Cited by 322Stroke Rehabilitation and RecoveryNerve injury and regenerationSpinal Cord Injury Research

Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke

Wahl, A. S., Omlor, W., Rubio, J. C., Chen, J. L., Zheng, H., Schröter, A., Gullo, M., Weinmann, O. +4 more·2014·Science

Abstract

Improving stroke recovery by timing treatment: Patients recovering from strokes often fight a long uphill battle, with mixed results. Studying the effect of physical training on regeneration from damaged nerves in a model of stroke in rats, Wahl et al. show that timing matters. First, the researchers gave the rats a stroke, which damaged their ability to reach for food pellets with their forelimbs. The researchers then gave them physical training and treated them with an antibody to encourage neural regeneration. The rats improved more when the researchers waited until after the antibody treatment to start the training. Damaged circuits, it seems, need a little time to regrow before being called into action. Science , this issue p. 1250

Integrity signals

Registry

Crossref · 10.1126/science.1253050

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Many studies have identified molecules that block axonal sprouting after CNS injury, such as myelin proteins or chondroitin sulfate proteoglycans.

    “There have been many studies of the molecules that block axonal sprouting after CNS injury, such as myelin proteins or chondroitin sulfate proteoglycans (CSPGs)8–10”
  • After stroke, axonal sprouting has been demonstrated in mice, rats and non-human primates.

    “After stroke, axonal sprouting has been demonstrated in mice, rats and non-human primates1–4,10,38.”
  • Much scientific study has focused on the molecular components of the injury response that block axonal sprouting, such as the glial growth inhibitors NogoA and the chondroitin sulfate proteoglycans.

    “Much scientific study has focused on the molecular components of the injury response that block axonal sprouting, such as the glial growth inhibitors NogoA and the chondroitin sulfate proteoglycans8–10.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Wahl, A. S., Omlor, W., Rubio, J. C., Chen, J. L., Zheng, H., Schröter, A., Gullo, M., Weinmann, O., Kobayashi, K., Helmchen, F., Ommer, B., & Schwab, M. E.
Affiliations
  • University of Zurich (CH)
  • Heidelberg University (DE)
  • Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.
  • National Institute for Physiological Sciences (JP)
Corresponding author
  • Wahl, A. S.
  • Schwab, M. E.
Venue
Science
Published
2014-06-13
Volume
344
Issue
6189
Pages
1250-1255
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2001165604
Cited by
322
References
34
Citations by year
2026: 7 · 2025: 25 · 2024: 11 · 2023: 23 · 2022: 30 · 2021: 28 · 2020: 23 · 2019: 35 · 2018: 29 · 2017: 42 · 2016: 33 · 2015: 26 · 2014: 10
FWCI
35.92
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Funders
Japan Society for the Promotion of Science (25560436)
Topics
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
Keywords
stroke, corticospinal tract, motor recovery, immunotherapy, neurite outgrowth inhibition, axonal sprouting, forelimb function, motor rehabilitation, intensive training, spinal cord, pharmacogenetics, functional recovery
MeSH terms
Nogo Proteins, Stroke Rehabilitation, Animals, Female, Immunotherapy, Motor Cortex, Myelin Proteins, Physical Conditioning, Animal, Pyramidal Tracts, Prosencephalon, Recovery of Function, Rats, Long-Evans, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review