Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke
Abstract
Improving stroke recovery by timing treatment: Patients recovering from strokes often fight a long uphill battle, with mixed results. Studying the effect of physical training on regeneration from damaged nerves in a model of stroke in rats, Wahl et al. show that timing matters. First, the researchers gave the rats a stroke, which damaged their ability to reach for food pellets with their forelimbs. The researchers then gave them physical training and treated them with an antibody to encourage neural regeneration. The rats improved more when the researchers waited until after the antibody treatment to start the training. Damaged circuits, it seems, need a little time to regrow before being called into action. Science , this issue p. 1250
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Many studies have identified molecules that block axonal sprouting after CNS injury, such as myelin proteins or chondroitin sulfate proteoglycans.
“There have been many studies of the molecules that block axonal sprouting after CNS injury, such as myelin proteins or chondroitin sulfate proteoglycans (CSPGs)8–10”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [10]
After stroke, axonal sprouting has been demonstrated in mice, rats and non-human primates.
“After stroke, axonal sprouting has been demonstrated in mice, rats and non-human primates1–4,10,38.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [10]
Much scientific study has focused on the molecular components of the injury response that block axonal sprouting, such as the glial growth inhibitors NogoA and the chondroitin sulfate proteoglycans.
“Much scientific study has focused on the molecular components of the injury response that block axonal sprouting, such as the glial growth inhibitors NogoA and the chondroitin sulfate proteoglycans8–10.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [10]
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Self-citation
- Authors
- Wahl, A. S., Omlor, W., Rubio, J. C., Chen, J. L., Zheng, H., Schröter, A., Gullo, M., Weinmann, O., Kobayashi, K., Helmchen, F., Ommer, B., & Schwab, M. E.
- Affiliations
- University of Zurich (CH)
- Heidelberg University (DE)
- Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.
- National Institute for Physiological Sciences (JP)
- Corresponding author
- Wahl, A. S.
- Schwab, M. E.
- ORCID
- Venue
- Science
- Published
- 2014-06-13
- Volume
- 344
- Issue
- 6189
- Pages
- 1250-1255
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2001165604
- Cited by
- 322
- References
- 34
- Citations by year
- 2026: 7 · 2025: 25 · 2024: 11 · 2023: 23 · 2022: 30 · 2021: 28 · 2020: 23 · 2019: 35 · 2018: 29 · 2017: 42 · 2016: 33 · 2015: 26 · 2014: 10
- FWCI
- 35.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (25560436)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Keywords
- stroke, corticospinal tract, motor recovery, immunotherapy, neurite outgrowth inhibition, axonal sprouting, forelimb function, motor rehabilitation, intensive training, spinal cord, pharmacogenetics, functional recovery
- MeSH terms
- Nogo Proteins, Stroke Rehabilitation, Animals, Female, Immunotherapy, Motor Cortex, Myelin Proteins, Physical Conditioning, Animal, Pyramidal Tracts, Prosencephalon, Recovery of Function, Rats, Long-Evans, Rats
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