The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Restoration of Visual Function by Enhancing Conduction in Regenerated Axons
Open accessAbstract
Although a number of repair strategies have been shown to promote axon outgrowth following neuronal injury in the mammalian central nervous system, it remains unclear whether regenerated axons establish functional synapses and support behavior. Here, in both juvenile and adult mice, we show that either PTEN and SOCS3 co-deletion, or co-overexpression of osteopontin (OPN)/insulin-like growth factor 1 (IGF1)/ciliary neurotrophic factor (CNTF), induces regrowth of retinal axons and formation of functional synapses in the superior colliculus (SC), but not significant recovery of visual function. Further analyses suggest that regenerated axons fail to conduct action potentials from the eye to the SC due to lack of myelination. Consistent with this idea, administration of voltage-gated potassium channel blockers restores conduction and results in increased visual acuity. Thus, enhancing both regeneration and conduction effectively improves function after optic nerve injury.
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Cites
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323
Self-citationPromoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
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Self-citationMotor skill learning requires active central myelination
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Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
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Self-citationModulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury
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Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke
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Retinocollicular synapse maturation and plasticity are regulated by correlated retinal waves
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Identification of a critical sulfation in chondroitin that inhibits axonal regeneration
Pearson, C. S., Mencio, C. P., Barber, A. C., Martin, K. R., & Geller, H. M. (2018) · eLife · doi:10.7554/elife.37139 · Cited by 75
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Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex
Mezydlo, A., Treiber, N., Ullrich Gavilanes, E. M., Eichenseer, K., Ancău, M., Wens, A., Ares Carral, C., Schifferer, M., Snaidero, N., Misgeld, T., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.03.031 · Cited by 63
Sekine, Y., Lin-Moore, A., Chenette, D. M., Wang, X., Jiang, Z., Cafferty, W. B., Hammarlund, M., & Strittmatter, S. M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.058 · Cited by 52
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Metadata
- Authors
- Bei, F., Lee, H. H. C., Liu, X., Gunner, G., Jin, H., Ma, L., Wang, C., Hou, L., Hensch, T. K., Frank, E., Sanes, J. R., Chen, C., Fagiolini, M., & He, Z.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 164
- Issue
- 1-2
- Pages
- 219-232
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2234093367
- Cited by
- 267
- References
- 9
- FWCI
- 15.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
