltrán, M., Dobie, R., Elks, P. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.10.566547 · Cited by 1
Congrès de l’association américaine de recherche contre le cancer — AACR 2016
Vicier, C., Guillebon, É. D., Kieffer, A., Turpin, A., Dumont, C., Bellesœur, A., Soares, D. G., & Lotz, J. (2016) · ONCOLOGIE · doi:10.1007/s10269-016-2647-z
Tumorőssejtek szerepe a melanoma progressziójában és heterogenitásában
Széky, B., Silló, P., Fábián, M., Mayer, B., Kárpáti, S., & Németh, K. (2016) · Orvosi Hetilap · doi:10.1556/650.2016.30487
Reactive Oxygen Species Signaling from the Perspective of the Stem Cell
Ghaffari, S., & Liang, R. H.-S. (2017) · Wiley eBooks · doi:10.1002/9781119374947.ch1
K16 as a novel regulator of Nrf2 function in glabrous skin: Implications for pachyonychia congenita and its treatment
Lu, R. G. (2016)
ヒト乳がん細胞株MDA-MB-231のCD44陽性細胞においてmicroRNA-17，microRNA-93はp21発現を抑制する
飯島堅太郎, 佐々木, 晶., 古屋, 貫., 小山田, 英., 土屋, 洋., 難波, 北., 牛腸, 俊., 木内, 祐., & 角田, ゆ. (2017) · Institutional Repositories DataBase (IRDB) · doi:10.14930/jshowaunivsoc.77.331
Protein Expression Changes Induced by 5-Fluorouracil in an Oral Cancer Cell Line as Determined by Immunoprecipitation High Performance Liquid Chromatography
Ys, K. (2017) · 대한구강악안면병리학회지 · doi:10.17779/kaomp.2017.41.6.001
Regulatory T cells in head and neck cancer
Orita, Y. (2018) · 耳鼻咽喉科免疫アレルギー · doi:10.5648/jjiao.36.35
CANCER STEM CELL BIOLOGY
Göktuna, S. İ., Chau, T. L., & Xhafa, E. (2019) · Trakya University Journal of Natural Sciences · doi:10.23902/trkjnat.483577
Multivariate relationships among nucleus and Golgi properties during fibrillar migration are robust to and unchanged by epithelial-to-mesenchymal transition
Luo, C. Y., Natividad, R. J., Lalli, M. L., & Asthagiri, A. R. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239188
Modeling the effects of EMT-immune dynamics on epithelial cancer progressionPreprint
Bergman, D. R., Karikomi, M. K., Yu, M., Nie, Q. H., & MacLean, A. L. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/615971
Skin Stem Cells in Cancer
Piccione, M., & Liddo, R. D. (2020) · Springer eBooks · doi:10.1007/978-981-15-5120-8_6
TGF-β Suppressed Succinat Dehydrogenase to Promote Osteosarcoma Chemo-Resistance Through An HIF1α Dependent MannerPreprint
Xu, Y., Li, Y., Xiang, F., Deng, Y., Li, Z., Yang, Y., & Wei, D. (2021) · Research Square · doi:10.21203/rs.3.rs-464382/v1
Phosphorylation of Smurf2 at Thr249 by Erk5 regulates TGF-β signaling
Iezaki, T., & Hinoi, E. (2021) · Folia Pharmacologica Japonica · doi:10.1254/fpj.21029
Classification of Estrogen Receptor-Positive Breast Cancer Based on Immunogenomic Profiling and Validation at Single-Cell Resolution
Ma, X., Chen, H., Yang, M. J., Ke, Z., Wang, M., Huang, T., & Li, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.722841
Regulation of ROS in Skin Stem Cells for Cancer Therapeutics
Najeeb, S., Suresh, S., Raga, S. S., Binumon, T. M., & Panicker, S. P. (2021) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_220-1
Podsumowanie
Inglot, M. (2014) · Politeja · doi:10.12797/politeja.11.2014.29.29
Development of arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic Acid/protein kinase D signalingPreprint
Jiang, Y., Guo, Y., Hao, J., Guenter, R. E., Lathia, J. D., Beck, A. W., Hattaway, R., Hurst, D. R., Wang, Q. J., Liu, Y., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-315714/v1
Exposure to Moringa oleifera microRNAs induces proteomic changes linked to tumorigenesis and epithelial-mesenchymal transition in HeLa cells
Potestà, M., Gismondi, A., DˈAmbrosio, C., Roglia, V., Camoni, L., Marra, M., Canini, A., Arena, S., Scaloni, A., Montesano, C., et al. (2023) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2023.100097
Advances in Molecular Perspectives of Tumor-Initiating Cells on Cancer Therapy
Wu, L. (2023) · Cellular and Molecular Medicine Research · doi:10.14740/cmmr10e
Influence of Tyrosine Kinase Inhibitors and Everolimus on TGFβ1 and TGF-β Receptor 2 in Squamous Cell Carcinoma Cells
Huber, L., KNÜTTEL, M. T., Kramer, B., Zaubitzer, L., Lammert, A., Scherl, C., Rotter, N., & Häußler, D. (2024) · Anticancer Research · doi:10.21873/anticanres.17147
Targeted inhibition of Ninjurin2 promotes chemosensitivity in chemoresistant gastric cancer by suppressing cancer-initiating cells
Shin, H. S., Choi, J.-I., Chung, H. W., Park, H. J., Park, H., Rim, J. H., & Lim, J. (2025) · Biomarker Research · doi:10.1186/s40364-025-00792-0
Unveiling Targeted Approaches to Combat Drug Resistance in Cancer Chemotherapy
Siddharth, Siddhant, Salahuddin, Mazumder, A., Kumar, R., & Debnath, A. (2025) · Current Pharmaceutical Design · doi:10.2174/0113816128380235250627143945
Cancer stem cells in cholangiocarcinoma: emerging roles as therapeutic targets
Panawan, O., Silsirivanit, A., & Araki, N. (2025) · Hepatoma Research · doi:10.20517/2394-5079.2025.05
BCAR3 confers resistance to cisplatin in head and neck squamous cell carcinoma by sustaining TGF-β/SMAD signaling
Wang, Y., Cheng, Z., Qiao, R., Zhao, Y., Li, H., Zhao, H., Lai, Q., & Teng, X. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112124
Human stem cell models for group 3 medulloblastoma uncover JARID1B as a regulator of the chromatin landscapePreprint
Qadeer, Z. A., Hou, E., Siegel, D., Westelman, S., Gudenas, B. L., Smith, K., Ismail, W. M., Wang, L., Johnson, M., Grele, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.06.689939
Additional file 3 of Single-cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers
Kabeer, F., Tran, H., Andronescu, M., Singh, G., Lee, H., Salehi, S., Wang, B., Biele, J., Brimhall, J., Gee, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26750714
Additional file 1 of Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
Cheng, Y., Mo, F., Li, Q., Han, X., Shi, H., Chen, S., Wei, Y., & Wei, X. (2021) · Figshare · doi:10.6084/m9.figshare.14370974
Additional file 2 of Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
Cheng, Y., Mo, F., Li, Q., Han, X., Shi, H., Chen, S., Wei, Y., & Wei, X. (2021) · Figshare · doi:10.6084/m9.figshare.14370977
Additional file 1 of The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-β and PD-L1
Yi, M., Zhang, J., Li, A., Niu, M., Yan, Y., Jiao, Y., Luo, S., Zhou, P., & Wu, K. (2021) · Figshare · doi:10.6084/m9.figshare.14053438
Additional file 2 of Single-cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers
Kabeer, F., Tran, H., Andronescu, M., Singh, G., Lee, H., Salehi, S., Wang, B., Biele, J., Brimhall, J., Gee, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26333394
Additional file 1 of TGF-β induced reprogramming and drug resistance in triple-negative breast cells
Guoyu, W., & Li, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19556284
Additional file 4 of Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
Cheng, Y., Mo, F., Li, Q., Han, X., Shi, H., Chen, S., Wei, Y., & Wei, X. (2021) · Figshare · doi:10.6084/m9.figshare.14370983
Additional file 1 of Single-cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers
Kabeer, F., Tran, H., Andronescu, M., Singh, G., Lee, H., Salehi, S., Wang, B., Biele, J., Brimhall, J., Gee, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26333247
Additional file 5 of Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
Cheng, Y., Mo, F., Li, Q., Han, X., Shi, H., Chen, S., Wei, Y., & Wei, X. (2021) · Figshare · doi:10.6084/m9.figshare.14370986
Additional file 6 of Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
Cheng, Y., Mo, F., Li, Q., Han, X., Shi, H., Chen, S., Wei, Y., & Wei, X. (2021) · Figshare · doi:10.6084/m9.figshare.14370989
Additional file 3 of Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
Cheng, Y., Mo, F., Li, Q., Han, X., Shi, H., Chen, S., Wei, Y., & Wei, X. (2021) · Figshare · doi:10.6084/m9.figshare.14370980
Additional file 1 of Deconvolution of tumor composition using partially available DNA methylation data
He, D., Chen, M., Wang, W., Song, C., & Qin, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20625024
Targeting mitochondrial metabolism in pancreatic cancer
Reyes‐Castellanos, G. (2021) · theses.fr (ABES) · doi:10.70675/461953f3z886ez4342za1e2z84c44a9fcaa6
The effect and molecular mechanism of N-Acetylglucosamine transferase-V in the pathogenesis of cancers
Zhang, F., Chen, L., Huang, Z., Zhang, J., He, Y., Jin, R.-R., Huang, Y., Xu, Y., Chen, A., Yin, X., et al. (2026) · Glycobiology · doi:10.1093/glycob/cwag036
Epithelial mesenchymal transition initiates precancer states in BRCA1 mutation carriersPreprint
Bar-Hai, N., Ben-Yishay, R., Arbili-Yarhi, S., Bernstein‐Molho, R., Goldinger, G., Balint‐Lahat, N., Menes, T. S., Herman, N., Noy, V., Mansour, A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.06.723061
GDF15 promotes 5-Fluorouracil and Oxaliplatin resistance by promoting stem cell-like phenotype in colorectal cancer
Hashimoto, M., Urabe, S., Hata, T., Chinen, Y., Haruna, K., Takeda, M., Sekido, Y., Hamabe, A., Ogino, T., Miyoshi, N., et al. (2026) · British Journal of Cancer · doi:10.1038/s41416-026-03379-0
The Janus face of phase II drug-metabolizing enzymes in hypoxia: guardian of antioxidant defense or accomplice in metabolic disorders?
Xin, Y., Wang, Q., Wang, S., Chang, Y., Liu, G., Duan, Y., Zhu, J., & Li, X. (2026) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2026.100326
Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma
Wang, Z., Liu, H. M., Wang, X., Teng, J., Zheng, Z., Zhang, J. I.-X., Xiao, W., Liang, Q., Li, J., Jia, X., et al. (2026) · Advanced Science · doi:10.1002/advs.202515158
Significance of GSH and H 2 S regulation for cancer: an intricate interplay between diet, microbiota, metabolic reprogramming, and immune health
Majumder, A., Majumder, S., Bano, S., Sen, K., & Nayak, K. B. (2026) · Redox Report · doi:10.1080/13510002.2026.2687238 · Cited by 1
FUS inactivation promotes leptomeningeal metastasis of lung cancer through the up-regulation of CD36
Lin, S., Yin, K., Zheng, M.-M., Tu, H., Li, W., Wu, Z., Zheng, D., Long, Y., Wu, Q., Li, D., et al. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.aee1083
BCL11B predetermines a persister state in breast cancer that is reversed by TNFα
Qi, Z., Gulati, G., Gleyzer, R., Kuo, A. H., Sikandar, S. S., Bai, H.-R., Ho, W. H. D., Qian, D.-L., Dirbas, F., Newman, A. M., et al. (2026) · Science Advances · doi:10.1126/sciadv.aec5436
Reframing cancer therapy through tumor plasticity
Shah, A. M., Marsh, B., & de Sauvage, F. J. (2026) · Nature Cancer · doi:10.1038/s43018-026-01232-0
Whole-organ analysis of TGF-beta-mediated remodelling of the tumour microenvironment by tissue clearing
Kubota, S. I. (2021) · Discovery Research Portal (University of Dundee) · doi:10.17867/10000158

Authors: Oshimori, N., Oristian, D., & Fuchs, E.
Affiliations: Rockefeller University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Fuchs, Elaine
ORCID: Oshimori, Naoki
Fuchs, Elaine
Venue: Cell
Publisher: Elsevier BV
Published: 2015-02
Volume: 160
Issue: 5
Pages: 963-976
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2015.01.043
PMC: PMC4509607
OpenAlex: W2120246444
Cited by: 471
References: 52
Citations by year: 2026: 18 · 2025: 25 · 2024: 35 · 2023: 46 · 2022: 40 · 2021: 60 · 2020: 51 · 2019: 52 · 2018: 41 · 2017: 42 · 2016: 46 · 2015: 13
FWCI: 20.54
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 390 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
New York State Department of Health
National Institutes of Health
Weill Cornell Medical College
Japan Society for the Promotion of Science
National Cancer Institute (R00CA178197, K99CA178197)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR031737)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: TGF-beta signaling, squamous cell carcinoma, cancer stem cells, tumor heterogeneity, drug resistance, tumor-stroma interface, tumor vasculature, cell cycle, p21, Nrf2, glutathione metabolism, lineage tracing, malignant progression, tumor invasion, aberrant differentiation
MeSH terms: Animals, Carcinoma, Squamous Cell, Cisplatin, Female, Glutathione, Head and Neck Neoplasms, Humans, Mice, Nude, Neoplasm Transplantation, Skin Neoplasms, Tetradecanoylphorbol Acetate, Neoplastic Stem Cells, 9,10-Dimethyl-1,2-benzanthracene, Signal Transduction, Transforming Growth Factor beta, Drug Resistance, Neoplasm, Gene Expression Profiling, NF-E2-Related Factor 2, Mice, Heterografts

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks